Role of heparan sulfate as a tissue-specific regulator of FGF-4 and FGF receptor recognition

Journal of Cell Biology

Volumn 155, Issue 5, 2001, Pages 845-857

  Allen, Benjamin L ^a   Filla, Mark S ^a   Rapraeger, Alan C ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Development; FGF receptors; Fibroblast growth factors; Heparan sulfate proteoglycan; Sulfation

Indexed keywords

FIBROBLAST GROWTH FACTOR 4; FIBROBLAST GROWTH FACTOR RECEPTOR; HEPARAN SULFATE; PROTEOGLYCAN; TYROSINE KINASE RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BLOOD VESSEL; CELL PROLIFERATION; CELL SURFACE; COMPLEX FORMATION; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENDOTHELIUM CELL; HEART; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; SULFATION;

ANIMALS; BRAIN; CELLS, CULTURED; EMBRYO; ENDOTHELIUM, VASCULAR; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR 4; FIBROBLAST GROWTH FACTORS; HEPARIN; HEPARITIN SULFATE; IMMUNOHISTOCHEMISTRY; ISOENZYMES; KIDNEY; LIVER; LUNG; MICE; MOLECULAR STRUCTURE; MYOCARDIUM; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; RECEPTORS, FIBROBLAST GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SKIN;

ANIMALIA;

EID: 0035956435     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200106075     Document Type: Article

References (68)

1. Vascular bed-specific expression of an endothelial cell gene is programmed by the tissue microenvironment
2. Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan rhat binds transforming growth factor-β
3. Potential mechanisms regulating the extracellular activities of basic fibroblast growth factor (FGF-2)
4. Basic fibroblast growth factor-induced angiogenic phenotype in mouse endothelium. A study of aortic and microvascular endothelial cell lines
5. Factors promoting tumor angiogenesis
6. CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor
7. Functions of cell surface heparan sulfare sulfate proteoglycans
8. Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase
9. Expression and localization of fibroblast growth factors and fibroblast growth factor receptors in the developing rat kidney
10. Differential ability of heparan sulfate proteoglycans to assemble the fibroblast growth factor receptor complex in situ
11. Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity
12. VEGF121, a vascular endothelial growth factor (VEGF) isoform lacking heparin binding ability, requires cell-surface heparan sulfates for efficient binding to the VEGF receptors of human melanoma cells
13. Paracrine and autocrine effects of fibroblast growth factor-4 in endothelial cells
14. Processing, secretion, and biological properties of a novel growth factor of the fibroblast growth factor family with oncogenic potential
15. Diversity does make a difference: Fibroblast growth factor-heparin interactions
16. The cell surface proteoglycan syndecan-1 mediates fibroblast growth factor-2 binding and activity
17. Glypicans in growth control and cancer
18. Heparin and heparan sulfate increase the radius of diffusion and action of basic fibroblast growth factor
19. Differential binding of fibroblast growth factor-2 and -7 to basement membrane heparan sulfate: Comparison of normal and abnormal human tissues
20. Glypican-1 is a VEGF165 binding proteoglycan that acts as an extracellular chaperone for VEGF165
21. Heparin protects basic and acidic FGF from inactivation
22. Fibroblast growth factor receptor signalling is dictated by specific heparan sulphare saccharides
23. Activating and inhibitory heparin sequences for FGF-2 (basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4
24. Molecular characterization and expression of heparan-sulfate 6-sulfotransferase. Complete cDNA cloning in human and partial cloning in Chinese hamster ovary cells
25. Matrix proteoglycans: From molecular design to cellular function
26. Proteoglycan forms of the lymphocyte homing receptor CD44 are alternatively spliced variants containing the v3 exon
27. Structural and functional diversity in the FGF receptor multigene family
28. An essential heparin-binding domain in the fibroblast growth factor receptor kinase
29. The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer
30. Molecular cloning and expression of Chinese hamster ovary cell heparan-sulfate 2-sulfotransferase
31. Syndecan-1 mediates cell spreading in transfected human lymphoblastoid (Raji) cells
32. Biosynthesis of heparin/heparan sulfate, cDNA cloning and expression of D-glucuronyl C5-epimerase from bovine lung
33. Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development
34. Heparan sulfate: A polyanion with multiple messages
35. Regulated diversity of heparan sulfate
36. Combined BMP-2 and FGF-4, but neither factor alone, induces cardiogenesis in non-precardiac embryonic mesoderm
37. Liver heparan sulfate structure. A novel molecular design
38. Minimal sequence in heparin/heparan sulfate required for binding of basic fibroblast growth factor
39. The roles of FGFs in the early development of vertebrate limbs
40. Determination of ligand-binding specificity by alternative splicing: Two distinct growth factor receptors encoded by a single gene
41. hst-1 transforming protein: Expression in silkworm cells and characterization as a novel heparin-binding growth factor
42. The complete sequence of perlecan, a basement membrane heparan sulfate proteoglycan, reveals extensive similarity with laminin A chain, low density lipoprotein-recepror, and the neural cell adhesion molecule
43. Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells
44. Receptor specificity of the fibroblast growth factor family
45. Heparin-binding EGF-like growth factor interacts with mouse blastocysts independently of ErbB1: A possible role for heparan sulfate proteoglycans and ErbB4 in blastocyst implantation
46. Cell surface heparan sulfate proteoglycans: Selective regulators of ligand-receptor encounters
47. Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin
48. Heparan sulfate oligosaccharides require 6-O-sulfation for promotion of basic fibroblast growth factor mitogenic activity
49. Heparan sulfate-growth factor interactions
50. Requirement ofheparan sulfate for bFGF-mediated fibroblast growth and myoblasr differentiation
51. Heparin binding and oligomerization of hepatocyte growth factor/scatter factor isoforms. Heparan sulfate glycosaminoglycan requirement for Met binding and signaling
52. Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization
53. Stimulation of DNA synthesis and cell proliferation of human mammary myoepithelial-like cells by hepatocyte growth factor/scatter factor depends on heparan sulfate proteoglycans and sustained phosphorylation of mitogenactivated protein kinases p42/44
54. Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase
55. Fibroblast growth factors: At the heart of angiogenesis anglogenesis
56. Developmental expression of fibroblast growth factor receptor-1 (cek-1; flg) during heart development
57. Fibroblast growth factors as multifunctional signaling factors
58. Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan
59. The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila
60. Identification of the basic fibroblast growth factor binding sequence in fibroblast heparan sulfate
61. Generation and application of type-specific anti-heparan sulfate antibodies using phage display technology. Further evidence for heparan sulfate heterogeneity in the kidney
62. Molecular characteristics of fibroblast growth factor-fibroblast growth factor receptor-heparin-like glycosaminoglycan complex
63. A single protein catalyzes both N-deacetylation and N-sulfation during the biosynthesis ofheparan sulfate
64. Differential splicing in the extracellular region of fibroblast growth factor receptor 1 generates receptor variants with different ligand-binding specificities
65. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor
66. Angiogenic activity of the recombinant hst-1 protein
67. Evidence that fibroblast growth factors 1 and 4 participate in regulation of cardiogenesis
68. The syndecans, tuners of transmembrane signaling