A metabolic activation mechanism of 7H-dibenzo[c,g]carbazole via O-quinone. Part 2: Covalent adducts of 7H-dibenzo[c,g]carbazole-3,4-dione with nucleic acid bases and nucleosides

Chemical Research in Toxicology

Volumn 15, Issue 7, 2002, Pages 915-921

  Xue, Weiling ^a   Siner, Angela ^a   Rance, Mark ^a   Jayasimhulu, Koka ^b   Talaska, Glenn ^a   Warshawsky, David ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7H DIBENZO[C,G]CARBAZOLE; 7H DIBENZO[C,G]CARBAZOLE 3,4 DIONE; ACETONE; ADENOSINE; CARBAZOLE DERIVATIVE; CYTOSINE; DEOXYCYTIDINE; DEOXYGUANOSINE; DIMETHYL SULFOXIDE; GUANOSINE; KETONE DERIVATIVE; NUCLEIC ACID BASE; NUCLEOSIDE; QUINONE DERIVATIVE; UNCLASSIFIED DRUG; 7H DIBENZO(C,G)CARBAZOLE; 7H DIBENZO(C,G)CARBAZOLE 3,4 DIONE; 7H-DIBENZO(C,G)CARBAZOLE; 7H-DIBENZO(C,G)CARBAZOLE-3,4-DIONE; CARCINOGEN; DNA;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; COVALENT BOND; DISSOCIATION; DRUG ANALYSIS; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMER; MASS SPECTROMETRY; METABOLIC ACTIVATION; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; ANIMAL; BIOTRANSFORMATION; CHEMISTRY; DNA ADDUCT; ELECTROSPRAY MASS SPECTROMETRY; LIVER; METABOLISM; MOUSE STRAIN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ANIMAL; BIOTRANSFORMATION; CARBAZOLES; CARCINOGENS, ENVIRONMENTAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA; DNA ADDUCTS; FEMALE; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, INBRED STRAINS; NUCLEOSIDES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUPPORT, U.S. GOV'T, P.H.S.; ANIMALS;

ANIMALIA;

EID: 0035996328     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0200156     Document Type: Article

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