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Volumn 205, Issue 1, 2009, Pages 50-56

Obese reversal by a chronic energy restricted diet leaves an increased Arc NPY/AgRP, but no alteration in POMC/CART, mRNA expression in diet-induced obese mice

Author keywords

Energy intake; Hypothalamus; Neuropeptide; Obese reversal; Obesity; Weight loss

Indexed keywords

AGOUTI RELATED PROTEIN; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; LEPTIN; MESSENGER RNA; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN;

EID: 70349299827     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2009.07.003     Document Type: Article
Times cited : (37)

References (53)
  • 1
    • 0041419354 scopus 로고    scopus 로고
    • Identification of hypothalamic nuclei involved in the orexigenic effect of melanin-concentrating hormone
    • Abbott C.R., Kennedy A.R., Wren A.M., Rossi M., Murphy K.G., Seal L.J., et al. Identification of hypothalamic nuclei involved in the orexigenic effect of melanin-concentrating hormone. Endocrinology 144 (2003) 3943-3949
    • (2003) Endocrinology , vol.144 , pp. 3943-3949
    • Abbott, C.R.1    Kennedy, A.R.2    Wren, A.M.3    Rossi, M.4    Murphy, K.G.5    Seal, L.J.6
  • 2
    • 4644228073 scopus 로고    scopus 로고
    • Effects of nutritional status and gonadal steroids on expression of appetite-regulatory genes in the hypothalamic arcuate nucleus of sheep
    • Archer Z.A., Findlay P.A., McMillen S.R., Rhind S.M., and Adam C.L. Effects of nutritional status and gonadal steroids on expression of appetite-regulatory genes in the hypothalamic arcuate nucleus of sheep. J Endocrinol 182 (2004) 409-419
    • (2004) J Endocrinol , vol.182 , pp. 409-419
    • Archer, Z.A.1    Findlay, P.A.2    McMillen, S.R.3    Rhind, S.M.4    Adam, C.L.5
  • 3
    • 33751191841 scopus 로고    scopus 로고
    • Role of neuropeptides in appetite regulation and obesity-a review
    • Arora S., and Anubhuti. Role of neuropeptides in appetite regulation and obesity-a review. Neuropeptides 40 (2006) 375-401
    • (2006) Neuropeptides , vol.40 , pp. 375-401
    • Arora, S.1    Anubhuti2
  • 4
    • 15544362925 scopus 로고    scopus 로고
    • The gut and energy balance: visceral allies in the obesity wars
    • Badman M.K., and Flier J.S. The gut and energy balance: visceral allies in the obesity wars. Science 307 (2005) 1909-1914
    • (2005) Science , vol.307 , pp. 1909-1914
    • Badman, M.K.1    Flier, J.S.2
  • 5
    • 0142116115 scopus 로고    scopus 로고
    • Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression
    • Bi S., Robinson B.M., and Moran T.H. Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression. Am J Physiol Regul Integr Comp Physiol 285 (2003) R1030-R1036
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.285
    • Bi, S.1    Robinson, B.M.2    Moran, T.H.3
  • 6
    • 34848929006 scopus 로고    scopus 로고
    • The physiology of body weight regulation: are we too efficient for our own good?
    • Dokken B.B., and Tsao T.-S. The physiology of body weight regulation: are we too efficient for our own good?. Diab Spectr 20 (2007) 166-170
    • (2007) Diab Spectr , vol.20 , pp. 166-170
    • Dokken, B.B.1    Tsao, T.-S.2
  • 7
    • 0032872203 scopus 로고    scopus 로고
    • Involvement of agouti-related protein, an endogenous antagonist of hypothalamic melanocortin receptor, in leptin action
    • Ebihara K., Ogawa Y., Katsuura G., Numata Y., Masuzaki H., Satoh N., et al. Involvement of agouti-related protein, an endogenous antagonist of hypothalamic melanocortin receptor, in leptin action. Diabetes 48 (1999) 2028-2033
    • (1999) Diabetes , vol.48 , pp. 2028-2033
    • Ebihara, K.1    Ogawa, Y.2    Katsuura, G.3    Numata, Y.4    Masuzaki, H.5    Satoh, N.6
  • 8
    • 9244234318 scopus 로고    scopus 로고
    • Effect of agouti-related protein in regulation of the hypothalamic-pituitary-thyroid axis in the melanocortin 4 receptor knockout mouse
    • Fekete C., Marks D.L., Sarkar S., Emerson C.H., Rand W.M., Cone R.D., et al. Effect of agouti-related protein in regulation of the hypothalamic-pituitary-thyroid axis in the melanocortin 4 receptor knockout mouse. Endocrinology 145 (2004) 4816-4821
    • (2004) Endocrinology , vol.145 , pp. 4816-4821
    • Fekete, C.1    Marks, D.L.2    Sarkar, S.3    Emerson, C.H.4    Rand, W.M.5    Cone, R.D.6
  • 9
    • 4344610421 scopus 로고    scopus 로고
    • Distribution of NPY receptors in the hypothalamus
    • Fetissov S.O., Kopp J., and Hokfelt T. Distribution of NPY receptors in the hypothalamus. Neuropeptides 38 (2004) 175-188
    • (2004) Neuropeptides , vol.38 , pp. 175-188
    • Fetissov, S.O.1    Kopp, J.2    Hokfelt, T.3
  • 10
    • 0038148559 scopus 로고    scopus 로고
    • Neuropeptide y targets in the hypothalamus: nitric oxide synthesizing neurones express Y1 receptor
    • Fetissov S.O., Xu Z.Q., Byrne L.C., Hassani H., Ernfors P., and Hokfelt T. Neuropeptide y targets in the hypothalamus: nitric oxide synthesizing neurones express Y1 receptor. J Neuroendocrinol 15 (2003) 754-760
    • (2003) J Neuroendocrinol , vol.15 , pp. 754-760
    • Fetissov, S.O.1    Xu, Z.Q.2    Byrne, L.C.3    Hassani, H.4    Ernfors, P.5    Hokfelt, T.6
  • 11
    • 0037123748 scopus 로고    scopus 로고
    • Characterization of diet-induced obese rats that develop persistent obesity after 6 months of high-fat followed by 1 month of low-fat diet
    • Gao J., Ghibaudi L., van Heek M., and Hwa J.J. Characterization of diet-induced obese rats that develop persistent obesity after 6 months of high-fat followed by 1 month of low-fat diet. Brain Res 936 (2002) 87-90
    • (2002) Brain Res , vol.936 , pp. 87-90
    • Gao, J.1    Ghibaudi, L.2    van Heek, M.3    Hwa, J.J.4
  • 12
    • 0032130554 scopus 로고    scopus 로고
    • Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
    • Hahn T.M., Breininger J.F., Baskin D.G., and Schwartz M.W. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nat Neurosci 1 (1998) 271-272
    • (1998) Nat Neurosci , vol.1 , pp. 271-272
    • Hahn, T.M.1    Breininger, J.F.2    Baskin, D.G.3    Schwartz, M.W.4
  • 14
    • 0032968698 scopus 로고    scopus 로고
    • Altered energy balance causes selective changes in melanocortin-4 (MC4-R), but not melanocortin-3 (MC3-R), receptors in specific hypothalamic regions: further evidence that activation of MC4-R is a physiological inhibitor of feeding
    • Harrold J.A., Widdowson P.S., and Williams G. Altered energy balance causes selective changes in melanocortin-4 (MC4-R), but not melanocortin-3 (MC3-R), receptors in specific hypothalamic regions: further evidence that activation of MC4-R is a physiological inhibitor of feeding. Diabetes 48 (1999) 267-271
    • (1999) Diabetes , vol.48 , pp. 267-271
    • Harrold, J.A.1    Widdowson, P.S.2    Williams, G.3
  • 15
    • 0033583796 scopus 로고    scopus 로고
    • Changes in hypothalamic agouti-related protein (AGRP), but not alpha-MSH or pro-opiomelanocortin concentrations in dietary-obese and food-restricted rats
    • Harrold J.A., Williams G., and Widdowson P.S. Changes in hypothalamic agouti-related protein (AGRP), but not alpha-MSH or pro-opiomelanocortin concentrations in dietary-obese and food-restricted rats. Biochem Biophys Res Commun 258 (1999) 574-577
    • (1999) Biochem Biophys Res Commun , vol.258 , pp. 574-577
    • Harrold, J.A.1    Williams, G.2    Widdowson, P.S.3
  • 16
    • 3242675175 scopus 로고    scopus 로고
    • Adipogenic and orexigenic effects of the ghrelin-receptor ligand tabimorelin are diminished in leptin-signalling-deficient ZDF rats
    • Holm A.M., Johansen P.B., Ahnfelt-Ronne I., and Romer J. Adipogenic and orexigenic effects of the ghrelin-receptor ligand tabimorelin are diminished in leptin-signalling-deficient ZDF rats. Eur J Endocrinol 150 (2004) 893-904
    • (2004) Eur J Endocrinol , vol.150 , pp. 893-904
    • Holm, A.M.1    Johansen, P.B.2    Ahnfelt-Ronne, I.3    Romer, J.4
  • 17
    • 0242353028 scopus 로고    scopus 로고
    • Altered levels of POMC, AgRP and MC4-R mRNA expression in the hypothalamus and other parts of the limbic system of mice prone or resistant to chronic high-energy diet-induced obesity
    • Huang X.F., Han M., South T., and Storlien L. Altered levels of POMC, AgRP and MC4-R mRNA expression in the hypothalamus and other parts of the limbic system of mice prone or resistant to chronic high-energy diet-induced obesity. Brain Res 992 (2003) 9-19
    • (2003) Brain Res , vol.992 , pp. 9-19
    • Huang, X.F.1    Han, M.2    South, T.3    Storlien, L.4
  • 18
    • 0038411365 scopus 로고    scopus 로고
    • The level of NPY receptor mRNA expression in diet-induced obese and resistant mice
    • Huang X.F., Han M., and Storlien L.H. The level of NPY receptor mRNA expression in diet-induced obese and resistant mice. Brain Res Mol Brain Res 115 (2003) 21-28
    • (2003) Brain Res Mol Brain Res , vol.115 , pp. 21-28
    • Huang, X.F.1    Han, M.2    Storlien, L.H.3
  • 19
    • 48349138756 scopus 로고    scopus 로고
    • Ventromedial hypothalamic NPY Y2 receptor in the maintenance of body weight in diet-induced obesity in mice
    • Huang X.F., Yu Y., Li Y., Tim S., Deng C., and Wang Q. Ventromedial hypothalamic NPY Y2 receptor in the maintenance of body weight in diet-induced obesity in mice. Neurochem Res 33 (2008) 1881-1888
    • (2008) Neurochem Res , vol.33 , pp. 1881-1888
    • Huang, X.F.1    Yu, Y.2    Li, Y.3    Tim, S.4    Deng, C.5    Wang, Q.6
  • 20
    • 18044392768 scopus 로고    scopus 로고
    • Differential expression of dopamine D2 and D4 receptor and tyrosine hydroxylase mRNA in mice prone, or resistant, to chronic high-fat diet-induced obesity
    • Huang X.F., Yu Y., Zavitsanou K., Han M., and Storlien L. Differential expression of dopamine D2 and D4 receptor and tyrosine hydroxylase mRNA in mice prone, or resistant, to chronic high-fat diet-induced obesity. Brain Res Mol Brain Res 135 (2005) 150-161
    • (2005) Brain Res Mol Brain Res , vol.135 , pp. 150-161
    • Huang, X.F.1    Yu, Y.2    Zavitsanou, K.3    Han, M.4    Storlien, L.5
  • 21
    • 0036293591 scopus 로고    scopus 로고
    • Leptin signaling, adiposity, and energy balance
    • Jequier E. Leptin signaling, adiposity, and energy balance. Ann NY Acad Sci 967 (2002) 379-388
    • (2002) Ann NY Acad Sci , vol.967 , pp. 379-388
    • Jequier, E.1
  • 22
    • 9444260471 scopus 로고    scopus 로고
    • Transcriptional regulation of agouti-related protein (Agrp) in transgenic mice
    • Kaelin C.B., Xu A.W., Lu X.-Y., and Barsh G.S. Transcriptional regulation of agouti-related protein (Agrp) in transgenic mice. Endocrinology 145 (2004) 5798-5806
    • (2004) Endocrinology , vol.145 , pp. 5798-5806
    • Kaelin, C.B.1    Xu, A.W.2    Lu, X.-Y.3    Barsh, G.S.4
  • 23
    • 4344638216 scopus 로고    scopus 로고
    • Y1 receptors regulate aggressive behavior by modulating serotonin pathways
    • Karl T., Lin S., Schwarzer C., Sainsbury A., Couzens M., Wittmann W., et al. Y1 receptors regulate aggressive behavior by modulating serotonin pathways. PNAS 101 (2004) 12742-12747
    • (2004) PNAS , vol.101 , pp. 12742-12747
    • Karl, T.1    Lin, S.2    Schwarzer, C.3    Sainsbury, A.4    Couzens, M.5    Wittmann, W.6
  • 24
    • 0034265703 scopus 로고    scopus 로고
    • Does weight loss maintenance become easier over time?
    • Klem M.L., Wing R.R., Lang W., McGuire M.T., and Hill J.O. Does weight loss maintenance become easier over time?. Obes Res 8 (2000) 438-444
    • (2000) Obes Res , vol.8 , pp. 438-444
    • Klem, M.L.1    Wing, R.R.2    Lang, W.3    McGuire, M.T.4    Hill, J.O.5
  • 25
    • 0030836728 scopus 로고    scopus 로고
    • A descriptive study of individuals successful at long-term maintenance of substantial weight loss
    • Klem M.L., Wing R.R., McGuire M.T., Seagle H.M., and Hill J.O. A descriptive study of individuals successful at long-term maintenance of substantial weight loss. Am J Clin Nutr 66 (1997) 239-246
    • (1997) Am J Clin Nutr , vol.66 , pp. 239-246
    • Klem, M.L.1    Wing, R.R.2    McGuire, M.T.3    Seagle, H.M.4    Hill, J.O.5
  • 27
    • 0037066584 scopus 로고    scopus 로고
    • Ups and downs for neuropeptides in body weight homeostasis: pharmacological potential of cocaine amphetamine regulated transcript and pre-proglucagon-derived peptides
    • Larsen P.J., Vrang N., Tang-Christensen M., Jensen P.B., Hay-Schmidt A., Romer J., et al. Ups and downs for neuropeptides in body weight homeostasis: pharmacological potential of cocaine amphetamine regulated transcript and pre-proglucagon-derived peptides. Eur J Pharmacol 440 (2002) 159-172
    • (2002) Eur J Pharmacol , vol.440 , pp. 159-172
    • Larsen, P.J.1    Vrang, N.2    Tang-Christensen, M.3    Jensen, P.B.4    Hay-Schmidt, A.5    Romer, J.6
  • 28
    • 2942648684 scopus 로고    scopus 로고
    • Circulating ghrelin is sensitive to changes in body weight during a diet and exercise program in normal-weight young women
    • Leidy H.J., Gardner J.K., Frye B.R., Snook M.L., Schuchert M.K., Richard E.L., et al. Circulating ghrelin is sensitive to changes in body weight during a diet and exercise program in normal-weight young women. J Clin Endocrinol Metab 89 (2004) 2659-2664
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2659-2664
    • Leidy, H.J.1    Gardner, J.K.2    Frye, B.R.3    Snook, M.L.4    Schuchert, M.K.5    Richard, E.L.6
  • 29
    • 1642276360 scopus 로고    scopus 로고
    • Chronic exercise lowers the defended body weight gain and adiposity in diet-induced obese rats
    • Levin B.E., and Dunn-Meynell A.A. Chronic exercise lowers the defended body weight gain and adiposity in diet-induced obese rats. Am J Physiol Regul Integr Comp Physiol 286 (2004) R771-R778
    • (2004) Am J Physiol Regul Integr Comp Physiol , vol.286
    • Levin, B.E.1    Dunn-Meynell, A.A.2
  • 30
    • 0030938684 scopus 로고    scopus 로고
    • Dysregulation of arcuate nucleus preproneuropeptide Y mRNA in diet-induced obese rats
    • Levin B.E., and Dunn-Meynell A.A. Dysregulation of arcuate nucleus preproneuropeptide Y mRNA in diet-induced obese rats. Am J Physiol 272 (1997) R1365-R1370
    • (1997) Am J Physiol , vol.272
    • Levin, B.E.1    Dunn-Meynell, A.A.2
  • 31
    • 0031958083 scopus 로고    scopus 로고
    • Defense of differing body weight set points in diet-induced obese and resistant rats
    • Levin B.E., and Keesey R.E. Defense of differing body weight set points in diet-induced obese and resistant rats. Am J Physiol 274 (1998) R412-419
    • (1998) Am J Physiol , vol.274
    • Levin, B.E.1    Keesey, R.E.2
  • 32
    • 0034107525 scopus 로고    scopus 로고
    • Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice
    • Lin S., Thomas T.C., Storlien L.H., and Huang X.F. Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice. Int J Obes Relat Metab Disord 24 (2000) 639-646
    • (2000) Int J Obes Relat Metab Disord , vol.24 , pp. 639-646
    • Lin, S.1    Thomas, T.C.2    Storlien, L.H.3    Huang, X.F.4
  • 35
    • 0031888157 scopus 로고    scopus 로고
    • Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin
    • Mizuno T.M., Kleopoulos S.P., Bergen H.T., Roberts J.L., Priest C.A., and Mobbs C.V. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin. Diabetes 47 (1998) 294-297
    • (1998) Diabetes , vol.47 , pp. 294-297
    • Mizuno, T.M.1    Kleopoulos, S.P.2    Bergen, H.T.3    Roberts, J.L.4    Priest, C.A.5    Mobbs, C.V.6
  • 36
    • 0033305272 scopus 로고    scopus 로고
    • Fasting regulates hypothalamic neuropeptide Y, agouti-related peptide, and proopiomelanocortin in diabetic mice independent of changes in leptin or insulin
    • Mizuno T.M., Makimura H., Silverstein J., Roberts J.L., Lopingco T., and Mobbs C.V. Fasting regulates hypothalamic neuropeptide Y, agouti-related peptide, and proopiomelanocortin in diabetic mice independent of changes in leptin or insulin. Endocrinology 140 (1999) 4551-4557
    • (1999) Endocrinology , vol.140 , pp. 4551-4557
    • Mizuno, T.M.1    Makimura, H.2    Silverstein, J.3    Roberts, J.L.4    Lopingco, T.5    Mobbs, C.V.6
  • 37
    • 0031054698 scopus 로고    scopus 로고
    • Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution
    • Montague C.T., Prins J.B., Sanders L., Digby J.E., and O'Rahilly S. Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution. Diabetes 46 (1997) 342-347
    • (1997) Diabetes , vol.46 , pp. 342-347
    • Montague, C.T.1    Prins, J.B.2    Sanders, L.3    Digby, J.E.4    O'Rahilly, S.5
  • 38
    • 0032852850 scopus 로고    scopus 로고
    • Leptin and neuropeptide Y (NPY) modulate nitric oxide synthase: further evidence for a role of nitric oxide in feeding
    • Morley J.E., Alshaher M.M., Farr S.A., Flood J.F., and Kumar V.B. Leptin and neuropeptide Y (NPY) modulate nitric oxide synthase: further evidence for a role of nitric oxide in feeding. Peptides 20 (1999) 595-600
    • (1999) Peptides , vol.20 , pp. 595-600
    • Morley, J.E.1    Alshaher, M.M.2    Farr, S.A.3    Flood, J.F.4    Kumar, V.B.5
  • 39
    • 0028916793 scopus 로고
    • Nitric oxide synthase inhibition and food intake: effects on motivation to eat and in female mice
    • Morley J.E., Farr S.A., Suarez M.D., and Flood J.F. Nitric oxide synthase inhibition and food intake: effects on motivation to eat and in female mice. Pharmacol Biochem Behav 50 (1995) 369-373
    • (1995) Pharmacol Biochem Behav , vol.50 , pp. 369-373
    • Morley, J.E.1    Farr, S.A.2    Suarez, M.D.3    Flood, J.F.4
  • 40
    • 0025776498 scopus 로고
    • Evidence that nitric oxide modulates food intake in mice
    • Morley J.E., and Flood J.F. Evidence that nitric oxide modulates food intake in mice. Life Sci 49 (1991) 707-711
    • (1991) Life Sci , vol.49 , pp. 707-711
    • Morley, J.E.1    Flood, J.F.2
  • 41
    • 33644665508 scopus 로고    scopus 로고
    • Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling
    • Morrison C.D., Morton G.J., Niswender K.D., Gelling R.W., and Schwartz M.W. Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling. Am J Physiol Endocrinol Metab 289 (2005) E1051-E1057
    • (2005) Am J Physiol Endocrinol Metab , vol.289
    • Morrison, C.D.1    Morton, G.J.2    Niswender, K.D.3    Gelling, R.W.4    Schwartz, M.W.5
  • 43
    • 0842303562 scopus 로고    scopus 로고
    • Agouti-related protein (83-132) is a competitive antagonist at the human melanocortin-4 receptor: no evidence for differential interactions with pro-opiomelanocortin-derived ligands
    • Pritchard L.E., Armstrong D., Davies N., Oliver R.L., Schmitz C.A., Brennand J.C., et al. Agouti-related protein (83-132) is a competitive antagonist at the human melanocortin-4 receptor: no evidence for differential interactions with pro-opiomelanocortin-derived ligands. J Endocrinol 180 (2004) 183-191
    • (2004) J Endocrinol , vol.180 , pp. 183-191
    • Pritchard, L.E.1    Armstrong, D.2    Davies, N.3    Oliver, R.L.4    Schmitz, C.A.5    Brennand, J.C.6
  • 44
    • 0027487229 scopus 로고
    • AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition Ad Hoc Writing Committee on the Reformulation of the AIN-76A Rodent Diet
    • Reeves P.G., Nielsen F.H., and Fahey Jr. G.C. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition Ad Hoc Writing Committee on the Reformulation of the AIN-76A Rodent Diet. J Nutr 123 (1993) 1939-1951
    • (1993) J Nutr , vol.123 , pp. 1939-1951
    • Reeves, P.G.1    Nielsen, F.H.2    Fahey Jr., G.C.3
  • 45
    • 0030775971 scopus 로고    scopus 로고
    • Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus
    • Schwartz M.W., Seeley R.J., Woods S.C., Weigle D.S., Campfield L.A., Burn P., et al. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 46 (1997) 2119-2123
    • (1997) Diabetes , vol.46 , pp. 2119-2123
    • Schwartz, M.W.1    Seeley, R.J.2    Woods, S.C.3    Weigle, D.S.4    Campfield, L.A.5    Burn, P.6
  • 46
  • 48
    • 9644308079 scopus 로고    scopus 로고
    • Changes of hypothalamic alpha-MSH and CART peptide expression in diet-induced obese rats
    • Tian D.R., Li X.D., Shi Y.S., Wan Y., Wang X.M., Chang J.K., et al. Changes of hypothalamic alpha-MSH and CART peptide expression in diet-induced obese rats. Peptides 25 (2004) 2147-2153
    • (2004) Peptides , vol.25 , pp. 2147-2153
    • Tian, D.R.1    Li, X.D.2    Shi, Y.S.3    Wan, Y.4    Wang, X.M.5    Chang, J.K.6
  • 49
    • 0034179783 scopus 로고    scopus 로고
    • Obesity: a disease or a biological adaptation?
    • Tremblay A., and Doucet E. Obesity: a disease or a biological adaptation?. Obes Rev 1 (2000) 27-35
    • (2000) Obes Rev , vol.1 , pp. 27-35
    • Tremblay, A.1    Doucet, E.2
  • 50
    • 33751548654 scopus 로고    scopus 로고
    • A comparative study of the central effects of specific Proopiomelancortin (POMC)-derived melanocortin peptides on food intake and body weight in Pomc null mice
    • Tung Y.C.L., Piper S.J., Yeung D., O'Rahilly S., and Coll A.P. A comparative study of the central effects of specific Proopiomelancortin (POMC)-derived melanocortin peptides on food intake and body weight in Pomc null mice. Endocrinology 147 (2006) 5940-5947
    • (2006) Endocrinology , vol.147 , pp. 5940-5947
    • Tung, Y.C.L.1    Piper, S.J.2    Yeung, D.3    O'Rahilly, S.4    Coll, A.P.5
  • 51
    • 0031738095 scopus 로고    scopus 로고
    • Short- and long-term changes in serum leptin in dieting obese women: effects of caloric restriction and weight loss
    • Wadden T.A., Considine R.V., Foster G.D., Anderson D.A., Sarwer D.B., and Caro J.S. Short- and long-term changes in serum leptin in dieting obese women: effects of caloric restriction and weight loss. J Clin Endocrinol Metab 83 (1998) 214-218
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 214-218
    • Wadden, T.A.1    Considine, R.V.2    Foster, G.D.3    Anderson, D.A.4    Sarwer, D.B.5    Caro, J.S.6
  • 52
    • 0036088134 scopus 로고    scopus 로고
    • Effects of dietary fat types on body fatness, leptin, and ARC leptin receptor, NPY, and AgRP mRNA expression
    • Wang H., Storlien L.H., and Huang X.F. Effects of dietary fat types on body fatness, leptin, and ARC leptin receptor, NPY, and AgRP mRNA expression. Am J Physiol Endocrinol Metab 282 (2002) E1352-E1359
    • (2002) Am J Physiol Endocrinol Metab , vol.282
    • Wang, H.1    Storlien, L.H.2    Huang, X.F.3
  • 53
    • 0032744366 scopus 로고    scopus 로고
    • Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat
    • Willesen M.G., Kristensen P., and Romer J. Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat. Neuroendocrinology 70 (1999) 306-316
    • (1999) Neuroendocrinology , vol.70 , pp. 306-316
    • Willesen, M.G.1    Kristensen, P.2    Romer, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.