메뉴 건너뛰기




Volumn 280, Issue 10, 2013, Pages 2307-2319

Heparanase in inflammation and inflammation-associated cancer

Author keywords

cancer; extracellular matrix; heparan sulfate; heparanase; inflammation; macrophages; tumor microenvironment

Indexed keywords

G 4000; GEMCITABINE; GLYCOSIDASE INHIBITOR; HEPARAN SULFATE; HEPARANASE; LAMINARAN SULFATE; M 402; PG 545; PI 88; PROTEOHEPARAN SULFATE; SST 0001; SURAMIN; UNCLASSIFIED DRUG;

EID: 84877691115     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12184     Document Type: Review
Times cited : (70)

References (139)
  • 1
    • 34247610845 scopus 로고    scopus 로고
    • Heparan sulphate proteoglycans fine-tune mammalian physiology
    • DOI 10.1038/nature05817, PII NATURE05817
    • Bishop JR, Schuksz M, &, Esko JD, (2007) Heparan sulphate proteoglycans fine-tune mammalian physiology. Nature 446, 1030-1037. (Pubitemid 46676065)
    • (2007) Nature , vol.446 , Issue.7139 , pp. 1030-1037
    • Bishop, J.R.1    Schuksz, M.2    Esko, J.D.3
  • 3
    • 79957605232 scopus 로고    scopus 로고
    • Proteoglycans in cancer biology, tumour microenvironment and angiogenesis
    • Iozzo RV, &, Sanderson RD, (2011) Proteoglycans in cancer biology, tumour microenvironment and angiogenesis. J Cell Mol Med 15, 1013-1031.
    • (2011) J Cell Mol Med , vol.15 , pp. 1013-1031
    • Iozzo, R.V.1    Sanderson, R.D.2
  • 4
    • 77956641177 scopus 로고    scopus 로고
    • Proteoglycans in health and disease: Novel roles for proteoglycans in malignancy and their pharmacological targeting
    • Theocharis AD, Skandalis SS, Tzanakakis GN, &, Karamanos NK, (2010) Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting. FEBS J 277, 3904-3923.
    • (2010) FEBS J , vol.277 , pp. 3904-3923
    • Theocharis, A.D.1    Skandalis, S.S.2    Tzanakakis, G.N.3    Karamanos, N.K.4
  • 5
    • 0346785274 scopus 로고    scopus 로고
    • Heparan Sulfate Core Proteins in Cell-Cell Signaling
    • DOI 10.1146/annurev.genet.37.061103.090226
    • Kramer KL, &, Yost HJ, (2003) Heparan sulfate core proteins in cell-cell signaling. Annu Rev Genet 37, 461-484. (Pubitemid 38043946)
    • (2003) Annual Review of Genetics , vol.37 , pp. 461-484
    • Kramer, K.L.1    Yost, H.J.2
  • 7
    • 0037333830 scopus 로고    scopus 로고
    • Heparan sulfate proteoglycan as a plasma membrane carrier
    • DOI 10.1016/S0968-0004(03)00031-8
    • Belting M, (2003) Heparan sulfate proteoglycan as a plasma membrane carrier. Trends Biochem Sci 28, 145-151. (Pubitemid 36293852)
    • (2003) Trends in Biochemical Sciences , vol.28 , Issue.3 , pp. 145-151
    • Belting, M.1
  • 8
    • 0031749471 scopus 로고    scopus 로고
    • Physiological degradation converts the soluble syndecan-1 ectodomain from an inhibitor to a potent activator of FGF-2
    • DOI 10.1038/nm0698-691
    • Kato M, Wang H, Kainulainen V, Fitzgerald ML, Ledbetter S, Ornitz DM, &, Bernfield M, (1998) Physiological degradation converts the soluble syndecan-1 ectodomain from an inhibitor to a potent activator of FGF-2. Nat Med 4, 691-697. (Pubitemid 28274669)
    • (1998) Nature Medicine , vol.4 , Issue.6 , pp. 691-697
    • Kato, M.1    Wang, H.2    Kainulainen, V.3    Fitzgerald, M.L.4    Ledbetter, S.5    Ornitz, D.M.6    Bernfield, M.7
  • 9
    • 0030018209 scopus 로고    scopus 로고
    • Involvement of heparan sulfate and related molecules in sequestration and growth promoting activity of fibroblast growth factor
    • DOI 10.1007/BF00437470
    • Vlodavsky I, Miao HQ, Medalion B, Danagher P, &, Ron D, (1996) Involvement of heparan sulfate and related molecules in sequestration and growth promoting activity of fibroblast growth factor. Cancer Metastasis Rev 15, 177-186. (Pubitemid 26236115)
    • (1996) Cancer and Metastasis Reviews , vol.15 , Issue.2 , pp. 177-186
    • Vlodavsky, I.1    Miao, H.-Q.2    Medalion, B.3    Danagher, P.4    Ron, D.5
  • 10
    • 0035782873 scopus 로고    scopus 로고
    • Heparan sulfate proteoglycans in invasion and metastasis
    • Sanderson RD, (2001) Heparan sulfate proteoglycans in invasion and metastasis. Semin Cell Dev Biol 12, 89-98.
    • (2001) Semin Cell Dev Biol , vol.12 , pp. 89-98
    • Sanderson, R.D.1
  • 11
    • 0035988837 scopus 로고    scopus 로고
    • Proteoglycans and tumor progression: Janus-faced molecules with contradictory functions in cancer
    • DOI 10.1016/S1044-579X(02)00021-4
    • Timar J, Lapis K, Dudas J, Sebestyen A, Kopper L, &, Kovalszky I, (2002) Proteoglycans and tumor progression: Janus-faced molecules with contradictory functions in cancer. Semin Cancer Biol 12, 173-186. (Pubitemid 34833061)
    • (2002) Seminars in Cancer Biology , vol.12 , Issue.3 , pp. 173-186
    • Timar, J.1    Lapis, K.2    Dudas, J.3    Sebestyen, A.4    Kopper, L.5    Kovalszky, I.6
  • 12
    • 34547313009 scopus 로고    scopus 로고
    • Mammalian heparanase: What is the message?
    • DOI 10.1111/j.1582-4934.2007.00039.x
    • Vreys V, &, David G, (2007) Mammalian heparanase: what is the message? J Cell Mol Med 11, 427-452. (Pubitemid 47153456)
    • (2007) Journal of Cellular and Molecular Medicine , vol.11 , Issue.3 , pp. 427-452
    • Vreys, V.1    David, G.2
  • 14
    • 0037387945 scopus 로고    scopus 로고
    • Syndecans in inflammation
    • DOI 10.1096/fj.02-0739rev
    • Gotte M, (2003) Syndecans in inflammation. FASEB J 17, 575-591. (Pubitemid 37221142)
    • (2003) FASEB Journal , vol.17 , Issue.6 , pp. 575-591
    • Gotte, M.1
  • 15
    • 70449604674 scopus 로고    scopus 로고
    • Heparin, heparan sulfate and heparanase in inflammatory reactions
    • Li JP, &, Vlodavsky I, (2009) Heparin, heparan sulfate and heparanase in inflammatory reactions. Thromb Haemost 102, 823-828.
    • (2009) Thromb Haemost , vol.102 , pp. 823-828
    • Li, J.P.1    Vlodavsky, I.2
  • 16
    • 33748683743 scopus 로고    scopus 로고
    • Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis
    • DOI 10.1016/j.biocel.2006.06.004, PII S1357272506001919
    • Ilan N, Elkin M, &, Vlodavsky I, (2006) Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis. Int J Biochem Cell Biol 38, 2018-2039. (Pubitemid 44397619)
    • (2006) International Journal of Biochemistry and Cell Biology , vol.38 , Issue.12 , pp. 2018-2039
    • Ilan, N.1    Elkin, M.2    Vlodavsky, I.3
  • 18
    • 33746088493 scopus 로고    scopus 로고
    • Heparanase expression in nasopharyngeal carcinoma inversely correlates with patient survival
    • DOI 10.1111/j.1365-2559.2006.02469.x
    • Bar-Sela G, Kaplan-Cohen V, Ilan N, Vlodavsky I, &, Ben-Izhak O, (2006) Heparanase expression in nasopharyngeal carcinoma inversely correlates with patient survival. Histopathology 49, 188-193. (Pubitemid 44079702)
    • (2006) Histopathology , vol.49 , Issue.2 , pp. 188-193
    • Bar-Sela, G.1    Kaplan-Cohen, V.2    Ilan, N.3    Vlodavsky, I.4    Ben-Izhak, O.5
  • 19
    • 33749823760 scopus 로고    scopus 로고
    • Heparanase expression in malignant salivary gland tumors inversely correlates with long-term survival
    • DOI 10.1593/neo.06382
    • Ben-Izhak O, Kaplan-Cohen V, Ilan N, Gan S, Vlodavsky I, &, Nagler R, (2006) Heparanase expression in malignant salivary gland tumors inversely correlates with long-term survival. Neoplasia 8, 879-884. (Pubitemid 44564843)
    • (2006) Neoplasia , vol.8 , Issue.10 , pp. 879-884
    • Ben-Izhak, O.1    Kaplan-Cohen, V.2    Ilan, N.3    Gan, S.4    Vlodavsky, I.5    Nagler, R.6
  • 20
    • 33845582727 scopus 로고    scopus 로고
    • Heparanase localization and expression by head and neck cancer: Correlation with tumor progression and patient survival
    • DOI 10.1593/neo.06577
    • Doweck I, Kaplan-Cohen V, Naroditsky I, Sabo E, Ilan N, &, Vlodavsky I, (2006) Heparanase localization and expression by head and neck cancer: correlation with tumor progression and patient survival. Neoplasia 8, 1055-1061. (Pubitemid 44936155)
    • (2006) Neoplasia , vol.8 , Issue.12 , pp. 1055-1061
    • Doweck, I.1    Kaplan-Cohen, V.2    Naroditsky, I.3    Sabo, E.4    Ilan, N.5    Vlodavsky, I.6
  • 29
    • 15744394403 scopus 로고    scopus 로고
    • Antisense-mediated suppression of heparanase gene inhibits melanoma cell invasion
    • DOI 10.1593/neo.04493
    • Roy M, Reiland J, Murry BP, Chouljenko V, Kousoulas KG, &, Marchetti D, (2005) Antisense-mediated suppression of Heparanase gene inhibits melanoma cell invasion. Neoplasia 7, 253-262. (Pubitemid 40411637)
    • (2005) Neoplasia , vol.7 , Issue.3 , pp. 253-262
    • Roy, M.1    Reiland, J.2    Murry, B.P.3    Chouljenko, V.4    Kousoulas, K.G.5    Marchetti, D.6
  • 31
    • 84860303171 scopus 로고    scopus 로고
    • Downregulation of heparanase by RNA interference inhibits invasion and tumorigenesis of hepatocellular cancer cells in vitro and in vivo
    • Xiong Z, Lu MH, Fan YH, Cao YL, Hu CJ, Wu YY, Wang SM, Luo G, Fang DC, Li C, et al,. (2012) Downregulation of heparanase by RNA interference inhibits invasion and tumorigenesis of hepatocellular cancer cells in vitro and in vivo. Int J Oncol 40, 1601-1609.
    • (2012) Int J Oncol , vol.40 , pp. 1601-1609
    • Xiong, Z.1    Lu, M.H.2    Fan, Y.H.3    Cao, Y.L.4    Hu, C.J.5    Wu, Y.Y.6    Wang, S.M.7    Luo, G.8    Fang, D.C.9    Li, C.10
  • 32
    • 84862698522 scopus 로고    scopus 로고
    • The endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymes
    • He YQ, Sutcliffe EL, Bunting KL, Li J, Goodall KJ, Poon IK, Hulett MD, Freeman C, Zafar A, McInnes RL, et al,. (2012) The endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymes. Transcription 3, 130-145.
    • (2012) Transcription , vol.3 , pp. 130-145
    • He, Y.Q.1    Sutcliffe, E.L.2    Bunting, K.L.3    Li, J.4    Goodall, K.J.5    Poon, I.K.6    Hulett, M.D.7    Freeman, C.8    Zafar, A.9    McInnes, R.L.10
  • 34
    • 0345275871 scopus 로고    scopus 로고
    • Heparanase Affects Adhesive and Tumorigenic Potential of Human Glioma Cells
    • Zetser A, Bashenko Y, Miao HQ, Vlodavsky I, &, Ilan N, (2003) Heparanase affects adhesive and tumorigenic potential of human glioma cells. Cancer Res 63, 7733-7741. (Pubitemid 37466704)
    • (2003) Cancer Research , vol.63 , Issue.22 , pp. 7733-7741
    • Zetser, A.1    Bashenko, Y.2    Miao, H.-Q.3    Vlodavsky, I.4    Ilan, N.5
  • 36
    • 32944479184 scopus 로고    scopus 로고
    • Heparanase induces vascular endothelial growth factor expression: Correlation with p38 phosphorylation levels and Src activation
    • DOI 10.1158/0008-5472.CAN-05-1811
    • Zetser A, Bashenko Y, Edovitsky E, Levy-Adam F, Vlodavsky I, &, Ilan N, (2006) Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation. Cancer Res 66, 1455-1463. (Pubitemid 43259926)
    • (2006) Cancer Research , vol.66 , Issue.3 , pp. 1455-1463
    • Zetser, A.1    Bashenko, Y.2    Edovitsky, E.3    Levy-Adam, F.4    Vlodavsky, I.5    Ilan, N.6
  • 37
    • 57749114628 scopus 로고    scopus 로고
    • Heparanase augments epidermal growth factor receptor phosphorylation: Correlation with head and neck tumor progression
    • Cohen-Kaplan V, Doweck I, Naroditsky I, Vlodavsky I, &, Ilan N, (2008) Heparanase augments epidermal growth factor receptor phosphorylation: correlation with head and neck tumor progression. Cancer Res 68, 10077-10085.
    • (2008) Cancer Res , vol.68 , pp. 10077-10085
    • Cohen-Kaplan, V.1    Doweck, I.2    Naroditsky, I.3    Vlodavsky, I.4    Ilan, N.5
  • 38
    • 84870368833 scopus 로고    scopus 로고
    • Heparanase enhances the insulin receptor signaling pathway to activate ERK in multiple myeloma
    • Purushothaman A, Babitz SK, &, Sanderson RD, (2012) Heparanase enhances the insulin receptor signaling pathway to activate ERK in multiple myeloma. J Biol Chem 287, 41288-41296.
    • (2012) J Biol Chem , vol.287 , pp. 41288-41296
    • Purushothaman, A.1    Babitz, S.K.2    Sanderson, R.D.3
  • 39
    • 45349091645 scopus 로고    scopus 로고
    • Dramatic regulation of heparanase activity and angiogenesis gene expression in synovium from patients with rheumatoid arthritis
    • DOI 10.1002/art.23489
    • Li RW, Freeman C, Yu D, Hindmarsh EJ, Tymms KE, Parish CR, &, Smith PN, (2008) Dramatic regulation of heparanase activity and angiogenesis gene expression in synovium from patients with rheumatoid arthritis. Arthritis Rheum 58, 1590-1600. (Pubitemid 351847512)
    • (2008) Arthritis and Rheumatism , vol.58 , Issue.6 , pp. 1590-1600
    • Li, R.W.1    Freeman, C.2    Yu, D.3    Hindmarsh, E.J.4    Tymms, K.E.5    Parish, C.R.6    Smith, P.N.7
  • 40
    • 33845684922 scopus 로고    scopus 로고
    • Heparanase upregulation by colonic epithelium in inflammatory bowel disease
    • DOI 10.1038/modpathol.3800710, PII 3800710
    • Waterman M, Ben-Izhak O, Eliakim R, Groisman G, Vlodavsky I, &, Ilan N, (2007) Heparanase upregulation by colonic epithelium in inflammatory bowel disease. Mod Pathol 20, 8-14. (Pubitemid 44967944)
    • (2007) Modern Pathology , vol.20 , Issue.1 , pp. 8-14
    • Waterman, M.1    Ben-Izhak, O.2    Eliakim, R.3    Groisman, G.4    Vlodavsky, I.5    Ilan, N.6
  • 44
    • 80052521778 scopus 로고    scopus 로고
    • Reactive oxygen species mediate high glucose-induced heparanase-1 production and heparan sulphate proteoglycan degradation in human and rat endothelial cells: A potential role in the pathogenesis of atherosclerosis
    • Rao G, Ding HG, Huang W, Le D, Maxhimer JB, Oosterhof A, van Kuppevelt T, Lum H, Lewis EJ, Reddy V, et al,. (2011) Reactive oxygen species mediate high glucose-induced heparanase-1 production and heparan sulphate proteoglycan degradation in human and rat endothelial cells: a potential role in the pathogenesis of atherosclerosis. Diabetologia 54, 1527-1538.
    • (2011) Diabetologia , vol.54 , pp. 1527-1538
    • Rao, G.1    Ding, H.G.2    Huang, W.3    Le, D.4    Maxhimer, J.B.5    Oosterhof, A.6    Van Kuppevelt, T.7    Lum, H.8    Lewis, E.J.9    Reddy, V.10
  • 46
    • 77950405370 scopus 로고    scopus 로고
    • Genetic variations in the heparanase gene (HPSE) associate with increased risk of GVHD following allogeneic stem cell transplantation: Effect of discrepancy between recipients and donors
    • Ostrovsky O, Shimoni A, Rand A, Vlodavsky I, &, Nagler A, (2010) Genetic variations in the heparanase gene (HPSE) associate with increased risk of GVHD following allogeneic stem cell transplantation: effect of discrepancy between recipients and donors. Blood 115, 2319-2328.
    • (2010) Blood , vol.115 , pp. 2319-2328
    • Ostrovsky, O.1    Shimoni, A.2    Rand, A.3    Vlodavsky, I.4    Nagler, A.5
  • 48
    • 20144371081 scopus 로고    scopus 로고
    • Heparanase inhibition reduces proteinuria in a model of accelerated anti-glomerular basement membrane antibody disease
    • DOI 10.1111/j.1440-1797.2005.00388.x
    • Levidiotis V, Freeman C, Tikellis C, Cooper ME, &, Power DA, (2005) Heparanase inhibition reduces proteinuria in a model of accelerated anti-glomerular basement membrane antibody disease. Nephrology (Carlton) 10, 167-173. (Pubitemid 40776277)
    • (2005) Nephrology , vol.10 , Issue.2 , pp. 167-173
    • Levidiotis, V.1    Freeman, C.2    Tikellis, C.3    Cooper, M.E.4    Power, D.A.5
  • 51
    • 84855460360 scopus 로고    scopus 로고
    • Heparan sulfate and heparanase play key roles in mouse beta cell survival and autoimmune diabetes
    • Ziolkowski AF, Popp SK, Freeman C, Parish CR, &, Simeonovic CJ, (2012) Heparan sulfate and heparanase play key roles in mouse beta cell survival and autoimmune diabetes. J Clin Invest 122, 132-141.
    • (2012) J Clin Invest , vol.122 , pp. 132-141
    • Ziolkowski, A.F.1    Popp, S.K.2    Freeman, C.3    Parish, C.R.4    Simeonovic, C.J.5
  • 52
    • 65249103282 scopus 로고    scopus 로고
    • Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases
    • Zcharia E, Jia J, Zhang X, Baraz L, Lindahl U, Peretz T, Vlodavsky I, &, Li JP, (2009) Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases. PLoS One 4, e5181.
    • (2009) PLoS One , vol.4
    • Zcharia, E.1    Jia, J.2    Zhang, X.3    Baraz, L.4    Lindahl, U.5    Peretz, T.6    Vlodavsky, I.7    Li, J.P.8
  • 55
    • 0022382680 scopus 로고
    • Degradation of heparan sulfate in the subendothelial extracellular matrix by a readily released heparanase from human neutrophils. Possible role in invasion through basement membranes
    • Matzner Y, Bar-Ner M, Yahalom J, Ishai-Michaeli R, Fuks Z, &, Vlodavsky I, (1985) Degradation of heparan sulfate in the subendothelial extracellular matrix by a readily released heparanase from human neutrophils. Possible role in invasion through basement membranes. J Clin Invest 76, 1306-1313. (Pubitemid 16193674)
    • (1985) Journal of Clinical Investigation , vol.76 , Issue.4 , pp. 1306-1313
    • Matzner, Y.1    Bar-Ner, M.2    Yahalom, J.3
  • 57
    • 40149092689 scopus 로고    scopus 로고
    • Pharmacological inhibition of DNA methylation induces proinvasive and prometastatic genes in vitro and in vivo
    • DOI 10.1593/neo.07947
    • Ateeq B, Unterberger A, Szyf M, &, Rabbani SA, (2008) Pharmacological inhibition of DNA methylation induces proinvasive and prometastatic genes in vitro and in vivo. Neoplasia 10, 266-278. (Pubitemid 351328580)
    • (2008) Neoplasia , vol.10 , Issue.3 , pp. 266-278
    • Ateeq, B.1    Unterberger, A.2    Szyf, M.3    Rabbani, S.A.4
  • 58
    • 0041382127 scopus 로고    scopus 로고
    • Role of promoter methylation in regulation of the mammalian heparanase gene
    • DOI 10.1038/sj.onc.1207056
    • Shteper PJ, Zcharia E, Ashhab Y, Peretz T, Vlodavsky I, &, Ben-Yehuda D, (2003) Role of promoter methylation in regulation of the mammalian heparanase gene. Oncogene 22, 7737-7749. (Pubitemid 37485533)
    • (2003) Oncogene , vol.22 , Issue.49 , pp. 7737-7749
    • Shteper, P.J.1    Zcharia, E.2    Ashhab, Y.3    Peretz, T.4    Vlodavsky, I.5    Ben-Yehuda, D.6
  • 61
    • 33745606964 scopus 로고    scopus 로고
    • Tumor suppressor p53 regulates heparanase gene expression
    • DOI 10.1038/sj.onc.1209425, PII 1209425
    • Baraz L, Haupt Y, Elkin M, Peretz T, &, Vlodavsky I, (2006) Tumor suppressor p53 regulates heparanase gene expression. Oncogene 25, 3939-3947. (Pubitemid 43990749)
    • (2006) Oncogene , vol.25 , Issue.28 , pp. 3939-3947
    • Baraz, L.1    Haupt, Y.2    Elkin, M.3    Peretz, T.4    Vlodavsky, I.5
  • 62
    • 0346118917 scopus 로고    scopus 로고
    • Regulation of Inducible Heparanase Gene Transcription in Activated T Cells by Early Growth Response 1
    • DOI 10.1074/jbc.M310154200
    • de Mestre AM, Khachigian LM, Santiago FS, Staykova MA, &, Hulett MD, (2003) Regulation of inducible heparanase gene transcription in activated T cells by early growth response 1. J Biol Chem 278, 50377-50385. (Pubitemid 37548881)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.50 , pp. 50377-50385
    • De Mestre, A.M.1    Khachigian, L.M.2    Santiago, F.S.3    Staykova, M.A.4    Hulett, M.D.5
  • 64
    • 0037088587 scopus 로고    scopus 로고
    • Cloning and characterization of the human heparanase-1 (HPR1) gene promoter. Role of GA-binding protein and Sp1 in regulating HPR1 basal promoter activity
    • DOI 10.1074/jbc.M105682200
    • Jiang P, Kumar A, Parrillo JE, Dempsey LA, Platt JL, Prinz RA, &, Xu X, (2002) Cloning and characterization of the human heparanase-1 (HPR1) gene promoter: role of GA-binding protein and Sp1 in regulating HPR1 basal promoter activity. J Biol Chem 277, 8989-8998. (Pubitemid 34952971)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.11 , pp. 8989-8998
    • Jiang, P.1    Kumar, A.2    Parrillo, J.E.3    Dempsey, L.A.4    Platt, J.L.5    Prinz, R.A.6    Xu, X.7
  • 65
    • 0037434721 scopus 로고    scopus 로고
    • Trans-activation of heparanase promoter by ETS transcription factors
    • DOI 10.1038/sj.onc.1206201
    • Lu WC, Liu YN, Kang BB, &, Chen JH, (2003) Trans-activation of heparanase promoter by ETS transcription factors. Oncogene 22, 919-923. (Pubitemid 36255827)
    • (2003) Oncogene , vol.22 , Issue.6 , pp. 919-923
    • Lu, W.C.1    Liu, Y.N.2    Kang, B.B.3    Chen, J.H.4
  • 66
    • 78449263436 scopus 로고    scopus 로고
    • Induction of heparanase-1 expression by mutant B-Raf kinase: Role of GA binding protein in heparanase-1 promoter activation
    • Rao G, Liu D, Xing M, Tauler J, Prinz RA, &, Xu X, (2010) Induction of heparanase-1 expression by mutant B-Raf kinase: role of GA binding protein in heparanase-1 promoter activation. Neoplasia 12, 946-956.
    • (2010) Neoplasia , vol.12 , pp. 946-956
    • Rao, G.1    Liu, D.2    Xing, M.3    Tauler, J.4    Prinz, R.A.5    Xu, X.6
  • 67
    • 0036672885 scopus 로고    scopus 로고
    • Heparanase-1 expression is associated with the metastatic potential of breast cancer
    • DOI 10.1067/msy.2002.125719
    • Maxhimer JB, Quiros RM, Stewart R, Dowlatshahi K, Gattuso P, Fan M, Prinz RA, &, Xu X, (2002) Heparanase-1 expression is associated with the metastatic potential of breast cancer. Surgery 132, 326-333. (Pubitemid 35024780)
    • (2002) Surgery , vol.132 , Issue.2 , pp. 326-333
    • Maxhimer, J.B.1    Quiros, R.M.2    Stewart, R.3    Dowlatshahi, K.4    Gattuso, P.5    Fan, M.6    Prinz, R.A.7    Xu, X.8
  • 69
    • 34347219755 scopus 로고    scopus 로고
    • Estradiol induces heparanase-1 expression and heparan sulphate proteoglycan degradation in human endometrium
    • Xu X, Ding J, Rao G, Shen J, Prinz RA, Rana N, &, Dmowski WP, (2007) Estradiol induces heparanase-1 expression and heparan sulphate proteoglycan degradation in human endometrium. Hum Reprod 22, 927-937.
    • (2007) Hum Reprod , vol.22 , pp. 927-937
    • Xu, X.1    Ding, J.2    Rao, G.3    Shen, J.4    Prinz, R.A.5    Rana, N.6    Dmowski, W.P.7
  • 70
    • 2142755820 scopus 로고    scopus 로고
    • Inflammatory Cytokines and Fatty Acids Regulate Endothelial Cell Heparanase Expression
    • DOI 10.1021/bi0356552
    • Chen G, Wang D, Vikramadithyan R, Yagyu H, Saxena U, Pillarisetti S, &, Goldberg IJ, (2004) Inflammatory cytokines and fatty acids regulate endothelial cell heparanase expression. Biochemistry 43, 4971-4977. (Pubitemid 38544450)
    • (2004) Biochemistry , vol.43 , Issue.17 , pp. 4971-4977
    • Chen, G.1    Wang, D.2    Vikramadithyan, R.3    Yagyu, H.4    Saxena, U.5    Pillarisetti, S.6    Goldberg, I.J.7
  • 72
    • 84864340290 scopus 로고    scopus 로고
    • Heparanase enzyme in chronic inflammatory bowel disease and colon cancer
    • Hermano E, Lerner I, &, Elkin M, (2012) Heparanase enzyme in chronic inflammatory bowel disease and colon cancer. Cell Mol Life Sci 15, 2501-2513.
    • (2012) Cell Mol Life Sci , vol.15 , pp. 2501-2513
    • Hermano, E.1    Lerner, I.2    Elkin, M.3
  • 75
    • 1242307804 scopus 로고    scopus 로고
    • Mechanism of Activation of Human Heparanase Investigated by Protein Engineering
    • DOI 10.1021/bi030203a
    • Nardella C, Lahm A, Pallaoro M, Brunetti M, Vannini A, &, Steinkuhler C, (2004) Mechanism of activation of human heparanase investigated by protein engineering. Biochemistry 43, 1862-1873. (Pubitemid 38233249)
    • (2004) Biochemistry , vol.43 , Issue.7 , pp. 1862-1873
    • Nardella, C.1    Lahm, A.2    Pallaoro, M.3    Brunetti, M.4    Vannini, A.5    Steinkuhler, C.6
  • 77
    • 49649094763 scopus 로고    scopus 로고
    • Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment
    • Abboud-Jarrous G, Atzmon R, Peretz T, Palermo C, Gadea BB, Joyce JA, &, Vlodavsky I, (2008) Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment. J Biol Chem 283, 18167-18176.
    • (2008) J Biol Chem , vol.283 , pp. 18167-18176
    • Abboud-Jarrous, G.1    Atzmon, R.2    Peretz, T.3    Palermo, C.4    Gadea, B.B.5    Joyce, J.A.6    Vlodavsky, I.7
  • 78
    • 0023112112 scopus 로고
    • Soluble antigen induces T lymphocytes to secrete an endoglycosidase that degrades the heparan sulfate moiety of subendothelial extracellular matrix
    • DOI 10.1002/jcp.1041300113
    • Fridman R, Lider O, Naparstek Y, Fuks Z, Vlodavsky I, &, Cohen IR, (1987) Soluble antigen induces T lymphocytes to secrete an endoglycosidase that degrades the heparan sulfate moiety of subendothelial extracellular matrix. J Cell Physiol 130, 85-92. (Pubitemid 17011051)
    • (1987) Journal of Cellular Physiology , vol.130 , Issue.1 , pp. 85-92
    • Fridman, R.1    Lider, O.2    Naparstek, Y.3
  • 80
    • 0024590281 scopus 로고
    • Suppression of experimental autoimmune diseases and prolongation of allograft survival by treatment of animals with low doses of heparins
    • Lider O, Baharav E, Mekori YA, Miller T, Naparstek Y, Vlodavsky I, &, Cohen IR, (1989) Suppression of experimental autoimmune diseases and prolongation of allograft survival by treatment of animals with low doses of heparins. J Clin Invest 83, 752-756. (Pubitemid 19080602)
    • (1989) Journal of Clinical Investigation , vol.83 , Issue.3 , pp. 752-756
    • Lider, O.1    Baharav, E.2    Mekori, Y.A.3    Miller, T.4    Naparstek, Y.5    Vlodavsky, I.6    Cohen, I.R.7
  • 81
    • 0021249299 scopus 로고
    • Activated T lymphocytes produce a matrix-degrading heparan sulphate endoglycosidase
    • Naparstek Y, Cohen IR, Fuks Z, &, Vlodavsky I, (1984) Activated T lymphocytes produce a matrix-degrading heparan sulphate endoglycosidase. Nature 310, 241-244. (Pubitemid 14090715)
    • (1984) Nature , vol.310 , Issue.5974 , pp. 241-244
    • Naparstek, Y.1    Cohen, I.R.2    Fuks, Z.3    Vlodavsky, I.4
  • 87
    • 34547176642 scopus 로고    scopus 로고
    • Unravelling the pathogenesis of inflammatory bowel disease
    • DOI 10.1038/nature06005, PII NATURE06005
    • Xavier RJ, &, Podolsky DK, (2007) Unravelling the pathogenesis of inflammatory bowel disease. Nature 448, 427-434. (Pubitemid 47123518)
    • (2007) Nature , vol.448 , Issue.7152 , pp. 427-434
    • Xavier, R.J.1    Podolsky, D.K.2
  • 88
    • 2142813761 scopus 로고    scopus 로고
    • A porous defense: The leaky epithelial barrier in intestinal disease
    • DOI 10.1038/labinvest.3700050
    • Clayburgh DR, Shen L, &, Turner JR, (2004) A porous defense: the leaky epithelial barrier in intestinal disease. Lab Invest 84, 282-291. (Pubitemid 41656483)
    • (2004) Laboratory Investigation , vol.84 , Issue.3 , pp. 282-291
    • Clayburgh, D.R.1    Shen, L.2    Turner, J.R.3
  • 90
    • 38149103259 scopus 로고    scopus 로고
    • Heparan sulfate and syndecan-1 are essential in maintaining murine and human intestinal epithelial barrier function
    • Bode L, Salvestrini C, Park PW, Li JP, Esko JD, Yamaguchi Y, Murch S, &, Freeze HH, (2008) Heparan sulfate and syndecan-1 are essential in maintaining murine and human intestinal epithelial barrier function. J Clin Invest 118, 229-238.
    • (2008) J Clin Invest , vol.118 , pp. 229-238
    • Bode, L.1    Salvestrini, C.2    Park, P.W.3    Li, J.P.4    Esko, J.D.5    Yamaguchi, Y.6    Murch, S.7    Freeze, H.H.8
  • 91
    • 0027476810 scopus 로고
    • Disruption of sulphated glycosaminoglycans in intestinal inflammation
    • DOI 10.1016/0140-6736(93)90485-Y
    • Murch SH, MacDonald TT, Walker-Smith JA, Levin M, Lionetti P, &, Klein NJ, (1993) Disruption of sulphated glycosaminoglycans in intestinal inflammation. Lancet 341, 711-714. (Pubitemid 23085176)
    • (1993) Lancet , vol.341 , Issue.8847 , pp. 711-714
    • Murch, S.H.1    MacDonald, T.T.2    Walker-Smith, J.A.3    Levin, M.4    Lionetti, P.5    Klein, N.J.6
  • 92
    • 0033519974 scopus 로고    scopus 로고
    • Heparin, cell adhesion, and pathogenesis of inflammatory bowel disease
    • DOI 10.1016/S0140-6736(98)09267-8
    • Day R, &, Forbes A, (1999) Heparin, cell adhesion, and pathogenesis of inflammatory bowel disease. Lancet 354, 62-65. (Pubitemid 29304311)
    • (1999) Lancet , vol.354 , Issue.9172 , pp. 62-65
    • Day, R.1    Forbes, A.2
  • 93
    • 0033388568 scopus 로고    scopus 로고
    • Expression of syndecan-1 in inflammatory bowel disease and a possible mechanism of heparin therapy
    • Day R, Ilyas M, Daszak P, Talbot I, &, Forbes A, (1999) Expression of syndecan-1 in inflammatory bowel disease and a possible mechanism of heparin therapy. Dig Dis Sci 44, 2508-2515. (Pubitemid 30027369)
    • (1999) Digestive Diseases and Sciences , vol.44 , Issue.12 , pp. 2508-2515
    • Day, R.1    Ilyas, M.2    Daszak, P.3    Talbot, I.4    Forbes, A.5
  • 95
    • 18144379144 scopus 로고    scopus 로고
    • Conditional signaling by toll-like receptor 4
    • DOI 10.1096/fj.04-3211fje
    • Brunn GJ, Bungum MK, Johnson GB, &, Platt JL, (2005) Conditional signaling by Toll-like receptor 4. FASEB J 19, 872-874. (Pubitemid 40617413)
    • (2005) FASEB Journal , vol.19 , Issue.7 , pp. 872-874
    • Brunn, G.J.1    Bungum, M.K.2    Johnson, G.B.3    Platt, J.L.4
  • 96
    • 35348904935 scopus 로고    scopus 로고
    • The structure and function of the endothelial glycocalyx layer
    • DOI 10.1146/annurev.bioeng.9.060906.151959
    • Weinbaum S, Tarbell JM, &, Damiano ER, (2007) The structure and function of the endothelial glycocalyx layer. Annu Rev Biomed Eng 9, 121-167. (Pubitemid 350246654)
    • (2007) Annual Review of Biomedical Engineering , vol.9 , pp. 121-167
    • Weinbaum, S.1    Tarbell, J.M.2    Damiano, E.R.3
  • 97
    • 0042190645 scopus 로고    scopus 로고
    • Endothelial cell glycocalyx modulates immobilization of leukocytes at the endothelial surface
    • DOI 10.1161/01.ATV.0000085630.24353.3D
    • Constantinescu AA, Vink H, &, Spaan JA, (2003) Endothelial cell glycocalyx modulates immobilization of leukocytes at the endothelial surface. Arterioscler Thromb Vasc Biol 23, 1541-1547. (Pubitemid 37108195)
    • (2003) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.23 , Issue.9 , pp. 1541-1547
    • Constantinescu, A.A.1    Vink, H.2    Spaan, J.A.E.3
  • 101
    • 0035956435 scopus 로고    scopus 로고
    • Role of heparan sulfate as a tissue-specific regulator of FGF-4 and FGF receptor recognition
    • Allen BL, Filla MS, &, Rapraeger AC, (2001) Role of heparan sulfate as a tissue-specific regulator of FGF-4 and FGF receptor recognition. J Cell Biol 155, 845-858.
    • (2001) J Cell Biol , vol.155 , pp. 845-858
    • Allen, B.L.1    Filla, M.S.2    Rapraeger, A.C.3
  • 102
    • 38449089309 scopus 로고    scopus 로고
    • Comparison of the effects of differentially sulphated bovine kidney- and porcine intestine-derived heparan sulphate on breast carcinoma cellular behaviour
    • Guo CH, Koo CY, Bay BH, Tan PH, &, Yip GW, (2007) Comparison of the effects of differentially sulphated bovine kidney- and porcine intestine-derived heparan sulphate on breast carcinoma cellular behaviour. Int J Oncol 31, 1415-1423.
    • (2007) Int J Oncol , vol.31 , pp. 1415-1423
    • Guo, C.H.1    Koo, C.Y.2    Bay, B.H.3    Tan, P.H.4    Yip, G.W.5
  • 103
    • 46749113163 scopus 로고    scopus 로고
    • The anti-inflammatory effects of heparin and related compounds
    • Young E, (2008) The anti-inflammatory effects of heparin and related compounds. Thromb Res 122, 743-752.
    • (2008) Thromb Res , vol.122 , pp. 743-752
    • Young, E.1
  • 105
    • 0021354360 scopus 로고
    • Metastatic melanoma cell heparanase. Characterization of heparan sulfate degradation fragments produced by B16 melanoma endoglucuronidase
    • Nakajima M, Irimura T, Di Ferrante N, &, Nicolson GL, (1984) Metastatic melanoma cell heparanase. Characterization of heparan sulfate degradation fragments produced by B16 melanoma endoglucuronidase. J Biol Chem 259, 2283-2290. (Pubitemid 14190344)
    • (1984) Journal of Biological Chemistry , vol.259 , Issue.4 , pp. 2283-2290
    • Nakajima, M.1    Irimura, T.2    Di Ferrante, N.3    Nicolson, G.L.4
  • 106
    • 0020640516 scopus 로고
    • Lymphoma cell-mediated degradation of sulfated proteoglycans in the subendothelial extracellular matrix: Relationship to tumor cell metastasis
    • Vlodavsky I, Fuks Z, Bar-Ner M, Ariav Y, &, Schirrmacher V, (1983) Lymphoma cell-mediated degradation of sulfated proteoglycans in the subendothelial extracellular matrix: relationship to tumor cell metastasis. Cancer Res 43, 2704-2711. (Pubitemid 13100536)
    • (1983) Cancer Research , vol.43 , Issue.6 , pp. 2704-2711
    • Vlodavsky, I.1    Fuks, Z.2    Bar Ner, M.3
  • 108
    • 33646879997 scopus 로고    scopus 로고
    • Spatial and temporal heparanase expression in colon mucosa throughout the adenoma-carcinoma sequence
    • DOI 10.1038/modpathol.3800603, PII 3800603
    • Doviner V, Maly B, Kaplan V, Gingis-Velitski S, Ilan N, Vlodavsky I, &, Sherman Y, (2006) Spatial and temporal heparanase expression in colon mucosa throughout the adenoma-carcinoma sequence. Mod Pathol 19, 878-888. (Pubitemid 43780459)
    • (2006) Modern Pathology , vol.19 , Issue.6 , pp. 878-888
    • Doviner, V.1    Maly, B.2    Kaplan, V.3    Gingis-Velitski, S.4    Ilan, N.5    Vlodavsky, I.6    Sherman, Y.7
  • 110
    • 84857377246 scopus 로고    scopus 로고
    • Small RNAs targeting transcription start site induce heparanase silencing through interference with transcription initiation in human cancer cells
    • Jiang G, Zheng L, Pu J, Mei H, Zhao J, Huang K, Zeng F, &, Tong Q, (2012) Small RNAs targeting transcription start site induce heparanase silencing through interference with transcription initiation in human cancer cells. PLoS One 7, e31379.
    • (2012) PLoS One , vol.7
    • Jiang, G.1    Zheng, L.2    Pu, J.3    Mei, H.4    Zhao, J.5    Huang, K.6    Zeng, F.7    Tong, Q.8
  • 111
    • 20444394457 scopus 로고    scopus 로고
    • A functional heparan sulfate mimetic implicates both heparanase and heparan sulfate in tumor angiogenesis and invasion in a mouse model of multistage cancer
    • DOI 10.1038/sj.onc.1208602
    • Joyce JA, Freeman C, Meyer-Morse N, Parish CR, &, Hanahan D, (2005) A functional heparan sulfate mimetic implicates both heparanase and heparan sulfate in tumor angiogenesis and invasion in a mouse model of multistage cancer. Oncogene 24, 4037-4051. (Pubitemid 40897051)
    • (2005) Oncogene , vol.24 , Issue.25 , pp. 4037-4051
    • Joyce, J.A.1    Freeman, C.2    Meyer-Morse, N.3    Parish, C.R.4    Hanahan, D.5
  • 112
    • 77950559481 scopus 로고    scopus 로고
    • Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis
    • Purushothaman A, Uyama T, Kobayashi F, Yamada S, Sugahara K, Rapraeger AC, &, Sanderson RD, (2010) Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis. Blood 115, 2449-2457.
    • (2010) Blood , vol.115 , pp. 2449-2457
    • Purushothaman, A.1    Uyama, T.2    Kobayashi, F.3    Yamada, S.4    Sugahara, K.5    Rapraeger, A.C.6    Sanderson, R.D.7
  • 114
    • 79952728727 scopus 로고    scopus 로고
    • Heparanase plays a dual role in driving hepatocyte growth factor (HGF) signaling by enhancing HGF expression and activity
    • Ramani VC, Yang Y, Ren Y, Nan L, &, Sanderson RD, (2011) Heparanase plays a dual role in driving hepatocyte growth factor (HGF) signaling by enhancing HGF expression and activity. J Biol Chem 286, 6490-6499.
    • (2011) J Biol Chem , vol.286 , pp. 6490-6499
    • Ramani, V.C.1    Yang, Y.2    Ren, Y.3    Nan, L.4    Sanderson, R.D.5
  • 115
    • 75849117800 scopus 로고    scopus 로고
    • Inflammation and oncogenesis: A vicious connection
    • Grivennikov SI, &, Karin M, (2010) Inflammation and oncogenesis: a vicious connection. Curr Opin Genet Dev 20, 65-71.
    • (2010) Curr Opin Genet Dev , vol.20 , pp. 65-71
    • Grivennikov, S.I.1    Karin, M.2
  • 116
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, &, Weinberg RA, (2011) Hallmarks of cancer: the next generation. Cell 144, 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 119
    • 34848893583 scopus 로고    scopus 로고
    • Histologic Inflammation Is a Risk Factor for Progression to Colorectal Neoplasia in Ulcerative Colitis: A Cohort Study
    • DOI 10.1053/j.gastro.2007.08.001, PII S0016508507014473
    • Gupta RB, Harpaz N, Itzkowitz S, Hossain S, Matula S, Kornbluth A, Bodian C, &, Ullman T, (2007) Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study. Gastroenterology 133, 1099-1105; quiz 1340-1. (Pubitemid 47494461)
    • (2007) Gastroenterology , vol.133 , Issue.4 , pp. 1099-1105
    • Gupta, R.B.1    Harpaz, N.2    Itzkowitz, S.3    Hossain, S.4    Matula, S.5    Kornbluth, A.6    Bodian, C.7    Ullman, T.8
  • 121
    • 77950950894 scopus 로고    scopus 로고
    • Macrophage diversity enhances tumor progression and metastasis
    • Qian BZ, &, Pollard JW, (2010) Macrophage diversity enhances tumor progression and metastasis. Cell 141, 39-51.
    • (2010) Cell , vol.141 , pp. 39-51
    • Qian, B.Z.1    Pollard, J.W.2
  • 122
    • 84864526455 scopus 로고    scopus 로고
    • Barrett's to oesophageal cancer sequence: A model of inflammatory-driven upper gastrointestinal cancer
    • Picardo SL, Maher SG, O'Sullivan JN, &, Reynolds JV, (2012) Barrett's to oesophageal cancer sequence: a model of inflammatory-driven upper gastrointestinal cancer. Dig Surg 29, 251-260.
    • (2012) Dig Surg , vol.29 , pp. 251-260
    • Picardo, S.L.1    Maher, S.G.2    O'Sullivan, J.N.3    Reynolds, J.V.4
  • 123
    • 84865510127 scopus 로고    scopus 로고
    • Inflammation-associated cancer development in digestive organs: Mechanisms and roles for genetic and epigenetic modulation
    • Chiba T, Marusawa H, &, Ushijima T, (2012) Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation. Gastroenterology 143, 550-563.
    • (2012) Gastroenterology , vol.143 , pp. 550-563
    • Chiba, T.1    Marusawa, H.2    Ushijima, T.3
  • 125
    • 0034906312 scopus 로고    scopus 로고
    • The clinicopathological significance of heparanase and basic fibroblast growth factor expressions in hepatocellular carcinoma
    • El-Assal ON, Yamanoi A, Ono T, Kohno H, &, Nagasue N, (2001) The clinicopathological significance of heparanase and basic fibroblast growth factor expressions in hepatocellular carcinoma. Clin Cancer Res 7, 1299-1305. (Pubitemid 32708684)
    • (2001) Clinical Cancer Research , vol.7 , Issue.5 , pp. 1299-1305
    • El-Assal, O.N.1    Yamanoi, A.2    Ono, T.3    Kohno, H.4    Nagasue, N.5
  • 126
    • 34248187724 scopus 로고    scopus 로고
    • Downregulating the expression of heparanase inhibits the invasion, angiogenesis and metastasis of human hepatocellular carcinoma
    • DOI 10.1016/j.bbrc.2007.04.068, PII S0006291X07008017
    • Zhang Y, Li L, Wang Y, Zhang J, Wei G, Sun Y, &, Shen F, (2007) Downregulating the expression of heparanase inhibits the invasion, angiogenesis and metastasis of human hepatocellular carcinoma. Biochem Biophys Res Commun 358, 124-129. (Pubitemid 46719090)
    • (2007) Biochemical and Biophysical Research Communications , vol.358 , Issue.1 , pp. 124-129
    • Zhang, Y.1    Li, L.2    Wang, Y.3    Zhang, J.4    Wei, G.5    Sun, Y.6    Shen, F.7
  • 127
    • 52549127242 scopus 로고    scopus 로고
    • High expression of heparanase is significantly associated with dedifferentiation and lymph node metastasis in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA and via HIF1a to HB-EGF and bFGF
    • discussion 1681-2.
    • Hoffmann AC, Mori R, Vallbohmer D, Brabender J, Drebber U, Baldus SE, Klein E, Azuma M, Metzger R, Hoffmann C, et al,. (2008) High expression of heparanase is significantly associated with dedifferentiation and lymph node metastasis in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA and via HIF1a to HB-EGF and bFGF. J Gastrointest Surg 12, 1674-1681; discussion 1681-2.
    • (2008) J Gastrointest Surg , vol.12 , pp. 1674-1681
    • Hoffmann, A.C.1    Mori, R.2    Vallbohmer, D.3    Brabender, J.4    Drebber, U.5    Baldus, S.E.6    Klein, E.7    Azuma, M.8    Metzger, R.9    Hoffmann, C.10
  • 128
    • 0032879625 scopus 로고    scopus 로고
    • Inhibition of heparanase activity and tumor metastasis by laminarin sulfate and synthetic phosphorothioate oligodeoxynucleotides
    • DOI 10.1002/(SICI)1097-0215(19991029)83:3<424::AID-IJC20>3.0.CO;2-L
    • Miao HQ, Elkin M, Aingorn E, Ishai-Michaeli R, Stein CA, &, Vlodavsky I, (1999) Inhibition of heparanase activity and tumor metastasis by laminarin sulfate and synthetic phosphorothioate oligodeoxynucleotides. Int J Cancer 83, 424-431. (Pubitemid 29455768)
    • (1999) International Journal of Cancer , vol.83 , Issue.3 , pp. 424-431
    • Miao, H.-Q.1    Elkin, M.2    Aingorn, E.3    Ishai-Michaeli, R.4    Stein, C.A.5    Vlodavsky, I.6
  • 129
    • 3242712146 scopus 로고    scopus 로고
    • The development of inhibitors of heparanase, a key enzyme involved in tumour metastasis, angiogenesis and inflammation
    • Ferro V, Hammond E, &, Fairweather JK, (2004) The development of inhibitors of heparanase, a key enzyme involved in tumour metastasis, angiogenesis and inflammation. Mini Rev Med Chem 4, 693-702. (Pubitemid 38961234)
    • (2004) Mini-Reviews in Medicinal Chemistry , vol.4 , Issue.6 , pp. 693-702
    • Ferro, V.1    Hammond, E.2    Fairweather, J.K.3
  • 131
    • 4143083982 scopus 로고    scopus 로고
    • Heparanase as a molecular target of cancer chemotherapy
    • DOI 10.1111/j.1349-7006.2004.tb02485.x
    • Simizu S, Ishida K, &, Osada H, (2004) Heparanase as a molecular target of cancer chemotherapy. Cancer Sci 95, 553-558. (Pubitemid 39089634)
    • (2004) Cancer Science , vol.95 , Issue.7 , pp. 553-558
    • Simizu, S.1    Ishida, K.2    Osada, H.3
  • 133
    • 34247637147 scopus 로고    scopus 로고
    • Heparanase: A target for drug discovery in cancer and inflammation
    • DOI 10.1038/sj.bjp.0707182, PII 0707182
    • McKenzie EA, (2007) Heparanase: a target for drug discovery in cancer and inflammation. Br J Pharmacol 151, 1-14. (Pubitemid 46675998)
    • (2007) British Journal of Pharmacology , vol.151 , Issue.1 , pp. 1-14
    • McKenzie, E.A.1
  • 135
    • 79951676056 scopus 로고    scopus 로고
    • PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models
    • Dredge K, Hammond E, Handley P, Gonda TJ, Smith MT, Vincent C, Brandt R, Ferro V, &, Bytheway I, (2011) PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models. Br J Cancer 104, 635-642.
    • (2011) Br J Cancer , vol.104 , pp. 635-642
    • Dredge, K.1    Hammond, E.2    Handley, P.3    Gonda, T.J.4    Smith, M.T.5    Vincent, C.6    Brandt, R.7    Ferro, V.8    Bytheway, I.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.