The endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymes

Transcription

Volumn 3, Issue 3, 2012, Pages 130-145

  He, Yi Qing ^a,g   Sutcliffe, Elissa L ^c   Bunting, Karen L ^c   Li, Jasmine ^a   Goodall, Katharine J ^f   Poon, Ivan K A ^f   Hulett, Mark D ^f   Freeman, Craig ^a   Zafar, Anjum ^b   Mcinnes, Russell L ^d   Taya, Toshiki ^e   Parish, Christopher R ^a   Rao, Sudha ^b  

^a Biology and Environment   (Australia)

^b UNIVERSITY OF CANBERRA   (Australia)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d AGILENT TECHNOLOGIES   (Australia)

^e YOKOGAWA ANALYTICAL SYSTEMS INC   (Japan)

^f LA TROBE UNIVERSITY   (Australia)

^g SUN YAT SEN UNIVERSITY   (China)

Author keywords

Chromatin; Heparanase; Histone methylation; Immune response genes; Inducible genes; T lymphocytes; Transcription

Indexed keywords

CD69 ANTIGEN; GAMMA INTERFERON; GELATINASE A; HEPARANASE; HISTONE H3; INTERLEUKIN 2; MESSENGER RNA; METHYLTRANSFERASE; PROTEIN LSD1; RNA POLYMERASE II; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; BETA GLUCURONIDASE; HISTONE; HISTONE DEMETHYLASE; SMALL INTERFERING RNA;

ARTICLE; CD69 GENE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME LOCALIZATION; EUCHROMATIN; GENE; GENE CONTROL; GENE OVEREXPRESSION; GENE SILENCING; GENETIC ASSOCIATION; HEPARANASE GENE; HISTONE METHYLATION; HISTONE MODIFICATION; HUMAN; HUMAN CELL; IFN GAMMA GENE; IMMUNOMODULATION; INTERLEUKIN 2 GENE; LEUKEMIA CELL LINE; MICROCHIP ANALYSIS; MMP 2 GENE; MMP 4 GENE; PROTEIN BINDING; T LYMPHOCYTE ACTIVATION; TNF ALPHA GENE; TRANSCRIPTION REGULATION; ANIMAL; C57BL MOUSE; CELL NUCLEUS; CHROMATIN; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC EPIGENESIS; GENETICS; METABOLISM; METHYLATION; MOUSE; REAL TIME POLYMERASE CHAIN REACTION; T LYMPHOCYTE; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CELL NUCLEUS; CHROMATIN; EPIGENESIS, GENETIC; FLUORESCENT ANTIBODY TECHNIQUE; GLUCURONIDASE; HISTONE DEMETHYLASES; HISTONES; HUMANS; METHYLATION; MICE; MICE, INBRED C57BL; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; T-LYMPHOCYTES; TRANSCRIPTIONAL ACTIVATION;

EID: 84862698522     PISSN: 21541264     EISSN: 21541272     Source Type: Journal    
DOI: 10.4161/trns.19998     Document Type: Article

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