Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-β in murine brain

Acta Neuropathologica

Volumn 124, Issue 4, 2012, Pages 465-478

  Zhang, Xiao ^a   Wang, Bo ^b,c   O'Callaghan, Paul ^a   Hjertström, Elina ^b   Jia, Juan ^b   Gong, Feng ^b,d   Zcharia, Eyal ^e   Nilsson, Lars N G ^a,f   Lannfelt, Lars ^a   Vlodavsky, Israel ^e   Lindahl, Ulf ^b   Li, Jin Ping ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^d BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^e TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^f UNIVERSITY OF OSLO   (Norway)

Author keywords

Alzheimer's disease; Amyloid ; Clearance; Heparan sulfate; Heparanase; Neuroinflammation

Indexed keywords

AMYLOID BETA PROTEIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; HEPARANASE; PROTEOHEPARAN SULFATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELL MIGRATION; CONTROLLED STUDY; ENCEPHALITIS; IMMUNOCOMPETENT CELL; IN VITRO STUDY; MACROPHAGE; MICROGLIA; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BLOTTING, WESTERN; BRAIN; CELL MOVEMENT; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLUCURONIDASE; HEPARAN SULFATE PROTEOGLYCANS; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL;

EID: 84866544077     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-012-0997-1     Document Type: Article

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