The genotoxic effect of carcinogenic PAHs, their artificial and environmental mixtures (EOM) on human diploid lung fibroblasts

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 547, Issue 1-2, 2004, Pages 109-121

  Binková, Blanka ^a   Šrám, Radim J ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Czech Republic)

Author keywords

B a A; B a P; B b F; B ghi P; B k F; Benz a anthracene; Benzo a pyrene; Benzo a pyrene r 7,t 8 dihydrodiol t 9,10 epoxide ; Benzo b fluoranthene; Benzo ghi perylene; Benzo k fluoranthene; BPDE; CHRY; Chrysene; DB ah A; DB al P; Dibenzo al pyrene

Indexed keywords

BENZ[A]ANTHRACENE; BENZO[A]PYRENE; BENZO[B]FLUORANTHENE; BENZO[GHI]PERYLENE; BENZO[K]FLUORANTHENE; CARCINOGEN; CHRYSENE; DIBENZ[A,H]ANTHRACENE; DIBENZO[A,L]PYRENE; INDENO[C,D]PYRENE; ORGANIC MATTER; PHOSPHORUS 32; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PROTEIN P21; PROTEIN P53; UNCLASSIFIED DRUG;

ADSORPTION; ARTICLE; CONTROLLED STUDY; DIPLOIDY; DNA ADDUCT; DNA BINDING; ENZYME INHIBITION; ENZYME SYNTHESIS; GENOTOXICITY; HUMAN; HUMAN CELL; ISOTOPE LABELING; LUNG FIBROBLAST; METABOLIC ACTIVATION; METABOLIC CAPACITY; NORMAL HUMAN; PARTICULATE MATTER; PRIORITY JOURNAL; PROTEIN EXPRESSION; TARGET CELL; WESTERN BLOTTING;

7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; BENZO(A)PYRENE; CARCINOGENS, ENVIRONMENTAL; CELLS, CULTURED; DIPLOIDY; DNA; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL EXPOSURE; FIBROBLASTS; HUMANS; LUNG; POLYCYCLIC HYDROCARBONS, AROMATIC; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

EID: 1542376626     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2003.12.006     Document Type: Article

References (43)

1. Carpenter D.O., Arcaro K.F., Spink D.C. Understanding the human health effects of chemical mixtures. Environ. Health Perspect. 110(Suppl. 1):2002;25-42.
2. Carpenter D.O., Arcaro K.F., Bush B., Niemi W.D., Pang S., Vakharia D.D. Human health and chemical mixtures: an overview. Environ. Health Perspect. 106(Suppl. 6):1998;1263-1270.
3. Mittal R.A.K., van Grieken R. Health risk assessment of urban suspended particulate matter with special reference to polycyclic aromatic hydrocarbons: a review. Rev. Environ. Health. 16:2001;169-189.
4. Boström C.E., Gerde P., Hanberg A., Jernström B., Johansson C., Kyrklund T., Rannung A., Törnquist M., Victorin K., Westerholm R. Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air. Environ. Health Perspect. 110(Suppl. 3):2002;451-487.
5. Binková B., Veselý D., Veselá D., Jelínek R., Šrám R.J. Genotoxicity and embryotoxicity of urban air particulate matter collected during winter and summer period in two different districts of the Czech Republic. Mutat. Res. 440:1999;45-58.
6. Dejmek J., Selevan S.G., Beneš I., Solanský I., Šrám R.J. Fetal growth and maternal exposure to particulate matter during pregnancy. Environ. Health Perspect. 107:1999;475-480.
7. Šrám R.J. Impact of air pollution on reproductive health. Environ. Health Perspect. 107:1999;A542-A543.
8. Dejmek J., Solanský I., Beneš I., Lenièek J., Šrám R.J. The impact of polycyclic aromatic hydrocarbons and fine particles on pregnancy outcome. Environ. Health Perspect. 108:2000;1159-1164.
9. Binková B., Černā M., Pastorková A., Jelínek R., Beneš I., Novák J., Šrám R.J. Biological activities of organic compounds adsorbed onto ambient air particles: comparison between the cities of Teplice and Prague during the summer and winter seasons 2000-2001. Mutat. Res. 525:2003;43-59.
10. Pope C.A., Thun M.J., Namboodiri M.M., Dockery D.W., Evans J.S., Speizer F.E., Heath C.W. Particulate air pollution as a predictor of mortality in a prospective study of U.S. adults. Am. J. Respir. Crit. Care Med. 151:1995;669-674.
11. Pope C.A., Burnett R.T., Thun M.J., Calle E.E., Krewski D., Ito K., Thurston G.D. Lung cancer, cardiopulmonary mortality and long-term exposure to fine particulate air pollution. JAMA. 287:2002;1132-1141.
12. IARC Monographs on the Evaluation of Carcinogenic Risk to Humans, Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs, vols. 1-42, Suppl. 7, International Agency for Research on Cancer, Lyon, France, 1987.
13. Page J.E., Zajc B., Oh-Hara T., Lakshman M.K., Sayer J.M., Jerina D.M., Dipple A. Sequence context profoundly influences the mutagenic potency of trans-opened benzo[a]pyrene-7,8-diol-9,10-epoxide-purine nucleoside adducts in site-specific mutation studies. Biochemistry. 37:1998;9127-9137.
14. Dipple A., Khan Q.A., Page J.E., Ponten I., Szeliga J. DNA reactions, mutagenic action and stealth properties of polycyclic hydrocarbon carcinogens. Int. J. Oncol. 14:1999;103-111.
15. Nesnow S., Ross J.A., Mass M.J., Stoner G.D. Mechanistic relationships between DNA adducts, oncogene mutations, and lung tumorogenesis in strain A mice. Exp. Lung Res. 24:1998;395-405.
16. Reeves W.R., Barhoumi R., Burghardt R.C., Lemke S.L., Mayura K., McDonald T.J., Philips T.D., Donnelly K.C. Evaluation of methods for predicting the toxicity of polycyclic aromatic hydrocarbon mixtures. Environ. Sci. Technol. 35:2001;1630-1636.
17. White P.A. The genotoxicity of priority polycyclic aromatic hydrocarbons in complex mixtures. Mutat. Res. 515:2002;85-98.
18. Smolarek T.A., Baird W.M., Fisher E.P., DiGiovanni j. Benzo(e)pyrene induced alterations in the binding of benzo(a)pyrene and 7,12-dimethylbenz(a) anthracene to DNA in Sencar mouse epidermis. Cancer Res. 47:1987;3701-3706.
19. Lau H.H.S., Baird W.M. The co-carcinogen benzo[e]pyrene increases the binding of low dose of the carcinogen benzo[a]pyrene to DNA in Sencar mouse epidermis. Cancer Lett. 63:1992;229-236.
20. Hughes N.C., Philips D.H. Covalent binding of dibenzopyrenes and bezo[a]pyrene to DNA: evidence for synergistic and inhibitory interactions when applied in combination to mouse skin. Carcinogenesis. 11:1990;1611-1619.
21. Nesnow S., Mass M.J., Ross J.A., Galati A.J., Lambert G.R., Gennings C., Carter W.H. Jr., Stoner G.D. Lung tumorigenic interactions in strain A/J mice of five environmental polycyclic aromatic hydrocarbons. Environ. Health Perspect. 106:1998;1337-1346.
22. Marston C.P., Pereira C., Ferguson J., Fisher K., Hedstrom O., Dashwood W.M., Baird W.M. Effect of a complex environmental mixture from coal tar containing polycyclic aromatic hydrocarbons (PAH) on tumor initiation, PAH-DNA binding and metabolic activation of carcinogenic PAH in mouse epidermis. Carcinogenesis. 22:2001;1077-1086.
23. J.A. Hickman, C. Dive (Eds.), Apotosis and Cancer Chemotherapy, Humana Press, Totowa, NJ, 1999.
24. Levine A.J. p53, the cellular gatekeeper for growth and division. Cell. 88:1997;323-331.
25. Janus F., Albrechtsen N., Dornreiter I., Wiesmuller L., Grosse F., Deppert W. The dual role model for p53 in maintaining genomic integrity. Cell. Mol. Life Sci. 55:1999;12-27.
26. Shaw P.H. The role of p53 in cell cycle regulation. Path. Res. Pract. 192:1996;669-675.
27. Bates S., Voudsen K.H. Mechanism of p53-mediated apoptosis. Cell. Mol. Life Sci. 55:1999;28-37.
28. WAF1 proteins and cell cycle distribution. Mutat. Res. 471:2000;57-70.
29. Phillips D.H., Castegnaro M. Standardization and validation of DNA adduct postlabelling methods: report of interlaboratory trials and production of recommended protocols. Mutagenesis. 14:1999;301-315.
30. 32P -postlabeling and HPLC analysis of DNA adducts Mutat. Res. 414:1998;77-94.
31. Kantor G.J., Setlow R.B. Rate and extent of DNA repair in nondividing human diploid fibroblasts. Cancer Res. 41:1981;819-825.
32. Calabrese E.J. Toxicological consequences of multiple chemical interactions: a primer. Toxicology. 105:1995;121-135.
33. Venkatachalam S., Denissenko M., Wani A.A. Modulation of (±)-anti-BPDE mediated p53 accumulation by inhibitors of protein kinase C and poly(ADP-ribose) polymerase. Oncogene. 14:1997;801-809.
34. Leonardo A.D., Linke S.P., Clarkin K., Wahl G.M. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev. 8:1994;2540-2551.
35. Bridges B.A. The role of DNA damage in stationary phase ('adaptive') mutation. Mutat. Res. 408:1998;1-9.
36. Arif J.M., Gupta R.C., Smith W.A. Tissue distribution of DNA adducts in rats treated by intramammillary injection with dibenzo[a,l]pyrene, 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene. Mutat. Res. 378:1997;31-39.
37. Prahalad A.K., Ross J.A., Nelson G.B., Roop B.C., King L.C., Nesnow S., Mass M.J. Dibenzo[al]pyrene-induced DNA adduction, tumorigenicity and Ki-ras oncogene mutations in strain A/J mouse lung. Carcinogenesis. 18:1997;1955-1963.
38. Mendelez-Colon V.J., Luch A., Seidel A., Baird W.M. Cancer initiation by polycyclic aromatic hydrocarbons results from formation of stable DNA adducts rather than apurinic sites. Carcinogenesis. 20:1999;1885-1891.
39. Rubin H. Synergistic mechanism in carcinogenesis by polycyclic aromatic hydrocarbons and by tobacco smoke: a bio-historical perspectives with updates. Carcinogenesis. 22:2001;1903-1930.
40. Swenberg J.A., La D.K., Scheller N.A., Wu K. Dose-response relationships for carcinogens. Toxicol. Lett. 82/83:1995;751-756.
41. Heussen G.A.H., van den Berg J.H.J., Dreef-van der Meulen H.C., Alink G.M. Carcinogenity study of outdoor airborne particulate matter in newborn male NMRI mice. Toxicol. Lett. 88:1996;23-28.
42. 32P -postlabeling analysis and unscheduled DNA synthesis Carcinogenesis. 14:1993;463-467.
43. Lloyd D.R., Hanawalt P.C. p53 controls global nucleotide excision repair of low levels of structurally diverse benzo(g)chrysene-DNA adducts in human fibroblats. Cancer Res. 62:2002;5288-5294.