메뉴 건너뛰기




Volumn 16, Issue 2, 2013, Pages 199-209

Toll-like receptor signalling and their therapeutic targeting in colorectal cancer

Author keywords

Colorectal cancer; Susceptibility; Toll like receptors; Tumorigenesis Treatment Prognosis

Indexed keywords

BCG VACCINE; CD133 ANTIGEN; COMPLEMENTARY DNA; CYCLOPHOSPHAMIDE; MEMBRANE RECEPTOR; MICRORNA; MYELOID DIFFERENTIATION FACTOR 88; NONSTEROID ANTIINFLAMMATORY AGENT; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7;

EID: 84877826018     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2013.03.017     Document Type: Review
Times cited : (30)

References (121)
  • 1
    • 0037425743 scopus 로고    scopus 로고
    • Gut flora in health and disease
    • DOI 10.1016/S0140-6736(03)12489-0
    • F. Guarner, and J.R. Malagelada Gut flora in health and disease Lancet 361 2003 512 519 (Pubitemid 36173720)
    • (2003) Lancet , vol.361 , Issue.9356 , pp. 512-519
    • Guarner, F.1    Malagelada, J.-R.2
  • 2
    • 44349132270 scopus 로고    scopus 로고
    • Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut
    • DOI 10.1038/nri2316, PII NRI2316
    • D. Artis Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut Nat Rev Immunol 8 2008 411 420 (Pubitemid 351733416)
    • (2008) Nature Reviews Immunology , vol.8 , Issue.6 , pp. 411-420
    • Artis, D.1
  • 3
    • 43549110706 scopus 로고    scopus 로고
    • Interplay of commensal and pathogenic bacteria, genetic mutations, and immunoregulatory defects in the pathogenesis of inflammatory bowel diseases
    • DOI 10.1111/j.1365-2796.2008.01962.x
    • C.D. Packey, and R.B. Sartor Interplay of commensal and pathogenic bacteria, genetic mutations, and immunoregulatory defects in the pathogenesis of inflammatory bowel diseases J Intern Med 263 2008 597 606 (Pubitemid 351678591)
    • (2008) Journal of Internal Medicine , vol.263 , Issue.6 , pp. 597-606
    • Packey, C.D.1    Sartor, R.B.2
  • 4
    • 33947694370 scopus 로고    scopus 로고
    • TLR signaling
    • DOI 10.1016/j.smim.2006.12.004, PII S1044532306001242, TLR-Mediated Innate Immune Recognition
    • T. Kawai, and S. Akira TLR signaling Semin Immunol 19 2007 24 32 (Pubitemid 46498752)
    • (2007) Seminars in Immunology , vol.19 , Issue.1 , pp. 24-32
    • Kawai, T.1    Akira, S.2
  • 5
    • 75649093343 scopus 로고    scopus 로고
    • Toll-like receptor signalling in the intestinal epithelium: How bacterial recognition shapes intestinal function
    • M.T. Abreu Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function Nat Rev Immunol 10 2010 131 144
    • (2010) Nat Rev Immunol , vol.10 , pp. 131-144
    • Abreu, M.T.1
  • 6
    • 0034445697 scopus 로고    scopus 로고
    • Differential alteration in intestinal epithelial cell expression of Toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease
    • DOI 10.1128/IAI.68.12.7010-7017.2000
    • E. Cario, and D.K. Podolsky Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease Infect Immun 68 2000 7010 7017 (Pubitemid 32463415)
    • (2000) Infection and Immunity , vol.68 , Issue.12 , pp. 7010-7017
    • Cario, E.1    Podolsky, D.K.2
  • 7
    • 39449127013 scopus 로고    scopus 로고
    • Expression of Toll-like receptor 2 (TLR2), TLR4, and CD14 in biopsy samples of patients with inflammatory bowel diseases: Upregulated expression of TLR2 in terminal ileum of patients with ulcerative colitis
    • DOI 10.1369/jhc.7A7303.2007
    • L. Frolova, P. Drastich, P. Rossmann, K. Klimesova, and H. Tlaskalova-Hogenova Expression of Toll-like receptor 2 (TLR2), TLR4, and CD14 in biopsy samples of patients with inflammatory bowel diseases: upregulated expression of TLR2 in terminal ileum of patients with ulcerative colitis J Histochem Cytochem 56 2008 267 274 (Pubitemid 351272998)
    • (2008) Journal of Histochemistry and Cytochemistry , vol.56 , Issue.3 , pp. 267-274
    • Frolova, L.1    Drastich, P.2    Rossmann, P.3    Klimesova, K.4    Tlaskalova-Hogenova, H.5
  • 8
    • 77956289824 scopus 로고    scopus 로고
    • Toll-like receptors in inflammatory bowel diseases: A decade later
    • E. Cario Toll-like receptors in inflammatory bowel diseases: a decade later Inflamm Bowel Dis 16 2010 1583 1597
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 1583-1597
    • Cario, E.1
  • 9
    • 36549082403 scopus 로고    scopus 로고
    • Toll-like receptor-4 (TLR4) promotes the development of colitis-associated colorectal tumors
    • M. Fukata, A. Chen, A. Vamadevan, J. Cohen, K. Breglio, and S. Krishnareddy Toll-like receptor-4 (TLR4) promotes the development of colitis-associated colorectal tumors Gastroenterology 133 2007 1869 1881
    • (2007) Gastroenterology , vol.133 , pp. 1869-1881
    • Fukata, M.1    Chen, A.2    Vamadevan, A.3    Cohen, J.4    Breglio, K.5    Krishnareddy, S.6
  • 11
    • 84855184185 scopus 로고    scopus 로고
    • Prophylactic and therapeutic implications of Toll-like receptor ligands
    • M. Hedayat, K. Takeda, and N. Rezaei Prophylactic and therapeutic implications of Toll-like receptor ligands Med Res Rev 32 2012 294 325
    • (2012) Med Res Rev , vol.32 , pp. 294-325
    • Hedayat, M.1    Takeda, K.2    Rezaei, N.3
  • 12
    • 80051814602 scopus 로고    scopus 로고
    • Targeting of Toll-like receptors: A decade of progress in combating infectious diseases
    • M. Hedayat, M.G. Netea, and N. Rezaei Targeting of Toll-like receptors: a decade of progress in combating infectious diseases Lancet Infect Dis 11 2011 702 712
    • (2011) Lancet Infect Dis , vol.11 , pp. 702-712
    • Hedayat, M.1    Netea, M.G.2    Rezaei, N.3
  • 13
    • 33646478589 scopus 로고    scopus 로고
    • Therapeutic targeting of pattern-recognition receptors
    • N. Rezaei Therapeutic targeting of pattern-recognition receptors Int Immunopharmacol 6 2006 863 869
    • (2006) Int Immunopharmacol , vol.6 , pp. 863-869
    • Rezaei, N.1
  • 14
    • 0035865012 scopus 로고    scopus 로고
    • Cancer risk in patients with inflammatory bowel disease: A population-based study
    • DOI 10.1002/1097-0142(20010215)91:4<854::AID-CNCR1073>3.0.CO;2-Z
    • C.N. Bernstein, J.F. Blanchard, E. Kliewer, and A. Wajda Cancer risk in patients with inflammatory bowel disease: a population-based study Cancer 91 2001 854 862 (Pubitemid 32173312)
    • (2001) Cancer , vol.91 , Issue.4 , pp. 854-862
    • Bernstein, C.N.1    Blanchard, J.F.2    Kliewer, E.3    Wajda, A.4
  • 15
    • 13844310155 scopus 로고    scopus 로고
    • Sporadic colorectal cancer - Role of the commensal microbiota
    • DOI 10.1016/j.femsle.2005.01.029
    • M.E. Hope, G.L. Hold, R. Kain, and E.M. El-Omar Sporadic colorectal cancer - role of the commensal microbiota FEMS Microbiol Lett 244 2005 1 7 (Pubitemid 40261172)
    • (2005) FEMS Microbiology Letters , vol.244 , Issue.1 , pp. 1-7
    • Hope, M.E.1    Hold, G.L.2    Kain, R.3    El-Omar, E.M.4
  • 16
    • 84857972715 scopus 로고    scopus 로고
    • Inflammation in sporadic colorectal cancer
    • S. Moossavi, and F. Bishehsari Inflammation in sporadic colorectal cancer Arch Iran Med 15 2012 166 170
    • (2012) Arch Iran Med , vol.15 , pp. 166-170
    • Moossavi, S.1    Bishehsari, F.2
  • 17
    • 84865534083 scopus 로고    scopus 로고
    • Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation
    • H. Shaked, L.J. Hofseth, A. Chumanevich, A.A. Chumanevich, J. Wang, and Y. Wang Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation Proc Natl Acad Sci U S A 109 2012 14007 14012
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 14007-14012
    • Shaked, H.1    Hofseth, L.J.2    Chumanevich, A.3    Chumanevich, A.A.4    Wang, J.5    Wang, Y.6
  • 18
    • 69449102284 scopus 로고    scopus 로고
    • Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors
    • M. Fukata, Y. Hernandez, D. Conduah, J. Cohen, A. Chen, and K. Breglio Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors Inflamm Bowel Dis 15 2009 997 1006
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 997-1006
    • Fukata, M.1    Hernandez, Y.2    Conduah, D.3    Cohen, J.4    Chen, A.5    Breglio, K.6
  • 19
    • 79958840965 scopus 로고    scopus 로고
    • Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis
    • M. Fukata, L. Shang, R. Santaolalla, J. Sotolongo, C. Pastorini, and C. España Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis Inflamm Bowel Dis 17 2011 1464 1473
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 1464-1473
    • Fukata, M.1    Shang, L.2    Santaolalla, R.3    Sotolongo, J.4    Pastorini, C.5    España, C.6
  • 20
    • 77958610178 scopus 로고    scopus 로고
    • Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer
    • 10.1371/journal.pone.0013027
    • E.L. Lowe, T.R. Crother, S. Rabizadeh, B. Hu, H. Wang, and S. Chen Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer PLoS One 5 9 2010 e13027 10.1371/journal.pone. 0013027
    • (2010) PLoS One , vol.5 , Issue.9 , pp. 13027
    • Lowe, E.L.1    Crother, T.R.2    Rabizadeh, S.3    Hu, B.4    Wang, H.5    Chen, S.6
  • 21
    • 78651330430 scopus 로고    scopus 로고
    • COSMIC: Mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
    • S.A. Forbes, N. Bindal, S. Bamford, C. Cole, C.Y. Kok, and D. Beare COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer Nucleic Acids Res 39 2011 D945 D950
    • (2011) Nucleic Acids Res , vol.39
    • Forbes, S.A.1    Bindal, N.2    Bamford, S.3    Cole, C.4    Kok, C.Y.5    Beare, D.6
  • 23
    • 78049484534 scopus 로고    scopus 로고
    • The tumor microenvironment of colorectal cancer: Stromal TLR-4 expression as a potential prognostic marker
    • R. Cammarota, V. Bertolini, G. Pennesi, E.O. Bucci, O. Gottardi, and C. Garlanda The tumor microenvironment of colorectal cancer: stromal TLR-4 expression as a potential prognostic marker J Transl Med 8 2010 112
    • (2010) J Transl Med , vol.8 , pp. 112
    • Cammarota, R.1    Bertolini, V.2    Pennesi, G.3    Bucci, E.O.4    Gottardi, O.5    Garlanda, C.6
  • 24
    • 77649272127 scopus 로고    scopus 로고
    • High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer
    • E.L. Wang, Z.R. Qian, M. Nakasono, T. Tanahashi, K. Yoshimoto, and Y. Bando High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer Br J Cancer 102 2010 908 915
    • (2010) Br J Cancer , vol.102 , pp. 908-915
    • Wang, E.L.1    Qian, Z.R.2    Nakasono, M.3    Tanahashi, T.4    Yoshimoto, K.5    Bando, Y.6
  • 25
    • 77957196909 scopus 로고    scopus 로고
    • Toll-like receptor (TLR) 7 and TLR8 expression on CD133 + cells in colorectal cancer points to a specific role for inflammation-induced TLRs in tumourigenesis and tumour progression
    • M. Grimm, M. Kim, A. Rosenwald, U. Heemann, C.T. Germer, and A.M. Waaga-Gasser Toll-like receptor (TLR) 7 and TLR8 expression on CD133 + cells in colorectal cancer points to a specific role for inflammation-induced TLRs in tumourigenesis and tumour progression Eur J Cancer 46 2010 2849 2857
    • (2010) Eur J Cancer , vol.46 , pp. 2849-2857
    • Grimm, M.1    Kim, M.2    Rosenwald, A.3    Heemann, U.4    Germer, C.T.5    Waaga-Gasser, A.M.6
  • 26
    • 84863981516 scopus 로고    scopus 로고
    • Study of the expression of Toll-like receptors in different histological types of colorectal polyps and their relationship with colorectal cancer
    • N. Eiró, L. González, L.O. González, A. Andicoechea, M. Fernández-Díaz, and A. Altadill Study of the expression of Toll-like receptors in different histological types of colorectal polyps and their relationship with colorectal cancer J Clin Immunol 32 2012 848 854
    • (2012) J Clin Immunol , vol.32 , pp. 848-854
    • Eiró, N.1    González, L.2    González, L.O.3    Andicoechea, A.4    Fernández-Díaz, M.5    Altadill, A.6
  • 27
    • 83355173190 scopus 로고    scopus 로고
    • Alteration of CXCR7 expression mediated by TLR4 promotes tumor cell proliferation and migration in human colorectal carcinoma
    • 10.1371/journal.pone.0027399
    • H. Xu, Q. Wu, S. Dang, M. Jin, J. Xu, and Y. Cheng Alteration of CXCR7 expression mediated by TLR4 promotes tumor cell proliferation and migration in human colorectal carcinoma PLoS One 6 12 2011 e27399 10.1371/journal.pone. 0027399
    • (2011) PLoS One , vol.6 , Issue.12 , pp. 27399
    • Xu, H.1    Wu, Q.2    Dang, S.3    Jin, M.4    Xu, J.5    Cheng, Y.6
  • 28
    • 70350497687 scopus 로고    scopus 로고
    • Invasion associated up-regulation of nuclear factor kappaB target genes in colorectal cancer
    • D. Horst, J. Budczies, T. Brabletz, T. Kirchner, and F. Hlubek Invasion associated up-regulation of nuclear factor kappaB target genes in colorectal cancer Cancer 115 2009 4946 4958
    • (2009) Cancer , vol.115 , pp. 4946-4958
    • Horst, D.1    Budczies, J.2    Brabletz, T.3    Kirchner, T.4    Hlubek, F.5
  • 29
    • 84855400887 scopus 로고    scopus 로고
    • Mucin depleted foci, colonic preneoplastic lesions lacking Muc2, show up-regulation of Tlr2 but not bacterial infiltration
    • 10.1371/journal.pone.0029918
    • A.P. Femia, A. Swidsinski, P. Dolara, M. Salvadori, A. Amedei, and G. Caderni Mucin depleted foci, colonic preneoplastic lesions lacking Muc2, show up-regulation of Tlr2 but not bacterial infiltration PLoS One 7 1 2012 e29918 10.1371/journal.pone.0029918
    • (2012) PLoS One , vol.7 , Issue.1 , pp. 29918
    • Femia, A.P.1    Swidsinski, A.2    Dolara, P.3    Salvadori, M.4    Amedei, A.5    Caderni, G.6
  • 30
    • 84877250369 scopus 로고    scopus 로고
    • Toll-like receptor 4 (TLR4) is expressed on intestinal stem cells and inhibits stem cell proliferation in the pathogenesis of intestinal inflammation
    • M.D. Neal, C.P. Sodhi, I. Yazji, A.M. Russo, R. Siggers, and H. Jia Toll-like receptor 4 (TLR4) is expressed on intestinal stem cells and inhibits stem cell proliferation in the pathogenesis of intestinal inflammation J Am Coll Surg 213 2011 S85
    • (2011) J Am Coll Surg , vol.213 , pp. 85
    • Neal, M.D.1    Sodhi, C.P.2    Yazji, I.3    Russo, A.M.4    Siggers, R.5    Jia, H.6
  • 32
    • 84861414639 scopus 로고    scopus 로고
    • Comprehensive literature review and statistical considerations for microarray meta-analysis
    • G.C. Tseng, D. Ghosh, and E. Feingold Comprehensive literature review and statistical considerations for microarray meta-analysis Nucleic Acids Res 40 2012 3785 3799
    • (2012) Nucleic Acids Res , vol.40 , pp. 3785-3799
    • Tseng, G.C.1    Ghosh, D.2    Feingold, E.3
  • 33
    • 41549166455 scopus 로고    scopus 로고
    • Meta-analysis of colorectal cancer gene expression profiling studies identifies consistently reported candidate biomarkers
    • DOI 10.1158/1055-9965.EPI-07-2615
    • S.K. Chan, O.L. Griffith, I.T. Tai, and S.J.M. Jones Meta-analysis of colorectal cancer gene expression profiling studies identifies consistently reported candidate biomarkers Cancer Epidemiol Biomarkers Prev 17 2008 543 552 (Pubitemid 351469203)
    • (2008) Cancer Epidemiology Biomarkers and Prevention , vol.17 , Issue.3 , pp. 543-552
    • Chan, S.K.1    Griffith, O.L.2    Tai, I.T.3    Jones, S.J.M.4
  • 35
    • 23844500657 scopus 로고    scopus 로고
    • Web-based data warehouse on gene expression in human colorectal cancer
    • DOI 10.1002/pmic.200402107
    • E. Sagynaliev, R. Steinert, G. Nestler, H. Lippert, M. Knoch, and M.A. Reymond Web-based data warehouse on gene expression in human colorectal cancer Proteomics 5 2005 3066 3078 (Pubitemid 41176473)
    • (2005) Proteomics , vol.5 , Issue.12 , pp. 3066-3078
    • Sagynaliev, E.1    Steinert, R.2    Nestler, G.3    Lippert, H.4    Knoch, M.5    Reymond, M.-A.6
  • 36
    • 84870628179 scopus 로고    scopus 로고
    • Systematic enrichment analysis of gene expression profiling studies identifies consensus pathways implicated in colorectal cancer development
    • J. Lascorz, K. Hemminki, and A. Försti Systematic enrichment analysis of gene expression profiling studies identifies consensus pathways implicated in colorectal cancer development J Carcinog 10 2011 7
    • (2011) J Carcinog , vol.10 , pp. 7
    • Lascorz, J.1    Hemminki, K.2    Försti, A.3
  • 37
    • 11244330609 scopus 로고    scopus 로고
    • Min mice are unique from those of embryonic intestine and identify novel gene targets dysregulated in human colorectal tumors
    • T. Reichling, K.H. Goss, D.J. Carson, R.W. Holdcraft, C. Ley-Ebert, and D. Witte Transcriptional profiles of intestinal tumors in Apc min mice are unique from those of embryonic intestine and identify novel gene targets dysregulated in human colorectal tumors Cancer Res 65 2005 166 176 (Pubitemid 40070807)
    • (2005) Cancer Research , vol.65 , Issue.1 , pp. 166-176
    • Reichling, T.1    Goss, K.H.2    Carson, D.J.3    Holdcraft, R.W.4    Ley-Ebert, C.5    Witte, D.6    Aronow, B.J.7    Groden, J.8
  • 39
    • 60649091298 scopus 로고    scopus 로고
    • Drosophila intestinal response to bacterial infection: Activation of host defense and stem cell proliferation
    • N. Buchon, N.A. Broderick, M. Poidevin, S. Pradervand, and B. Lemaitre Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation Cell Host Microbe 5 2009 200 211
    • (2009) Cell Host Microbe , vol.5 , pp. 200-211
    • Buchon, N.1    Broderick, N.A.2    Poidevin, M.3    Pradervand, S.4    Lemaitre, B.5
  • 40
    • 39549123040 scopus 로고    scopus 로고
    • Toll-like receptor polymorphisms and susceptibility to human disease
    • DOI 10.1042/CS20070214
    • E.A. Misch, and T.R. Hawn Toll-like receptor polymorphisms and susceptibility to human disease Clin Sci (Lond) 114 2008 347 360 (Pubitemid 351397384)
    • (2008) Clinical Science , vol.114 , Issue.5-6 , pp. 347-360
    • Misch, E.A.1    Hawn, T.R.2
  • 41
    • 77949751401 scopus 로고    scopus 로고
    • Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies
    • S. Lindström, D.J. Hunter, H. Grönberg, P. Stattin, F. Wiklund, and J. Xu Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies Cancer Epidemiol Biomarkers Prev 19 2010 873 876
    • (2010) Cancer Epidemiol Biomarkers Prev , vol.19 , pp. 873-876
    • Lindström, S.1    Hunter, D.J.2    Grönberg, H.3    Stattin, P.4    Wiklund, F.5    Xu, J.6
  • 42
    • 67849092262 scopus 로고    scopus 로고
    • Impact of Toll-like receptors [TLR] 2 (- 196 to - 174 del) and TLR 4 (Asp299Gly, Thr399Ile) in cervical cancer susceptibility in North Indian women
    • S. Pandey, R.D. Mittal, M. Srivastava, K. Srivastava, S. Singh, and S. Srivastava Impact of Toll-like receptors [TLR] 2 (- 196 to - 174 del) and TLR 4 (Asp299Gly, Thr399Ile) in cervical cancer susceptibility in North Indian women Gynecol Oncol 114 2009 501 505
    • (2009) Gynecol Oncol , vol.114 , pp. 501-505
    • Pandey, S.1    Mittal, R.D.2    Srivastava, M.3    Srivastava, K.4    Singh, S.5    Srivastava, S.6
  • 43
    • 77954680620 scopus 로고    scopus 로고
    • Toll-like receptor (TLR) and nucleosome-binding oligomerization domain (NOD) gene polymorphisms and endometrial cancer risk
    • K.A. Ashton, A. Proietto, G. Otton, I. Symonds, M. McEvoy, and J. Attia Toll-like receptor (TLR) and nucleosome-binding oligomerization domain (NOD) gene polymorphisms and endometrial cancer risk BMC Cancer 10 2010 382
    • (2010) BMC Cancer , vol.10 , pp. 382
    • Ashton, K.A.1    Proietto, A.2    Otton, G.3    Symonds, I.4    McEvoy, M.5    Attia, J.6
  • 44
    • 77953444175 scopus 로고    scopus 로고
    • Genetic variation in toll-like receptor signalling and the risk of inflammatory and immune diseases
    • S.C. Corr, and L.A.J. O'Neill Genetic variation in toll-like receptor signalling and the risk of inflammatory and immune diseases J Innate Immun 1 2009 350 357
    • (2009) J Innate Immun , vol.1 , pp. 350-357
    • Corr, S.C.1    O'Neill, L.A.J.2
  • 45
    • 84859920121 scopus 로고    scopus 로고
    • Toll-like receptor genes and their association with colon and rectal cancer development and prognosis
    • M. Slattery, J. Herrick, K. Bondurant, and R. Wolff Toll-like receptor genes and their association with colon and rectal cancer development and prognosis Int J Cancer 130 2012 2974 2980
    • (2012) Int J Cancer , vol.130 , pp. 2974-2980
    • Slattery, M.1    Herrick, J.2    Bondurant, K.3    Wolff, R.4
  • 47
    • 79955531832 scopus 로고    scopus 로고
    • TLR-3 polymorphism is an independent prognostic marker for stage II colorectal cancer
    • F.A. Castro, A. Försti, S. Buch, H. Kalthoff, C. Krauss, and M. Bauer TLR-3 polymorphism is an independent prognostic marker for stage II colorectal cancer Eur J Cancer 47 2011 1203 1210
    • (2011) Eur J Cancer , vol.47 , pp. 1203-1210
    • Castro, F.A.1    Försti, A.2    Buch, S.3    Kalthoff, H.4    Krauss, C.5    Bauer, M.6
  • 48
    • 84871617221 scopus 로고    scopus 로고
    • Functional polymorphisms of Toll-like receptors 2 and 4 alter the risk for colorectal carcinoma in Europeans
    • P. Pimentel-nunes, A.L. Teixeira, C. Pereira, M. Gomes, C. Brandão, and C. Rodrigues Functional polymorphisms of Toll-like receptors 2 and 4 alter the risk for colorectal carcinoma in Europeans Dig Liver Dis 45 2013 63 69
    • (2013) Dig Liver Dis , vol.45 , pp. 63-69
    • Pimentel-Nunes, P.1    Teixeira, A.L.2    Pereira, C.3    Gomes, M.4    Brandão, C.5    Rodrigues, C.6
  • 49
    • 72849106592 scopus 로고    scopus 로고
    • Resolving RNA complexity to decipher regulatory rules governing biological networks
    • D.D. Licatalosi, and R.B. Darnell Resolving RNA complexity to decipher regulatory rules governing biological networks Nat Rev Genet 11 2010 75 87
    • (2010) Nat Rev Genet , vol.11 , pp. 75-87
    • Licatalosi, D.D.1    Darnell, R.B.2
  • 50
    • 0036006290 scopus 로고    scopus 로고
    • Regulation of interleukin-1- and lipopolysaccharide-induced NF-κB activation by alternative splicing of MyD88
    • DOI 10.1016/S0960-9822(02)00712-1, PII S0960982202007121
    • S. Janssens, K. Burns, J. Tschopp, and R. Beyaert Regulation of interleukin-1- and lipopolysaccharide-induced NF-κB activation by alternative splicing of MyD88 Curr Biol 12 2002 467 471 (Pubitemid 34248892)
    • (2002) Current Biology , vol.12 , Issue.6 , pp. 467-471
    • Janssens, S.1    Burns, K.2    Tschopp, J.3    Beyaert, R.4
  • 51
    • 0042236366 scopus 로고    scopus 로고
    • S, a splice variant of MyD88, differentially modulates NF-κB- and AP-1-dependent gene expression
    • DOI 10.1016/S0014-5793(03)00747-6
    • S. Janssens, K. Burns, E. Vercammen, J. Tschopp, and R. Beyaert MyD88s, a splice variant of MyD88, differentially modulates NF-κB- and AP-1-dependent gene expression FEBS Lett 548 2003 103 107 (Pubitemid 37281258)
    • (2003) FEBS Letters , vol.548 , Issue.1-3 , pp. 103-107
    • Janssens, S.1    Burns, K.2    Vercammen, E.3    Tschopp, J.4    Beyaert, R.5
  • 53
    • 15544369643 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease
    • DOI 10.1016/S1473-3099(05)01308-3
    • N.W.J. Schröder, and R.R. Schumann Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease Lancet Infect Dis 5 2005 156 164 (Pubitemid 40568671)
    • (2005) Lancet Infectious Diseases , vol.5 , Issue.3 , pp. 156-164
    • Schroder, N.W.J.1    Schumann, R.R.2
  • 56
    • 34248381345 scopus 로고    scopus 로고
    • The polymorphism P315L of human toll-like receptor 1 impairs innate immune sensing of microbial cell wall components
    • K.O. Omueti, D.J. Mazur, K.S. Thompson, E.A. Lyle, and R.I. Tapping The polymorphism P315L of human toll-like receptor 1 impairs innate immune sensing of microbial cell wall components J Immunol 178 2007 6387 6394 (Pubitemid 46729197)
    • (2007) Journal of Immunology , vol.178 , Issue.10 , pp. 6387-6394
    • Omueti, K.O.1    Mazur, D.J.2    Thompson, K.S.3    Lyle, E.A.4    Tapping, R.I.5
  • 57
    • 67649231565 scopus 로고    scopus 로고
    • Colitis-associated variant of TLR2 causes impaired mucosal repair due to TFF3 deficiency
    • D.K. Podolsky, G. Gerken, A. Eyking, and E. Cario Colitis-associated variant of TLR2 causes impaired mucosal repair due to TFF3 deficiency Gastroenterology 137 2009 209 220
    • (2009) Gastroenterology , vol.137 , pp. 209-220
    • Podolsky, D.K.1    Gerken, G.2    Eyking, A.3    Cario, E.4
  • 58
    • 34447318082 scopus 로고    scopus 로고
    • Characterization and investigation of single nucleotide polymorphisms and a novel TLR2 mutation in the human TLR2 gene
    • DOI 10.1093/hmg/ddm070
    • S. Merx, M. Neumaier, H. Wagner, C.J. Kirschning, and P. Ahmad-Nejad Characterization and investigation of single nucleotide polymorphisms and a novel TLR2 mutation in the human TLR2 gene Hum Mol Genet 16 2007 1225 1232 (Pubitemid 47062718)
    • (2007) Human Molecular Genetics , vol.16 , Issue.10 , pp. 1225-1232
    • Merx, S.1    Neumaier, M.2    Wagner, H.3    Kirschning, C.J.4    Ahmad-Nejad, P.5
  • 61
    • 33746637209 scopus 로고    scopus 로고
    • Characterization and functional investigation of single nucleotide polymorphisms (SNPs) in the human TLR5 gene
    • S. Merx, W. Zimmer, M. Neumaier, and P. Ahmad-Nejad Characterization and functional investigation of single nucleotide polymorphisms (SNPs) in the human TLR5 gene Hum Mutat 27 2006 293
    • (2006) Hum Mutat , vol.27 , pp. 293
    • Merx, S.1    Zimmer, W.2    Neumaier, M.3    Ahmad-Nejad, P.4
  • 62
    • 78449248630 scopus 로고    scopus 로고
    • A naturally occurring variant in human TLR9, P99L, is associated with loss of CpG oligonucleotide responsiveness
    • A.V. Kubarenko, S. Ranjan, A. Rautanen, T.C. Mills, S. Wong, and F. Vannberg A naturally occurring variant in human TLR9, P99L, is associated with loss of CpG oligonucleotide responsiveness J Biol Chem 285 2010 36486 36494
    • (2010) J Biol Chem , vol.285 , pp. 36486-36494
    • Kubarenko, A.V.1    Ranjan, S.2    Rautanen, A.3    Mills, T.C.4    Wong, S.5    Vannberg, F.6
  • 63
    • 81855176234 scopus 로고    scopus 로고
    • Toll-like receptor 4 variant D299G induces features of neoplastic progression in Caco-2 intestinal cells and is associated with advanced human colon cancer
    • A. Eyking, B. Ey, M. Rünzi, A.I. Roig, H. Reis, and K.W. Schmid Toll-like receptor 4 variant D299G induces features of neoplastic progression in Caco-2 intestinal cells and is associated with advanced human colon cancer Gastroenterology 141 2011 2154 2165
    • (2011) Gastroenterology , vol.141 , pp. 2154-2165
    • Eyking, A.1    Ey, B.2    Rünzi, M.3    Roig, A.I.4    Reis, H.5    Schmid, K.W.6
  • 64
    • 0035183413 scopus 로고    scopus 로고
    • Reduced risk of colorectal cancer among long-term users of aspirin and nonaspirin nonsteroidal antiinflammatory drugs
    • DOI 10.1097/00001648-200101000-00015
    • L.A. Garcia Rodriguez, and C. Huertta-Alvarez Reduced risk of colorectal cancer among long-term users of aspirin and nonaspirin nonsteroidal antiinflammatory drugs Epidemiology 12 2001 88 93 (Pubitemid 32006467)
    • (2001) Epidemiology , vol.12 , Issue.1 , pp. 88-93
    • Garcia Rodriguez, L.A.1    Huerta-Alvarez, C.2
  • 65
    • 77953744639 scopus 로고    scopus 로고
    • Diet index-based and empirically derived dietary patterns are associated with colorectal risk
    • P.E. Miller, P. Lazarus, S.M. Lesko, J.E. Muscat, G. Harper, and A.J. Cross Diet index-based and empirically derived dietary patterns are associated with colorectal risk J Nutr 140 2010 1267 1273
    • (2010) J Nutr , vol.140 , pp. 1267-1273
    • Miller, P.E.1    Lazarus, P.2    Lesko, S.M.3    Muscat, J.E.4    Harper, G.5    Cross, A.J.6
  • 66
    • 68549092793 scopus 로고    scopus 로고
    • Lifestyle factors and colorectal cancer risk (2): A systematic review and meta-analysis of associations with leisure-time physical activity
    • D.J. Harriss, G. Atkinson, A. Batterham, K. George, N. Tim Cable, and T. Reilly Lifestyle factors and colorectal cancer risk (2): a systematic review and meta-analysis of associations with leisure-time physical activity Colorectal Dis 11 2009 689 701
    • (2009) Colorectal Dis , vol.11 , pp. 689-701
    • Harriss, D.J.1    Atkinson, G.2    Batterham, A.3    George, K.4    Tim Cable, N.5    Reilly, T.6
  • 68
    • 0346732903 scopus 로고    scopus 로고
    • Alcohol Consumption, Smoking, and Subsequent Risk of Colorectal Cancer in Middle-Aged and Elderly Japanese Men and Women: Japan Public Health Center-based Prospective Study
    • T. Otani, M. Iwasaki, and S. Yamamoto Alcohol consumption, smoking, and subsequent risk of colorectal cancer in middle-aged and elderly Japanese men and women: japan public health center-based prospective study Cancer Epidemiol Biomarkers Prev 12 2003 1492 1500 (Pubitemid 38031754)
    • (2003) Cancer Epidemiology Biomarkers and Prevention , vol.12 , Issue.12 , pp. 1492-1500
    • Otani, T.1    Iwasaki, M.2    Yamamoto, S.3    Sobue, T.4    Hanaoka, T.5    Inoue, M.6    Tsugane, S.7
  • 69
    • 1242292420 scopus 로고    scopus 로고
    • Genomic instability and colon cancer
    • DOI 10.1023/A:1025861527711
    • W.M. Grady Genomic instability and colon cancer Cancer Metastasis Rev 23 2004 11 27 (Pubitemid 38221594)
    • (2004) Cancer and Metastasis Reviews , vol.23 , Issue.1-2 , pp. 11-27
    • Grady, W.M.1
  • 71
    • 0032754664 scopus 로고    scopus 로고
    • Prospective assessment of allelic losses at 4p14-16 in colorectal cancer: Two mutational patterns and a locus associated with poorer survival
    • R. Arribas, M. Ribas, R.A. Risques, L. Masramon, and S. To Prospective assessment of allelic losses at 4p14-16 in colorectal cancer: two mutational patterns and a locus associated with poorer survival Clin Cancer Res 5 1999 3454 3459
    • (1999) Clin Cancer Res , vol.5 , pp. 3454-3459
    • Arribas, R.1    Ribas, M.2    Risques, R.A.3    Masramon, L.4    To, S.5
  • 72
    • 39849088293 scopus 로고    scopus 로고
    • Are there tumor suppressor genes on chromosome 4p in sporadic colorectal carcinoma?
    • H.T. Zheng, L.X. Jiang, Z.C. Lv, D.P. Li, C.Z. Zhou, and J.J. Gao Are there tumor suppressor genes on chromosome 4p in sporadic colorectal carcinoma? World J Gastroenterol 14 2008 90 94
    • (2008) World J Gastroenterol , vol.14 , pp. 90-94
    • Zheng, H.T.1    Jiang, L.X.2    Lv, Z.C.3    Li, D.P.4    Zhou, C.Z.5    Gao, J.J.6
  • 74
    • 33644885017 scopus 로고    scopus 로고
    • The order of genetic events associated with colorectal cancer progression inferred from meta-analysis of copy number changes
    • DOI 10.1002/gcc.20261
    • C.B. Diep, K. Kleivi, F.R. Ribeiro, M.R. Teixeira, O.C. Lindgjærde, and R.A. Lothe The Order of genetic events associated with colorectal cancer progression inferred from meta-analysis of copy number changes Genes Chromosomes Cancer 41 2006 31 41 (Pubitemid 46930859)
    • (2006) Genes Chromosomes and Cancer , vol.45 , Issue.1 , pp. 31-41
    • Diep, C.B.1    Kleivi, K.2    Ribeiro, F.R.3    Teixeira, M.R.4    Lindgjaerde, O.C.5    Lothe, R.A.6
  • 75
    • 79960073532 scopus 로고    scopus 로고
    • A trio of microRNAs that control Toll-like receptor signalling
    • S.R. Quinn, and L.A. O'Neill A trio of microRNAs that control Toll-like receptor signalling Int Immunol 23 2011 421 425
    • (2011) Int Immunol , vol.23 , pp. 421-425
    • Quinn, S.R.1    O'Neill, L.A.2
  • 76
    • 80455154984 scopus 로고    scopus 로고
    • Weak seed-pairing stability and high target-site abundance decrease the proficiency of lys-6 and other miRNAs
    • D.M. Garcia, D. Baek, C. Shin, G.W. Bell, A. Grimson, and D.P. Bartel Weak seed-pairing stability and high target-site abundance decrease the proficiency of lys-6 and other miRNAs Nat Struct Mol Biol 18 2011 1139 1146
    • (2011) Nat Struct Mol Biol , vol.18 , pp. 1139-1146
    • Garcia, D.M.1    Baek, D.2    Shin, C.3    Bell, G.W.4    Grimson, A.5    Bartel, D.P.6
  • 78
    • 84859129420 scopus 로고    scopus 로고
    • Mirna expression profiles identify drivers in colorectal and pancreatic cancers
    • 10.1371/journal.pone.0033663
    • A. Piepoli, F. Tavano, M. Copetti, T. Mazza, O. Palumbo, and A. Panza Mirna expression profiles identify drivers in colorectal and pancreatic cancers PLoS One 7 3 2012 e33663 10.1371/journal.pone.0033663
    • (2012) PLoS One , vol.7 , Issue.3 , pp. 33663
    • Piepoli, A.1    Tavano, F.2    Copetti, M.3    Mazza, T.4    Palumbo, O.5    Panza, A.6
  • 79
    • 82555189387 scopus 로고    scopus 로고
    • Complex patterns of altered microRNA expression during the adenoma-adenocarcinoma sequence for microsatellite-stable colorectal cancer
    • A.N. Bartley, H. Yao, B.A. Barkoh, C. Ivan, B.M. Mishra, and A. Rashid Complex patterns of altered microRNA expression during the adenoma- adenocarcinoma sequence for microsatellite-stable colorectal cancer Clin Cancer Res 17 2011 7283 7293
    • (2011) Clin Cancer Res , vol.17 , pp. 7283-7293
    • Bartley, A.N.1    Yao, H.2    Barkoh, B.A.3    Ivan, C.4    Mishra, B.M.5    Rashid, A.6
  • 80
    • 79751489596 scopus 로고    scopus 로고
    • Molecular genetics of colorectal cancer
    • E.R. Fearon Molecular genetics of colorectal cancer Annu Rev Pathol 6 2011 479 507
    • (2011) Annu Rev Pathol , vol.6 , pp. 479-507
    • Fearon, E.R.1
  • 81
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • DOI 10.1038/nature01322
    • L.M. Coussens, and Z. Werb Inflammation and cancer Nature 420 2002 860 867 (Pubitemid 36019639)
    • (2002) Nature , vol.420 , Issue.6917 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 82
    • 20444432334 scopus 로고    scopus 로고
    • Toll-like receptors on tumor cells facilitate evasion of immune surveillance
    • DOI 10.1158/0008-5472.CAN-05-0784
    • B. Huang, J. Zhao, H. Li, K.L. He, Y. Chen, and S.H. Chen Toll-like receptors on tumor cells facilitate evasion of immune surveillance Cancer Res 65 2005 5009 5014 (Pubitemid 40827306)
    • (2005) Cancer Research , vol.65 , Issue.12 , pp. 5009-5014
    • Huang, B.1    Zhao, J.2    Li, H.3    He, K.-L.4    Chen, Y.5    Mayer, L.6    Unkeless, J.C.7    Xiong, H.8
  • 83
    • 48549106083 scopus 로고    scopus 로고
    • Toll-like receptor 5 engagement modulates tumor development and growth in a mouse xenograft model of human colon cancer
    • S.H. Rhee, E. Im, and C. Pothoulakis Toll-like receptor 5 engagement modulates tumor development and growth in a mouse xenograft model of human colon cancer Gastroenterology 135 2008 518 528
    • (2008) Gastroenterology , vol.135 , pp. 518-528
    • Rhee, S.H.1    Im, E.2    Pothoulakis, C.3
  • 84
    • 77957788924 scopus 로고    scopus 로고
    • An apple oligogalactan prevents against inflammation and carcinogenesis by targeting LPS/TLR4/NF-κB pathway in a mouse model of colitis-associated colon cancer
    • L. Liu, Y.H. Li, Y.B. Niu, Y. Sun, Z.J. Guo, and Q. Li An apple oligogalactan prevents against inflammation and carcinogenesis by targeting LPS/TLR4/NF-κB pathway in a mouse model of colitis-associated colon cancer Carcinogenesis 31 2010 1822 1832
    • (2010) Carcinogenesis , vol.31 , pp. 1822-1832
    • Liu, L.1    Li, Y.H.2    Niu, Y.B.3    Sun, Y.4    Guo, Z.J.5    Li, Q.6
  • 85
    • 79959924217 scopus 로고    scopus 로고
    • Prebiotic treatment reduced preneoplastic lesions through the downregulation of toll like receptor 4 in a chemo induced carcinogenic model
    • M. Fukuda, Y. Komiyama, K. Mitsuyama, A. Andoh, T. Aoyama, and Y. Matsumoto Prebiotic treatment reduced preneoplastic lesions through the downregulation of toll like receptor 4 in a chemo induced carcinogenic model J Clin Biochem Nutr 49 2011 57 61
    • (2011) J Clin Biochem Nutr , vol.49 , pp. 57-61
    • Fukuda, M.1    Komiyama, Y.2    Mitsuyama, K.3    Andoh, A.4    Aoyama, T.5    Matsumoto, Y.6
  • 86
    • 77954314592 scopus 로고    scopus 로고
    • Epithelial-specific blockade of MyD88-dependent pathway causes spontaneous small intestinal inflammation
    • J. Gong, J. Xu, W. Zhu, X. Gao, N. Li, and J. Li Epithelial-specific blockade of MyD88-dependent pathway causes spontaneous small intestinal inflammation Clin Immunol 136 2010 245 256
    • (2010) Clin Immunol , vol.136 , pp. 245-256
    • Gong, J.1    Xu, J.2    Zhu, W.3    Gao, X.4    Li, N.5    Li, J.6
  • 87
    • 34447296425 scopus 로고    scopus 로고
    • Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88
    • DOI 10.1126/science.1140488
    • S. Rakoff-Nahoum, and R. Medzhitov Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88 Science 317 2007 124 127 (Pubitemid 47056471)
    • (2007) Science , vol.317 , Issue.5834 , pp. 124-127
    • Rakoff-Nahoum, S.1    Medzhitov, R.2
  • 88
    • 67650299380 scopus 로고    scopus 로고
    • Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility
    • 10.1371/journal.pone.0006026
    • J.M. Uronis, M. Mühlbauer, H.H. Herfarth, T.C. Rubinas, G.S. Jones, and C. Jobin Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility PLoS One 4 6 2009 e6026 10.1371/journal.pone. 0006026
    • (2009) PLoS One , vol.4 , Issue.6 , pp. 6026
    • Uronis, J.M.1    Mühlbauer, M.2    Herfarth, H.H.3    Rubinas, T.C.4    Jones, G.S.5    Jobin, C.6
  • 90
    • 84856558003 scopus 로고    scopus 로고
    • Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-γ + IL-17 + polyfunctional T cells that mediate rejection of murine tumors
    • N.A. Marshall, K.C. Galvin, A.B. Corcoran, L. Boon, R. Higgs, and K.H.G. Mills Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-γ + IL-17 + polyfunctional T cells that mediate rejection of murine tumors Cancer Res 72 2012 581 591
    • (2012) Cancer Res , vol.72 , pp. 581-591
    • Marshall, N.A.1    Galvin, K.C.2    Corcoran, A.B.3    Boon, L.4    Higgs, R.5    Mills, K.H.G.6
  • 91
    • 79960956913 scopus 로고    scopus 로고
    • Systemic cancer therapy with a small molecule agonist of Toll-like receptor 7 can be improved by circumventing TLR tolerance
    • C. Bourquin, C. Hotz, D. Noerenberg, A. Voelkl, S. Heidegger, and L.C. Roetzer Systemic cancer therapy with a small molecule agonist of Toll-like receptor 7 can be improved by circumventing TLR tolerance Cancer Res 71 2011 5123 5133
    • (2011) Cancer Res , vol.71 , pp. 5123-5133
    • Bourquin, C.1    Hotz, C.2    Noerenberg, D.3    Voelkl, A.4    Heidegger, S.5    Roetzer, L.C.6
  • 92
    • 77950670280 scopus 로고    scopus 로고
    • Reciprocal regulation of activating and inhibitory Fcγ receptors by TLR7/8 activation: Implications for tumor immunotherapy
    • J.P. Butchar, P. Mehta, S.E. Justiniano, K.D. Guenterberg, S.V. Kondadasula, and X. Mo Reciprocal regulation of activating and inhibitory Fcγ receptors by TLR7/8 activation: implications for tumor immunotherapy Clin Cancer Res 16 2010 2065 2075
    • (2010) Clin Cancer Res , vol.16 , pp. 2065-2075
    • Butchar, J.P.1    Mehta, P.2    Justiniano, S.E.3    Guenterberg, K.D.4    Kondadasula, S.V.5    Mo, X.6
  • 93
    • 81155130926 scopus 로고    scopus 로고
    • Inhibition and promotion of tumor growth with adeno-associated virus carcinoembryonic antigen vaccine and Toll-like receptor agonists
    • P.L. Triozzi, W. Aldrich, and S. Ponnazhagan Inhibition and promotion of tumor growth with adeno-associated virus carcinoembryonic antigen vaccine and Toll-like receptor agonists Cancer Gene Ther 18 2011 850 858
    • (2011) Cancer Gene Ther , vol.18 , pp. 850-858
    • Triozzi, P.L.1    Aldrich, W.2    Ponnazhagan, S.3
  • 95
    • 77955433721 scopus 로고    scopus 로고
    • Potentiation of the antitumor effects of imidazoquinoline immune response modifiers by cyclophosphamide
    • C.D. Dumitru, M.A. Antonysamy, M.A. Tomai, and K.E. Lipson Potentiation of the antitumor effects of imidazoquinoline immune response modifiers by cyclophosphamide Cancer Biol Ther 10 2010 155 165
    • (2010) Cancer Biol Ther , vol.10 , pp. 155-165
    • Dumitru, C.D.1    Antonysamy, M.A.2    Tomai, M.A.3    Lipson, K.E.4
  • 96
    • 77953435969 scopus 로고    scopus 로고
    • Antitumor activity and immune response induction of a dual agonist of Toll-like receptors 7 and 8
    • D. Wang, M. Precopio, T. Lan, D. Yu, J.X. Tang, and E.R. Kandimalla Antitumor activity and immune response induction of a dual agonist of Toll-like receptors 7 and 8 Mol Cancer Ther 9 2010 1788 1797
    • (2010) Mol Cancer Ther , vol.9 , pp. 1788-1797
    • Wang, D.1    Precopio, M.2    Lan, T.3    Yu, D.4    Tang, J.X.5    Kandimalla, E.R.6
  • 97
    • 33646351049 scopus 로고    scopus 로고
    • Immunotherapy with dendritic cells and CpG oligonucleotides can be combined with chemotherapy without loss of efficacy in a mouse model of colon cancer
    • DOI 10.1002/ijc.21681
    • C. Bourquin, S. Schreiber, S. Beck, G. Hartmann, and S. Endres Immunotherapy with dendritic cells and CpG oligonucleotides can be combined with chemotherapy without loss of efficacy in a mouse model of colon cancer Int J Cancer 118 2006 2790 2795 (Pubitemid 43673358)
    • (2006) International Journal of Cancer , vol.118 , Issue.11 , pp. 2790-2795
    • Bourquin, C.1    Schreiber, S.2    Beck, S.3    Hartmann, G.4    Endres, S.5
  • 100
    • 0036785631 scopus 로고    scopus 로고
    • PeritumoralCpG DNA elicits a coordinated response of CD8 T cells and innate effectors to cure established tumors in a murine colon carcinoma model
    • K. Heckelsmiller, K. Rall, S. Beck, A. Schlamp, J. Seiderer, and B. Jahrsdörfer PeritumoralCpG DNA elicits a coordinated response of CD8 T cells and innate effectors to cure established tumors in a murine colon carcinoma model J Immunol 169 2002 3892 3899
    • (2002) J Immunol , vol.169 , pp. 3892-3899
    • Heckelsmiller, K.1    Rall, K.2    Beck, S.3    Schlamp, A.4    Seiderer, J.5    Jahrsdörfer, B.6
  • 102
    • 34447281533 scopus 로고    scopus 로고
    • Experimental therapy for colon cancer: Anti-cancer effects of TLR9 agonism, combination with other therapeutic modalities, and dependence upon p53
    • E.R. Rayburn, W. Wang, R. Zhang, and H. Wang Experimental therapy for colon cancer: anti-cancer effects of TLR9 agonism, combination with other therapeutic modalities, and dependence upon p53 Int J Oncol 30 2007 1511 1519
    • (2007) Int J Oncol , vol.30 , pp. 1511-1519
    • Rayburn, E.R.1    Wang, W.2    Zhang, R.3    Wang, H.4
  • 103
    • 80054095608 scopus 로고    scopus 로고
    • Toll-like receptor 9 agonist Imo cooperates with cetuximab in K-Ras mutant colorectal and pancreatic cancers
    • R. Rosa, D. Melisi, V. Damiano, R. Bianco, S. Garofalo, and T. Gelardi Toll-like receptor 9 agonist Imo cooperates with cetuximab in K-Ras mutant colorectal and pancreatic cancers Clin Cancer Res 17 2011 6531 6541
    • (2011) Clin Cancer Res , vol.17 , pp. 6531-6541
    • Rosa, R.1    Melisi, D.2    Damiano, V.3    Bianco, R.4    Garofalo, S.5    Gelardi, T.6
  • 104
    • 0037273076 scopus 로고    scopus 로고
    • Intra-tumoral injection of CpG results in the inhibition of tumor growth in murine Colon-26 and B-16 tumors
    • DOI 10.1023/A:1021927621813
    • S. Sharma, C.P. Karakousis, H. Takita, K. Shin, and S.P. Brooks Intra-tumoral injection of CpG results in the inhibition of tumor growth in murine colon-26 and B-16 tumors Biotechnol Lett 25 2003 149 153 (Pubitemid 36189361)
    • (2003) Biotechnology Letters , vol.25 , Issue.2 , pp. 149-153
    • Sharma, S.1    Karakousis, C.P.2    Takita, H.3    Shin, K.4    Brooks, S.P.5
  • 105
    • 6944256671 scopus 로고    scopus 로고
    • Cytokines and chemokines are expressed at different levels in small and large murine colon-26 tumors following intratumoral injections of CpG ODN
    • DOI 10.1593/neo.04166
    • S. Sharma, C.P. Karakousis, H. Takita, K. Shin, and S.P. Brooks Cytokines and chemokines are expressed at different levels in small and large murine colon-26 tumors following intratumoral injections of CpG ODN Neoplasia 6 2004 523 528 (Pubitemid 39411088)
    • (2004) Neoplasia , vol.6 , Issue.5 , pp. 523-528
    • Sharma, S.1    Karakousis, C.P.2    Takita, H.3    Shin, K.4    Brooks, S.P.5
  • 107
    • 17144398046 scopus 로고    scopus 로고
    • Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection
    • C. Guiducci, A.P. Vicari, S. Sangaletti, G. Trinchieri, and M.P. Colombo Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection Cancer Res 65 2005 3437 3446 (Pubitemid 40524630)
    • (2005) Cancer Research , vol.65 , Issue.8 , pp. 3437-3446
    • Guiducci, C.1    Vicari, A.P.2    Sangaletti, S.3    Trinchieri, G.4    Colombo, M.P.5
  • 108
    • 58149477220 scopus 로고    scopus 로고
    • Stimulatory effects of CpGoligodeoxynucleotide on dendritic cell-based immunotherapy of colon cancer in CEA/HLA-A2 transgenic mice
    • A. Saha, M. Bhattacharya-Chatterjee, K.A. Foon, E. Celis, and S.K. Chatterjee Stimulatory effects of CpGoligodeoxynucleotide on dendritic cell-based immunotherapy of colon cancer in CEA/HLA-A2 transgenic mice Int J Cancer 124 2009 877 888
    • (2009) Int J Cancer , vol.124 , pp. 877-888
    • Saha, A.1    Bhattacharya-Chatterjee, M.2    Foon, K.A.3    Celis, E.4    Chatterjee, S.K.5
  • 110
    • 57749117219 scopus 로고    scopus 로고
    • CpG-ODN-based immunotherapy is effective in controlling the growth of metastasized tumor cells
    • H.A. Kim, H.M. Ko, H.W. Ju, K.J. Kim, S.G. Roh, and H.K. Lee CpG-ODN-based immunotherapy is effective in controlling the growth of metastasized tumor cells Cancer Lett 274 2009 160 164
    • (2009) Cancer Lett , vol.274 , pp. 160-164
    • Kim, H.A.1    Ko, H.M.2    Ju, H.W.3    Kim, K.J.4    Roh, S.G.5    Lee, H.K.6
  • 111
    • 84892676537 scopus 로고    scopus 로고
    • CpG ODN, toll like receptor (TLR)-9 agonist, inhibits metastatic colon adenocarcinoma in a murine hepatic tumor model
    • I.Y. Kim, X. Yan, S. Tohme, A. Ahmed, C. Cordon-Cardo, and H.M.C.S. Kumara CpG ODN, toll like receptor (TLR)-9 agonist, inhibits metastatic colon adenocarcinoma in a murine hepatic tumor model J Surg Res 7 2011 1 7
    • (2011) J Surg Res , vol.7 , pp. 1-7
    • Kim, I.Y.1    Yan, X.2    Tohme, S.3    Ahmed, A.4    Cordon-Cardo, C.5    Kumara, H.M.C.S.6
  • 112
    • 55849130757 scopus 로고    scopus 로고
    • CD4 + CD25 + Tregs control the TRAIL-dependent cytotoxicity of tumor-infiltrating DCs in rodent models of colon cancer
    • S. Roux, L. Apetoh, F. Chalmin, S. Ladoire, G. Mignot, and P.E. Puig CD4 + CD25 + Tregs control the TRAIL-dependent cytotoxicity of tumor-infiltrating DCs in rodent models of colon cancer J Clin Invest 118 2008 3751 3761
    • (2008) J Clin Invest , vol.118 , pp. 3751-3761
    • Roux, S.1    Apetoh, L.2    Chalmin, F.3    Ladoire, S.4    Mignot, G.5    Puig, P.E.6
  • 113
    • 77956915557 scopus 로고    scopus 로고
    • Ligand-independent toll-like receptor signals generated by ectopic overexpression of MyD88 generate local and systemic antitumor immunity
    • Z.C. Hartman, T. Osada, O. Glass, X.Y. Yang, G.J. Lei, and H.K. Lyerly Ligand-independent toll-like receptor signals generated by ectopic overexpression of MyD88 generate local and systemic antitumor immunity Cancer Res 70 2010 7209 7220
    • (2010) Cancer Res , vol.70 , pp. 7209-7220
    • Hartman, Z.C.1    Osada, T.2    Glass, O.3    Yang, X.Y.4    Lei, G.J.5    Lyerly, H.K.6
  • 115
    • 62149131898 scopus 로고    scopus 로고
    • Silencing of TLR4 decreases liver tumor burden in a murine model of colorectal metastasis and hepatic steatosis
    • T.M. Earl, I.B. Nicoud, J.M. Pierce, J.P. Wright, N.E. Majoras, and J.E. Rubin Silencing of TLR4 decreases liver tumor burden in a murine model of colorectal metastasis and hepatic steatosis Ann Surg Oncol 16 2009 1043 1050
    • (2009) Ann Surg Oncol , vol.16 , pp. 1043-1050
    • Earl, T.M.1    Nicoud, I.B.2    Pierce, J.M.3    Wright, J.P.4    Majoras, N.E.5    Rubin, J.E.6
  • 116
    • 79952236601 scopus 로고    scopus 로고
    • LPS-induced TLR4 signaling in human colorectal cancer cells increases β1 integrin-mediated cell adhesion and liver metastasis
    • R.Y.C. Hsu, C.H.F. Chan, J.D. Spicer, M.C. Rousseau, B. Giannias, and S. Rousseau LPS-induced TLR4 signaling in human colorectal cancer cells increases β1 integrin-mediated cell adhesion and liver metastasis Cancer Res 71 2011 1989 1998
    • (2011) Cancer Res , vol.71 , pp. 1989-1998
    • Hsu, R.Y.C.1    Chan, C.H.F.2    Spicer, J.D.3    Rousseau, M.C.4    Giannias, B.5    Rousseau, S.6
  • 117
    • 33645238579 scopus 로고    scopus 로고
    • Polymorphism of CD14 gene but not the mutation of TLR4 gene is associated with colorectal cancer in Chinese patients
    • Q. Guo, J. Zhu, and B. Xia Polymorphism of CD14 gene but not the mutation of TLR4 gene is associated with colorectal cancer in Chinese patients J Gastroenterol Hepatol 21 2006 92 97
    • (2006) J Gastroenterol Hepatol , vol.21 , pp. 92-97
    • Guo, Q.1    Zhu, J.2    Xia, B.3
  • 119
    • 70350588993 scopus 로고    scopus 로고
    • Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer
    • K.K. Tsilidis, K.J. Helzlsouer, M.W. Smith, V. Grinberg, J. Hoffman-Bolton, and S.L. Clipp Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer Cancer Causes Control 20 2009 1739 1751
    • (2009) Cancer Causes Control , vol.20 , pp. 1739-1751
    • Tsilidis, K.K.1    Helzlsouer, K.J.2    Smith, M.W.3    Grinberg, V.4    Hoffman-Bolton, J.5    Clipp, S.L.6
  • 120
    • 79959545223 scopus 로고    scopus 로고
    • Phase i study utilizing a novel antigen-presenting cell-targeted vaccine with Toll-like receptor stimulation to induce immunity to self antigens in cancer patients
    • M.A. Morse, R. Chapman, J. Powderly, K. Blackwell, T. Keler, and J. Green Phase I study utilizing a novel antigen-presenting cell-targeted vaccine with Toll-like receptor stimulation to induce immunity to self antigens in cancer patients Clin Cancer Res 17 2011 4844 4853
    • (2011) Clin Cancer Res , vol.17 , pp. 4844-4853
    • Morse, M.A.1    Chapman, R.2    Powderly, J.3    Blackwell, K.4    Keler, T.5    Green, J.6
  • 121
    • 84878308202 scopus 로고    scopus 로고
    • [internet] Clinicaltrials.gov 2008 Jul 17 [cited 2011 Sep 25] National Library of Medicine (US) Bethesda (MD) [Available from: ]
    • ClinicalTrials.gov [Internet] Identifier NCT00719199, study of FOLFIRI plus cetuximab plus IMO-2055 in patients with colorectal cancer 2008 Jul 17 [cited 2011 Sep 25] Feb 29 2000 National Library of Medicine (US) Bethesda (MD) [Available from: http://clinicaltrials.gov/ct2/show/NCT00719199?term= NCT00719199&rank=1 ]
    • (2000) Identifier NCT00719199, Study of FOLFIRI Plus Cetuximab Plus IMO-2055 in Patients with Colorectal Cancer


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.