메뉴 건너뛰기




Volumn 108, Issue 3, 2009, Pages 732-740

Mechanism of okadaic acid-induced neuronal death and the effect of estrogens

Author keywords

Estradiol; Estrogen analogues; Okadaic acid; Oxidative stress; Phosphatases; Protein kinases

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 17ALPHA ESTRADIOL; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CASPASE 3; ESTRADIOL; GLUTAMIC ACID; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR; REACTIVE OXYGEN METABOLITE;

EID: 58149328523     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05805.x     Document Type: Article
Times cited : (33)

References (46)
  • 1
    • 0027162369 scopus 로고
    • Okadaic acid induces early changes in microtubule-associated protein 2 and tau phosphorylation prior to neurodegeneration in cultured cortical neurons
    • Arias C., Sharma N., Davies P. Shafit-Zagardo B. (1993) Okadaic acid induces early changes in microtubule-associated protein 2 and tau phosphorylation prior to neurodegeneration in cultured cortical neurons. J. Neurochem. 61, 673 682.
    • (1993) J. Neurochem. , vol.61 , pp. 673-682
    • Arias, C.1    Sharma, N.2    Davies, P.3    Shafit-Zagardo, B.4
  • 2
    • 0025823502 scopus 로고
    • The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells
    • Boe R., Gjertsen B. T., Vintermyr O. K., Houge G., Lanotte M. Doskeland S. O. (1991) The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells. Exp. Cell Res. 195, 237 246.
    • (1991) Exp. Cell Res. , vol.195 , pp. 237-246
    • Boe, R.1    Gjertsen, B.T.2    Vintermyr, O.K.3    Houge, G.4    Lanotte, M.5    Doskeland, S.O.6
  • 3
    • 33947626638 scopus 로고    scopus 로고
    • Oxidative stress in neurodegenerative disorders
    • Butterfield D. A. (2006) Oxidative stress in neurodegenerative disorders. Antioxid. Redox Signal. 8, 1971 1973.
    • (2006) Antioxid. Redox Signal. , vol.8 , pp. 1971-1973
    • Butterfield, D.A.1
  • 5
    • 0027686249 scopus 로고
    • Oxidative stress, glutamate, and neurodegenerative disorders
    • Coyle J. T. Puttfarcken P. (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science 262, 689 695.
    • (1993) Science , vol.262 , pp. 689-695
    • Coyle, J.T.1    Puttfarcken, P.2
  • 7
    • 0026079797 scopus 로고
    • The marine toxin okadaic acid is a potent neurotoxin for cultured cerebellar neurons
    • Fernandez M. T., Zitko V., Gascon S. Novelli A. (1991) The marine toxin okadaic acid is a potent neurotoxin for cultured cerebellar neurons. Life Sci. 49, PL157 PL162.
    • (1991) Life Sci. , vol.49
    • Fernandez, M.T.1    Zitko, V.2    Gascon, S.3    Novelli, A.4
  • 8
    • 0030602178 scopus 로고    scopus 로고
    • Inhibition of protein phosphatases induces IGF-1-blocked neurotrophin-insensitive neuronal apoptosis
    • Fernandez-Sanchez M. T., Garcia-Rodriguez A., Diaz-Trelles R. Novelli A. (1996) Inhibition of protein phosphatases induces IGF-1-blocked neurotrophin-insensitive neuronal apoptosis. FEBS Lett. 398, 106 112.
    • (1996) FEBS Lett. , vol.398 , pp. 106-112
    • Fernandez-Sanchez, M.T.1    Garcia-Rodriguez, A.2    Diaz-Trelles, R.3    Novelli, A.4
  • 9
    • 4444383980 scopus 로고    scopus 로고
    • Activity of protein phosphatase calcineurin is decreased in sporadic and familial amyotrophic lateral sclerosispatients
    • Ferri A., Nencini M., Battistini S. et al. (2004) Activity of protein phosphatase calcineurin is decreased in sporadic and familial amyotrophic lateral sclerosispatients. J. Neurochem. 90, 1237 1242.
    • (2004) J. Neurochem. , vol.90 , pp. 1237-1242
    • Ferri, A.1    Nencini, M.2    Battistini, S.3
  • 10
    • 0029113874 scopus 로고
    • Phosphatase activity toward abnormally phosphorylated tau: Decrease in Alzheimer disease brain
    • Gong C. X., Shaikh S., Wang J. Z., Zaidi T., Grundke-Iqbal I. Iqbal K. (1995) Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain. J. Neurochem. 65, 732 738.
    • (1995) J. Neurochem. , vol.65 , pp. 732-738
    • Gong, C.X.1    Shaikh, S.2    Wang, J.Z.3    Zaidi, T.4    Grundke-Iqbal, I.5    Iqbal, K.6
  • 11
    • 85047686351 scopus 로고    scopus 로고
    • The nonfeminizing enantiomer of 17beta-estradiol exerts protective effects in neuronal cultures and a rat model of cerebral ischemia
    • Green P. S., Yang S. H., Nilsson K. R., Kumar A. S., Covey D. F. Simpkins J. W. (2001) The nonfeminizing enantiomer of 17beta-estradiol exerts protective effects in neuronal cultures and a rat model of cerebral ischemia. Endocrinology 142, 400 406.
    • (2001) Endocrinology , vol.142 , pp. 400-406
    • Green, P.S.1    Yang, S.H.2    Nilsson, K.R.3    Kumar, A.S.4    Covey, D.F.5    Simpkins, J.W.6
  • 12
    • 33846855791 scopus 로고    scopus 로고
    • Different mechanisms account for extracellular-signal regulated kinase activation in distinct brain regions following global ischemia and reperfusion
    • Ho Y., Logue E., Callaway C. W. DeFranco D. B. (2007) Different mechanisms account for extracellular-signal regulated kinase activation in distinct brain regions following global ischemia and reperfusion. Neuroscience 145, 248 255.
    • (2007) Neuroscience , vol.145 , pp. 248-255
    • Ho, Y.1    Logue, E.2    Callaway, C.W.3    Defranco, D.B.4
  • 14
    • 0033229985 scopus 로고    scopus 로고
    • Estrogen modulation of G-protein-coupled receptors
    • Kelly M. J. Wagner E. J. (1999) Estrogen modulation of G-protein-coupled receptors. Trends Endocrinol. Metab. 10, 369 374.
    • (1999) Trends Endocrinol. Metab. , vol.10 , pp. 369-374
    • Kelly, M.J.1    Wagner, E.J.2
  • 15
    • 0033555253 scopus 로고    scopus 로고
    • Signalling pathway leading to an activation of mitogen-activated protein kinase by stimulating M3 muscarinic receptor
    • Kim J. Y., Yang M. S., Oh C. D., Kim K. T., Ha M. J., Kang S. S. Chun J. S. (1999) Signalling pathway leading to an activation of mitogen-activated protein kinase by stimulating M3 muscarinic receptor. Biochem. J. 337, 275 280.
    • (1999) Biochem. J. , vol.337 , pp. 275-280
    • Kim, J.Y.1    Yang, M.S.2    Oh, C.D.3    Kim, K.T.4    Ha, M.J.5    Kang, S.S.6    Chun, J.S.7
  • 16
    • 0042679510 scopus 로고    scopus 로고
    • Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice
    • Kins S., Kurosinski P., Nitsch R. M. Gotz J. (2003) Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice. Am. J. Pathol. 163, 833 843.
    • (2003) Am. J. Pathol. , vol.163 , pp. 833-843
    • Kins, S.1    Kurosinski, P.2    Nitsch, R.M.3    Gotz, J.4
  • 17
    • 34247613558 scopus 로고    scopus 로고
    • Activation of PKCdelta and p38delta MAPK during okadaic acid dependent keratinocyte apoptosis
    • Kraft C. A., Efimova T. Eckert R. L. (2007) Activation of PKCdelta and p38delta MAPK during okadaic acid dependent keratinocyte apoptosis. Arch. Dermatol. Res. 299, 71 83.
    • (2007) Arch. Dermatol. Res. , vol.299 , pp. 71-83
    • Kraft, C.A.1    Efimova, T.2    Eckert, R.L.3
  • 18
    • 1642442504 scopus 로고    scopus 로고
    • Transient phosphatidylinositol 3-kinase inhibition protects immature primary cortical neurons from oxidative toxicity via suppression of extracellular signal-regulated kinase activation
    • Levinthal D. J. DeFranco D. B. (2004) Transient phosphatidylinositol 3-kinase inhibition protects immature primary cortical neurons from oxidative toxicity via suppression of extracellular signal-regulated kinase activation. J. Biol. Chem. 279, 11206 11213.
    • (2004) J. Biol. Chem. , vol.279 , pp. 11206-11213
    • Levinthal, D.J.1    Defranco, D.B.2
  • 19
    • 0036790627 scopus 로고    scopus 로고
    • Neuroprotective effects of a novel non-receptor-binding estrogen analogue: In vitro and in vivo analysis
    • Liu R., Yang S. H., Perez E. et al. (2002) Neuroprotective effects of a novel non-receptor-binding estrogen analogue: in vitro and in vivo analysis. Stroke 33, 2485 2491.
    • (2002) Stroke , vol.33 , pp. 2485-2491
    • Liu, R.1    Yang, S.H.2    Perez, E.3
  • 20
    • 0035078659 scopus 로고    scopus 로고
    • Neurodegenerative disorders and ischemic brain diseases
    • Mattson M. P., Duan W., Pedersen W. A. Culmsee C. (2001) Neurodegenerative disorders and ischemic brain diseases. Apoptosis 6, 69 81.
    • (2001) Apoptosis , vol.6 , pp. 69-81
    • Mattson, M.P.1    Duan, W.2    Pedersen, W.A.3    Culmsee, C.4
  • 22
    • 4344559517 scopus 로고    scopus 로고
    • Erk1/2 phosphorylation and reactive oxygen species formation via nitric oxide and Akt-1/Raf-1 crosstalk in cultured rat cerebellar granule cells exposed to the organic solvent 1,2,4-trimethylcyclohexane
    • Myhre O., Sterri S. H., Bogen I. L. Fonnum F. (2004) Erk1/2 phosphorylation and reactive oxygen species formation via nitric oxide and Akt-1/Raf-1 crosstalk in cultured rat cerebellar granule cells exposed to the organic solvent 1,2,4-trimethylcyclohexane. Toxicol. Sci 80, 296 303.
    • (2004) Toxicol. Sci , vol.80 , pp. 296-303
    • Myhre, O.1    Sterri, S.H.2    Bogen, I.L.3    Fonnum, F.4
  • 23
    • 0037087099 scopus 로고    scopus 로고
    • Dual action of estrogen on glutamate-induced calcium signaling: Mechanisms requiring interaction between estrogen receptors and src/mitogen activated protein kinase pathway
    • Nilsen J., Chen S. Brinton R. D. (2002) Dual action of estrogen on glutamate-induced calcium signaling: mechanisms requiring interaction between estrogen receptors and src/mitogen activated protein kinase pathway. Brain Res. 930, 216 234.
    • (2002) Brain Res. , vol.930 , pp. 216-234
    • Nilsen, J.1    Chen, S.2    Brinton, R.D.3
  • 24
    • 12244279939 scopus 로고    scopus 로고
    • Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease
    • Pei J. J., Braak H., An W. L., Winblad B., Cowburn R. F., Iqbal K. Grundke-Iqbal I. (2002) Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease. Brain Res. Mol. Brain Res. 109, 45 55.
    • (2002) Brain Res. Mol. Brain Res. , vol.109 , pp. 45-55
    • Pei, J.J.1    Braak, H.2    An, W.L.3    Winblad, B.4    Cowburn, R.F.5    Iqbal, K.6    Grundke-Iqbal, I.7
  • 25
    • 0042679509 scopus 로고    scopus 로고
    • Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease
    • Pei J. J., Gong C. X., An W. L., Winblad B., Cowburn R. F., Grundke-Iqbal I. Iqbal K. (2003) Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease. Am. J. Pathol. 163, 845 858.
    • (2003) Am. J. Pathol. , vol.163 , pp. 845-858
    • Pei, J.J.1    Gong, C.X.2    An, W.L.3    Winblad, B.4    Cowburn, R.F.5    Grundke-Iqbal, I.6    Iqbal, K.7
  • 26
    • 14744293013 scopus 로고    scopus 로고
    • Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo
    • Perez E., Liu R., Yang S. H., Cai Z. Y., Covey D. F. Simpkins J. W. (2005) Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo. Brain Res. 1038, 216 222.
    • (2005) Brain Res. , vol.1038 , pp. 216-222
    • Perez, E.1    Liu, R.2    Yang, S.H.3    Cai, Z.Y.4    Covey, D.F.5    Simpkins, J.W.6
  • 27
    • 33845757628 scopus 로고    scopus 로고
    • Phosphorylation inhibits turnover of the tau protein by the proteasome: Influence of RCAN1 and oxidative stress
    • Poppek D., Keck S., Ermak G., Jung T., Stolzing A., Ullrich O., Davies K. J. Grune T. (2006) Phosphorylation inhibits turnover of the tau protein by the proteasome: influence of RCAN1 and oxidative stress. Biochem. J. 400, 511 520.
    • (2006) Biochem. J. , vol.400 , pp. 511-520
    • Poppek, D.1    Keck, S.2    Ermak, G.3    Jung, T.4    Stolzing, A.5    Ullrich, O.6    Davies, K.J.7    Grune, T.8
  • 28
    • 17644410079 scopus 로고    scopus 로고
    • Phosphothreonine-212 of Alzheimer abnormally hyperphosphorylated tau is a preferred substrate of protein phosphatase-1
    • Rahman A., Grundke-Iqbal I. Iqbal K. (2005) Phosphothreonine-212 of Alzheimer abnormally hyperphosphorylated tau is a preferred substrate of protein phosphatase-1. Neurochem. Res. 30, 277 287.
    • (2005) Neurochem. Res. , vol.30 , pp. 277-287
    • Rahman, A.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 29
    • 0036890757 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase regulates growth factor-induced mitogenesis of rat pulmonary myofibroblasts
    • Rice A. B., Ingram J. L. Bonner J. C. (2002) p38 mitogen-activated protein kinase regulates growth factor-induced mitogenesis of rat pulmonary myofibroblasts. Am. J. Respir. Cell Mol. Biol. 27, 759 765.
    • (2002) Am. J. Respir. Cell Mol. Biol. , vol.27 , pp. 759-765
    • Rice, A.B.1    Ingram, J.L.2    Bonner, J.C.3
  • 31
    • 0028805786 scopus 로고
    • Induction of oxidative stress by okadaic acid is required for activation of transcription factor NF-kappa B
    • Schmidt K. N., Traenckner E. B., Meier B. Baeuerle P. A. (1995) Induction of oxidative stress by okadaic acid is required for activation of transcription factor NF-kappa B. J. Biol. Chem. 270, 27136 27142.
    • (1995) J. Biol. Chem. , vol.270 , pp. 27136-27142
    • Schmidt, K.N.1    Traenckner, E.B.2    Meier, B.3    Baeuerle, P.A.4
  • 32
    • 0039791449 scopus 로고    scopus 로고
    • Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes
    • Schonwasser D. C., Marais R. M., Marshall C. J. Parker P. J. (1998) Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes. Mol. Cell. Biol. 18, 790 798.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 790-798
    • Schonwasser, D.C.1    Marais, R.M.2    Marshall, C.J.3    Parker, P.J.4
  • 33
    • 0027974133 scopus 로고
    • Assessing oxygen radicals as mediators in activation of inducible eukaryotic transcription factor NF-kappa B
    • Schreck R. Baeuerle P. A. (1994) Assessing oxygen radicals as mediators in activation of inducible eukaryotic transcription factor NF-kappa B. Methods Enzymol. 234, 151 163.
    • (1994) Methods Enzymol. , vol.234 , pp. 151-163
    • Schreck, R.1    Baeuerle, P.A.2
  • 35
    • 0344097487 scopus 로고    scopus 로고
    • Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: Convergence of estrogen and neurotrophin signaling pathways
    • Singh M., Setalo G. Jr., Guan X., Warren M. Toran-Allerand C. D. (1999) Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: convergence of estrogen and neurotrophin signaling pathways. J. Neurosci. 19, 1179 1188.
    • (1999) J. Neurosci. , vol.19 , pp. 1179-1188
    • Singh, M.1    Setalo Jr., G.2    Guan, X.3    Warren, M.4    Toran-Allerand, C.D.5
  • 36
    • 0342803689 scopus 로고    scopus 로고
    • Estrogen-induced activation of the mitogen-activated protein kinase cascade in the cerebral cortex of estrogen receptor-alpha knock-out mice
    • Singh M., Setalo G. Jr., Guan X., Frail D. E. Toran-Allerand C. D. (2000) Estrogen-induced activation of the mitogen-activated protein kinase cascade in the cerebral cortex of estrogen receptor-alpha knock-out mice. J. Neurosci. 20, 1694 1700.
    • (2000) J. Neurosci. , vol.20 , pp. 1694-1700
    • Singh, M.1    Setalo Jr., G.2    Guan, X.3    Frail, D.E.4    Toran-Allerand, C.D.5
  • 38
    • 33947644871 scopus 로고    scopus 로고
    • Protein oxidation and lipid peroxidation in brain of subjects with Alzheimer's disease: Insights into mechanism of neurodegeneration from redox proteomics
    • Sultana R., Perluigi M. Butterfield D. A. (2006) Protein oxidation and lipid peroxidation in brain of subjects with Alzheimer's disease: insights into mechanism of neurodegeneration from redox proteomics. Antioxid. Redox Signal. 8, 2021 2037.
    • (2006) Antioxid. Redox Signal. , vol.8 , pp. 2021-2037
    • Sultana, R.1    Perluigi, M.2    Butterfield, D.A.3
  • 41
    • 53249130976 scopus 로고    scopus 로고
    • Protein phosphatase 1, protein phosphatase 2A, and calcineurin play a role in estrogen-mediated neuroprotection
    • Yi K. D. Simpkins J. W. (2008) Protein phosphatase 1, protein phosphatase 2A, and calcineurin play a role in estrogen-mediated neuroprotection. Endocrinology 149, 5235 5243.
    • (2008) Endocrinology , vol.149 , pp. 5235-5243
    • Yi, K.D.1    Simpkins, J.W.2
  • 42
    • 23444450596 scopus 로고    scopus 로고
    • Role of protein phosphatases in estrogen-mediated neuroprotection
    • Yi K. D., Chung J., Pang P. Simpkins J. W. (2005) Role of protein phosphatases in estrogen-mediated neuroprotection. J. Neurosci. 25, 7191 7198.
    • (2005) J. Neurosci. , vol.25 , pp. 7191-7198
    • Yi, K.D.1    Chung, J.2    Pang, P.3    Simpkins, J.W.4
  • 43
    • 40849094517 scopus 로고    scopus 로고
    • Estrogen receptor-independent neuroprotection via protein phosphatase preservation and attenuation of persistent extracellular signal-regulated kinase 1/2 activation
    • Yi K. D., Cai Z. Y., Covey D. F. Simpkins J. W. (2008) Estrogen receptor-independent neuroprotection via protein phosphatase preservation and attenuation of persistent extracellular signal-regulated kinase 1/2 activation. J. Pharmacol. Exp. Ther. 324, 1188 1195.
    • (2008) J. Pharmacol. Exp. Ther. , vol.324 , pp. 1188-1195
    • Yi, K.D.1    Cai, Z.Y.2    Covey, D.F.3    Simpkins, J.W.4
  • 44
    • 33646133879 scopus 로고    scopus 로고
    • BACE inhibitor reduces APP-beta-C-terminal fragment accumulation in axonal swellings of okadaic acid-induced neurodegeneration
    • Yoon S. Y., Choi J. E., Yoon J. H., Huh J. W. Kim D. H. (2006) BACE inhibitor reduces APP-beta-C-terminal fragment accumulation in axonal swellings of okadaic acid-induced neurodegeneration. Neurobiol. Dis. 22, 435 444.
    • (2006) Neurobiol. Dis. , vol.22 , pp. 435-444
    • Yoon, S.Y.1    Choi, J.E.2    Yoon, J.H.3    Huh, J.W.4    Kim, D.H.5
  • 45
    • 0035800196 scopus 로고    scopus 로고
    • Estrogen protects against beta-amyloid-induced neurotoxicity in rat hippocampal neurons by activation of Akt
    • Zhang L., Rubinow D. R., Xaing G., Li B. S., Chang Y. H., Maric D., Barker J. L. Ma W. (2001) Estrogen protects against beta-amyloid-induced neurotoxicity in rat hippocampal neurons by activation of Akt. Neuroreport 12, 1919 1923.
    • (2001) Neuroreport , vol.12 , pp. 1919-1923
    • Zhang, L.1    Rubinow, D.R.2    Xaing, G.3    Li, B.S.4    Chang, Y.H.5    Maric, D.6    Barker, J.L.7    Ma, W.8
  • 46
    • 27544454121 scopus 로고    scopus 로고
    • Selective estrogen receptor modulators (SERMs) for the brain: Current status and remaining challenges for developing NeuroSERMs
    • Zhao L., O'Neill K. Brinton R. D. (2005) Selective estrogen receptor modulators (SERMs) for the brain: Current status and remaining challenges for developing NeuroSERMs. Brain Res. Rev. 49, 472 493.
    • (2005) Brain Res. Rev. , vol.49 , pp. 472-493
    • Zhao, L.1    O'Neill, K.2    Brinton, R.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.