Aneugenic potential of the anticancer drugs melphalan and chlorambucil. The involvement of apoptosis and chromosome segregation regulating proteins

Journal of Applied Toxicology

Volumn 33, Issue 7, 2013, Pages 537-545

  Efthimiou, Maria ^a   Stephanou, Georgia ^a   Demopoulos, Nikos A ^a   Nikolaropoulos, Sotiris S ^a  

^a UNIVERSITY OF PATRAS   (Greece)

Author keywords

Anticancer drugs; Apoptosis; Chromosome segregation regulating proteins; Melphalan and chlorambucil aneugenic potential; Supernumerary centrosomes

Indexed keywords

AURORA A KINASE; AURORA B KINASE; BETA TUBULIN; CHLORAMBUCIL; CLASTOGEN; GAMMA TUBULIN; MELPHALAN; REGULATOR PROTEIN; SURVIVIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CENTROSOME; CHROMOSOME; CHROMOSOME DAMAGE; CHROMOSOME SEGREGATION; DOWN REGULATION; FLUORESCENCE MICROSCOPY; GENETIC DAMAGE; IMMUNOFLUORESCENCE; METABOLITE; MICRONUCLEUS; MOUSE; MUTAGENIC ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; ANNEXIN A5; ANTINEOPLASTIC AGENTS, ALKYLATING; APOPTOSIS; BLOTTING, WESTERN; CENTROSOME; CHLORAMBUCIL; CHROMOSOME BREAKAGE; CHROMOSOME SEGREGATION; FIBROBLASTS; FLUORESCENT ANTIBODY TECHNIQUE; INHIBITOR OF APOPTOSIS PROTEINS; MELPHALAN; MICE; MICROSCOPY, FLUORESCENCE; MICROTUBULES; NEUROPROTECTIVE AGENTS; PROPIDIUM; PROTEIN-SERINE-THREONINE KINASES; REPRESSOR PROTEINS; TUBULIN;

EID: 84878175056     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1743     Document Type: Article

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