Comparative study of genetic activity of chlorambucil's active metabolite steroidal esters: The role of steroidal skeleton on aneugenic potential

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 689, Issue 1-2, 2010, Pages 1-11

  Efthimiou, M ^a   Ouranou, D ^a   Stephanou, G ^a   Demopoulos, N A ^a   Nikolaropoulos, S S ^a   Alevizos, Ph ^a  

^a UNIVERSITY OF PATRAS   (Greece)

Author keywords

Aneugenic potential; Clastogenicity; Lipophilicity; Micronucleation; Nitrogen mustard analogues; Supernumerary centrosomes

Indexed keywords

3B HYDROXY 17B ACETAMIDE 7A AZA B HOMOANDROST 5 EN 7 ONE 4 N,N BIS(2 CHLOROETHYL)AMINOPHENYLACETIC ACID; 3B HYDROXY 17B ACETAMIDEANDROST 5 EN 7 ONE 4 N,N BIS(2 CHLOROETHYL)AMINOPHENYLACETIC ACID; 3B HYDROXY 7A ,17A DIAZA B,D DIHOMOANDROST 5 EN 7, 17 DIONE 4 N,N BIS(2 CHLOROETHYL)AMINOPHENYLACETIC ACID; 3B HYDROXY 7A AZA B HOMOANDROST 5 EN 7,17 DIONE 4 N,N BIS(2 CHLOROETHYL)AMINOPHENYLACETIC ACID; 3B HYDROXYCHOLEST 5 EN 7 ONE 4 N,N BIS(2 CHLOROETHYL)AMINOPHENYLACETIC ACID; 4 N,N BIS(2 CHLOROETHYL)AMINOPHENYLACETIC ACID; AK 333; AK 409; AK 433; BETA TUBULIN; CHLORAMBUCIL; CHLORAMBUCIL DERIVATIVE; DRUG METABOLITE; EA 92; EA 97; GAMMA TUBULIN; UNCLASSIFIED DRUG;

ANEUGENIC ACTIVITY; ANEUPLOIDY; ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CENTROSOME; CHROMOSOME BREAKAGE; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINESIS BLOCK MICRONUCLEUS TEST; DNA PROBE; DRUG ACTIVITY; DRUG METABOLISM; DRUG STRUCTURE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; HYDROPHILICITY; IN VITRO STUDY; LIPOPHILICITY; LYMPHOCYTE; MICRONUCLEUS; MICRONUCLEUS TEST; MITOSIS SPINDLE; MOUSE; NONHUMAN; PHARMACOGENETICS; PRIORITY JOURNAL;

ANEUGENS; ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; CELLS, CULTURED; CHLORAMBUCIL; ESTERS; HUMANS; LYMPHOCYTES; MICE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MITOTIC SPINDLE APPARATUS; STEROIDS;

EID: 77953915240     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2010.04.001     Document Type: Article

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