Microsatellite GT polymorphism in the toll-like receptor 2 is associated with colorectal cancer

Clinical Genetics

Volumn 70, Issue 2, 2006, Pages 156-160

  Boraska Jelavic T ^a   Barisic M ^b   Drmic Hofman, I ^a   Boraska, V ^b   Vrdoljak, E ^a   Peruzovic M ^b   Hozo, I ^a   Puljiz, Z ^a   Terzić, Janoš ^b,c  

^a UNIVERSITY HOSPITAL SPLIT   (Croatia)

^b UNIVERSITY OF SPLIT   (Croatia)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Colorectal cancer; Polymorphisms; Toll like receptor 2; Toll like receptor 4

Indexed keywords

ASPARAGINE; GLYCINE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; MICROSATELLITE DNA; TLR2 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; COLORECTAL CANCER; CONTROLLED STUDY; CROATIA; CROHN DISEASE; DNA DETERMINATION; ETHNOLOGY; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; ULCERATIVE COLITIS; COLORECTAL TUMOR; GENETIC POLYMORPHISM; GENETICS; MIDDLE AGED;

AGED; COLORECTAL NEOPLASMS; CROATIA; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; POLYMORPHISM, GENETIC; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 33745815169     PISSN: 00099163     EISSN: 13990004     Source Type: Journal    
DOI: 10.1111/j.1399-0004.2006.00651.x     Document Type: Article

References (28)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005: 55: 74-108.
2. Fearon ER, Vogelstein B. A genetic model of colorectal tumorigenesis. Cell 1990: 61: 759-767.
3. Itzkowitz SH, Yio X. Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: The role of inflammation. Am J Physiol Gastrointest Liver Physiol 2004: 287: G7-G17.
4. Oshima M, Taketo MM. COX selectivity and animal models for colon cancer. Curr Pharm Des 2002: 8: 1021-1034.
5. Jump RL, Levine AD. Mechanisms of natural tolerance in the intestine: implications for inflammatory bowel disease. Inflamm Bowel Dis 2004: 10: 462-478.
6. Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004: 118: 229-241.
7. Greten FR, Eckmann L, Greten TF et al. IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 2004: 118: 285-296.
8. Pikarsky E, Porat RM, Stein I et al. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 2004: 431: 461-466.
9. Takeuchi O, Hoshino K, Kawai T et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 1999: 11: 443-451.
10. Du X, Poltorak A, Silva M, Beutler B. Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor. Blood Cells Mol Dis 1999: 25: 328-338.
11. Yoshimura A, Lien E, Ingalls RR, Tuomanen E, Dziarski R, Golenbock D. Cutting edge: Recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J Immunol 1999: 163: 1-5.
12. Schwandner R, Dziarski R, Wesche H, Rothe M, Kirschning CJ. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem 1999: 274: 17406-17409.
13. Brightbill HD, Libraty DH, Krutzik SR et al. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science 1999: 285: 732-736.
14. Werts C, Tapping RI, Mathison JC et al. Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism. Nat Immunol 2001: 2: 346-352.
15. Lorenz E, Mira JP, Cornish KL, Arbour NC, Schwartz DA. A novel polymorphism in the Toll-like receptor 2 gene and its potential association with staphylococcal infection. Infect Immun 2000: 68: 6398-6401.
16. Yim JJ, Ding L, Schaffer AA, Park GY, Shim Y, Holland SM. A microsatellite polymorphism in intron 2 of human Toll-like receptor 2 gene: Functional implications and racial differences. FEMS Immunol Med Microbiol 2004: 40: 163-169.
17. Yim JJ, Lee HW, Lee HS et al. The association between microsatellite polymorphisms in intron II of the human Toll-like receptor 2 gene and tuberculosis among Koreans. Genes Immun 2006: 7: 150-155.
18. Arbour N, Lorenz E, Schutte B et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 2000: 25: 187-191.
19. Franchimont D, Vermiere S, Housni HE et al. Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis. Gut 2004: 53: 987-992.
20. Gazouli M, Mantzaris G, Kotsinas A et al. Association between polymorphisms in the Toll-like receptor 4, CD14, and CARD15/NOD2 and inflammatory bowel disease in the Greek population. World J Gastroenterol 2005: 11: 681-685.
21. Torok HP, Glas J, Tonenchi L, Mussack T, Folwaczny C. Polymorphisms of the lipopolysaccharide-signaling complex in inflammatory bowel disease: association of a mutation in the toll-like receptor 4 gene with ulcerative colitis. Clin Immunol 2004: 112: 85-91.
22. Lorenz E, Frees KL, Schwartz DA. Determination of the TLR4 genotype using allele-specific PCR. BioTechniques 2001: 31: 22-24.
23. Zhao JH, Curtis D, Sham PC. Model-free analysis and permutation tests for allelic associations. Hum Hered 2000: 50: 133-139.
24. Tsuge M, Hamamoto R, Silva FP et al. A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5'flanking region of SMYD3 is a risk factor for human cancers. Nat Genet 2005: 37: 1104-1107.
25. Michel O, LeVan TD, Stern D et al. Systemic responsiveness to lipopolysaccharide and polymorphisms in the toll-like receptor 4 gene in human beings. J Allergy Clin Immunol 2003: 112: 923-929.
26. Cario E, Podolsky DK. Differential alteration in intestinal cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect Immun 2000: 68: 7010-7017.
27. Okamoto M, Sato M. Toll-like receptor signaling in anti-cancer immunity. J Med Invest 2003: 50: 9-24.
28. Tsuji S, Matsumoto M, Takeuchi O et al. Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guerin: Involvement of toll-like receptors. Infect Immun 2000: 68: 6883-6890.