메뉴 건너뛰기




Volumn 37, Issue , 2013, Pages 163-172

Okadaic acid induced neurotoxicity: An emerging tool to study Alzheimer's disease pathology

Author keywords

Alzheimer's disease; Neurotoxicity; Okadaic acid

Indexed keywords

AMYLOID BETA PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROTRANSMITTER; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; TAU PROTEIN;

EID: 84878863522     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2013.05.002     Document Type: Review
Times cited : (120)

References (130)
  • 1
    • 0033677809 scopus 로고    scopus 로고
    • C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease
    • Abraha A., Ghoshal N., Gamblin T.C., Cryns V., Berry R.W., Kuret J., et al. C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease. J Cell Sci 2000, 113(Pt 21):3737-3745.
    • (2000) J Cell Sci , vol.113 , Issue.PART 21 , pp. 3737-3745
    • Abraha, A.1    Ghoshal, N.2    Gamblin, T.C.3    Cryns, V.4    Berry, R.W.5    Kuret, J.6
  • 2
    • 56949092585 scopus 로고    scopus 로고
    • Okadaic acid protects human neuroblastoma SH-SY5Y cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis
    • Ahn K.H., Kim Y.S., Kim S.Y., Huh Y., Park C., Jeong J.W. Okadaic acid protects human neuroblastoma SH-SY5Y cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis. Neurosci Lett 2009, 449(2):93-97.
    • (2009) Neurosci Lett , vol.449 , Issue.2 , pp. 93-97
    • Ahn, K.H.1    Kim, Y.S.2    Kim, S.Y.3    Huh, Y.4    Park, C.5    Jeong, J.W.6
  • 3
    • 0027162369 scopus 로고
    • Okadaic acid induces early changes in microtubule-associated protein 2 and tau phosphorylation prior to neurodegeneration in cultured cortical neurons
    • Arias C., Sharma N., Davies P., Shafit-Zagardo B. Okadaic acid induces early changes in microtubule-associated protein 2 and tau phosphorylation prior to neurodegeneration in cultured cortical neurons. J Neurochem 1993, 61(2):673-682.
    • (1993) J Neurochem , vol.61 , Issue.2 , pp. 673-682
    • Arias, C.1    Sharma, N.2    Davies, P.3    Shafit-Zagardo, B.4
  • 4
    • 0032191966 scopus 로고    scopus 로고
    • The protein phosphatase inhibitor okadaic acid induces heat shock protein expression and neurodegeneration in rat hippocampus in vivo
    • Arias C., Becerra-Garcia F., Arrieta I., Tapia R. The protein phosphatase inhibitor okadaic acid induces heat shock protein expression and neurodegeneration in rat hippocampus in vivo. Exp Neurol 1998, 153(2):242-254.
    • (1998) Exp Neurol , vol.153 , Issue.2 , pp. 242-254
    • Arias, C.1    Becerra-Garcia, F.2    Arrieta, I.3    Tapia, R.4
  • 5
    • 34548036227 scopus 로고    scopus 로고
    • Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
    • Ballatore C., Lee V.M., Trojanowski J.Q. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat Rev Neurosci 2007, 8(9):663-672.
    • (2007) Nat Rev Neurosci , vol.8 , Issue.9 , pp. 663-672
    • Ballatore, C.1    Lee, V.M.2    Trojanowski, J.Q.3
  • 6
    • 84868514765 scopus 로고    scopus 로고
    • Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies
    • Ballatore C., Brunden K.R., Huryn D.M., Trojanowski J.Q., Lee V.M., Smith A.B. Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies. J Med Chem 2012, 55(21):8979-8996.
    • (2012) J Med Chem , vol.55 , Issue.21 , pp. 8979-8996
    • Ballatore, C.1    Brunden, K.R.2    Huryn, D.M.3    Trojanowski, J.Q.4    Lee, V.M.5    Smith, A.B.6
  • 7
    • 0035707590 scopus 로고    scopus 로고
    • Concentration-dependent effects of protein phosphatase (PP) inhibitors implicate PP1 and PP2A in different stages of memory formation
    • Bennett P.C., Zhao W., Ng K.T. Concentration-dependent effects of protein phosphatase (PP) inhibitors implicate PP1 and PP2A in different stages of memory formation. Neurobiol Learn Mem 2001, 75(1):91-110.
    • (2001) Neurobiol Learn Mem , vol.75 , Issue.1 , pp. 91-110
    • Bennett, P.C.1    Zhao, W.2    Ng, K.T.3
  • 8
    • 0142011166 scopus 로고    scopus 로고
    • Novel effects on memory observed following unilateral intracranial administration of okadaic acid, cyclosporin A, FK506 and [MeVal4]CyA
    • Bennett P.C., Moutsoulas P., Lawen A., Perini E., Ng K.T. Novel effects on memory observed following unilateral intracranial administration of okadaic acid, cyclosporin A, FK506 and [MeVal4]CyA. Brain Res 2003, 988(1-2):56-68.
    • (2003) Brain Res , vol.988 , Issue.1-2 , pp. 56-68
    • Bennett, P.C.1    Moutsoulas, P.2    Lawen, A.3    Perini, E.4    Ng, K.T.5
  • 9
    • 0023691731 scopus 로고
    • Inhibitory effect of a marine- sponge toxin, okadaic acid, on protein phosphatases
    • Bialojan C., Takai A. Inhibitory effect of a marine- sponge toxin, okadaic acid, on protein phosphatases. Biochem J 1988, 256:283-290.
    • (1988) Biochem J , vol.256 , pp. 283-290
    • Bialojan, C.1    Takai, A.2
  • 11
    • 0025183062 scopus 로고
    • Induction of Alzheimer antigens by an uncoupler of oxidative phosphorylation
    • Blass J.P., Baker A.C., Ko L., Black R.S. Induction of Alzheimer antigens by an uncoupler of oxidative phosphorylation. Arch Neurol 1990, 47(8):864-869.
    • (1990) Arch Neurol , vol.47 , Issue.8 , pp. 864-869
    • Blass, J.P.1    Baker, A.C.2    Ko, L.3    Black, R.S.4
  • 12
    • 0027476024 scopus 로고
    • A synaptic model of memory: long-term potentiation in the hippocampus
    • Bliss T.V., Collingridge G.L. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 1993, 361(6407):31-39.
    • (1993) Nature , vol.361 , Issue.6407 , pp. 31-39
    • Bliss, T.V.1    Collingridge, G.L.2
  • 13
    • 0025823502 scopus 로고
    • The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells
    • Boe R., Gjertsen B.T., Vintermyr O.K., Houge G., Lanotte M., Doskeland S.O. The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells. Exp Cell Res 1991, 195(1):237-246.
    • (1991) Exp Cell Res , vol.195 , Issue.1 , pp. 237-246
    • Boe, R.1    Gjertsen, B.T.2    Vintermyr, O.K.3    Houge, G.4    Lanotte, M.5    Doskeland, S.O.6
  • 14
    • 0043172479 scopus 로고    scopus 로고
    • The glutamatergic system and Alzheimer's disease: therapeutic implications
    • Butterfield D.A., Pocernich C.B. The glutamatergic system and Alzheimer's disease: therapeutic implications. CNS Drugs 2003, 17:641-652.
    • (2003) CNS Drugs , vol.17 , pp. 641-652
    • Butterfield, D.A.1    Pocernich, C.B.2
  • 15
    • 0030093869 scopus 로고    scopus 로고
    • Apoptosis induced in neuronal cultures by either the phosphatase inhibitor okadaic acid or the kinase inhibitor staurosporine is attenuated by isoquinolinesulfonamides H-7, H-8, and H-9
    • Cagnoli C.M., Kharlamov E., Atabay C., Uz T., Manev H. Apoptosis induced in neuronal cultures by either the phosphatase inhibitor okadaic acid or the kinase inhibitor staurosporine is attenuated by isoquinolinesulfonamides H-7, H-8, and H-9. J Mol Neurosci 1996, 7(1):65-76.
    • (1996) J Mol Neurosci , vol.7 , Issue.1 , pp. 65-76
    • Cagnoli, C.M.1    Kharlamov, E.2    Atabay, C.3    Uz, T.4    Manev, H.5
  • 16
    • 84860216294 scopus 로고    scopus 로고
    • Intraneuronal Aβ accumulation, amyloid plaques, and synapse pathology in Alzheimer's disease
    • Capetillo-Zarate E., Gracia L., Tampellini D., Gouras G.K. Intraneuronal Aβ accumulation, amyloid plaques, and synapse pathology in Alzheimer's disease. Neurodegener Dis 2012, 10(1-4):56-59.
    • (2012) Neurodegener Dis , vol.10 , Issue.1-4 , pp. 56-59
    • Capetillo-Zarate, E.1    Gracia, L.2    Tampellini, D.3    Gouras, G.K.4
  • 18
    • 3042513691 scopus 로고    scopus 로고
    • Mitochondria dysfunction of Alzheimer's disease cybrids enhances Abeta toxicity
    • Cardoso S.M., Santana I., Swerdlow R.H., Oliveira C.R. Mitochondria dysfunction of Alzheimer's disease cybrids enhances Abeta toxicity. J Neurochem 2004, 89(6):1417-1426.
    • (2004) J Neurochem , vol.89 , Issue.6 , pp. 1417-1426
    • Cardoso, S.M.1    Santana, I.2    Swerdlow, R.H.3    Oliveira, C.R.4
  • 19
    • 79954473644 scopus 로고    scopus 로고
    • Neurobiological aspects of Alzheimer's disease
    • Chopra K., Misra S., Kuhad A. Neurobiological aspects of Alzheimer's disease. Expert Opin Ther Targets 2011, 15(5):535-555.
    • (2011) Expert Opin Ther Targets , vol.15 , Issue.5 , pp. 535-555
    • Chopra, K.1    Misra, S.2    Kuhad, A.3
  • 20
    • 0000933192 scopus 로고
    • β-Amyloid precursor protein-like immunoreactivity can be altered in humans by drugs affecting neurotransmitter function
    • Clarke N.A., Webster M., Francis P.T., Procter A.W., Hodgkiss A.D., Bowen D.M. β-Amyloid precursor protein-like immunoreactivity can be altered in humans by drugs affecting neurotransmitter function. Neurodegeneration 1993, 2:243-248.
    • (1993) Neurodegeneration , vol.2 , pp. 243-248
    • Clarke, N.A.1    Webster, M.2    Francis, P.T.3    Procter, A.W.4    Hodgkiss, A.D.5    Bowen, D.M.6
  • 21
    • 0024985037 scopus 로고
    • The structure and regulation of protein phosphatases
    • Cohen P. The structure and regulation of protein phosphatases. Adv Second Messenger Phosphoprotein Res 1990, 24:230-235.
    • (1990) Adv Second Messenger Phosphoprotein Res , vol.24 , pp. 230-235
    • Cohen, P.1
  • 22
    • 9944252377 scopus 로고    scopus 로고
    • Receptor trafficking and synaptic plasticity
    • Collingridge G.L., Isaac J.T., Wang Y.T. Receptor trafficking and synaptic plasticity. Nat Rev Neurosci 2004, 5(12):952-962.
    • (2004) Nat Rev Neurosci , vol.5 , Issue.12 , pp. 952-962
    • Collingridge, G.L.1    Isaac, J.T.2    Wang, Y.T.3
  • 24
    • 84855394783 scopus 로고    scopus 로고
    • Oxidative stress, mitochondrial dysfunction, and aging
    • Cui H., Kong Y., Zhang H. Oxidative stress, mitochondrial dysfunction, and aging. J Signal Transduct 2012, 646354.
    • (2012) J Signal Transduct , pp. 646354
    • Cui, H.1    Kong, Y.2    Zhang, H.3
  • 25
    • 13944269577 scopus 로고    scopus 로고
    • Cognitive sequelae of intravenous amphetamine self-administration in rats: evidence for selective effects on attentional performance
    • Dalley J.W., Theobald D.E., Berry D., Milstein J.A., Laane K., Everitt B.J., et al. Cognitive sequelae of intravenous amphetamine self-administration in rats: evidence for selective effects on attentional performance. Neuropsychopharmacology 2005, 30(3):525-537.
    • (2005) Neuropsychopharmacology , vol.30 , Issue.3 , pp. 525-537
    • Dalley, J.W.1    Theobald, D.E.2    Berry, D.3    Milstein, J.A.4    Laane, K.5    Everitt, B.J.6
  • 26
    • 0025269152 scopus 로고
    • Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity
    • DeKosky S.T., Scheff S.W. Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. Ann Neurol 1990, 27(5):457-464.
    • (1990) Ann Neurol , vol.27 , Issue.5 , pp. 457-464
    • DeKosky, S.T.1    Scheff, S.W.2
  • 27
    • 80052505578 scopus 로고    scopus 로고
    • Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by alpha7 and beta2* nicotinic stimulation
    • Del Barrio L., Martin-de-Saavedra M.D., Romero A., Parada E., Egea J., Avila J., et al. Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by alpha7 and beta2* nicotinic stimulation. Toxicol Sci 2011, 123(1):193-205.
    • (2011) Toxicol Sci , vol.123 , Issue.1 , pp. 193-205
    • Del Barrio, L.1    Martin-de-Saavedra, M.D.2    Romero, A.3    Parada, E.4    Egea, J.5    Avila, J.6
  • 28
    • 33847369469 scopus 로고    scopus 로고
    • The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins
    • Dickey C.A., Kamal A., Lundgren K., Klosak N., Bailey R.M., Dunmore J., et al. The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. J Clin Invest 2007, 117(3):648-658.
    • (2007) J Clin Invest , vol.117 , Issue.3 , pp. 648-658
    • Dickey, C.A.1    Kamal, A.2    Lundgren, K.3    Klosak, N.4    Bailey, R.M.5    Dunmore, J.6
  • 29
    • 77956407624 scopus 로고    scopus 로고
    • The role of tau kinases in Alzheimer's disease
    • Dolan P.J., Johnson G.V. The role of tau kinases in Alzheimer's disease. Curr Opin Drug Discov Devel 2010, 13(5):595-603.
    • (2010) Curr Opin Drug Discov Devel , vol.13 , Issue.5 , pp. 595-603
    • Dolan, P.J.1    Johnson, G.V.2
  • 30
    • 0035374588 scopus 로고    scopus 로고
    • Protein phosphatases regulate DNA-dependent protein kinase activity
    • Douglas P., Moorhead G.B., Ye R., Lees-Miller S.P. Protein phosphatases regulate DNA-dependent protein kinase activity. J Biol Chem 2001, 276(22):18992-18998.
    • (2001) J Biol Chem , vol.276 , Issue.22 , pp. 18992-18998
    • Douglas, P.1    Moorhead, G.B.2    Ye, R.3    Lees-Miller, S.P.4
  • 33
    • 0031444893 scopus 로고    scopus 로고
    • Inhibiting the formation of classical C3-convertase on the Alzheimer's beta-amyloid peptide
    • Emmerling M.R., Spiegel K., Watson M.D. Inhibiting the formation of classical C3-convertase on the Alzheimer's beta-amyloid peptide. Immunopharmacology 1997, 38(1-2):101-109.
    • (1997) Immunopharmacology , vol.38 , Issue.1-2 , pp. 101-109
    • Emmerling, M.R.1    Spiegel, K.2    Watson, M.D.3
  • 34
    • 0034637560 scopus 로고    scopus 로고
    • Tau phosphorylation at serine 396 and serine 404 by human recombinant tau protein kinase II inhibits tau's ability to promote microtubule assembly
    • Evans D.B., Rank K.B., Bhattacharya K., Thomsen D.R., Gurney M.E., Sharma S.K. Tau phosphorylation at serine 396 and serine 404 by human recombinant tau protein kinase II inhibits tau's ability to promote microtubule assembly. J Biol Chem 2000, 275(32):24977-24983.
    • (2000) J Biol Chem , vol.275 , Issue.32 , pp. 24977-24983
    • Evans, D.B.1    Rank, K.B.2    Bhattacharya, K.3    Thomsen, D.R.4    Gurney, M.E.5    Sharma, S.K.6
  • 35
    • 0026079797 scopus 로고
    • The marine toxin okadaic acid is a potent neurotoxin for cultured cerebellar neurons
    • Fernandez M.T., Zitko V., Gascon S., Novelli A. The marine toxin okadaic acid is a potent neurotoxin for cultured cerebellar neurons. Life Sci 1991, 49(19):PL157-PL162.
    • (1991) Life Sci , vol.49 , Issue.19
    • Fernandez, M.T.1    Zitko, V.2    Gascon, S.3    Novelli, A.4
  • 37
    • 0030602178 scopus 로고    scopus 로고
    • Inhibition of protein phosphatases induces IGF-1-blocked neurotrophin-insensitive neuronal apoptosis
    • Fernandez-Sanchez M.T., Garcia-Rodriguez A., Diaz-Trelles R., Novelli A. Inhibition of protein phosphatases induces IGF-1-blocked neurotrophin-insensitive neuronal apoptosis. FEBS Lett 1996, 398(1):106-112.
    • (1996) FEBS Lett , vol.398 , Issue.1 , pp. 106-112
    • Fernandez-Sanchez, M.T.1    Garcia-Rodriguez, A.2    Diaz-Trelles, R.3    Novelli, A.4
  • 38
    • 0030499463 scopus 로고    scopus 로고
    • Pyramidal neurone modulation: a therapeutic target for Alzheimer's disease
    • Francis P.T. Pyramidal neurone modulation: a therapeutic target for Alzheimer's disease. Neurodegeneration 1996, 5(4):461-465.
    • (1996) Neurodegeneration , vol.5 , Issue.4 , pp. 461-465
    • Francis, P.T.1
  • 40
    • 1442335380 scopus 로고    scopus 로고
    • First evidence of dinophysistoxin-1 ester and carcinogenic polycyclic aromatic hydrocarbons in smoked bivalves collected in the Patagonia fjords
    • Garcia C., Gonzalez V., Cornejo C., Palma-Fleming H., Lagos N. First evidence of dinophysistoxin-1 ester and carcinogenic polycyclic aromatic hydrocarbons in smoked bivalves collected in the Patagonia fjords. Toxicon 2004, 43:121-131.
    • (2004) Toxicon , vol.43 , pp. 121-131
    • Garcia, C.1    Gonzalez, V.2    Cornejo, C.3    Palma-Fleming, H.4    Lagos, N.5
  • 42
    • 0027214404 scopus 로고
    • Phosphoprotein phosphatase activities in Alzheimer disease brain
    • Gong C.X., Singh T.J., Grundke-Iqbal I., Iqbal K. Phosphoprotein phosphatase activities in Alzheimer disease brain. J Neurochem 1993, 61(3):921-927.
    • (1993) J Neurochem , vol.61 , Issue.3 , pp. 921-927
    • Gong, C.X.1    Singh, T.J.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 43
    • 0034088846 scopus 로고    scopus 로고
    • Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain, implications for neurofibrillary degeneration in Alzheimer's disease
    • Gong C.X., Lidsky T., Wegiel J., Zuck L., Grundke-Iqbal I., Iqbal K. Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain, implications for neurofibrillary degeneration in Alzheimer's disease. J Biol Chem 2000, 275(8):5535-5544.
    • (2000) J Biol Chem , vol.275 , Issue.8 , pp. 5535-5544
    • Gong, C.X.1    Lidsky, T.2    Wegiel, J.3    Zuck, L.4    Grundke-Iqbal, I.5    Iqbal, K.6
  • 44
    • 0345700240 scopus 로고    scopus 로고
    • Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices
    • Gong C.X., Wang J.Z., Iqbal K., Grundke-Iqbal I. Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices. Neurosci Lett 2003, 340(2):107-110.
    • (2003) Neurosci Lett , vol.340 , Issue.2 , pp. 107-110
    • Gong, C.X.1    Wang, J.Z.2    Iqbal, K.3    Grundke-Iqbal, I.4
  • 46
    • 0035666080 scopus 로고    scopus 로고
    • Spatial memory deficit and neurodegeneration induced by the direct injection of okadaic acid into the hippocampus in rats
    • He J., Yamada K., Zou L.B., Nabeshima T. Spatial memory deficit and neurodegeneration induced by the direct injection of okadaic acid into the hippocampus in rats. J Neural Transm 2001, 108(12):1435-1443.
    • (2001) J Neural Transm , vol.108 , Issue.12 , pp. 1435-1443
    • He, J.1    Yamada, K.2    Zou, L.B.3    Nabeshima, T.4
  • 47
    • 23844547937 scopus 로고    scopus 로고
    • Olanzapine attenuates the okadaic acid-induced spatial memory impairment and hippocampal cell death in rats
    • He J., Yang Y., Xu H., Zhang X., Li X.M. Olanzapine attenuates the okadaic acid-induced spatial memory impairment and hippocampal cell death in rats. Neuropsychopharmacology 2005, 30(8):1511-1520.
    • (2005) Neuropsychopharmacology , vol.30 , Issue.8 , pp. 1511-1520
    • He, J.1    Yang, Y.2    Xu, H.3    Zhang, X.4    Li, X.M.5
  • 48
    • 17844364885 scopus 로고    scopus 로고
    • Serial evaluation of fatty acid metabolism in rats with myocardial infarction by pinhole SPECT
    • Hirai T., Nohara R., Ogoh S., Chen L.G., Kataoka K., Li X.H., et al. Serial evaluation of fatty acid metabolism in rats with myocardial infarction by pinhole SPECT. J Nucl Cardiol 2001, 8(4):472-481.
    • (2001) J Nucl Cardiol , vol.8 , Issue.4 , pp. 472-481
    • Hirai, T.1    Nohara, R.2    Ogoh, S.3    Chen, L.G.4    Kataoka, K.5    Li, X.H.6
  • 49
    • 0036627865 scopus 로고    scopus 로고
    • The pathological cascade of Alzheimer's disease: the role of inflammation and its therapeutic implications
    • Hoozemans J.J., Veerhuis R., Rozemuller A.J., Eikelenboom P. The pathological cascade of Alzheimer's disease: the role of inflammation and its therapeutic implications. Drugs Today (Barc) 2002, 38(6):429-443.
    • (2002) Drugs Today (Barc) , vol.38 , Issue.6 , pp. 429-443
    • Hoozemans, J.J.1    Veerhuis, R.2    Rozemuller, A.J.3    Eikelenboom, P.4
  • 50
    • 0025202331 scopus 로고
    • Regulation of neurotransmitter receptor desensitization by protein phosphorylation
    • Huganir R.L., Greengard P. Regulation of neurotransmitter receptor desensitization by protein phosphorylation. Neuron 1990, 5(5):555-567.
    • (1990) Neuron , vol.5 , Issue.5 , pp. 555-567
    • Huganir, R.L.1    Greengard, P.2
  • 51
    • 72049129673 scopus 로고    scopus 로고
    • Okadaic acid (ICV) induced memory impairment in rats: a suitable experimental model to test anti-dementia activity
    • Kamat P.K., Tota S., Saxena G., Shukla R., Nath C. Okadaic acid (ICV) induced memory impairment in rats: a suitable experimental model to test anti-dementia activity. Brain Res 2010, 1309:66-74.
    • (2010) Brain Res , vol.1309 , pp. 66-74
    • Kamat, P.K.1    Tota, S.2    Saxena, G.3    Shukla, R.4    Nath, C.5
  • 52
    • 80054795374 scopus 로고    scopus 로고
    • Mitochondrial dysfunction: a crucial event in okadaic acid (ICV) induced memory impairment and apoptotic cell death in rat brain
    • Kamat P.K., Tota S., Shukla R., Ali S., Najmi A.K., Nath C. Mitochondrial dysfunction: a crucial event in okadaic acid (ICV) induced memory impairment and apoptotic cell death in rat brain. Pharmacol Biochem Behav 2011, 100(2):311-319.
    • (2011) Pharmacol Biochem Behav , vol.100 , Issue.2 , pp. 311-319
    • Kamat, P.K.1    Tota, S.2    Shukla, R.3    Ali, S.4    Najmi, A.K.5    Nath, C.6
  • 53
    • 84860707019 scopus 로고    scopus 로고
    • A study on neuroinflammatory marker in brain areas of okadaic acid (ICV) induced memory impaired rats
    • Kamat P.K., Tota S., Rai S., Swarnkar S., Shukla R., Nath C. A study on neuroinflammatory marker in brain areas of okadaic acid (ICV) induced memory impaired rats. Life Sci 2012, 90(19-20):713-720.
    • (2012) Life Sci , vol.90 , Issue.19-20 , pp. 713-720
    • Kamat, P.K.1    Tota, S.2    Rai, S.3    Swarnkar, S.4    Shukla, R.5    Nath, C.6
  • 54
    • 84864491691 scopus 로고    scopus 로고
    • Okadaic acid induced neurotoxicity leads to central cholinergic dysfunction in rats
    • Kamat P.K., Tota S., Rai S., Shukla R., Ali S., Najmi A.K., et al. Okadaic acid induced neurotoxicity leads to central cholinergic dysfunction in rats. Eur J Pharmacol 2012, 690(1-3):90-98.
    • (2012) Eur J Pharmacol , vol.690 , Issue.1-3 , pp. 90-98
    • Kamat, P.K.1    Tota, S.2    Rai, S.3    Shukla, R.4    Ali, S.5    Najmi, A.K.6
  • 55
    • 84876027041 scopus 로고    scopus 로고
    • Okadaic acid-induced tau phosphorylation in rat brain: role of NMDA receptor
    • in press
    • Kamat P.K., Rai S., Swarnkar S., Shukla R., Ali S., Najmi A.K., Nath C. Okadaic acid-induced tau phosphorylation in rat brain: role of NMDA receptor. Neuroscience 2013, in press. 10.1016/j.neuroscience.2013.01.075.
    • (2013) Neuroscience
    • Kamat, P.K.1    Rai, S.2    Swarnkar, S.3    Shukla, R.4    Ali, S.5    Najmi, A.K.6    Nath, C.7
  • 56
    • 0031969880 scopus 로고    scopus 로고
    • Amyloid beta-peptide inhibits high-affinity choline uptake and acetylcholine release in rat hippocampal slices
    • Kar S., Issa A.M., Seto D., Auld D.S., Collier B., Quirion R. Amyloid beta-peptide inhibits high-affinity choline uptake and acetylcholine release in rat hippocampal slices. J Neurochem 1998, 70(5):2179-2187.
    • (1998) J Neurochem , vol.70 , Issue.5 , pp. 2179-2187
    • Kar, S.1    Issa, A.M.2    Seto, D.3    Auld, D.S.4    Collier, B.5    Quirion, R.6
  • 57
    • 11344265672 scopus 로고    scopus 로고
    • Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease
    • Kar S., Slowikowski S.P., Westaway D., Mount H.T. Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease. J Psychiatry Neurosci 2004, 29(6):427-441.
    • (2004) J Psychiatry Neurosci , vol.29 , Issue.6 , pp. 427-441
    • Kar, S.1    Slowikowski, S.P.2    Westaway, D.3    Mount, H.T.4
  • 58
    • 0042679510 scopus 로고    scopus 로고
    • Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice
    • Kins S., Kurosinski P., Nitsch R.M., Gotz J. Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice. Am J Pathol 2003, 163(3):833-843.
    • (2003) Am J Pathol , vol.163 , Issue.3 , pp. 833-843
    • Kins, S.1    Kurosinski, P.2    Nitsch, R.M.3    Gotz, J.4
  • 59
    • 34547395389 scopus 로고    scopus 로고
    • Modulation of hippocampal calcium signalling and plasticity by serine/threonine protein phosphatases
    • Koss D.J., Hindley K.P., Riedel G., Platt B. Modulation of hippocampal calcium signalling and plasticity by serine/threonine protein phosphatases. J Neurochem 2007, 102(4):1009-1023.
    • (2007) J Neurochem , vol.102 , Issue.4 , pp. 1009-1023
    • Koss, D.J.1    Hindley, K.P.2    Riedel, G.3    Platt, B.4
  • 60
    • 79960473407 scopus 로고    scopus 로고
    • Co-pathological connected primary neurons in a microfluidic device for Alzheimer studies
    • Kunze A., Meissner R., Brando S., Renaud P. Co-pathological connected primary neurons in a microfluidic device for Alzheimer studies. Biotechnol Bioeng 2011, 108(9):2241-2245.
    • (2011) Biotechnol Bioeng , vol.108 , Issue.9 , pp. 2241-2245
    • Kunze, A.1    Meissner, R.2    Brando, S.3    Renaud, P.4
  • 61
    • 2442465965 scopus 로고    scopus 로고
    • Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration
    • Li L., Sengupta A., Haque N., Grundke-Iqbal I., Iqbal K. Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration. FEBS Lett 2004, 566(1-3):261-269.
    • (2004) FEBS Lett , vol.566 , Issue.1-3 , pp. 261-269
    • Li, L.1    Sengupta, A.2    Haque, N.3    Grundke-Iqbal, I.4    Iqbal, K.5
  • 62
    • 6344269168 scopus 로고    scopus 로고
    • Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain
    • Li X., An W.L., Alafuzoff I., Soininen H., Winblad B., Pei J.J. Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain. Neuroreport 2004, 15(14):2237-2240.
    • (2004) Neuroreport , vol.15 , Issue.14 , pp. 2237-2240
    • Li, X.1    An, W.L.2    Alafuzoff, I.3    Soininen, H.4    Winblad, B.5    Pei, J.J.6
  • 63
    • 33646008860 scopus 로고    scopus 로고
    • Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fasting
    • Li X., Lu F., Wang J.Z., Gong C.X. Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fasting. Eur J Neurosci 2006, 23(8):2078-2086.
    • (2006) Eur J Neurosci , vol.23 , Issue.8 , pp. 2078-2086
    • Li, X.1    Lu, F.2    Wang, J.Z.3    Gong, C.X.4
  • 64
    • 77951623547 scopus 로고    scopus 로고
    • Maintained activity of glycogen synthase kinase-3beta despite of its phosphorylation at serine-9 in okadaic acid-induced neurodegenerative model
    • Lim Y.W., Yoon S.Y., Choi J.E., Kim S.M., Lee H.S., Choe H., et al. Maintained activity of glycogen synthase kinase-3beta despite of its phosphorylation at serine-9 in okadaic acid-induced neurodegenerative model. Biochem Biophys Res Commun 2010, 395(2):207-212.
    • (2010) Biochem Biophys Res Commun , vol.395 , Issue.2 , pp. 207-212
    • Lim, Y.W.1    Yoon, S.Y.2    Choi, J.E.3    Kim, S.M.4    Lee, H.S.5    Choe, H.6
  • 65
    • 78049278306 scopus 로고    scopus 로고
    • Axonal alpha7 nicotinic ACh receptors modulate presynaptic NMDA receptor expression and structural plasticity of glutamatergic presynaptic boutons
    • Lin H., Vicini S., Hsu F.C., Doshi S., Takano H., Coulter D.A., et al. Axonal alpha7 nicotinic ACh receptors modulate presynaptic NMDA receptor expression and structural plasticity of glutamatergic presynaptic boutons. Proc Natl Acad Sci U S A 2012, 107(38):16661-16666.
    • (2012) Proc Natl Acad Sci U S A , vol.107 , Issue.38 , pp. 16661-16666
    • Lin, H.1    Vicini, S.2    Hsu, F.C.3    Doshi, S.4    Takano, H.5    Coulter, D.A.6
  • 66
    • 33750347347 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    • Lin M.T., Beal M.F. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 2006, 443(7113):787-795.
    • (2006) Nature , vol.443 , Issue.7113 , pp. 787-795
    • Lin, M.T.1    Beal, M.F.2
  • 67
    • 0036160863 scopus 로고    scopus 로고
    • Alzheimer-like tau phosphorylation induced by wortmannin in vivo and its attenuation by melatonin
    • Liu S.J., Wang J.Z. Alzheimer-like tau phosphorylation induced by wortmannin in vivo and its attenuation by melatonin. Acta Pharmacol Sin 2002, 23(2):183-187.
    • (2002) Acta Pharmacol Sin , vol.23 , Issue.2 , pp. 183-187
    • Liu, S.J.1    Wang, J.Z.2
  • 68
    • 0037480707 scopus 로고    scopus 로고
    • Protein phosphatase 2A-linked and -unlinked caspase-dependent pathways for downregulation of Akt kinase triggered by 4-hydroxynonenal
    • Liu W., Akhand A.A., Takeda K., Kawamoto Y., Itoigawa M., Kato M., et al. Protein phosphatase 2A-linked and -unlinked caspase-dependent pathways for downregulation of Akt kinase triggered by 4-hydroxynonenal. Cell Death Differ 2003, 10(7):772-781.
    • (2003) Cell Death Differ , vol.10 , Issue.7 , pp. 772-781
    • Liu, W.1    Akhand, A.A.2    Takeda, K.3    Kawamoto, Y.4    Itoigawa, M.5    Kato, M.6
  • 69
    • 0028675873 scopus 로고
    • Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells
    • Lovestone S., Reynolds C.H., Latimer D., Davis D.R., Anderton B.H., Gallo J.M., et al. Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells. Curr Biol 1994, 4(12):1077-1086.
    • (1994) Curr Biol , vol.4 , Issue.12 , pp. 1077-1086
    • Lovestone, S.1    Reynolds, C.H.2    Latimer, D.3    Davis, D.R.4    Anderton, B.H.5    Gallo, J.M.6
  • 70
    • 34250166501 scopus 로고    scopus 로고
    • NMDA receptor-mediated extracellular adenosine accumulation is blocked by phosphatase 1/2A inhibitors
    • Lu Y., Rosenberg P.A. NMDA receptor-mediated extracellular adenosine accumulation is blocked by phosphatase 1/2A inhibitors. Brain Res 2007, 1155:116-124.
    • (2007) Brain Res , vol.1155 , pp. 116-124
    • Lu, Y.1    Rosenberg, P.A.2
  • 71
    • 30944456272 scopus 로고    scopus 로고
    • Effects of microcystins over short- and long-term memory and oxidative stress generation in hippocampus of rats
    • Maidana M., Carlis V., Galhardi F.G., Yunes J.S., Geracitano L.A., Monserrat J.M., et al. Effects of microcystins over short- and long-term memory and oxidative stress generation in hippocampus of rats. Chem Biol Interact 2006, 159(3):223-234.
    • (2006) Chem Biol Interact , vol.159 , Issue.3 , pp. 223-234
    • Maidana, M.1    Carlis, V.2    Galhardi, F.G.3    Yunes, J.S.4    Geracitano, L.A.5    Monserrat, J.M.6
  • 72
    • 79952105548 scopus 로고    scopus 로고
    • Post-translational modifications of tau protein: implications for Alzheimer's disease
    • Martin L., Latypova X., Terro F. Post-translational modifications of tau protein: implications for Alzheimer's disease. Neurochem Int 2011, 58(4):458-471.
    • (2011) Neurochem Int , vol.58 , Issue.4 , pp. 458-471
    • Martin, L.1    Latypova, X.2    Terro, F.3
  • 73
    • 0033902601 scopus 로고    scopus 로고
    • Aging enhances the activation of the permeability transition pore in mitochondria
    • Mather M., Rottenberg H. Aging enhances the activation of the permeability transition pore in mitochondria. Biochem Biophys Res Commun 2000, 273(2):603-608.
    • (2000) Biochem Biophys Res Commun , vol.273 , Issue.2 , pp. 603-608
    • Mather, M.1    Rottenberg, H.2
  • 74
    • 0029958289 scopus 로고    scopus 로고
    • Evidence for enterohepatic circulation of okadaic acid in mice
    • Matias W.G., Creppy E.E. Evidence for enterohepatic circulation of okadaic acid in mice. Toxic Subst Mech 1996, 15:405-414.
    • (1996) Toxic Subst Mech , vol.15 , pp. 405-414
    • Matias, W.G.1    Creppy, E.E.2
  • 75
    • 0027945346 scopus 로고
    • Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau
    • Matsuo E.S., Shin R.W., Billingsley M.L., Van deVoorde A., O'Connor M., Trojanowski J.Q., et al. Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau. Neuron 1994, 13(4):989-1002.
    • (1994) Neuron , vol.13 , Issue.4 , pp. 989-1002
    • Matsuo, E.S.1    Shin, R.W.2    Billingsley, M.L.3    Van deVoorde, A.4    O'Connor, M.5    Trojanowski, J.Q.6
  • 77
    • 0028177988 scopus 로고
    • Characterization of multiple molecular forms of Mg(2+)-dependent protein phosphatase from Saccharomyces cerevisiae
    • Murakami T., Kobayashi T., Terasawa T., Ohnishi M., Kato S., Sasahara Y., et al. Characterization of multiple molecular forms of Mg(2+)-dependent protein phosphatase from Saccharomyces cerevisiae. J Biochem 1994, 115(4):762-766.
    • (1994) J Biochem , vol.115 , Issue.4 , pp. 762-766
    • Murakami, T.1    Kobayashi, T.2    Terasawa, T.3    Ohnishi, M.4    Kato, S.5    Sasahara, Y.6
  • 78
    • 84863641754 scopus 로고    scopus 로고
    • Protein tau: prime cause of synaptic and neuronal degeneration in Alzheimer's disease
    • Natalia C.B., Clara T., Fred V.L. Protein tau: prime cause of synaptic and neuronal degeneration in Alzheimer's disease. Int J Alzheimers Dis 2012, 10.1155/2012/251426.
    • (2012) Int J Alzheimers Dis
    • Natalia, C.B.1    Clara, T.2    Fred, V.L.3
  • 79
    • 35548982628 scopus 로고    scopus 로고
    • Bioenergetics of mitochondria in cultured neurons and their role in glutamate excitotoxicity
    • Nicholls D.G., Johnson-Cadwell L., Vesce S., Jekabsons M., Yadava N. Bioenergetics of mitochondria in cultured neurons and their role in glutamate excitotoxicity. J Neurosci Res 2007, 85(15):3206-3212.
    • (2007) J Neurosci Res , vol.85 , Issue.15 , pp. 3206-3212
    • Nicholls, D.G.1    Johnson-Cadwell, L.2    Vesce, S.3    Jekabsons, M.4    Yadava, N.5
  • 80
    • 7144256256 scopus 로고    scopus 로고
    • Basic and clinical studies on the measurement of tau protein in cerebrospinal fluid as a biological marker for Alzheimer's disease and related disorders: multicenter study in Japan
    • Nishimura T., Takeda M., Nakamura Y., Yosbida Y., Arai H., Sasaki H., et al. Basic and clinical studies on the measurement of tau protein in cerebrospinal fluid as a biological marker for Alzheimer's disease and related disorders: multicenter study in Japan. Methods Find Exp Clin Pharmacol 1998, 20(3):227-235.
    • (1998) Methods Find Exp Clin Pharmacol , vol.20 , Issue.3 , pp. 227-235
    • Nishimura, T.1    Takeda, M.2    Nakamura, Y.3    Yosbida, Y.4    Arai, H.5    Sasaki, H.6
  • 81
    • 0030497927 scopus 로고    scopus 로고
    • From acetylcholine to amyloid: neurotransmitters and the pathology of Alzheimer's disease
    • Nitsch R.M. From acetylcholine to amyloid: neurotransmitters and the pathology of Alzheimer's disease. Neurodegeneration 1996, 5(4):477-482.
    • (1996) Neurodegeneration , vol.5 , Issue.4 , pp. 477-482
    • Nitsch, R.M.1
  • 82
    • 75949101857 scopus 로고    scopus 로고
    • Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease
    • Nunomura A., Tamaoki T., Tanaka K., Motohashi N., Nakamura M., Hayashi T., et al. Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease. Neurobiol Dis 2010, 37(3):731-737.
    • (2010) Neurobiol Dis , vol.37 , Issue.3 , pp. 731-737
    • Nunomura, A.1    Tamaoki, T.2    Tanaka, K.3    Motohashi, N.4    Nakamura, M.5    Hayashi, T.6
  • 83
    • 0022521048 scopus 로고
    • Excitatory amino acid-releasing and cholinergic neurones in Alzheimer's disease
    • Palmer A.M., Procter A.W., Stratmann G.C., Bowen D.M. Excitatory amino acid-releasing and cholinergic neurones in Alzheimer's disease. Neurosci Lett 1986, 66(2):199-204.
    • (1986) Neurosci Lett , vol.66 , Issue.2 , pp. 199-204
    • Palmer, A.M.1    Procter, A.W.2    Stratmann, G.C.3    Bowen, D.M.4
  • 84
    • 0030614508 scopus 로고    scopus 로고
    • The regulatory Ser262 of microtubule-associated protein tau is phosphorylated by phosphorylase kinase
    • Paudel H.K. The regulatory Ser262 of microtubule-associated protein tau is phosphorylated by phosphorylase kinase. J Biol Chem 1997, 272(3):1777-1785.
    • (1997) J Biol Chem , vol.272 , Issue.3 , pp. 1777-1785
    • Paudel, H.K.1
  • 85
  • 86
    • 2542612948 scopus 로고    scopus 로고
    • Learning from NMDA receptor trafficking: clues to the development and maturation of glutamatergic synapses
    • Perez-Otano I., Ehlers M.D. Learning from NMDA receptor trafficking: clues to the development and maturation of glutamatergic synapses. Neurosignals 2004, 13(4):175-189.
    • (2004) Neurosignals , vol.13 , Issue.4 , pp. 175-189
    • Perez-Otano, I.1    Ehlers, M.D.2
  • 87
    • 33845757628 scopus 로고    scopus 로고
    • Phosphorylation inhibits turnover of the tau protein by the proteasome: influence of RCAN1 and oxidative stress
    • Poppek D., Keck S., Ermak G., Jung T., Stolzing A., Ullrich O., et al. Phosphorylation inhibits turnover of the tau protein by the proteasome: influence of RCAN1 and oxidative stress. Biochem J 2006, 400(3):511-520.
    • (2006) Biochem J , vol.400 , Issue.3 , pp. 511-520
    • Poppek, D.1    Keck, S.2    Ermak, G.3    Jung, T.4    Stolzing, A.5    Ullrich, O.6
  • 88
    • 77950366745 scopus 로고    scopus 로고
    • PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta
    • Qian W., Shi J., Yin X., Iqbal K., Grundke-Iqbal I., Gong C.X., et al. PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta. J Alzheimers Dis 2010, 19(4):1221-1229.
    • (2010) J Alzheimers Dis , vol.19 , Issue.4 , pp. 1221-1229
    • Qian, W.1    Shi, J.2    Yin, X.3    Iqbal, K.4    Grundke-Iqbal, I.5    Gong, C.X.6
  • 89
    • 0029799230 scopus 로고    scopus 로고
    • Behavioral approaches to the treatment of Alzheimer's disease: research strategies
    • Radebaugh T.S., Buckholtz N., Khachaturian Z. Behavioral approaches to the treatment of Alzheimer's disease: research strategies. Int Psychogeriatr 1996, 8(Suppl. 1):7-12.
    • (1996) Int Psychogeriatr , vol.8 , Issue.SUPPL. 1 , pp. 7-12
    • Radebaugh, T.S.1    Buckholtz, N.2    Khachaturian, Z.3
  • 90
    • 27744511921 scopus 로고    scopus 로고
    • High cholesterol diet induces tau hyperphosphorylation in apolipoprotein E deficient mice
    • Rahman A., Akterin S., Flores-Morales A., Crisby M., Kivipelto M., Schultzberg M., et al. High cholesterol diet induces tau hyperphosphorylation in apolipoprotein E deficient mice. FEBS Lett 2005, 579(28):6411-6416.
    • (2005) FEBS Lett , vol.579 , Issue.28 , pp. 6411-6416
    • Rahman, A.1    Akterin, S.2    Flores-Morales, A.3    Crisby, M.4    Kivipelto, M.5    Schultzberg, M.6
  • 91
    • 84872185890 scopus 로고    scopus 로고
    • A study on neuroinflammation and NMDA receptor function in STZ (ICV) induced memory impaired rats
    • pii: S0165-5728(12)00252-4
    • Rai S., Kamat P.K., Nath C., Shukla R. A study on neuroinflammation and NMDA receptor function in STZ (ICV) induced memory impaired rats. J Neuroimmunol 2012, pii: S0165-5728(12)00252-4.
    • (2012) J Neuroimmunol
    • Rai, S.1    Kamat, P.K.2    Nath, C.3    Shukla, R.4
  • 92
    • 49649119504 scopus 로고    scopus 로고
    • Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases
    • Reynolds C.H., Garwood C.J., Wray S., Price C., Kellie S., Perera T., et al. Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases. J Biol Chem 2008, 283(26):18177-18186.
    • (2008) J Biol Chem , vol.283 , Issue.26 , pp. 18177-18186
    • Reynolds, C.H.1    Garwood, C.J.2    Wray, S.3    Price, C.4    Kellie, S.5    Perera, T.6
  • 93
    • 0029670637 scopus 로고    scopus 로고
    • Activation of m1 muscarinic acetylcholine receptor regulates tau phosphorylation in transfected PC12 cells
    • Sadot E., Gurwitz D., Barg J., Behar L., Ginzburg I., Fisher A. Activation of m1 muscarinic acetylcholine receptor regulates tau phosphorylation in transfected PC12 cells. J Neurochem 1996, 66(2):877-880.
    • (1996) J Neurochem , vol.66 , Issue.2 , pp. 877-880
    • Sadot, E.1    Gurwitz, D.2    Barg, J.3    Behar, L.4    Ginzburg, I.5    Fisher, A.6
  • 94
    • 34249788738 scopus 로고    scopus 로고
    • Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders
    • Sas K., Robotka H., Toldi J., Vecsei L. Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders. J Neurol Sci 2007, 257(1-2):221-239.
    • (2007) J Neurol Sci , vol.257 , Issue.1-2 , pp. 221-239
    • Sas, K.1    Robotka, H.2    Toldi, J.3    Vecsei, L.4
  • 96
    • 24644463251 scopus 로고    scopus 로고
    • Calcium and protein phosphatase 1/2A attenuate N-methyl-D-aspartate receptor activity in the anoxic turtle cortex
    • Shin D.S., Wilkie M.P., Pamenter M.E., Buck L.T. Calcium and protein phosphatase 1/2A attenuate N-methyl-D-aspartate receptor activity in the anoxic turtle cortex. Comp Biochem Physiol A Mol Integr Physiol 2005, 142(September (1)):50-57.
    • (2005) Comp Biochem Physiol A Mol Integr Physiol , vol.142 , Issue.1 SEPTEMBER , pp. 50-57
    • Shin, D.S.1    Wilkie, M.P.2    Pamenter, M.E.3    Buck, L.T.4
  • 97
    • 8544252384 scopus 로고    scopus 로고
    • Expression of the tumor necrosis factor alpha gene and early response genes by nodularin, a liver tumor promoter in primary cultured rat hepatocytes
    • Sueoka E., Sueoka N., Okabe S., Kozu T., Ohta T., Suganuma M., et al. Expression of the tumor necrosis factor alpha gene and early response genes by nodularin, a liver tumor promoter in primary cultured rat hepatocytes. Cancer Res Clin Oncol 1997, 123:413-419.
    • (1997) Cancer Res Clin Oncol , vol.123 , pp. 413-419
    • Sueoka, E.1    Sueoka, N.2    Okabe, S.3    Kozu, T.4    Ohta, T.5    Suganuma, M.6
  • 98
    • 0034111582 scopus 로고    scopus 로고
    • Protective effect of L-deprenyl against apoptosis induced by okadaic acid in cultured neuronal cells
    • Suuronen T., Kolehmainen P., Salminen A. Protective effect of L-deprenyl against apoptosis induced by okadaic acid in cultured neuronal cells. Biochem Pharmacol 2000, 59(12):1589-1595.
    • (2000) Biochem Pharmacol , vol.59 , Issue.12 , pp. 1589-1595
    • Suuronen, T.1    Kolehmainen, P.2    Salminen, A.3
  • 99
    • 0023648079 scopus 로고
    • Smooth muscle phosphatase inhibition and force enhancement by block sponge toxin
    • Takai A., Bialojan C., Troschka M., Ruegg J.C. Smooth muscle phosphatase inhibition and force enhancement by block sponge toxin. FEBS Lett 1987, 217:81-84.
    • (1987) FEBS Lett , vol.217 , pp. 81-84
    • Takai, A.1    Bialojan, C.2    Troschka, M.3    Ruegg, J.C.4
  • 100
    • 33747425620 scopus 로고    scopus 로고
    • GSK-3 is essential in the pathogenesis of Alzheimer's disease
    • Takashima A. GSK-3 is essential in the pathogenesis of Alzheimer's disease. J Alzheimers Dis 2006, 9(3 Suppl.):309-317.
    • (2006) J Alzheimers Dis , vol.9 , Issue.3 SUPPL. , pp. 309-317
    • Takashima, A.1
  • 101
    • 33645078163 scopus 로고    scopus 로고
    • Influence of proinflammatory cytokines on Actinobacillus actinomycetemcomitans specific IgG responses
    • Tanaka S., Fakher M., Barbour S.E., Schenkein H.A., Tew J.G. Influence of proinflammatory cytokines on Actinobacillus actinomycetemcomitans specific IgG responses. J Periodontal Res 2006, 41(1):1-9.
    • (2006) J Periodontal Res , vol.41 , Issue.1 , pp. 1-9
    • Tanaka, S.1    Fakher, M.2    Barbour, S.E.3    Schenkein, H.A.4    Tew, J.G.5
  • 102
    • 0034970822 scopus 로고    scopus 로고
    • Cumulative inactivation of the outward potassium current: a likely mechanism underlying electrical memory in human atrial myocytes
    • Tessier S., Godreau D., Vranckx R., Lang-Lazdunski L., Mercadier J.J., Hatem S.N. Cumulative inactivation of the outward potassium current: a likely mechanism underlying electrical memory in human atrial myocytes. J Mol Cell Cardiol 2001, 33(4):755-767.
    • (2001) J Mol Cell Cardiol , vol.33 , Issue.4 , pp. 755-767
    • Tessier, S.1    Godreau, D.2    Vranckx, R.3    Lang-Lazdunski, L.4    Mercadier, J.J.5    Hatem, S.N.6
  • 103
    • 0034307466 scopus 로고    scopus 로고
    • Protein phosphatase-mediated regulation of protein kinase C during long-term depression in the adult hippocampus in vivo
    • Thiels E., Kanterewicz B.I., Knapp L.T., Barrionuevo G., Klann E. Protein phosphatase-mediated regulation of protein kinase C during long-term depression in the adult hippocampus in vivo. J Neurosci 2000, 20(19):7199-7207.
    • (2000) J Neurosci , vol.20 , Issue.19 , pp. 7199-7207
    • Thiels, E.1    Kanterewicz, B.I.2    Knapp, L.T.3    Barrionuevo, G.4    Klann, E.5
  • 104
    • 2942642325 scopus 로고    scopus 로고
    • Injection of okadaic acid into the meynert nucleus basalis of rat brain induces decreased acetylcholine level and spatial memory deficit
    • Tian Q., Lin Z.Q., Wang X.C., Chen J., Wang Q., Gong C.X., et al. Injection of okadaic acid into the meynert nucleus basalis of rat brain induces decreased acetylcholine level and spatial memory deficit. Neuroscience 2004, 126(2):277-284.
    • (2004) Neuroscience , vol.126 , Issue.2 , pp. 277-284
    • Tian, Q.1    Lin, Z.Q.2    Wang, X.C.3    Chen, J.4    Wang, Q.5    Gong, C.X.6
  • 105
    • 84857727442 scopus 로고    scopus 로고
    • PP2A and Alzheimer disease
    • Torrent L., Ferrer I. PP2A and Alzheimer disease. Curr Alzheimer Res 2012, 9(2):248-256.
    • (2012) Curr Alzheimer Res , vol.9 , Issue.2 , pp. 248-256
    • Torrent, L.1    Ferrer, I.2
  • 107
    • 56349100062 scopus 로고    scopus 로고
    • Influence of LPS-induced neuroinflammation on acetylcholinesterase activity in rat brain
    • Tyagi E., Agrawal R., Nath C., Shukla R. Influence of LPS-induced neuroinflammation on acetylcholinesterase activity in rat brain. J Neuroimmunol 2008, 205(1-2):51-56.
    • (2008) J Neuroimmunol , vol.205 , Issue.1-2 , pp. 51-56
    • Tyagi, E.1    Agrawal, R.2    Nath, C.3    Shukla, R.4
  • 108
    • 79955035020 scopus 로고    scopus 로고
    • Induction of oxidative DNA damage by the marine toxin okadaic acid depends on human cell type
    • Valdiglesias V., Laffon B., Pasaro E., Cemeli E., Anderson D., Mendez J. Induction of oxidative DNA damage by the marine toxin okadaic acid depends on human cell type. Toxicon 2011, 57(6):882-888.
    • (2011) Toxicon , vol.57 , Issue.6 , pp. 882-888
    • Valdiglesias, V.1    Laffon, B.2    Pasaro, E.3    Cemeli, E.4    Anderson, D.5    Mendez, J.6
  • 109
    • 33646178141 scopus 로고    scopus 로고
    • Beta-protein/A4 deposits are not associated with hyperphosphorylated tau in somatostatin neurons in the hypothalamus of Alzheimer's disease patients
    • van de Nes J.A., Konermann S., Nafe R., Swaab D.F. Beta-protein/A4 deposits are not associated with hyperphosphorylated tau in somatostatin neurons in the hypothalamus of Alzheimer's disease patients. Acta Neuropathol 2006, 111(2):126-138.
    • (2006) Acta Neuropathol , vol.111 , Issue.2 , pp. 126-138
    • van de Nes, J.A.1    Konermann, S.2    Nafe, R.3    Swaab, D.F.4
  • 110
    • 0029998294 scopus 로고    scopus 로고
    • Cellular phosphorylation of tau by GSK-3 beta influences tau binding to microtubules and microtubule organisation
    • Wagner U., Utton M., Gallo J.M., Miller C.C. Cellular phosphorylation of tau by GSK-3 beta influences tau binding to microtubules and microtubule organisation. J Cell Sci 1996, 109(Pt 6):1537-1543.
    • (1996) J Cell Sci , vol.109 , Issue.PART 6 , pp. 1537-1543
    • Wagner, U.1    Utton, M.2    Gallo, J.M.3    Miller, C.C.4
  • 111
    • 0035914046 scopus 로고    scopus 로고
    • Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer disease brain and in okadaic acid-treated SY5Y cells
    • Wang J., Tung Y.C., Wang Y., Li X.T., Iqbal K., Grundke-Iqbal I. Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer disease brain and in okadaic acid-treated SY5Y cells. FEBS Lett 2001, 507(1):81-87.
    • (2001) FEBS Lett , vol.507 , Issue.1 , pp. 81-87
    • Wang, J.1    Tung, Y.C.2    Wang, Y.3    Li, X.T.4    Iqbal, K.5    Grundke-Iqbal, I.6
  • 112
    • 3242725514 scopus 로고    scopus 로고
    • Melatonin attenuates isoproterenol-induced protein kinase A overactivation and tau hyperphosphorylation in rat brain
    • Wang D.L., Ling Z.Q., Cao F.Y., Zhu L.Q., Wang J.Z. Melatonin attenuates isoproterenol-induced protein kinase A overactivation and tau hyperphosphorylation in rat brain. J Pineal Res 2004, 37(1):11-16.
    • (2004) J Pineal Res , vol.37 , Issue.1 , pp. 11-16
    • Wang, D.L.1    Ling, Z.Q.2    Cao, F.Y.3    Zhu, L.Q.4    Wang, J.Z.5
  • 113
    • 84863263718 scopus 로고    scopus 로고
    • Role of APP and Abeta in synaptic physiology
    • Wang Z., Yang L., Zheng H. Role of APP and Abeta in synaptic physiology. Curr Alzheimer Res 2012, 9(2):217-226.
    • (2012) Curr Alzheimer Res , vol.9 , Issue.2 , pp. 217-226
    • Wang, Z.1    Yang, L.2    Zheng, H.3
  • 114
    • 0023516670 scopus 로고
    • Nicotinic and muscarinic cholinergic receptors in Alzheimer's disease and related disorders
    • Whitehouse P.J., Kellar K.J. Nicotinic and muscarinic cholinergic receptors in Alzheimer's disease and related disorders. J Neural Transm Suppl 1987, 24:175-182.
    • (1987) J Neural Transm Suppl , vol.24 , pp. 175-182
    • Whitehouse, P.J.1    Kellar, K.J.2
  • 115
    • 0020397384 scopus 로고
    • Alzheimer's disease, correlation of cortical choline acetyltransferase activity with the severity of dementia and histological abnormalities
    • Wilcock G.K., Esiri M.M., Bowen D.M., Smith C.C. Alzheimer's disease, correlation of cortical choline acetyltransferase activity with the severity of dementia and histological abnormalities. J Neurol Sci 1982, 57(2-3):407-417.
    • (1982) J Neurol Sci , vol.57 , Issue.2-3 , pp. 407-417
    • Wilcock, G.K.1    Esiri, M.M.2    Bowen, D.M.3    Smith, C.C.4
  • 116
    • 48749116491 scopus 로고    scopus 로고
    • Neural stem cells improve learning and memory in rats with Alzheimer's disease
    • Wu S., Sasaki A., Yoshimoto R., Kawahara Y., Manabe T., Kataoka K., et al. Neural stem cells improve learning and memory in rats with Alzheimer's disease. Pathobiology 2008, 75(3):186-194.
    • (2008) Pathobiology , vol.75 , Issue.3 , pp. 186-194
    • Wu, S.1    Sasaki, A.2    Yoshimoto, R.3    Kawahara, Y.4    Manabe, T.5    Kataoka, K.6
  • 117
    • 67649389595 scopus 로고    scopus 로고
    • Dynamics of mitochondrial structure during apoptosis and the enigma of Opa1
    • Yamaguchi R., Perkins G. Dynamics of mitochondrial structure during apoptosis and the enigma of Opa1. Biochim Biophys Acta 2009, 1787(8):963-972.
    • (2009) Biochim Biophys Acta , vol.1787 , Issue.8 , pp. 963-972
    • Yamaguchi, R.1    Perkins, G.2
  • 118
    • 53249130976 scopus 로고    scopus 로고
    • Protein phosphatase 1, protein phosphatase 2A, and calcineurin play a role in estrogen-mediated neuroprotection
    • Yi K.D., Simpkins J.W. Protein phosphatase 1, protein phosphatase 2A, and calcineurin play a role in estrogen-mediated neuroprotection. Endocrinology 2008, 149(10):5235-5243.
    • (2008) Endocrinology , vol.149 , Issue.10 , pp. 5235-5243
    • Yi, K.D.1    Simpkins, J.W.2
  • 119
    • 23444450596 scopus 로고    scopus 로고
    • Role of protein phosphatases in estrogen-mediated neuroprotection
    • Yi K.D., Chung J., Pang P., Simpkins J.W. Role of protein phosphatases in estrogen-mediated neuroprotection. J Neurosci 2005, 25(31):7191-7198.
    • (2005) J Neurosci , vol.25 , Issue.31 , pp. 7191-7198
    • Yi, K.D.1    Chung, J.2    Pang, P.3    Simpkins, J.W.4
  • 120
    • 58149328523 scopus 로고    scopus 로고
    • Mechanism of okadaic acid-induced neuronal death and the effect of estrogens
    • Yi K.D., Covey D.F., Simpkins J.W. Mechanism of okadaic acid-induced neuronal death and the effect of estrogens. J Neurochem 2009, 108(3):732-740.
    • (2009) J Neurochem , vol.108 , Issue.3 , pp. 732-740
    • Yi, K.D.1    Covey, D.F.2    Simpkins, J.W.3
  • 121
    • 77049107343 scopus 로고    scopus 로고
    • Acetyl-L-carnitine attenuates okadaic acid induced tau hyperphosphorylation and spatial memory impairment in rats
    • Yin Y.Y., Liu H., Cong X.B., Liu Z., Wang Q., Wang J.Z., et al. Acetyl-L-carnitine attenuates okadaic acid induced tau hyperphosphorylation and spatial memory impairment in rats. J Alzheimers Dis 2010, 19(2):735-746.
    • (2010) J Alzheimers Dis , vol.19 , Issue.2 , pp. 735-746
    • Yin, Y.Y.1    Liu, H.2    Cong, X.B.3    Liu, Z.4    Wang, Q.5    Wang, J.Z.6
  • 122
    • 33646133879 scopus 로고    scopus 로고
    • BACE inhibitor reduces APP-beta-C-terminal fragment accumulation in axonal swellings of okadaic acid-induced neurodegeneration
    • Yoon S.Y., Choi J.E., Yoon J.H., Huh J.W., Kim D.H. BACE inhibitor reduces APP-beta-C-terminal fragment accumulation in axonal swellings of okadaic acid-induced neurodegeneration. Neurobiol Dis 2006, 22(2):435-444.
    • (2006) Neurobiol Dis , vol.22 , Issue.2 , pp. 435-444
    • Yoon, S.Y.1    Choi, J.E.2    Yoon, J.H.3    Huh, J.W.4    Kim, D.H.5
  • 123
    • 0037204539 scopus 로고    scopus 로고
    • Apoptosis and successful aging
    • Zhang Y., Herman B. Apoptosis and successful aging. Mech Ageing Dev 2002, 123(6):563-565.
    • (2002) Mech Ageing Dev , vol.123 , Issue.6 , pp. 563-565
    • Zhang, Y.1    Herman, B.2
  • 124
    • 77955516619 scopus 로고    scopus 로고
    • Okadaic acid induces tau phosphorylation in SH-SY5Y cells in an estrogen-preventable manner
    • Zhang Z., Simpkins J.W. Okadaic acid induces tau phosphorylation in SH-SY5Y cells in an estrogen-preventable manner. Brain Res 2010, 1345:176-181.
    • (2010) Brain Res , vol.1345 , pp. 176-181
    • Zhang, Z.1    Simpkins, J.W.2
  • 125
    • 77958001015 scopus 로고    scopus 로고
    • An okadaic acid-induced model of tauopathy and cognitive deficiency
    • Zhang Z., Simpkins J.W. An okadaic acid-induced model of tauopathy and cognitive deficiency. Brain Res 2010, 1359:233-246.
    • (2010) Brain Res , vol.1359 , pp. 233-246
    • Zhang, Z.1    Simpkins, J.W.2
  • 126
    • 42149162262 scopus 로고    scopus 로고
    • Protective effect of (-) clausenamide against neurotoxicity induced by okadaic acid and beta-amyloid peptide25-3
    • Zhang J., Cheng Y., Zhang J.T. Protective effect of (-) clausenamide against neurotoxicity induced by okadaic acid and beta-amyloid peptide25-3. Yao Xue Xue Bao 2007, 42(9):935-942.
    • (2007) Yao Xue Xue Bao , vol.42 , Issue.9 , pp. 935-942
    • Zhang, J.1    Cheng, Y.2    Zhang, J.T.3
  • 127
    • 0028294444 scopus 로고
    • Effect of PKC inhibitors and activators on memory
    • Zhao W.Q., Sedman G.L., Gibbs M.E., Ng K.T. Effect of PKC inhibitors and activators on memory. Behav Brain Res 1994, 60(2):151-160.
    • (1994) Behav Brain Res , vol.60 , Issue.2 , pp. 151-160
    • Zhao, W.Q.1    Sedman, G.L.2    Gibbs, M.E.3    Ng, K.T.4
  • 129
    • 49349110718 scopus 로고    scopus 로고
    • Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A
    • Zhou X.W., Gustafsson J.A., Tanila H., Bjorkdahl C., Liu R., Winblad B., et al. Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A. Neurobiol Dis 2008, 31(3):386-394.
    • (2008) Neurobiol Dis , vol.31 , Issue.3 , pp. 386-394
    • Zhou, X.W.1    Gustafsson, J.A.2    Tanila, H.3    Bjorkdahl, C.4    Liu, R.5    Winblad, B.6
  • 130
    • 84874916126 scopus 로고    scopus 로고
    • Pretreatment with memantine prevents Alzheimer-like alterations induced by intrahippocampal okadaic acid administration in rats
    • Zimmer E.R., Kalinine E., Haas C.B., Torrez V.R., Souza D.O., Muller A.P., et al. Pretreatment with memantine prevents Alzheimer-like alterations induced by intrahippocampal okadaic acid administration in rats. Curr Alzheimer Res 2012 Dec, 9(10):1182-1190.
    • (2012) Curr Alzheimer Res , vol.9 , Issue.10 , pp. 1182-1190
    • Zimmer, E.R.1    Kalinine, E.2    Haas, C.B.3    Torrez, V.R.4    Souza, D.O.5    Muller, A.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.