Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity

Journal of Biological Chemistry

Volumn 285, Issue 36, 2010, Pages 28010-28019

  Levy Adam, Flonia ^a   Feld, Sari ^a   Cohen Kaplan, Victoria ^a   Shteingauz, Anna ^a   Gross, Miriam ^a   Arvatz, Gil ^a   Naroditsky, Inna ^b   Ilan, Neta ^a   Doweck, Ilana ^c   Vlodavsky, Israel ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b Department of Pathology Rambam Health Care Campus ^*  (Israel)

^c CARMEL MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

PATHOLOGY;

ANGIOGENESIS; CARCINOMA PATIENTS; ENZYMATIC ACTIVITIES; HEAD AND NECK; HEAD-AND-NECK CANCER; HEPARAN SULFATES; HEPARANASE; HIGH AFFINITY; IN-CELL; LYMPH NODE; PATHOLOGICAL DISORDERS; PROTEOLYTIC PROCESSING; SEQUENCE HOMOLOGY; SOLID TUMORS; TUMOR CELLS; TUMOR METASTASIS;

TUMORS;

HEPARAN SULFATE; HEPARANASE; HEPARANASE 2; MYC PROTEIN; UNCLASSIFIED DRUG; BETA GLUCURONIDASE; PROTEIN BINDING;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; METASTASIS; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; TUMOR RECURRENCE; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; HEAD AND NECK TUMOR; METABOLISM; MOLECULAR GENETICS; PATHOLOGY; PROTEIN TRANSPORT; TUMOR CELL LINE;

AMINO ACID SEQUENCE; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCURONIDASE; HEAD AND NECK NEOPLASMS; HEPARITIN SULFATE; HUMANS; MOLECULAR SEQUENCE DATA; NEOPLASM METASTASIS; PROTEIN BINDING; PROTEIN TRANSPORT;

EID: 77956253916     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.116384     Document Type: Article

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