Genotoxic potential of organic extracts from particle emissions of diesel and rapeseed oil powered engines

Toxicology Letters

Volumn 212, Issue 1, 2012, Pages 11-17

  Topinka, Jan ^a   Milcova, Alena ^a   Schmuczerova, Jana ^a   Mazac, Martin ^b   Pechout, Martin ^b   Vojtisek Lom, Michal ^b  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Czech Republic)

^b TECHNICAL UNIVERSITY OF LIBEREC   (Czech Republic)

Author keywords

Biodiesel; Diesel emissions; DNA adducts; Genotoxicity; PAHs; Vegetable oil

Indexed keywords

BIODIESEL; DNA; ORGANIC MATTER; POLYCYCLIC AROMATIC HYDROCARBON; RAPESEED OIL;

ANIMAL TISSUE; ARTICLE; CHEMICAL ANALYSIS; COMBUSTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIESEL ENGINE; DNA ADDUCT; EXHAUST GAS; GENOTOXICITY; MOTOR VEHICLE; NONHUMAN; PRIORITY JOURNAL; RAPESEED OIL POWERED ENGINE; RAT; THYMUS;

ANIMALS; DNA ADDUCTS; GASOLINE; LIVER; MICROSOMES, LIVER; MUTAGENS; PARTICULATE MATTER; PLANT OILS; POLYCYCLIC HYDROCARBONS, AROMATIC; RATS; STATISTICS, NONPARAMETRIC; VEHICLE EMISSIONS;

BRASSICA NAPUS; RATTUS;

EID: 84860993357     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.04.017     Document Type: Article

References (40)

1. Abbass, M.K., Andrews, G.E., Williams, P.T., Bartle, K.D., Davies, I.L., Lalah, J.O., 1990. The composition of the organic fraction of particulate emissions of a diesel engine operated on vegetable oil. SAE Technical Paper 901563. Society of Automotive Engineers, Warrensdale, PA, USA.
2. Binkova B., Topinka J., Sram R.J., Sevastyanova O., Novakova Z., Schmuczerova J., Kalina I., Popov T., Farmer P.B. In vitro genotoxicity of PAH mixtures and organic extract from urban air particles. Part I: acellular assay. Mutation Research 2007, 620:114-122.
3. Bünger J., Krahl J., Baum K., Schröder O., Müller M., Westphal G., Ruhnau P., Schulz T.G., Hallier E. Cytotoxic and mutagenic effects, particle size and concentration analysis of diesel engine emissions using biodiesel and petrol diesel as fuel. Archives of Toxicology 2000, 74:490-498.
4. Bünger J., Krahl J., Munack A., Ruschel Y., Schröder O., Emmert B., Westphal G., Müller M. Strong mutagenic effects of diesel engine emissions using vegetable oil as fuel. Archives of Toxicology 2007, 81:599-603.
5. Claxton L.D., Matthews P.P., Warren S.H. The genotoxicity of ambient outdoor air, a review: salmonella mutagenicity. Mutation Research 2004, 567:347-399.
6. Czerwinski, J., Zimmerli, Y., Kasper, M., Meyer, M., 2008. A modern HD-diesel engine with rapeseed oil, DPF and SCR. SAE Technical Paper 2008-01-1382. Society of Automotive Engineers, Warrensdale, PA, USA.
7. Dorn, B., Wehmann, C., Winterhalter, R., Zahoransky, R., 2007. Particle and gaseous emissions of diesel engines fuelled by different non-esterified plant oils. Society of Automotive Engineers, Warrensdale, PA, USA, paper no. 2007-24-0127.
8. Durbin T.D., Collins J., Norbeck J., Smith M. Effects of biodiesel, biodiesel blends, and a synthetic diesel on emissions from light heavy-duty diesel vehicles. Environmental Science and Technology 2000, 34:349-355.
9. Finch G.L., Hobbs C.H., Blair L.F., Barr E.B., Hahn F.F., Jaramillo R.J., Kubatko J.E., March T.H., White R.K., Krone J.R., Ménache M.G., Nikula K.J., Mauderly J.L., Van Gerpen J., Merceica M.D., Zielinska B., Stankowski L., Burling K., Howell S. Effects of subchronic inhalation exposure of rats to emissions from a diesel engine burning soybean oil-derived biodiesel fuel. Inhalation Toxicology 2002, 14:1017-1048.
10. Gerde P., Muggenburg B.A., Lundborg M., Dahl A.R. The rapid alveolar absorption of diesel soot-adsorbed benzo(a)pyrene: bioavailability, metabolism and dosimetry of an inhaled particle-borne carcinogen. Carcinogenesis 2001, 22:741-749.
11. 32P-postlabeling analysis of aromatic carcinogen: DNA adducts. Cancer Research 1985, 45:5656-5662.
12. IARC - International Agency for Research on Cancer and World Health Organization, 2010. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 92: Some Non-heterocyclic Polycyclic Aromatic Hydrocarbons and Some Related Exposures.
13. Kado N.Y., Okamoto R.A., Kuzmicky P.A., Rathbun C.J., Hsieh D.P.H. Integrated supercritical fluid extraction, bioassay and chemical screening methods for analyzing vapor-phase compounds of an environmental complex mixture: diesel exhaust. Chemosphere 1996, 33:495-516.
14. Kalam M.A., Saifullah M.G., Masjuki H.H., Husnawan M., Mahlia T.M.I. PAH and other emissions from coconut oil blended fuels. Journal of Scientific and Industrial Research 2008, 67:1031-1035.
15. Karavalakis G., Fontaras G., Ampatzoglou D., Kousoulidou M., Stournas S., Samaras Z., Bakeas E. Effects of low concentration biodiesel blends application on modern passenger cars. Part 3: impact on PAH, nitro-PAH, and oxy-PAH emissions. Environmental Pollution 2010, 158:1584-1594.
16. Kittelson D.B., Watts W.F., Johnson J.P. On-road and laboratory evaluation of combustion aerosols. Part 1: summary of diesel engine results. Journal of Aerosol Science 2006, 37:913-930.
17. Kittelson D.B., Watts W.F., Johnson J.P., Schauer J.J., Lawson D.R. On-road and laboratory evaluation of combustion aerosols. Part 2: summary of spark ignition engine results. Journal of Aerosol Science 2006, 37:931-949.
18. Knothe G., Sharp C.A., Ryan T.W. Exhaust emissions of biodiesel, petrodiesel, neat methyl esters, and alkanes in a new technology engine. Energy Fuels 2006, 20:403-408.
19. Krahl, J., 2007. Comparison of emissions and mutagenicity from biodiesel, vegetable oil, GTL and diesel fuel. Society of Automotive Engineers, Warrensdale, PA, USA, paper no. 2007-01-4042.
20. Lance, D., Andersson, J., 2004. Emissions performance of pure vegetable oil in two european light duty vehicles. Society of Automotive Engineers, Warrensdale, PA, USA, paper no. 2004-01-1881.
21. Lapuerta M., Armas O., Rodríguez-Fernández J. Effect of biodiesel blends on diesel engine emissions. Progress in Energy and Combustion Science 2008, 34:198-223.
22. Lea-Langton, A., 2008. Comparison of particulate PAH emissions for diesel, biodiesel and cooking oil using a heavy duty DI diesel engine. SAE Technical Paper 2008-01-1811. Society of Automotive Engineers, Warrensdale, PA, USA.
23. Li H., Banner C.D., Mason G.G., Westerholm R.N., Rafter J.J. Determination of polycyclic aromatic compounds and dioxin receptor ligands present in diesel exhaust particulate extracts. Atmospheric Environment 1996, 30:3537-3546.
24. Mauderly J.L. Toxicological and epidemiological evidence for health risks from inhaled engine emissions. Environmental Health Perspectives 1994, 102:165-171.
25. Mauderly J.L. Health issues concerning inhalation of petroleum diesel and biodiesel exhaust. Plant Oils as Fuels: Present State of Science and Future Developments 1997, 92-103. Springer, Berlin. N. Martini, J. Schell (Eds.).
26. Mills G.A., Howard A.G. Preliminary investigation of polynuclear aromatic hydrocarbon emissions from a diesel engine operating on vegetable oil-based alternative fuels. Journal of the Institute of Energy 1983, 56:131-137.
27. Park E.J., Roh J., Kang M.S., Kim S.N., Kim Y., Coi S. Biological responses to diesel exhaust particles (DEPs) depend on the physicochemical properties of the DEPs. PLoS ONE 2011, 6:10.
28. Phillips D.H., Castegnaro M. Standardization and validation of DNA adduct postlabelling methods: report of interlaboratory trials and production of recommended protocols. Mutagenesis 1999, 14:301-315.
29. 32P-postlabelling test for structurally diverse DNA adducts. Carcinogenesis 1986, 7:1543-1551.
30. Smith W.A., Arif J.M., Gupta R.C. Effect of cancer chemopreventive agents on microsome-mediated DNA adduction of the breast carcinogen dibenzo[a,l]pyrene. Mutation Research 1998, 412:307-314.
31. Thuneke K., Emberger P., Gassner T., Remmele E. Mutagenic potential of particle emissions of a vegetable oil compatible tractor. Proceedings of 16th European Biomass Conference & Exhibition 2008.
32. Topinka J., Schwarz L.R., Wiebel F.J., Cerna M., Wolff T. Genotoxicity of urban air pollution in the Czech Republic. Part2: DNA adduct formation in mammalian cells by extractable organic matter. Mutation Research 2000, 469:83-93.
33. Topinka J., Rossner P., Milcova A., Schmuczerova J., Svecova V., Sram R.J. DNA adducts and oxidative DNA damage induced by organic extracts from PM2.5 in an acellular assay. Toxicology Letters 2010, 198:304-311.
34. Topinka J., Hovorka J., Milcova A., Schmuczerova J., Krouzek J., Rossner P., Sram R.J. DNA adducts and oxidative DNA damage induced by organic extracts from PM2.5 in an acellular assay. Toxicology Letters 2011, 202:186-192.
35. Vojtisek-Lom, M., Pechout, M., BlaŽek, J., Moc, L., Hlavenka, T., 2009a. Effects of current and prior operating conditions on particulate matter emissions from a diesel engine operated on heated rapeseed oil. SAE Technical Paper 2009-01-1913. Society of Automotive Engineers, Warrensdale, PA, USA.
36. Vojtisek-Lom, M., BlaŽek, J., Dufek, M., Fenkl, M., 2009b. Investigation of combustion rates and injection and ignition onset of heated rapeseed oil in direct-injection turbodiesel engines. SAE Technical Paper 2009-01-1914. Society of Automotive Engineers, Warrensdale, PA, USA.
37. Vojtisek-Lom, M., Pechout, M., Mazač, M., 2011a. Experimental investigation of rapeseed oil combustion in a modern common-rail diesel engine. SAE Technical Paper 2011-24-0104. Society of Automotive Engineers, Warrensdale, PA, USA.
38. Vojtisek-Lom M., Pechout M., Mazač M., Dittrich A., čihák M. Particulate matter measurement with an improvised full-flow dilution tunnel. Proceedings of XLII. International Scientific Conference KOKA 2011 2011, Technológ, 3, 2011, ISSN 1337-8996.
39. Yang H.H., Chien S.M., Lo M.Y., Lan J.C.W., Lu W.C., Ku Y.Y. Effects of biodiesel on emissions of regulated air pollutants and polycyclic aromatic hydrocarbons under engine durability testing. Atmospheric Environment 2007, 41(34):7232-7240.
40. Zou L., Atkinson S. Characterising vehicle emissions from the burning of biodiesel made from vegetable oil. Environmental Technology 2003, 24(10):1253-1260.