Competitive inhibition of carcinogen-activating CYP1A1 and CYP1B1 enzymes by a standardized complex mixture of PAH extracted from coal tar

International Journal of Cancer

Volumn 120, Issue 6, 2007, Pages 1161-1168

  Mahadevan, Brinda ^a   Marston, Charis P ^a   Luch, Andreas ^b,d   Dashwood, Wan Mohaiza ^a   Brooks, Eric ^a   Pereira, Cliff ^a   Doehmer, Johannes ^c   Baird, William M ^a  

^a OREGON STATE UNIVERSITY   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c GenPharmTox BioTech AG   (Germany)

^d FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

Author keywords

Chemical inhibition; Coal tar; Cytochrome P450; DNA adducts; Polycyclic aromatic hydrocarbons

Indexed keywords

CARCINOGEN; COAL TAR; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; DNA; ETHOXYRESORUFIN DEETHYLASE; PHOSPHORUS 33; POLYCYCLIC AROMATIC HYDROCARBON;

ANIMAL CELL; ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; CANCER CELL CULTURE; CHEMICAL CARCINOGENESIS; COMPETITIVE INHIBITION; DNA ADDUCT; DNA BINDING; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME INHIBITION; ISOTOPE LABELING; MICROSOME; NONHUMAN; PRIORITY JOURNAL; XENOBIOTIC METABOLISM;

ARYL HYDROCARBON HYDROXYLASES; BENZO(A)PYRENE; BENZOPYRENES; CARCINOGENS; COAL TAR; COMPLEX MIXTURES; CYTOCHROME P-450 CYP1A1; DNA; DNA ADDUCTS; HUMANS; POLYCYCLIC HYDROCARBONS, AROMATIC; TUMOR CELLS, CULTURED;

EID: 33846990104     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.22466     Document Type: Article

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