메뉴 건너뛰기




Volumn 57, Issue 1, 2010, Pages 90-100

Preferential up-regulation of heparanase and cyclooxygenase-2 in carcinogenesis of Barrett's oesophagus and intestinal-type gastric carcinoma

Author keywords

Barrett's oesophagus; cyclooxygenase 2; heparanase; intestinal type gastric carcinoma

Indexed keywords

CYCLOOXYGENASE 2; HEPARANASE; MESSENGER RNA; BETA GLUCURONIDASE; PRIMER DNA; RNA;

EID: 77954562497     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2010.03594.x     Document Type: Article
Times cited : (20)

References (52)
  • 1
    • 0033580405 scopus 로고    scopus 로고
    • Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma
    • Lagergren J, Bergström R, Lindgren A, Nyrén O. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N. Engl. J. Med. 1999 340 825 831.
    • (1999) N. Engl. J. Med. , vol.340 , pp. 825-831
    • Lagergren, J.1    Bergström, R.2    Lindgren, A.3    Nyrén, O.4
  • 2
    • 0027249544 scopus 로고
    • Barrett's esophagus: Pathogenesis, epidemiology, functional abnormalities, malignant degeneration, and surgical management
    • Stein HJ, Siewert JR. Barrett's esophagus: pathogenesis, epidemiology, functional abnormalities, malignant degeneration, and surgical management. Dysphagia 1993 8 276 288.
    • (1993) Dysphagia , vol.8 , pp. 276-288
    • Stein, H.J.1    Siewert, J.R.2
  • 4
    • 0027065034 scopus 로고
    • Human gastric carcinogenesis: A multistep and multifactorial process - First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention
    • Correa P. Human gastric carcinogenesis: a multistep and multifactorial process - First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res. 1992 52 6735 6740.
    • (1992) Cancer Res. , vol.52 , pp. 6735-6740
    • Correa, P.1
  • 5
    • 12644292106 scopus 로고
    • The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma
    • Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. Acta Pathol. Microbiol. Scand. 1965 64 31 49.
    • (1965) Acta Pathol. Microbiol. Scand. , vol.64 , pp. 31-49
    • Lauren, P.1
  • 6
    • 34250703132 scopus 로고    scopus 로고
    • Helicobacter pylori infection and related gastrointestinal diseases
    • Makola D, Peura DA, Crowe SE. Helicobacter pylori infection and related gastrointestinal diseases. J. Clin. Gastroenterol. 2007 41 548 558.
    • (2007) J. Clin. Gastroenterol. , vol.41 , pp. 548-558
    • Makola, D.1    Peura, D.A.2    Crowe, S.E.3
  • 7
    • 0035999158 scopus 로고    scopus 로고
    • Mammalian heparanase: Involvement in cancer metastasis, angiogenesis and normal development
    • Vlodavsky I, Goldshmidt O, Zcharia E et al. Mammalian heparanase: involvement in cancer metastasis, angiogenesis and normal development. Semin. Cancer Biol. 2002 12 121 129.
    • (2002) Semin. Cancer Biol. , vol.12 , pp. 121-129
    • Vlodavsky, I.1    Goldshmidt, O.2    Zcharia, E.3
  • 8
    • 0034904048 scopus 로고    scopus 로고
    • Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis
    • DOI 10.1172/JCI200113662
    • Vlodavsky I, Friedmann Y. Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis. J. Clin. Invest. 2001 108 341 347. (Pubitemid 32730777)
    • (2001) Journal of Clinical Investigation , vol.108 , Issue.3 , pp. 341-347
    • Vlodavsky, I.1    Friedmann, Y.2
  • 9
    • 19944433489 scopus 로고    scopus 로고
    • Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models
    • Zcharia E, Zilka R, Yaar A et al. Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models. FASEB J. 2005 19 211 221.
    • (2005) FASEB J. , vol.19 , pp. 211-221
    • Zcharia, E.1    Zilka, R.2    Yaar, A.3
  • 10
    • 0034827642 scopus 로고    scopus 로고
    • Heparanase protein and gene expression in bladder cancer
    • Gohji K, Okamoto M, Kitazawa S et al. Heparanase protein and gene expression in bladder cancer. J. Urol. 2001 166 1286 1290.
    • (2001) J. Urol. , vol.166 , pp. 1286-1290
    • Gohji, K.1    Okamoto, M.2    Kitazawa, S.3
  • 11
    • 0033810052 scopus 로고    scopus 로고
    • Expression of heparanase in normal, dysplastic, and neoplastic human colonic mucosa and stroma. Evidence for its role in colonic tumorigenesis
    • Friedmann Y, Vlodavsky I, Aingorn H et al. Expression of heparanase in normal, dysplastic, and neoplastic human colonic mucosa and stroma. Evidence for its role in colonic tumorigenesis. Am. J. Pathol. 2000 157 1167 1175.
    • (2000) Am. J. Pathol. , vol.157 , pp. 1167-1175
    • Friedmann, Y.1    Vlodavsky, I.2    Aingorn, H.3
  • 12
    • 18444385059 scopus 로고    scopus 로고
    • Heparanase: A key enzyme in invasion and metastasis of gastric carcinoma
    • Tang W, Nakamura Y, Tsujimoto M et al. Heparanase: a key enzyme in invasion and metastasis of gastric carcinoma. Mod. Pathol. 2002 15 593 598.
    • (2002) Mod. Pathol. , vol.15 , pp. 593-598
    • Tang, W.1    Nakamura, Y.2    Tsujimoto, M.3
  • 13
    • 0036672885 scopus 로고    scopus 로고
    • Heparanase-1 expression is associated with the metastatic potential of breast cancer
    • Maxhimer JB, Quiros RM, Stewart R et al. Heparanase-1 expression is associated with the metastatic potential of breast cancer. Surgery 2002 132 326 333.
    • (2002) Surgery , vol.132 , pp. 326-333
    • Maxhimer, J.B.1    Quiros, R.M.2    Stewart, R.3
  • 14
    • 0034764665 scopus 로고    scopus 로고
    • Loss of syndecan-1 and increased expression of heparanase in invasive esophageal carcinomas
    • Mikami S, Ohashi K, Usui Y et al. Loss of syndecan-1 and increased expression of heparanase in invasive esophageal carcinomas. Jpn. J. Cancer Res. 2001 92 1062 1073.
    • (2001) Jpn. J. Cancer Res. , vol.92 , pp. 1062-1073
    • Mikami, S.1    Ohashi, K.2    Usui, Y.3
  • 16
    • 28144446990 scopus 로고    scopus 로고
    • Heparanase is involved in angiogenesis in esophageal cancer through induction of cyclooxygenase-2
    • Okawa T, Naomoto Y, Nobuhisa T et al. Heparanase is involved in angiogenesis in esophageal cancer through induction of cyclooxygenase-2. Clin. Cancer Res. 2005 11 7995 8005.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 7995-8005
    • Okawa, T.1    Naomoto, Y.2    Nobuhisa, T.3
  • 17
    • 33644854118 scopus 로고    scopus 로고
    • COX-2 induction by heparanase in the progression of breast cancer
    • Imada T, Matsuoka J, Nobuhisa T et al. COX-2 induction by heparanase in the progression of breast cancer. Int. J. Mol. Med. 2006 17 221 228.
    • (2006) Int. J. Mol. Med. , vol.17 , pp. 221-228
    • Imada, T.1    Matsuoka, J.2    Nobuhisa, T.3
  • 18
    • 33747819586 scopus 로고    scopus 로고
    • The close relationship between heparanase and cyclooxygenase-2 expressions in signet-ring cell carcinoma of the stomach
    • Ohtawa Y, Naomoto Y, Shirakawa Y et al. The close relationship between heparanase and cyclooxygenase-2 expressions in signet-ring cell carcinoma of the stomach. Hum. Pathol. 2006 37 1145 1152.
    • (2006) Hum. Pathol. , vol.37 , pp. 1145-1152
    • Ohtawa, Y.1    Naomoto, Y.2    Shirakawa, Y.3
  • 19
    • 0033590207 scopus 로고    scopus 로고
    • The role of cyclooxygenases in inflammation, cancer, and development
    • Williams CS, Mann M, DuBois RN. The role of cyclooxygenases in inflammation, cancer, and development. Oncogene 1999 18 7908 7916.
    • (1999) Oncogene , vol.18 , pp. 7908-7916
    • Williams, C.S.1    Mann, M.2    Dubois, R.N.3
  • 20
    • 0028803728 scopus 로고
    • Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
    • Tsujii M, DuBois RN. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell 1995 83 493 501.
    • (1995) Cell , vol.83 , pp. 493-501
    • Tsujii, M.1    Dubois, R.N.2
  • 21
    • 0030952695 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential
    • Tsujii M, Kawano S, DuBois RN. Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. Proc. Natl. Acad. Sci. USA 1997 94 3336 3340.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 3336-3340
    • Tsujii, M.1    Kawano, S.2    Dubois, R.N.3
  • 22
    • 0030606276 scopus 로고    scopus 로고
    • Self-promotion? Intimate connections between APC and prostaglandin H synthase-2
    • Prescott SM, White RL. Self-promotion? Intimate connections between APC and prostaglandin H synthase-2. Cell 1996 87 783 786.
    • (1996) Cell , vol.87 , pp. 783-786
    • Prescott, S.M.1    White, R.L.2
  • 23
    • 0035045145 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression in the Barrett's metaplasia-dysplasia- adenocarcinoma sequence
    • Morris CD, Armstrong GR, Bigley G, Green H, Attwood SE. Cyclooxygenase-2 expression in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence. Am. J. Gastroenterol. 2001 96 990 996.
    • (2001) Am. J. Gastroenterol. , vol.96 , pp. 990-996
    • Morris, C.D.1    Armstrong, G.R.2    Bigley, G.3    Green, H.4    Attwood, S.E.5
  • 24
    • 0038192391 scopus 로고    scopus 로고
    • Cyclooxygenase-2 is expressed frequently and early in Barrett's oesophagus and associated adenocarcinoma
    • Lagorce C, Paraf F, Vidaud D et al. Cyclooxygenase-2 is expressed frequently and early in Barrett's oesophagus and associated adenocarcinoma. Histopathology 2003 42 457 465.
    • (2003) Histopathology , vol.42 , pp. 457-465
    • Lagorce, C.1    Paraf, F.2    Vidaud, D.3
  • 26
    • 33845660390 scopus 로고    scopus 로고
    • Barrett's oesophagus - A pathologist's view
    • Flejou JF, Svrcek M. Barrett's oesophagus - a pathologist's view. Histopathology 2007 50 3 14.
    • (2007) Histopathology , vol.50 , pp. 3-14
    • Flejou, J.F.1    Svrcek, M.2
  • 27
    • 56249096859 scopus 로고    scopus 로고
    • Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinoma
    • Takubo K, Aida J, Naomoto Y et al. Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinoma. Hum. Pathol. 2009 40 65 74.
    • (2009) Hum. Pathol. , vol.40 , pp. 65-74
    • Takubo, K.1    Aida, J.2    Naomoto, Y.3
  • 28
    • 0033588093 scopus 로고    scopus 로고
    • Human heparanase. Purification, characterization, cloning, and expression
    • Toyoshima M, Nakajima M. Human heparanase. Purification, characterization, cloning, and expression. J. Biol. Chem. 1999 274 24153 24160.
    • (1999) J. Biol. Chem. , vol.274 , pp. 24153-24160
    • Toyoshima, M.1    Nakajima, M.2
  • 29
    • 0037799669 scopus 로고    scopus 로고
    • Heparanase expression correlates with invasion and poor prognosis in gastric cancers
    • Takaoka M, Naomoto Y, Ohkawa T et al. Heparanase expression correlates with invasion and poor prognosis in gastric cancers. Lab. Invest. 2003 83 613 622.
    • (2003) Lab. Invest. , vol.83 , pp. 613-622
    • Takaoka, M.1    Naomoto, Y.2    Ohkawa, T.3
  • 30
    • 14344264011 scopus 로고    scopus 로고
    • Barrett's oesophagus: From metaplasia to dysplasia and cancer
    • Flejou JF. Barrett's oesophagus: from metaplasia to dysplasia and cancer. Gut 2005 54 6 12.
    • (2005) Gut , vol.54 , pp. 6-12
    • Flejou, J.F.1
  • 31
    • 33747111083 scopus 로고    scopus 로고
    • Barrett's esophagus and its progression to adenocarcinoma
    • Maley CC, Rustgi AK. Barrett's esophagus and its progression to adenocarcinoma. J. Natl. Compr. Canc. Netw. 2006 4 367 374.
    • (2006) J. Natl. Compr. Canc. Netw. , vol.4 , pp. 367-374
    • Maley, C.C.1    Rustgi, A.K.2
  • 32
    • 0032528178 scopus 로고    scopus 로고
    • Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas
    • Wilson KT, Fu S, Ramanujam KS, Meltzer SJ. Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas. Cancer Res. 1998 58 2929 2934.
    • (1998) Cancer Res. , vol.58 , pp. 2929-2934
    • Wilson, K.T.1    Fu, S.2    Ramanujam, K.S.3    Meltzer, S.J.4
  • 35
    • 0026722647 scopus 로고
    • Expression of heparanase by platelets and circulating cells of the immune system: Possible involvement in diapedesis and extravasation
    • Vlodavsky I, Eldor A, Haimovitz-Friedman A et al. Expression of heparanase by platelets and circulating cells of the immune system: possible involvement in diapedesis and extravasation. Invasion Metastasis 1992 12 112 127.
    • (1992) Invasion Metastasis , vol.12 , pp. 112-127
    • Vlodavsky, I.1    Eldor, A.2    Haimovitz-Friedman, A.3
  • 36
    • 0031689543 scopus 로고    scopus 로고
    • Cyclooxygenase in biology and disease
    • Dubois RN, Abramson SB, Crofford L et al. Cyclooxygenase in biology and disease. FASEB J. 1998 12 1063 1073.
    • (1998) FASEB J. , vol.12 , pp. 1063-1073
    • Dubois, R.N.1    Abramson, S.B.2    Crofford, L.3
  • 37
    • 0037088587 scopus 로고    scopus 로고
    • Cloning and characterization of the human heparanase-1 (HPR1) gene promoter: Role of GA-binding protein and Sp1 in regulating HPR1 basal promoter activity
    • Jiang P, Kumar A, Parrillo JE et al. Cloning and characterization of the human heparanase-1 (HPR1) gene promoter: role of GA-binding protein and Sp1 in regulating HPR1 basal promoter activity. J. Biol. Chem. 2002 277 8989 8998.
    • (2002) J. Biol. Chem. , vol.277 , pp. 8989-8998
    • Jiang, P.1    Kumar, A.2    Parrillo, J.E.3
  • 38
    • 0037434721 scopus 로고    scopus 로고
    • Trans-activation of heparanase promoter by ETS transcription factors
    • Lu WC, Liu YN, Kang BB, Chen JH. Trans-activation of heparanase promoter by ETS transcription factors. Oncogene 2003 22 919 923.
    • (2003) Oncogene , vol.22 , pp. 919-923
    • Lu, W.C.1    Liu, Y.N.2    Kang, B.B.3    Chen, J.H.4
  • 39
    • 21344458126 scopus 로고    scopus 로고
    • Heparanase-1 gene expression and regulation by high glucose in renal epithelial cells: A potential role in the pathogenesis of proteinuria in diabetic patients
    • Maxhimer JB, Somenek M, Rao G et al. Heparanase-1 gene expression and regulation by high glucose in renal epithelial cells: a potential role in the pathogenesis of proteinuria in diabetic patients. Diabetes 2005 54 2172 2178.
    • (2005) Diabetes , vol.54 , pp. 2172-2178
    • Maxhimer, J.B.1    Somenek, M.2    Rao, G.3
  • 41
    • 19944432186 scopus 로고    scopus 로고
    • Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer
    • Ogishima T, Shiina H, Breault JE et al. Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer. Clin. Cancer Res. 2005 11 1028 1036.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 1028-1036
    • Ogishima, T.1    Shiina, H.2    Breault, J.E.3
  • 42
    • 27144527031 scopus 로고    scopus 로고
    • Promoter CpG hypomethylation and transcription factor EGR1 hyperactivate heparanase expression in bladder cancer
    • Ogishima T, Shiina H, Breault JE et al. Promoter CpG hypomethylation and transcription factor EGR1 hyperactivate heparanase expression in bladder cancer. Oncogene 2005 24 6765 6772.
    • (2005) Oncogene , vol.24 , pp. 6765-6772
    • Ogishima, T.1    Shiina, H.2    Breault, J.E.3
  • 43
    • 33745606964 scopus 로고    scopus 로고
    • Tumor suppressor p53 regulates heparanase gene expression
    • Baraz L, Haupt Y, Elkin M, Peretz T, Vlodavsky I. Tumor suppressor p53 regulates heparanase gene expression. Oncogene 2006 25 3939 3947.
    • (2006) Oncogene , vol.25 , pp. 3939-3947
    • Baraz, L.1    Haupt, Y.2    Elkin, M.3    Peretz, T.4    Vlodavsky, I.5
  • 44
    • 0037809358 scopus 로고    scopus 로고
    • Early p53 mutations in nondysplastic Barrett's tissue detected by the restriction site mutation (RSM) methodology
    • Jenkins GJ, Doak SH, Griffiths AP et al. Early p53 mutations in nondysplastic Barrett's tissue detected by the restriction site mutation (RSM) methodology. Br. J. Cancer 2003 88 1271 1276.
    • (2003) Br. J. Cancer , vol.88 , pp. 1271-1276
    • Jenkins, G.J.1    Doak, S.H.2    Griffiths, A.P.3
  • 45
    • 17844393849 scopus 로고    scopus 로고
    • Detection of peritoneal micrometastasis by reverse transcriptase- polymerase chain reaction for heparanase mRNA and cytology in peritoneal wash samples
    • Wang Z, Zhang X, Xu H, Zhou X, Jiang Z, Lu C. Detection of peritoneal micrometastasis by reverse transcriptase-polymerase chain reaction for heparanase mRNA and cytology in peritoneal wash samples. J. Surg. Oncol. 2005 90 59 65.
    • (2005) J. Surg. Oncol. , vol.90 , pp. 59-65
    • Wang, Z.1    Zhang, X.2    Xu, H.3    Zhou, X.4    Jiang, Z.5    Lu, C.6
  • 46
    • 13244274950 scopus 로고    scopus 로고
    • Positive association of heparanase expression with tumor invasion and lymphatic metastasis in gastric carcinoma
    • DOI 10.1038/modpathol.3800282
    • Wang Z, Xu H, Jiang L, Zhou X, Lu C, Zhang X. Positive association of heparanase expression with tumor invasion and lymphatic metastasis in gastric carcinoma. Mod. Pathol. 2005 18 205 211. (Pubitemid 40188627)
    • (2005) Modern Pathology , vol.18 , Issue.2 , pp. 205-211
    • Wang, Z.1    Xu, H.2    Jiang, L.3    Zhou, X.4    Lu, C.5    Zhang, X.6
  • 47
    • 0035569918 scopus 로고    scopus 로고
    • Heparanase gene expression and metastatic potential in human gastric cancer
    • Endo K, Maejara U, Baba H et al. Heparanase gene expression and metastatic potential in human gastric cancer. Anticancer Res. 2001 21 3365 3369.
    • (2001) Anticancer Res. , vol.21 , pp. 3365-3369
    • Endo, K.1    Maejara, U.2    Baba, H.3
  • 48
    • 0042763083 scopus 로고    scopus 로고
    • Diffuse and intestinal type gastric carcinomas differ in their expression of apoptosis related proteins
    • Woude CJ, Kleibeuker JH, Tiebosch AT et al. Diffuse and intestinal type gastric carcinomas differ in their expression of apoptosis related proteins. J. Clin. Pathol. 2003 56 699 702.
    • (2003) J. Clin. Pathol. , vol.56 , pp. 699-702
    • Woude, C.J.1    Kleibeuker, J.H.2    Tiebosch, A.T.3
  • 49
    • 0034772266 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-2 in dysplasia of the stomach and in intestinal-type gastric adenocarcinoma
    • Saukkonen K, Nieminen O, van Rees B et al. Expression of cyclooxygenase-2 in dysplasia of the stomach and in intestinal-type gastric adenocarcinoma. Clin. Cancer Res. 2001 7 1923 1931.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 1923-1931
    • Saukkonen, K.1    Nieminen, O.2    Van Rees, B.3
  • 50
    • 0037910076 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression is associated with well-differentiated and intestinal-type pathways in gastric carcinogenesis
    • Joo YE, Oh WT, Rew JS, Park CS, Choi SK, Kim SJ. Cyclooxygenase-2 expression is associated with well-differentiated and intestinal-type pathways in gastric carcinogenesis. Digestion 2002 66 222 229.
    • (2002) Digestion , vol.66 , pp. 222-229
    • Joo, Y.E.1    Oh, W.T.2    Rew, J.S.3    Park, C.S.4    Choi, S.K.5    Kim, S.J.6
  • 51
    • 0036229792 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression is increased in early intestinal-type gastric cancer and gastric mucosa with intestinal metaplasia
    • Yamagata R, Shimoyama T, Fukuda S, Yoshimura T, Tanaka M, Munakata A. Cyclooxygenase-2 expression is increased in early intestinal-type gastric cancer and gastric mucosa with intestinal metaplasia. Eur. J. Gastroenterol. Hepatol. 2002 14 347 349.
    • (2002) Eur. J. Gastroenterol. Hepatol. , vol.14 , pp. 347-349
    • Yamagata, R.1    Shimoyama, T.2    Fukuda, S.3    Yoshimura, T.4    Tanaka, M.5    Munakata, A.6
  • 52
    • 3242680815 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression in human gastric tubular adenomas and carcinomas; Correlation with intratumoral microvessel density and apoptotic index
    • Honjo S, Kase S, Osaki M, Ardyanto TD, Kaibara N, Ito H. Cyclooxygenase-2 expression in human gastric tubular adenomas and carcinomas; correlation with intratumoral microvessel density and apoptotic index. Anticancer Res. 2004 24 1439 1444.
    • (2004) Anticancer Res. , vol.24 , pp. 1439-1444
    • Honjo, S.1    Kase, S.2    Osaki, M.3    Ardyanto, T.D.4    Kaibara, N.5    Ito, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.