Comparison of TCDD and PCB CYP1A induction sensitivities in fresh hepatocytes from human donors, sprague-dawley rats, and rhesus monkeys and HepG2 cells

Toxicological Sciences

Volumn 87, Issue 2, 2005, Pages 508-519

  Silkworth, Jay B ^a   Koganti, Aruna ^b   Illouz, Kati ^a   Possolo, Antonio ^a   Zhao, Ming ^a   Hamilton, Stephen B ^a  

^a GENERAL ELECTRIC COMPANY   (United States)

^b In Vitro Technologies Inc   (United States)

Author keywords

CYP1A1; CYP1A2; Cytochrome P450 1A; Dioxin; Dioxin equivalents; HepG2 cells; Human hepatocytes; PCB; Polychlorinated biphenyls; Relative potency factors; Risk assessment; TCDD; TEQ

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 3,3',4,4',5 PENTACHLOROBIPHENYL; AROCLOR 1254; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; ETHOXYRESORUFIN DEETHYLASE; MESSENGER RNA; POLYCHLORINATED BIPHENYL;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CELL STRAIN HEPG2; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; HEALTH HAZARD; HUMAN; HUMAN CELL; LIVER CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; RAT; RAT STRAIN; RHESUS MONKEY; RISK ASSESSMENT; SENSITIVITY ANALYSIS; SPECIES COMPARISON; SPECIES DIFFERENCE;

ANIMALS; CELLS, CULTURED; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; ENZYME INDUCTION; HEPATOCYTES; HUMANS; MACACA MULATTA; POLYCHLORINATED BIPHENYLS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SPECIES SPECIFICITY; TETRACHLORODIBENZODIOXIN;

ANIMALIA; MACACA MULATTA; RODENTIA;

EID: 24944446096     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfi261     Document Type: Article

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