Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: Roles of PAH interactions and PAH metabolites

Toxicology and Applied Pharmacology

Volumn 226, Issue 3, 2008, Pages 213-224

  Spink, David C ^a   Wu, Susan J ^a   Spink, Barbara C ^a   Hussain, Mirza M ^a   Vakharia, Dilip D ^a   Pentecost, Brian T ^a   Kaminsky, Laurence S ^a  

^a WADSWORTH CENTER   (United States)

Author keywords

Aryl hydrocarbon receptor; Benzo(a)pyrene; Benzo(k)fluoranthene; CYP1 induction; PAH metabolism

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; BENZO[A]PYRENE; BENZO[K]FLUORANTHENE; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; ESTRADIOL; ETHOXYRESORUFIN DEETHYLASE; LUCIFERASE;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CARCINOGENICITY; CATALYSIS; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME SUBSTRATE COMPLEX; ESTROGEN METABOLISM; FLUORESCENCE; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MASS SPECTROMETRY; OXIDATION; PROMOTER REGION;

BENZO(A)PYRENE; BIOTRANSFORMATION; BREAST NEOPLASMS; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; ENZYME INDUCTION; FEMALE; FLUORENES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MICROSOMES, LIVER;

EID: 38649143706     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2007.08.024     Document Type: Article

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