Genetic effects caused by potent antileukemic steroidal esters of chlorambucil's active metabolite

Anti-Cancer Drugs

Volumn 16, Issue 1, 2005, Pages 67-75

  Kouloumenta, Asimina ^a   Stephanou, Georgia ^a   Demopoulos, Nikos A ^a   Nikolaropoulos, Sotiris S ^a  

^a UNIVERSITY OF PATRAS   (Greece)

Author keywords

Chromosome breakage; Chromosome delay; DNA excision repairable lesions; Fluorescence in situ hybridization; Nitrogen mustard steroidal esters; Structure activity relationship

Indexed keywords

3BETA HYDROXY 13ALPHA AZA DEXTRO HOMO 5ALPHA ANDROSTAN 17 ONE 4 N,N BIS(2 CHLOROETHYL)AMINOPHENYL ACETATE; 3BETA HYDROXY 13ALPHA AZA DEXTRO HOMO ANDROST 5 EN 7,17 DIONE 4 N,N BIS (2 CHLOROETHYL)AMINOPHENYL ACETATE; 3BETA HYDROXY ANDROST 5 EN 7,17 DIONE 4 N,N BIS (2 CHLOROETHYL)AMINOPHENYL ACETATE; ALKYLATING AGENT; ANTILEUKEMIC AGENT; CHLORAMBUCIL; CYTARABINE; DRUG METABOLITE; STEROID; UNCLASSIFIED DRUG;

ADULT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOKINESIS; CYTOTOXICITY; DNA ALKYLATION; DRUG ACTIVITY; EXCISION REPAIR; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HEREDITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE CULTURE; MALE; MICRONUCLEUS TEST; NORMAL HUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ADULT; ALKYLATION; ANTINEOPLASTIC AGENTS, ALKYLATING; CELLS, CULTURED; CHLORAMBUCIL; DNA; ESTERS; FEMALE; HUMANS; LEUKEMIA; LYMPHOCYTES; MALE;

EID: 12544250371     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-200501000-00010     Document Type: Article

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