Modulation of the heparanase-inhibiting activity of heparin through selective desulfation, graded N-acetylation, and glycol splitting

Journal of Biological Chemistry

Volumn 280, Issue 13, 2005, Pages 12103-12113

  Naggi, Annamaria ^a   Casu, Benito ^a   Perez, Marta ^a   Torri, Giangiacomo ^a   Cassinelli, Giuseppe ^a   Penco, Sergio ^b   Pisano, Claudio ^b   Giannini, Giuseppe ^b   Ishai Michaeli, Rivka ^c   Vlodavsky, Israel ^d  

^a Istituto di Ricerche Chimiche e Biochimiche G Ronzoni   (Italy)

^b Sigma Tau SpA   (Italy)

^c HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^d TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLATION; BLOOD; CELLS; ENZYME KINETICS; GROWTH KINETICS; SULFUR COMPOUNDS; TUMORS;

BLOOD-BORNE TUMOR CELLS; EXTRACELLULAR MATRIX (ECM); HEPARAN SULFATE (HS); HEPARANASE-INHIBITING ACTIVITY;

ENZYME INHIBITION;

DISACCHARIDE; FIBROBLAST GROWTH FACTOR; GLUCURONIC ACID; GLYCOL; HEPARANASE; HEPARIN; HEPARIN DERIVATIVE; RECOMBINANT ENZYME; SULFATE; URONIC ACID;

ACETYLATION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME INHIBITION; EXTRACELLULAR MATRIX; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SULFATION;

ACETYLATION; ANIMALS; CARBOHYDRATE SEQUENCE; CATTLE; CELLS, CULTURED; CHO CELLS; CORNEA; CRICETINAE; DISACCHARIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; FIBROBLAST GROWTH FACTOR 2; GLUCURONIC ACID; GLUCURONIDASE; GLYCOLS; HEPARIN; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; URONIC ACIDS;

EID: 20144388264     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M414217200     Document Type: Article

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