Centrosome amplification induced by hydroxyurea leads to aneuploidy in pRB deficient human and mouse fibroblasts

Cancer Letters

Volumn 238, Issue 1, 2006, Pages 153-160

  Lentini, Laura ^a   Iovino, Flora ^a   Amato, Angela ^a   Di Leonardo, Aldo ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

Aneuploidy; Centrosome amplification; CIN; pRB

Indexed keywords

HYDROXYUREA; ONCOPROTEIN; PROTEIN E6; PROTEIN E7; PROTEIN P53;

ANEUPLOIDY; ANIMAL CELL; ARTICLE; CELL CYCLE; CENTROSOME; CONTROLLED STUDY; DNA SYNTHESIS; EMBRYO; FIBROBLAST; GENE AMPLIFICATION; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 16; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING;

ANEUPLOIDY; ANIMALS; CELL LINE; CELLS, CULTURED; CENTROSOME; CHROMOSOMAL INSTABILITY; FIBROBLASTS; HUMANS; HYDROXYUREA; MICE; RETINOBLASTOMA PROTEIN;

MURINAE;

EID: 33744904709     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2005.07.005     Document Type: Article

References (19)

1. D'Assoro A.B., Lingle W.L., and Salisbury J.L. Centrosome amplification and the development of cancer. Oncogene 21 (2002) 6146-6153
2. Jallepalli P.V., Waizenegger I.C., Bunz F., Langer S., Speicher M.R., Peters J.M., et al. Securin is required for chromosomal stability in human cells. Cell 105 (2001) 445-457
3. Michel L.S., Liberal V., Chatterjee A., Kirchwegger R., Pasche B., Gerald W., et al. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature 409 (2001) 355-359
4. Cahill D.P., Lengauer C., Yu J., Riggins G.J., Willson J.K., Markowitz S.D., et al. Mutations of mitotic checkpoint genes in human cancers. Nature 392 (1998) 300-303
5. Lentini L., Pipitone L., and Di Leonardo A. Functional inactivation of pRB results in aneuploid mammalian cells after release from a mitotic block. Neoplasia 4 (2002) 380-387
6. Brinkley B.R. Managing the centrosome numbers game: from chaos to stability in cancer cell division. Trends Cell Biol. 11 (2001) 18-21
7. Meraldi P., Lukas J., Fry A.M., Bartek J., and Nigg E.A. Centrosome duplication in mammalian somatic cells requires E2F and Cdk2- cyclin A. Nat. Cell Biol. 1 (1999) 88-93
8. D'Assoro A.B., Busby R., Suino K., Delva E., Almodovar-Mercado G.J., Johnson H., et al. Genotoxic stress leads to centrosome amplification in breast cancer cell lines that have an inactive G1/S cell cycle checkpoint. Oncogene 23 (2004) 4068-4075
9. Duensing S., Duensing A., Crum C.P., and Munger K. Human papillomavirus type 16 E7 oncoprotein-induced abnormal centrosome synthesis is an early event in the evolving malignant phenotype. Cancer Res. 61 (2001) 2356-2360
10. Borel F., Lacroix F.B., and Margolis R. Prolonged arrest of mammalian cells at the G1S boundary results in permanent S phasis stasis. J. Cell Sci. 115 (2002) 2829-2838
11. Marino S., Vooijs M., van Der Gulden H., Jonkers J., and Berns A. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev. 14 (2000) 994-1004
12. Pihan G.A., Purohit A., Wallace J., Malhotra R., Liotta L., and Doxsey S.J. Centrosome defects can account for cellular and genetic changes that characterize prostate cancer progression. Cancer Res. 61 (2001) 2212-2219
13. Sato N., Mizumoto K., Nakamura M., Nakamura K., Kusumoto M., Niiyama H., et al. Centrosome abnormalities in pancreatic ductal carcinoma. Clin. Cancer Res. 5 (1999) 963-970
14. Duensing S., and Munger K. Centrosome abnormalities and genomic instability induced by human papillomavirus oncoproteins. Prog. Cell Cycle Res. 5 (2003) 383-391
15. Tarapore P., and Fukasawa K. Loss of p53 and centrosome hyperamplification. Oncogene 21 (2002) 6234-6240
16. Duensing S., Lee L.Y., Duensing A., Basile J., Piboonniyom S., Gonzalez S., et al. The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle. Proc. Natl Acad. Sci. USA 97 (2000) 10002-10007 [18]
17. Duensing S., and Munger K. Human papillomavirus type 16 E7 oncoprotein can induce abnormal centrosome duplication through a mechanism independent of inactivation of retinoblastoma protein family members. J. Virol. 77 (2003) 12331-12335
18. Linke S.P., Clarkin K.C., Di Leonardo A., Tsou A., and Wahl G.M. A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Dev. 10 (1996) 934-947
19. Nigg E.A. Centrosome aberrations: cause or consequence of cancer progression?. Nat. Rev. Cancer (2002) 815-825