The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis

Nature Medicine

Volumn 18, Issue 8, 2012, Pages 1217-1223

  Schmidt, Eric P ^a,b   Yang, Yimu ^a   Janssen, William J ^c   Gandjeva, Aneta ^a   Perez, Mario J ^a   Barthel, Lea ^c   Zemans, Rachel L ^c   Bowman, Joel C ^a   Koyanagi, Dan E ^a   Yunt, Zulma X ^c   Smith, Lynelle P ^a   Cheng, Sara S ^a   Overdier, Katherine H ^b   Thompson, Kathy R ^b   Geraci, Mark W ^a   Douglas, Ivor S ^a,b   Pearse, David B ^d   Tuder, Rubin M ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b DENVER HEALTH MEDICAL CENTER   (United States)

^c DEPARTMENT OF MEDICINE   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPARAN SULFATE; HEPARANASE; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEGRADATION; ENDOTOXEMIA; ENZYME ACTIVATION; ENZYME INHIBITION; GLYCOCALYX; LUNG ENDOTHELIUM; MALE; MICROSCOPY; MORTALITY; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SEPSIS;

ACUTE LUNG INJURY; ADOPTIVE TRANSFER; ANIMALS; CELL ADHESION; DISEASE MODELS, ANIMAL; ENDOTHELIUM; ENDOTOXEMIA; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GLUCURONIDASE; GLYCOCALYX; HEPARITIN SULFATE; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTESTINAL PERFORATION; LIPOPOLYSACCHARIDES; LUNG; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHILS; PULMONARY ALVEOLI; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RESPIRATORY INSUFFICIENCY; TUMOR NECROSIS FACTOR-ALPHA; VENTILATOR-INDUCED LUNG INJURY;

MUS;

EID: 84864702347     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2843     Document Type: Article

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