The development of inhibitors of heparanase, a key enzyme involved in tumour metastasis, angiogenesis and inflammation

Mini-Reviews in Medicinal Chemistry

Volumn 4, Issue 6, 2004, Pages 693-702

  Ferro, Vito ^a   Hammond, Edward ^a   Fairweather, Jon K ^a  

^a Progen Pharmaceuticals Limited   (Australia)

Author keywords

Angiogenesis; Endo glucuronidase; Heparan sulfate; Heparanase; Inflammation; Inhibitors; Metastasis

Indexed keywords

(4 HYDROXYPHENOXY)ACETIC ACID; 1 DEOXYNOJIRIMYCIN; 1,2 DIHYDROCATECHOL; ANGIOGENESIS INHIBITOR; ANTICOAGULANT AGENT; ANTINEOPLASTIC AGENT; BETA GLUCURONIDASE; CARRAGEENAN; CRM 646 A; CRM 646 B; CYCLODEXTRIN DERIVATIVE; DEXTRAN SULFATE; ENZYME INHIBITOR; FUCOIDIN; GLYCOSAMINOGLYCAN; GM 1474; HEPARAN SULFATE; HEPARANASE; HEPARIN; HEPARIN DERIVATIVE; LAMINARAN; MALTOHEPTAOSIDE DERIVATIVE; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; OLIGOSACCHARIDE; PENTOSAN POLYSULFATE; PI 88; POLYSACCHARIDE SULFATE; RG 13577; SIALIDASE INHIBITOR; SIASTATIN B DERIVATIVE; SURAMIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIANGIOGENIC ACTIVITY; ANTICOAGULATION; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; BASEMENT MEMBRANE; CANCER INHIBITION; CLINICAL TRIAL; DRUG DESIGN; DRUG ISOLATION; ENZYME INHIBITION; ENZYME STRUCTURE; EXTRACELLULAR MATRIX; HUMAN; METASTASIS INHIBITION; MULTIPLE MYELOMA; NONHUMAN; PROTEIN FUNCTION; SHORT SURVEY; SIDE EFFECT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 3242712146     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389557043403729     Document Type: Short Survey

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