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Volumn 9, Issue 10, 2012, Pages 1182-1190

Pretreatment with memantine prevents Alzheimer-like alterations induced by intrahippocampal okadaic acid administration in rats

Author keywords

Alzheimer's disease; Cdk5; Glutamate; Learning and memory; Memantine; Okadaic acid; Tau

Indexed keywords

CYCLIN DEPENDENT KINASE 5; GLUTAMIC ACID; MEMANTINE; OKADAIC ACID; PROTEIN P25; TAU PROTEIN;

EID: 84874916126     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/156720512804142877     Document Type: Article
Times cited : (24)

References (66)
  • 1
    • 77952037818 scopus 로고    scopus 로고
    • Anti-aging herbal medicine--how and why can they be used in aging-associated neurodegenerative diseases
    • Ho YS, KF So, RC Chang. Anti-aging herbal medicine--how and why can they be used in aging-associated neurodegenerative diseases? Ageing Res Rev 9(3): 354-62 (2010).
    • (2010) Ageing Res Rev , vol.9 , Issue.3 , pp. 354-362
    • Ho, Y.S.1    So, K.F.2    Chang, R.C.3
  • 2
    • 0022616654 scopus 로고
    • Alzheimer's disease
    • Katzman R. Alzheimer's disease. N Engl J Med 314(15): 964-73 (1986).
    • (1986) N Engl J Med , vol.314 , Issue.15 , pp. 964-973
    • Katzman, R.1
  • 4
    • 77951776829 scopus 로고    scopus 로고
    • Alzheimer's disease: Strategies for disease modification
    • Citron, M. Alzheimer's disease: strategies for disease modification. Nat Rev Drug Discov 9(5): 387-98 (2010).
    • (2010) Nat Rev Drug Discov , vol.9 , Issue.5 , pp. 387-398
    • Citron, M.1
  • 5
    • 33847339301 scopus 로고    scopus 로고
    • NSAIDs and Alzheimer disease: Epidemiological, animal model and clinical studies
    • McGeer PL, McGeer EG. NSAIDs and Alzheimer disease: epidemiological, animal model and clinical studies. Neurobiol Aging 28(5): 639-47 (2007).
    • (2007) Neurobiol Aging , vol.28 , Issue.5 , pp. 639-647
    • McGeer, P.L.1    McGeer, E.G.2
  • 6
    • 79957946047 scopus 로고    scopus 로고
    • Neurovascular function in Alzheimer's disease patients and experimental models
    • Nicolakakis NE Hamel. Neurovascular function in Alzheimer's disease patients and experimental models. J Cereb Blood Flow Metab (2011).
    • (2011) J Cereb Blood Flow Metab
    • Hamel, N.N.E.1
  • 7
    • 7044231698 scopus 로고    scopus 로고
    • Dementia of Alzheimer's disease and other neurodegenerative disorders--memantine, a new hope
    • Sonkusare SK, Kaul CL, Ramarao P. Dementia of Alzheimer's disease and other neurodegenerative disorders--memantine, a new hope. Pharmacol Res 51(1): 1-17 (2005).
    • (2005) Pharmacol Res , vol.51 , Issue.1 , pp. 1-17
    • Sonkusare, S.K.1    Kaul, C.L.2    Ramarao, P.3
  • 9
    • 0025277960 scopus 로고
    • Excitatory amino acids and synaptic transmission: The evidence for a physiological function
    • Headley PM, Grillner S. Excitatory amino acids and synaptic transmission: the evidence for a physiological function. Trends Pharmacol Sci 11(5): 205-11 (1990).
    • (1990) Trends Pharmacol Sci , vol.11 , Issue.5 , pp. 205-211
    • Headley, P.M.1    Grillner, S.2
  • 10
    • 0035001341 scopus 로고    scopus 로고
    • Glutamate uptake
    • Danbolt NC. Glutamate uptake. Prog Neurobiol 65(1): 1-105 (2001).
    • (2001) Prog Neurobiol , vol.65 , Issue.1 , pp. 1-105
    • Danbolt, N.C.1
  • 11
    • 1842524064 scopus 로고    scopus 로고
    • Glutamate transporters: Animal models to neurologic disease
    • Maragakis NJ, Rothstein JD. Glutamate transporters: animal models to neurologic disease. Neurobiol Dis 15(3): 461-73 (2004).
    • (2004) Neurobiol Dis , vol.15 , Issue.3 , pp. 461-473
    • Maragakis, N.J.1    Rothstein, J.D.2
  • 13
    • 79952449645 scopus 로고    scopus 로고
    • Subchronic memantine administration on spatial learning, exploratory activity, and nestbuilding in an APP/PS1 mouse model of Alzheimer's disease
    • Filali M, Lalonde R, Rivest S. Subchronic memantine administration on spatial learning, exploratory activity, and nestbuilding in an APP/PS1 mouse model of Alzheimer's disease. Neuropharmacology 60(6): 930-6 (2011).
    • (2011) Neuropharmacology , vol.60 , Issue.6 , pp. 930-936
    • Filali, M.1    Lalonde, R.2    Rivest, S.3
  • 14
    • 0033540060 scopus 로고    scopus 로고
    • Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
    • Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai LH, et al. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature 402(6762): 615-22 (1999).
    • (1999) Nature , vol.402 , Issue.6762 , pp. 615-622
    • Patrick, G.N.1    Zukerberg, L.2    Nikolic, M.3    de la Monte, S.4    Dikkes, P.5    Tsai, L.H.6
  • 15
    • 77953892400 scopus 로고    scopus 로고
    • Molecular mechanisms of neurodegeneration in Alzheimer's disease
    • Crews L, Masliah E. Molecular mechanisms of neurodegeneration in Alzheimer's disease. Hum Mol Genet 19(R1): R12-20 (2010).
    • (2010) Hum Mol Genet , vol.19 , Issue.1 R , pp. 12-20
    • Crews, L.1    Masliah, E.2
  • 16
    • 38349009068 scopus 로고    scopus 로고
    • Cdk5 regulates the phosphorylation of tyrosine 1472 NR2B and the surface expression of NMDA receptors
    • Zhang S, Edelmann L, Liu J, Crandall JE, Morabito MA. Cdk5 regulates the phosphorylation of tyrosine 1472 NR2B and the surface expression of NMDA receptors. J Neurosci 28(2): 415-24 (2008).
    • (2008) J Neurosci , vol.28 , Issue.2 , pp. 415-424
    • Zhang, S.1    Edelmann, L.2    Liu, J.3    Crandall, J.E.4    Morabito, M.A.5
  • 17
    • 33746924907 scopus 로고    scopus 로고
    • Memantine treatment in mild to moderate Alzheimer disease: A 24-week randomized, controlled trial
    • Peskind ER, Potkin SG, Pomara N, Ott BR, Graham SM, Olin JT, et al. Memantine treatment in mild to moderate Alzheimer disease: a 24-week randomized, controlled trial. Am J Geriatr Psychiatry 14(8): 704-15 (2006).
    • (2006) Am J Geriatr Psychiatry , vol.14 , Issue.8 , pp. 704-715
    • Peskind, E.R.1    Potkin, S.G.2    Pomara, N.3    Ott, B.R.4    Graham, S.M.5    Olin, J.T.6
  • 18
    • 0345872128 scopus 로고    scopus 로고
    • Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: A randomized controlled trial
    • Tariot PN, Farlow MR, Grossberg GT, Graham SM, McDonald S, Gergel I, et al. Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial. JAMA 291(3): 317-24 (2004).
    • (2004) JAMA , vol.291 , Issue.3 , pp. 317-324
    • Tariot, P.N.1    Farlow, M.R.2    Grossberg, G.T.3    Graham, S.M.4    McDonald, S.5    Gergel, I.6
  • 20
    • 0032983786 scopus 로고    scopus 로고
    • Memantine in severe dementia: Results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine)
    • Winblad B, Poritis N. Memantine in severe dementia: results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine). Int J Geriatr Psychiatry 14(2): 135-46 (1999).
    • (1999) Int J Geriatr Psychiatry , vol.14 , Issue.2 , pp. 135-146
    • Winblad, B.1    Poritis, N.2
  • 21
    • 70449732262 scopus 로고    scopus 로고
    • Update on the use of memantine in Alzheimer's disease
    • van Marum RJ. Update on the use of memantine in Alzheimer's disease. Neuropsychiatr Dis Treat 5: 237-47 (2009).
    • (2009) Neuropsychiatr Dis Treat , vol.5 , pp. 237-247
    • van Marum, R.J.1
  • 23
    • 62549090539 scopus 로고    scopus 로고
    • Pre-ischemic treatment with memantine reversed the neurochemical and behavioural parameters but not energy metabolites in middle cerebral artery occluded rats
    • Babu CS, Ramanathan M. Pre-ischemic treatment with memantine reversed the neurochemical and behavioural parameters but not energy metabolites in middle cerebral artery occluded rats. Pharmacol Biochem Behav 92(3): 424-32 (2009).
    • (2009) Pharmacol Biochem Behav , vol.92 , Issue.3 , pp. 424-432
    • Babu, C.S.1    Ramanathan, M.2
  • 24
    • 72049129673 scopus 로고    scopus 로고
    • Okadaic acid (ICV) induced memory impairment in rats: A suitable experimental model to test anti-dementia activity
    • Kamat PK, Tota S, Saxena G, Shukla R, Nath C. Okadaic acid (ICV) induced memory impairment in rats: a suitable experimental model to test anti-dementia activity. Brain Res 1309: 66-74 (2010).
    • (2010) Brain Res , vol.1309 , pp. 66-74
    • Kamat, P.K.1    Tota, S.2    Saxena, G.3    Shukla, R.4    Nath, C.5
  • 25
    • 0028786849 scopus 로고
    • Paired helical filament-like phosphorylation of tau, deposition of beta/A4-amyloid and memory impairment in rat induced by chronic inhibition of phosphatase 1 and 2A
    • Arendt T, Holzer M, Fruth R, Bruckner MK, Gartner U. Paired helical filament-like phosphorylation of tau, deposition of beta/A4-amyloid and memory impairment in rat induced by chronic inhibition of phosphatase 1 and 2A. Neuroscience 69(3): 691-8 (1995).
    • (1995) Neuroscience , vol.69 , Issue.3 , pp. 691-698
    • Arendt, T.1    Holzer, M.2    Fruth, R.3    Bruckner, M.K.4    Gartner, U.5
  • 26
    • 0031798653 scopus 로고    scopus 로고
    • The use of okadaic acid in vivo and the induction of molecular changes typical for Alzheimer's disease
    • Arendt T, Holzer M, Bruckner MK, Janke C, Gartner U. The use of okadaic acid in vivo and the induction of molecular changes typical for Alzheimer's disease. Neuroscience 85(4): 1337-40 (1998).
    • (1998) Neuroscience , vol.85 , Issue.4 , pp. 1337-1340
    • Arendt, T.1    Holzer, M.2    Bruckner, M.K.3    Janke, C.4    Gartner, U.5
  • 27
    • 0036434293 scopus 로고    scopus 로고
    • Okadaic acid induces epileptic seizures and hyperphosphorylation of the NR2B subunit of the NMDA receptor in rat hippocampus in vivo
    • Arias C, Montiel T, Pena F, Ferrera P, Tapia R. Okadaic acid induces epileptic seizures and hyperphosphorylation of the NR2B subunit of the NMDA receptor in rat hippocampus in vivo. Exp Neurol 177(1): 284-91 (2002).
    • (2002) Exp Neurol , vol.177 , Issue.1 , pp. 284-291
    • Arias, C.1    Montiel, T.2    Pena, F.3    Ferrera, P.4    Tapia, R.5
  • 28
    • 0034680902 scopus 로고    scopus 로고
    • Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain
    • Bennecib M, Gong CX, Grundke-Iqbal I, Iqbal K. Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain. FEBS Lett 485(1): 87-93 (2000).
    • (2000) FEBS Lett , vol.485 , Issue.1 , pp. 87-93
    • Bennecib, M.1    Gong, C.X.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 29
    • 80052846665 scopus 로고    scopus 로고
    • Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease
    • Reddy PH. Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease. Brain Res 1415: 136-48 (2011).
    • (2011) Brain Res , vol.1415 , pp. 136-148
    • Reddy, P.H.1
  • 30
    • 84863230105 scopus 로고    scopus 로고
    • The microtubule-stabilizing agent, epothilone d, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice
    • Zhang B, Carroll J, Trojanowski JQ, Yao Y, Iba M, Potuzak JS, et al. The microtubule-stabilizing agent, epothilone d, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. J Neurosci 32(11): 3601-11 (2012).
    • (2012) J Neurosci , vol.32 , Issue.11 , pp. 3601-3611
    • Zhang, B.1    Carroll, J.2    Trojanowski, J.Q.3    Yao, Y.4    Iba, M.5    Potuzak, J.S.6
  • 31
    • 33846538660 scopus 로고    scopus 로고
    • Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model
    • Yoshiyama Y, Higuchi M, Zhang B, Huang SM, Iwata N, Saido TC, et al. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 53(3): 337-51 (2007).
    • (2007) Neuron , vol.53 , Issue.3 , pp. 337-351
    • Yoshiyama, Y.1    Higuchi, M.2    Zhang, B.3    Huang, S.M.4    Iwata, N.5    Saido, T.C.6
  • 32
    • 70149121742 scopus 로고    scopus 로고
    • Social isolation prevents exercise-induced proliferation of hippocampal progenitor cells in female rats
    • Leasure JL, Decker L. Social isolation prevents exercise-induced proliferation of hippocampal progenitor cells in female rats. Hippocampus 19(10): 907-12 (2009).
    • (2009) Hippocampus , vol.19 , Issue.10 , pp. 907-912
    • Leasure, J.L.1    Decker, L.2
  • 33
    • 79960440188 scopus 로고    scopus 로고
    • Memantine prevents aluminum-induced cognitive deficit in rats
    • Abdel-Aal RA, Assi AA, Kostandy BB. Memantine prevents aluminum-induced cognitive deficit in rats. Behav Brain Res 225(1): 31-8 (2011).
    • (2011) Behav Brain Res , vol.225 , Issue.1 , pp. 31-38
    • Abdel-Aal, R.A.1    Assi, A.A.2    Kostandy, B.B.3
  • 35
    • 0032191966 scopus 로고    scopus 로고
    • The protein phosphatase inhibitor okadaic acid induces heat shock protein expression and neurodegeneration in rat hippocampus in vivo
    • Arias C, Becerra-Garcia F, Arrieta I, Tapia R. The protein phosphatase inhibitor okadaic acid induces heat shock protein expression and neurodegeneration in rat hippocampus in vivo. Exp Neurol 153(2): 242-54 (1998).
    • (1998) Exp Neurol , vol.153 , Issue.2 , pp. 242-254
    • Arias, C.1    Becerra-Garcia, F.2    Arrieta, I.3    Tapia, R.4
  • 36
    • 0035666080 scopus 로고    scopus 로고
    • Spatial memory deficit and neurodegeneration induced by the direct injection of okadaic acid into the hippocampus in rats
    • He J, Yamada K, Zou LB, Nabeshima T. Spatial memory deficit and neurodegeneration induced by the direct injection of okadaic acid into the hippocampus in rats. J Neural Transm 108(12): 1435-43 (2001).
    • (2001) J Neural Transm , vol.108 , Issue.12 , pp. 1435-1443
    • He, J.1    Yamada, K.2    Zou, L.B.3    Nabeshima, T.4
  • 37
    • 23844547937 scopus 로고    scopus 로고
    • Olanzapine attenuates the okadaic acid-induced spatial memory impairment and hippocampal cell death in rats
    • He J, Yang Y, Xu H, Zhang X, Li XM. Olanzapine attenuates the okadaic acid-induced spatial memory impairment and hippocampal cell death in rats. Neuropsychopharmacology 30(8): 1511-20 (2005).
    • (2005) Neuropsychopharmacology , vol.30 , Issue.8 , pp. 1511-1520
    • He, J.1    Yang, Y.2    Xu, H.3    Zhang, X.4    Li, X.M.5
  • 38
    • 0037470154 scopus 로고    scopus 로고
    • The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: A review
    • Prut L, Belzung C. The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. Eur J Pharmacol 463(1-3): 3-33 (2003).
    • (2003) Eur J Pharmacol , vol.463 , Issue.1-3 , pp. 3-33
    • Prut, L.1    Belzung, C.2
  • 39
    • 77957312623 scopus 로고    scopus 로고
    • Metabolic and behavioral effects of chronic olanzapine treatment and cafeteria diet in rats
    • Muller AP, Tort AH, Gnoatto J, Moreira JD, Vinadé ER, Perry ML, et al. Metabolic and behavioral effects of chronic olanzapine treatment and cafeteria diet in rats. Behav Pharmacol 21(7): 668-75 (2010).
    • (2010) Behav Pharmacol , vol.21 , Issue.7 , pp. 668-675
    • Muller, A.P.1    Tort, A.H.2    Gnoatto, J.3    Moreira, J.D.4    Vinadé, E.R.5    Perry, M.L.6
  • 40
    • 0017613512 scopus 로고
    • A simplification of the protein assay method of Lowry et al. which is more generally applicable
    • Peterson GL. A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal Biochem 83(2): 346-56 (1977).
    • (1977) Anal Biochem , vol.83 , Issue.2 , pp. 346-356
    • Peterson, G.L.1
  • 42
    • 34548299424 scopus 로고    scopus 로고
    • Developing pharmacological therapies for Alzheimer disease
    • Iqbal K, Grundke-Iqbal I. Developing pharmacological therapies for Alzheimer disease. Cell Mol Life Sci 64(17): 2234-44 (2007).
    • (2007) Cell Mol Life Sci , vol.64 , Issue.17 , pp. 2234-2244
    • Iqbal, K.1    Grundke-Iqbal, I.2
  • 43
    • 77958001015 scopus 로고    scopus 로고
    • An okadaic acid-induced model of tauopathy and cognitive deficiency
    • Zhang Z, Simpkins JW. An okadaic acid-induced model of tauopathy and cognitive deficiency. Brain Res 1359: 233-46 (2010).
    • (2010) Brain Res , vol.1359 , pp. 233-246
    • Zhang, Z.1    Simpkins, J.W.2
  • 44
    • 0037728833 scopus 로고    scopus 로고
    • Inhibition of protein phosphatase 2A-and protein phosphatase 1-induced tau hyperphosphorylation and impairment of spatial memory retention in rats
    • Sun L, Liu SY, Zhou XW, Wang XC, Liu R, Wang Q, et al. Inhibition of protein phosphatase 2A-and protein phosphatase 1-induced tau hyperphosphorylation and impairment of spatial memory retention in rats. Neuroscience 118(4): 1175-82 (2003).
    • (2003) Neuroscience , vol.118 , Issue.4 , pp. 1175-1182
    • Sun, L.1    Liu, S.Y.2    Zhou, X.W.3    Wang, X.C.4    Liu, R.5    Wang, Q.6
  • 45
    • 0037194791 scopus 로고    scopus 로고
    • Protein phosphatase 1 is a molecular constraint on learning and memory
    • Genoux D, Haditsch U, Knobloch M, Michalon A, Storm D, Mansuy IM. Protein phosphatase 1 is a molecular constraint on learning and memory. Nature 418(6901): 970-5 (2002).
    • (2002) Nature , vol.418 , Issue.6901 , pp. 970-975
    • Genoux, D.1    Haditsch, U.2    Knobloch, M.3    Michalon, A.4    Storm, D.5    Mansuy, I.M.6
  • 46
    • 0028170809 scopus 로고
    • Protein serine/threonine phosphatases--new avenues for cell regulation
    • Shenolikar S. Protein serine/threonine phosphatases--new avenues for cell regulation. Annu Rev Cell Biol 10: 55-86 (1994).
    • (1994) Annu Rev Cell Biol , vol.10 , pp. 55-86
    • Shenolikar, S.1
  • 47
    • 79960632825 scopus 로고    scopus 로고
    • Glutamate receptors in preclinical research on Alzheimer's disease: Update on recent advances
    • Hu NW, Ondrejcak T, Rowan MJ. Glutamate receptors in preclinical research on Alzheimer's disease: Update on recent advances. Pharmacol Biochem Behav (2011).
    • (2011) Pharmacol Biochem Behav
    • Hu, N.W.1    Ondrejcak, T.2    Rowan, M.J.3
  • 48
    • 33745370049 scopus 로고    scopus 로고
    • Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine
    • Chohan MO, Khatoon S, Iqbal IG, Iqbal K. Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine. FEBS Lett 580(16): 3973-9 (2006).
    • (2006) FEBS Lett , vol.580 , Issue.16 , pp. 3973-3979
    • Chohan, M.O.1    Khatoon, S.2    Iqbal, I.G.3    Iqbal, K.4
  • 49
    • 77953797283 scopus 로고    scopus 로고
    • Cerebrospinal fluid concentrations of functionally important amino acids and metabolic compounds in patients with mild cognitive impairment and Alzheimer's disease
    • Kaiser E, Schoenknecht P, Kassner S, Hildebrandt W, Kinscherf R, Schroeder J, et al. Cerebrospinal fluid concentrations of functionally important amino acids and metabolic compounds in patients with mild cognitive impairment and Alzheimer's disease. Neurodegener Dis 7(4): 251-9 (2010).
    • (2010) Neurodegener Dis , vol.7 , Issue.4 , pp. 251-259
    • Kaiser, E.1    Schoenknecht, P.2    Kassner, S.3    Hildebrandt, W.4    Kinscherf, R.5    Schroeder, J.6
  • 50
    • 77953911484 scopus 로고    scopus 로고
    • Memantine depresses glutamate release through inhibition of voltage-dependent Ca2+ entry and protein kinase C in rat cerebral cortex nerve terminals: An NMDA receptor-independent mechanism
    • Lu CW, Lin TY, Wang SJ. Memantine depresses glutamate release through inhibition of voltage-dependent Ca2+ entry and protein kinase C in rat cerebral cortex nerve terminals: an NMDA receptor-independent mechanism. Neurochem Int 57(2): 168-76 (2010).
    • (2010) Neurochem Int , vol.57 , Issue.2 , pp. 168-176
    • Lu, C.W.1    Lin, T.Y.2    Wang, S.J.3
  • 51
    • 18544390506 scopus 로고    scopus 로고
    • Post-translational modifications of tau protein in Alzheimer's disease
    • Gong CX, Liu F, Grundke-Iqbal I, Iqbal K. Post-translational modifications of tau protein in Alzheimer's disease. J Neural Transm 112(6): 813-38 (2005).
    • (2005) J Neural Transm , vol.112 , Issue.6 , pp. 813-838
    • Gong, C.X.1    Liu, F.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 52
    • 33750510335 scopus 로고    scopus 로고
    • PKA modulates GSK-3beta-and cdk5-catalyzed phosphorylation of tau in site-and kinase-specific manners
    • Liu F, Liang Z, Shi J, Yin D, El-Akkad E, Grundke-Iqbal I, et al. PKA modulates GSK-3beta-and cdk5-catalyzed phosphorylation of tau in site-and kinase-specific manners. FEBS Lett 580(26): 6269-74 (2006).
    • (2006) FEBS Lett , vol.580 , Issue.26 , pp. 6269-6274
    • Liu, F.1    Liang, Z.2    Shi, J.3    Yin, D.4    El-Akkad, E.5    Grundke-Iqbal, I.6
  • 53
    • 0027978170 scopus 로고
    • p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5
    • Tsai LH, Delalle I, Caviness VS, Jr., Chae T, Harlow E. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature 371(6496): 419-23 (1994).
    • (1994) Nature , vol.371 , Issue.6496 , pp. 419-423
    • Tsai, L.H.1    Delalle, I.2    Caviness Jr., V.S.3    Chae, T.4    Harlow, E.5
  • 54
    • 0028122011 scopus 로고
    • A brain-specific activator of cyclin-dependent kinase 5
    • Lew J, Huang QQ, Qi Z, Winkfein RJ, Aebersold R, Hunt T, et al. A brain-specific activator of cyclin-dependent kinase 5. Nature 371(6496): 423-6 (1994).
    • (1994) Nature , vol.371 , Issue.6496 , pp. 423-426
    • Lew, J.1    Huang, Q.Q.2    Qi, Z.3    Winkfein, R.J.4    Aebersold, R.5    Hunt, T.6
  • 55
    • 0141542665 scopus 로고    scopus 로고
    • Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors
    • Wang J, Liu S, Fu Y, Wang JH, Lu Y. Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors. Nat Neurosci 6(10): 1039-47 (2003).
    • (2003) Nat Neurosci , vol.6 , Issue.10 , pp. 1039-1047
    • Wang, J.1    Liu, S.2    Fu, Y.3    Wang, J.H.4    Lu, Y.5
  • 57
    • 79954633210 scopus 로고    scopus 로고
    • The role of Cdk5 in cognition and neuropsychiatric and neurological pathology
    • Barnett DG, Bibb JA. The role of Cdk5 in cognition and neuropsychiatric and neurological pathology. Brain Res Bull 85(1-2): 9-13 (2011).
    • (2011) Brain Res Bull , vol.85 , Issue.1-2 , pp. 9-13
    • Barnett, D.G.1    Bibb, J.A.2
  • 58
    • 76149101242 scopus 로고    scopus 로고
    • Correlation of longitudinal cerebrospinal fluid biomarkers with cognitive decline in healthy older adults
    • Stomrud E, Hansson O, Zetterberg H, Blennow K, Minthon L, Londos E. Correlation of longitudinal cerebrospinal fluid biomarkers with cognitive decline in healthy older adults. Arch Neurol 67(2): 217-23 (2010).
    • (2010) Arch Neurol , vol.67 , Issue.2 , pp. 217-223
    • Stomrud, E.1    Hansson, O.2    Zetterberg, H.3    Blennow, K.4    Minthon, L.5    Londos, E.6
  • 60
    • 0021888963 scopus 로고
    • Putative amino acid transmitters in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer's dementia
    • Smith CC, Bowen DM, Francis PT, Snowden JS, Neary D. Putative amino acid transmitters in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer's dementia. J Neurol Neurosurg Psychiatry 48(5): 469-71 (1985).
    • (1985) J Neurol Neurosurg Psychiatry , vol.48 , Issue.5 , pp. 469-471
    • Smith, C.C.1    Bowen, D.M.2    Francis, P.T.3    Snowden, J.S.4    Neary, D.5
  • 61
  • 62
    • 70449372172 scopus 로고    scopus 로고
    • Use of genetic variation as biomarkers for Alzheimer's disease
    • Reitz CR Mayeux. Use of genetic variation as biomarkers for Alzheimer's disease. Ann NY Acad Sci 1180: 75-96 (2009).
    • (2009) Ann NY Acad Sci , vol.1180 , pp. 75-96
    • Mayeux, R.C.R.1
  • 63
    • 70350662460 scopus 로고    scopus 로고
    • Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease
    • van Exel E, P Eikelenboom, Comijs H, Frölich M, Smit JH, Stek ML, et al. Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease. Arch Gen Psychiatry 66(11): 1263-70 (2009).
    • (2009) Arch Gen Psychiatry , vol.66 , Issue.11 , pp. 1263-1270
    • van Exel, E.1    Eikelenboom, P.2    Comijs, H.3    Frölich, M.4    Smit, J.H.5    Stek, M.L.6
  • 64
    • 80052669683 scopus 로고    scopus 로고
    • Biomarkers of the dementia
    • Shoji M. Biomarkers of the dementia. Int J Alzheimers Dis 2011: 564321 (2011).
    • (2011) Int J Alzheimers Dis , pp. 564321
    • Shoji, M.1


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