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Volumn 75, Issue 3, 2008, Pages 186-194

Neural stem cells improve learning and memory in rats with Alzheimer's disease

Author keywords

Alzheimer's disease; Nerve growth factor; Neural stem cells; Recombination adeno associated virus

Indexed keywords

GREEN FLUORESCENT PROTEIN; NERVE GROWTH FACTOR; OKADAIC ACID;

EID: 48749116491     PISSN: 10152008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000124979     Document Type: Article
Times cited : (76)

References (56)
  • 1
    • 33750731675 scopus 로고    scopus 로고
    • 100 years and counting: Prospects for defeating Alzheimer's disease
    • Roberson ED, Mucke L: 100 years and counting: prospects for defeating Alzheimer's disease. Science 2006;3:781-784.
    • (2006) Science , vol.3 , pp. 781-784
    • Roberson, E.D.1    Mucke, L.2
  • 3
    • 0029896354 scopus 로고    scopus 로고
    • Mechanisms of neuronal degeneration in Alzheimer's disease
    • Yankner BA: Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron 1996;16:921-932.
    • (1996) Neuron , vol.16 , pp. 921-932
    • Yankner, B.A.1
  • 5
    • 33750334671 scopus 로고    scopus 로고
    • Alzheimer's disease
    • Turner RS: Alzheimer's disease. Semin Neurol 2006;26:499-506.
    • (2006) Semin Neurol , vol.26 , pp. 499-506
    • Turner, R.S.1
  • 6
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • Selkoe DJ: Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 2001;81:741-766.
    • (2001) Physiol Rev , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 7
    • 33750634113 scopus 로고    scopus 로고
    • Alzheimer's discovery
    • Dahm R: Alzheimer's discovery. Curr Biol 2006;16:R906-R910.
    • (2006) Curr Biol , vol.16
    • Dahm, R.1
  • 8
    • 24644453571 scopus 로고    scopus 로고
    • The role of apoptotic pathways in Alzheimer's disease neurodegeneration and cell death
    • LeBlanc AC: The role of apoptotic pathways in Alzheimer's disease neurodegeneration and cell death. Curr Alzheimer Res 2005;2:389-402.
    • (2005) Curr Alzheimer Res , vol.2 , pp. 389-402
    • LeBlanc, A.C.1
  • 9
    • 0021256895 scopus 로고
    • Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
    • Glenner GG, Wong CW: Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 1984;120:885-890.
    • (1984) Biochem Biophys Res Commun , vol.120 , pp. 885-890
    • Glenner, G.G.1    Wong, C.W.2
  • 10
    • 17144456734 scopus 로고    scopus 로고
    • Olesen OF: Tau, amyloid and Alzheimer's disease. Ugeskr Laeger 1994;156:1116-1117, 1121-1124.
    • Olesen OF: Tau, amyloid and Alzheimer's disease. Ugeskr Laeger 1994;156:1116-1117, 1121-1124.
  • 11
    • 33747033678 scopus 로고    scopus 로고
    • Pathogenic mechanisms in Alzheimer's disease
    • Pastorino L, Lu KP: Pathogenic mechanisms in Alzheimer's disease. Eur J Pharmacol 2006;545:29-38.
    • (2006) Eur J Pharmacol , vol.545 , pp. 29-38
    • Pastorino, L.1    Lu, K.P.2
  • 12
    • 0031007546 scopus 로고    scopus 로고
    • Regulated phosphorylation and dephosphorylation of tau protein: Effects on microtubule interaction, intracellular trafficking and neurodegeneration
    • Billingsley ML, Kincaid RL: Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration. Biochem J 1997;323:577-591.
    • (1997) Biochem J , vol.323 , pp. 577-591
    • Billingsley, M.L.1    Kincaid, R.L.2
  • 13
    • 24144499309 scopus 로고    scopus 로고
    • Paired helical filaments (PHFs) are a family of single filament structures with a common helical turn period:negatively stained PHF imaged by TEM and measured before and after sonication, deglycosylation, and dephosphorylation
    • Ruben GC, Wang JZ, Iqbal K: Paired helical filaments (PHFs) are a family of single filament structures with a common helical turn period:negatively stained PHF imaged by TEM and measured before and after sonication, deglycosylation, and dephosphorylation. Microsc Res Tech 2005;67:175-195.
    • (2005) Microsc Res Tech , vol.67 , pp. 175-195
    • Ruben, G.C.1    Wang, J.Z.2    Iqbal, K.3
  • 14
    • 0023200370 scopus 로고
    • Histopathological criteria for progressive dementia disorders: Clinicopathological correlation and classification by multivariate data analysis
    • Alafuzoff I, Iqbal K, Friden H, Adolfsson R, Winblad B: Histopathological criteria for progressive dementia disorders: clinicopathological correlation and classification by multivariate data analysis. Acta Neuropathol 1987;74:209-225.
    • (1987) Acta Neuropathol , vol.74 , pp. 209-225
    • Alafuzoff, I.1    Iqbal, K.2    Friden, H.3    Adolfsson, R.4    Winblad, B.5
  • 15
    • 0032213015 scopus 로고    scopus 로고
    • Brain lesions, pathogenic and etiologic hypotheses of Alzheimer's disease
    • Dessi F, Colle MA, Hauw JJ, Duyckaerts C: Brain lesions, pathogenic and etiologic hypotheses of Alzheimer's disease. Rev Prat 1998;48:1873-1878.
    • (1998) Rev Prat , vol.48 , pp. 1873-1878
    • Dessi, F.1    Colle, M.A.2    Hauw, J.J.3    Duyckaerts, C.4
  • 17
    • 33846631371 scopus 로고    scopus 로고
    • Introduction to neural stem cells
    • Komblum HI: Introduction to neural stem cells. Stroke 2007;38:810-816.
    • (2007) Stroke , vol.38 , pp. 810-816
    • Komblum, H.I.1
  • 18
    • 33745018941 scopus 로고    scopus 로고
    • Neural stem cells may be uniquely suited for combined gene therapy and cell replacement: Evidence from engraftment of neurotrophin-3-expressing stem cells in hypoxic-ischemic brain injury
    • Park KI, Himes BT, Stieg PE, Tessler A, Fischer I, Snyder EY: Neural stem cells may be uniquely suited for combined gene therapy and cell replacement: evidence from engraftment of neurotrophin-3-expressing stem cells in hypoxic-ischemic brain injury. Exp Neurol 2006;199:179-190.
    • (2006) Exp Neurol , vol.199 , pp. 179-190
    • Park, K.I.1    Himes, B.T.2    Stieg, P.E.3    Tessler, A.4    Fischer, I.5    Snyder, E.Y.6
  • 20
    • 34250311572 scopus 로고    scopus 로고
    • Adult neurogenesis as a potential therapy for neurodegenerative diseases
    • Jordan JD, Ming GL, Song H: Adult neurogenesis as a potential therapy for neurodegenerative diseases. Discov Med 2006;6:144-147.
    • (2006) Discov Med , vol.6 , pp. 144-147
    • Jordan, J.D.1    Ming, G.L.2    Song, H.3
  • 22
    • 0029902122 scopus 로고    scopus 로고
    • Long-term functional recovery from age-induced spatial memory impairments by nerve growth factor (NGF) gene transfer to the rat basal forebrain
    • Martínez-Serrano A, Fischer W, Söderström S, Ebendal T, Björklund A: Long-term functional recovery from age-induced spatial memory impairments by nerve growth factor (NGF) gene transfer to the rat basal forebrain. Proc Natl Acad Sci USA 1996;93:6355-6360.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 6355-6360
    • Martínez-Serrano, A.1    Fischer, W.2    Söderström, S.3    Ebendal, T.4    Björklund, A.5
  • 23
    • 0027285510 scopus 로고
    • GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
    • Lin LF, Doherty D, Lile J, Bektesh S, Collins F: GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 1993;260:1130-1132.
    • (1993) Science , vol.260 , pp. 1130-1132
    • Lin, L.F.1    Doherty, D.2    Lile, J.3    Bektesh, S.4    Collins, F.5
  • 24
    • 33846462480 scopus 로고    scopus 로고
    • Stem cell transplantation for Huntington's disease
    • Dunnett SB, Rosser AF: Stem cell transplantation for Huntington's disease. Exp Neurol 2007;203:279-292.
    • (2007) Exp Neurol , vol.203 , pp. 279-292
    • Dunnett, S.B.1    Rosser, A.F.2
  • 27
    • 0021173996 scopus 로고
    • Development of a water-maze procedure for studying spatial learning in the rat
    • Morris R: Development of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 1984;11:47-60.
    • (1984) J Neurosci Methods , vol.11 , pp. 47-60
    • Morris, R.1
  • 28
    • 0025210629 scopus 로고
    • Ubiquitin immunoelectron microscopy of dystrophic neurites in cerebellar senile plaques of Alzheimer's disease
    • Dickson DW, Wertkin A, Mattiace LA, Fier E, Kress Y, Davies P, Yen SH: Ubiquitin immunoelectron microscopy of dystrophic neurites in cerebellar senile plaques of Alzheimer's disease. Acta Neuropathol 1990;79:486-493.
    • (1990) Acta Neuropathol , vol.79 , pp. 486-493
    • Dickson, D.W.1    Wertkin, A.2    Mattiace, L.A.3    Fier, E.4    Kress, Y.5    Davies, P.6    Yen, S.H.7
  • 29
    • 48749102411 scopus 로고    scopus 로고
    • Carson F, Freida L: Histotechnology: A Self-Instructional Text. Chicago, American Society for Clinical Pathology, 1990, pp 167-169.
    • Carson F, Freida L: Histotechnology: A Self-Instructional Text. Chicago, American Society for Clinical Pathology, 1990, pp 167-169.
  • 31
    • 0030813929 scopus 로고    scopus 로고
    • Selective destruction of stable microtubules and axons by inhibitors of protein serine/threonine phosphatases in cultured human neurons
    • Merrick SE, Trojanowski JQ, Lee VY: Selective destruction of stable microtubules and axons by inhibitors of protein serine/threonine phosphatases in cultured human neurons. J Neurosci 1997;17:5726-5737.
    • (1997) J Neurosci , vol.17 , pp. 5726-5737
    • Merrick, S.E.1    Trojanowski, J.Q.2    Lee, V.Y.3
  • 32
    • 33751245561 scopus 로고    scopus 로고
    • Tau protein abnormalities associated with the progression of Alzheimer disease type dementia
    • Harotunia V, Davies P, Vianna C, Buxbaum JD, Purohit DP: Tau protein abnormalities associated with the progression of Alzheimer disease type dementia. Neurobiol Aging 2007;28:1-7.
    • (2007) Neurobiol Aging , vol.28 , pp. 1-7
    • Harotunia, V.1    Davies, P.2    Vianna, C.3    Buxbaum, J.D.4    Purohit, D.P.5
  • 33
    • 34547395389 scopus 로고    scopus 로고
    • Modulation of hippocampal calcium signalling and plasticity by serine/threonine protein phosphatases
    • Koss DJ, Hindley KP, Riedel G, Platt B: Modulation of hippocampal calcium signalling and plasticity by serine/threonine protein phosphatases. J Neurochem 2007;102:1009-1023.
    • (2007) J Neurochem , vol.102 , pp. 1009-1023
    • Koss, D.J.1    Hindley, K.P.2    Riedel, G.3    Platt, B.4
  • 34
    • 0035075793 scopus 로고    scopus 로고
    • PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus
    • Vogelsberg-Ragaglia V, Schuck T, Trojanowski JQ, Lee VM-Y: PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus. Exp Neurol 2001;168:402-412.
    • (2001) Exp Neurol , vol.168 , pp. 402-412
    • Vogelsberg-Ragaglia, V.1    Schuck, T.2    Trojanowski, J.Q.3    Lee, V.M.-Y.4
  • 35
    • 0033526128 scopus 로고    scopus 로고
    • Enhanced survival and morphological features of basal forebrain cholinergic neurons in vitro: Role of neurotrophins and other potential cortically derived cholinergic trophic factors
    • Ha DH, Robertson RT, Roshanaei M, Weiss JH: Enhanced survival and morphological features of basal forebrain cholinergic neurons in vitro: role of neurotrophins and other potential cortically derived cholinergic trophic factors. J Comp Neurol 1999;406:156-170.
    • (1999) J Comp Neurol , vol.406 , pp. 156-170
    • Ha, D.H.1    Robertson, R.T.2    Roshanaei, M.3    Weiss, J.H.4
  • 36
    • 33746543038 scopus 로고    scopus 로고
    • Nerve growth factor, neural stem cells and Alzheimer's disease
    • Heese K, Low JW, Inoue H: Nerve growth factor, neural stem cells and Alzheimer's disease. Neurosignals 2006-2007;15:1-12.
    • (2006) Neurosignals , vol.15 , pp. 1-12
    • Heese, K.1    Low, J.W.2    Inoue, H.3
  • 37
    • 33746561758 scopus 로고    scopus 로고
    • In vitro analysis of mouse neural stem cells genetically modified to stably express human NGF by a novel multigenic viral expression system
    • Genciarelli C, Budoni M, Mercanti D, Fernandez E, Pallini R, Aloe L, Cimino V, Maira G, Casalbore P: In vitro analysis of mouse neural stem cells genetically modified to stably express human NGF by a novel multigenic viral expression system. Neurol Res 2006;28:505-512.
    • (2006) Neurol Res , vol.28 , pp. 505-512
    • Genciarelli, C.1    Budoni, M.2    Mercanti, D.3    Fernandez, E.4    Pallini, R.5    Aloe, L.6    Cimino, V.7    Maira, G.8    Casalbore, P.9
  • 38
    • 24944536068 scopus 로고    scopus 로고
    • A new tool in the battle against Alzheimer's disease and aging: Ex vivo gene therapy
    • Ebert AD, Svendsen CN: A new tool in the battle against Alzheimer's disease and aging: ex vivo gene therapy. Rejuvenation Res 2005;8:131-134.
    • (2005) Rejuvenation Res , vol.8 , pp. 131-134
    • Ebert, A.D.1    Svendsen, C.N.2
  • 39
    • 0037654372 scopus 로고    scopus 로고
    • Growth-factor gene therapy for neurodegenerative disorders
    • Tuszynski MH: Growth-factor gene therapy for neurodegenerative disorders. Lancet Neurol 2002;1:51-57.
    • (2002) Lancet Neurol , vol.1 , pp. 51-57
    • Tuszynski, M.H.1
  • 40
    • 0032845156 scopus 로고    scopus 로고
    • Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy
    • Smith DE, Roberts J, Gage FH, Tuszynski MH: Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy. Proc Natl Acad Sci USA 1999;96:10893-10898.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 10893-10898
    • Smith, D.E.1    Roberts, J.2    Gage, F.H.3    Tuszynski, M.H.4
  • 41
    • 0030002982 scopus 로고    scopus 로고
    • Gene therapy in the adult primate brain: Intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration
    • Tuszynski MH, Roberts J, Senut MC, Gage FH: Gene therapy in the adult primate brain: intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration. Gene Ther 1996;3:305-314.
    • (1996) Gene Ther , vol.3 , pp. 305-314
    • Tuszynski, M.H.1    Roberts, J.2    Senut, M.C.3    Gage, F.H.4
  • 42
    • 25844486970 scopus 로고    scopus 로고
    • Alzheimer's disease and neural transplantation as prospective cell therapy
    • Oliveira AA Jr, Hodges HM: Alzheimer's disease and neural transplantation as prospective cell therapy. Curr Alzheimer Res 2005;2:79-95.
    • (2005) Curr Alzheimer Res , vol.2 , pp. 79-95
    • Oliveira Jr, A.A.1    Hodges, H.M.2
  • 43
    • 17844394405 scopus 로고    scopus 로고
    • Neural stem cells and their use as therapeutic tool in neurological disorders
    • Pluchino S, Zanotti L, Deleidi M, Martino G: Neural stem cells and their use as therapeutic tool in neurological disorders. Brain Res Rev 2005;48:211-219.
    • (2005) Brain Res Rev , vol.48 , pp. 211-219
    • Pluchino, S.1    Zanotti, L.2    Deleidi, M.3    Martino, G.4
  • 44
    • 0034869892 scopus 로고    scopus 로고
    • Developmental expression of fibroblast growth factor (FGF) receptors in neural stem cell progeny: Modulation of neuronal and glial lineages by basic FGF treatment
    • Reimers D, Lopez-Toledano MA, Mason I, Cuevas P, Redondo C, Herranz AS, Lobo MV, Bazan E: Developmental expression of fibroblast growth factor (FGF) receptors in neural stem cell progeny: modulation of neuronal and glial lineages by basic FGF treatment. Neurol Res 2001;23:612-621.
    • (2001) Neurol Res , vol.23 , pp. 612-621
    • Reimers, D.1    Lopez-Toledano, M.A.2    Mason, I.3    Cuevas, P.4    Redondo, C.5    Herranz, A.S.6    Lobo, M.V.7    Bazan, E.8
  • 46
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the etiology of Alzheimer's disease
    • Hardy J, Allsop D: Amyloid deposition as the central event in the etiology of Alzheimer's disease. Trends Pharmacol Sci 1991;12:383-388.
    • (1991) Trends Pharmacol Sci , vol.12 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 47
    • 33846015514 scopus 로고    scopus 로고
    • Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles
    • Oddo S, Vasilevko V, Caccamo A, Kitazawa M, Cribbs DH, LaFerla FM: Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. J Biol Chem 2006;281:39413-39423.
    • (2006) J Biol Chem , vol.281 , pp. 39413-39423
    • Oddo, S.1    Vasilevko, V.2    Caccamo, A.3    Kitazawa, M.4    Cribbs, D.H.5    LaFerla, F.M.6
  • 49
    • 25844486970 scopus 로고    scopus 로고
    • Alzheimer's disease and neural transplantation as prospective cell therapy
    • Oliveira AA Jr, Hodges HM: Alzheimer's disease and neural transplantation as prospective cell therapy. Curr Alzheimer Res 2005;2:79-95.
    • (2005) Curr Alzheimer Res , vol.2 , pp. 79-95
    • Oliveira Jr, A.A.1    Hodges, H.M.2
  • 51
    • 0036581270 scopus 로고    scopus 로고
    • Opinion: Neural stem cell therapy for neurological diseases: dreams and reality
    • Rossi F, Cattaneo E: Opinion: neural stem cell therapy for neurological diseases: dreams and reality. Nat Rev Neurosci 2002;3:401-409.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 401-409
    • Rossi, F.1    Cattaneo, E.2
  • 52
    • 0037162691 scopus 로고    scopus 로고
    • Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors
    • Nakatomi H, Kuriu T, Okabe S, Yamamoto S, Hatano O, Kawahara N, Tamura A, Kirino T, Nakafuku M: Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell 2002;110:429-441.
    • (2002) Cell , vol.110 , pp. 429-441
    • Nakatomi, H.1    Kuriu, T.2    Okabe, S.3    Yamamoto, S.4    Hatano, O.5    Kawahara, N.6    Tamura, A.7    Kirino, T.8    Nakafuku, M.9
  • 53
    • 0035665838 scopus 로고    scopus 로고
    • Stem cell strategies for neuroreplacement therapy in Alzheimer's disease
    • Sugaya K, Brannen CL: Stem cell strategies for neuroreplacement therapy in Alzheimer's disease. Med Hypotheses 2001;57:697-700.
    • (2001) Med Hypotheses , vol.57 , pp. 697-700
    • Sugaya, K.1    Brannen, C.L.2
  • 54
    • 0026010866 scopus 로고
    • Exogenous nerve growth factor stimulates choline acetyltransferase activity in aging Fischer 344 male rats
    • Williams LR: Exogenous nerve growth factor stimulates choline acetyltransferase activity in aging Fischer 344 male rats. Neurobiol Aging 1991;12:39-46.
    • (1991) Neurobiol Aging , vol.12 , pp. 39-46
    • Williams, L.R.1
  • 56
    • 0032539698 scopus 로고    scopus 로고
    • Ex vivo nerve growth factor gene transfer to the basal forebrain in presymptomatic middle-aged rats prevents the development of cholinergic neuron atrophy and cognitive impairment during aging
    • Martinez-Serrano A, Björklund A: Ex vivo nerve growth factor gene transfer to the basal forebrain in presymptomatic middle-aged rats prevents the development of cholinergic neuron atrophy and cognitive impairment during aging. Proc Natl Acad Sci USA 1998;95:1858-1863.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 1858-1863
    • Martinez-Serrano, A.1    Björklund, A.2


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