Sustained induction of cytochrome P4501A1 in human hepatoma cells by co-exposure to benzo[a]pyrene and 7H-dibenzo[c,g]carbazole underlies the synergistic effects on DNA adduct formation

Toxicology and Applied Pharmacology

Volumn 271, Issue 1, 2013, Pages 1-12

  Gábelová, Alena ^a   Poláková, Veronika ^a   Prochazka, Gabriela ^b   Kretová, Miroslava ^a   Poloncová, Katarína ^a   Regendová, Eva ^a   Luciaková, Katarína ^a   Segerbäck, Dan ^b  

^a CANCER RESEARCH INSTITUTE   (Slovakia)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Binary mixture; CYP1A1 mRNA expression; DNA adducts; Hprt gene mutations; Micronuclei

Indexed keywords

7H DIBENZO[C,G]CARBAZOLE; AROMATIC HYDROCARBON; BENZO[A]PYRENE; CARBAZOLE DERIVATIVE; CYTOCHROME P450 1A1; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL SURVIVAL; CELL VIABILITY; CYTOTOXICITY; DNA ADDUCT; DOWN REGULATION; GENE MUTATION; HEPATOMA CELL; HUMAN; HUMAN CELL; MICRONUCLEUS; NONHUMAN; POLLUTANT; PROTEIN EXPRESSION; RAT; UPREGULATION;

BINARY MIXTURE; CYP1A1 MRNA EXPRESSION; DNA ADDUCTS; HPRT GENE MUTATIONS; MICRONUCLEI;

ANIMALS; BENZO(A)PYRENE; CARBAZOLES; CARCINOGENS; CARCINOMA, HEPATOCELLULAR; CELL LINE; CRICETINAE; CRICETULUS; CYTOCHROME P-450 CYP1A1; DNA ADDUCTS; DRUG SYNERGISM; ENZYME INDUCTION; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MICRONUCLEI, CHROMOSOME-DEFECTIVE; RATS; RNA, MESSENGER; SPECIES SPECIFICITY; TIME FACTORS; UP-REGULATION;

CRICETULUS GRISEUS; RATTUS;

EID: 84878741136     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.04.016     Document Type: Article

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