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Volumn 7, Issue 2, 2012, Pages

Small RNAs targeting transcription start site induce heparanase silencing through interference with transcription initiation in human cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

ARGONAUTE 1 PROTEIN; ARGONAUTE 2 PROTEIN; BISULFITE; EARLY GROWTH RESPONSE FACTOR 1; HEPARANASE; RNA POLYMERASE II; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR IIB; TRANSCRIPTION FACTOR SP1; ARGONAUTE PROTEIN; BETA GLUCURONIDASE; EIF2C1 PROTEIN, HUMAN; EIF2C2 PROTEIN, HUMAN; HISTONE; INITIATION FACTOR;

EID: 84857377246     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031379     Document Type: Article
Times cited : (54)

References (51)
  • 1
    • 33748683743 scopus 로고    scopus 로고
    • Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis
    • Ilan N, Elkin M, Vlodavsky I, (2006) Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis. Int J Biochem Cell Biol 38: 2018-2039.
    • (2006) Int J Biochem Cell Biol , vol.38 , pp. 2018-2039
    • Ilan, N.1    Elkin, M.2    Vlodavsky, I.3
  • 2
    • 0021354360 scopus 로고
    • Metastatic melanoma cell heparanase. Characterization of heparan sulfate degradation fragments produced by B16 melanoma endoglucuronidase
    • Nakajima M, Irimura T, Di Ferrante N, Nicolson GL, (1984) Metastatic melanoma cell heparanase. Characterization of heparan sulfate degradation fragments produced by B16 melanoma endoglucuronidase. J Biol Chem 259: 2283-2290.
    • (1984) J Biol Chem , vol.259 , pp. 2283-2290
    • Nakajima, M.1    Irimura, T.2    Di Ferrante, N.3    Nicolson, G.L.4
  • 3
  • 4
    • 0034904048 scopus 로고    scopus 로고
    • Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis
    • Vlodavsky I, Friedmann Y, (2001) Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis. J Clin Invest 108: 341-347.
    • (2001) J Clin Invest , vol.108 , pp. 341-347
    • Vlodavsky, I.1    Friedmann, Y.2
  • 5
    • 19944432186 scopus 로고    scopus 로고
    • Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer
    • Ogishima T, Shiina H, Breault JE, Tabatabai L, Bassett WW, et al. (2005) Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer. Clin Cancer Res 11: 1028-1036.
    • (2005) Clin Cancer Res , vol.11 , pp. 1028-1036
    • Ogishima, T.1    Shiina, H.2    Breault, J.E.3    Tabatabai, L.4    Bassett, W.W.5
  • 6
    • 27144527031 scopus 로고    scopus 로고
    • Promoter CpG hypomethylation and transcription factor EGR1 hyperactivate heparanase expression in bladder cancer
    • Ogishima T, Shiina H, Breault JE, Terashima M, Honda S, et al. (2005) Promoter CpG hypomethylation and transcription factor EGR1 hyperactivate heparanase expression in bladder cancer. Oncogene 24: 6765-6772.
    • (2005) Oncogene , vol.24 , pp. 6765-6772
    • Ogishima, T.1    Shiina, H.2    Breault, J.E.3    Terashima, M.4    Honda, S.5
  • 7
    • 18444385059 scopus 로고    scopus 로고
    • Heparanase: a key enzyme in invasion and metastasis of gastric carcinoma
    • Tang W, Nakamura Y, Tsujimoto M, Sato M, Wang X, et al. (2002) Heparanase: a key enzyme in invasion and metastasis of gastric carcinoma. Mod Pathol 15: 593-598.
    • (2002) Mod Pathol , vol.15 , pp. 593-598
    • Tang, W.1    Nakamura, Y.2    Tsujimoto, M.3    Sato, M.4    Wang, X.5
  • 8
    • 13244274950 scopus 로고    scopus 로고
    • Positive association of heparanase expression with tumor invasion and lymphatic metastasis in gastric carcinoma
    • Wang Z, Xu H, Jiang L, Zhou X, Lu C, et al. (2004) Positive association of heparanase expression with tumor invasion and lymphatic metastasis in gastric carcinoma. Mod Pathol 18: 205-211.
    • (2004) Mod Pathol , vol.18 , pp. 205-211
    • Wang, Z.1    Xu, H.2    Jiang, L.3    Zhou, X.4    Lu, C.5
  • 9
    • 14644435784 scopus 로고    scopus 로고
    • Short interfering RNAs as a tool for cancer gene therapy
    • Izquierdo M, (2004) Short interfering RNAs as a tool for cancer gene therapy. Cancer Gene Ther 12: 217-227.
    • (2004) Cancer Gene Ther , vol.12 , pp. 217-227
    • Izquierdo, M.1
  • 10
    • 31044433795 scopus 로고    scopus 로고
    • The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells
    • Weinberg MS, Villeneuve LM, Ehsani A, Amarzguioui M, Aagaard L, et al. (2006) The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells. RNA 12: 256-262.
    • (2006) RNA , vol.12 , pp. 256-262
    • Weinberg, M.S.1    Villeneuve, L.M.2    Ehsani, A.3    Amarzguioui, M.4    Aagaard, L.5
  • 11
    • 66249108936 scopus 로고    scopus 로고
    • Promoter targeted small RNAs induce long-term transcriptional gene silencing in human cells
    • Hawkins PG, Santoso S, Adams C, Anest V, Morris KV, (2009) Promoter targeted small RNAs induce long-term transcriptional gene silencing in human cells. Nucleic Acids Res 37: 2984-2995.
    • (2009) Nucleic Acids Res , vol.37 , pp. 2984-2995
    • Hawkins, P.G.1    Santoso, S.2    Adams, C.3    Anest, V.4    Morris, K.V.5
  • 12
    • 63649088662 scopus 로고    scopus 로고
    • Mobilization-competent lentiviral vector- mediated sustained transcriptional modulation of HIV-1 Expression
    • Turner AM, De La Cruz J, Morris KV, (2009) Mobilization-competent lentiviral vector- mediated sustained transcriptional modulation of HIV-1 Expression. Mol Ther 17: 360-368.
    • (2009) Mol Ther , vol.17 , pp. 360-368
    • Turner, A.M.1    de la Cruz, J.2    Morris, K.V.3
  • 13
    • 20844435197 scopus 로고    scopus 로고
    • Short hairpin RNA-directed cytosine (CpG) methylation of the RASSF1A gene promoter in HeLa cells
    • Castanotto D, Tommasi S, Li M, Li H, Yanow S, et al. (2005) Short hairpin RNA-directed cytosine (CpG) methylation of the RASSF1A gene promoter in HeLa cells. Mol Ther 12: 179-183.
    • (2005) Mol Ther , vol.12 , pp. 179-183
    • Castanotto, D.1    Tommasi, S.2    Li, M.3    Li, H.4    Yanow, S.5
  • 14
    • 33644854871 scopus 로고    scopus 로고
    • A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory
    • Murayama A, Sakura K, Nakama M, Yasuzawa-Tanaka K, Fujita E, et al. (2006) A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory. EMBO J 25: 1081-1092.
    • (2006) EMBO J , vol.25 , pp. 1081-1092
    • Murayama, A.1    Sakura, K.2    Nakama, M.3    Yasuzawa-Tanaka, K.4    Fujita, E.5
  • 15
    • 67650299463 scopus 로고    scopus 로고
    • Control of alternative splicing through siRNA-mediated transcriptional gene silencing
    • Alló M, Buggiano V, Fededa JP, Petrillo E, Schor I, et al. (2009) Control of alternative splicing through siRNA-mediated transcriptional gene silencing. Nat Struct Mol Biol 16: 717-724.
    • (2009) Nat Struct Mol Biol , vol.16 , pp. 717-724
    • Alló, M.1    Buggiano, V.2    Fededa, J.P.3    Petrillo, E.4    Schor, I.5
  • 16
    • 0036123111 scopus 로고    scopus 로고
    • Computational detection and location of transcription start sites in mammalian genomic DNA
    • Down TA, Hubbard TJ, (2002) Computational detection and location of transcription start sites in mammalian genomic DNA. Genome Res 12: 458-461.
    • (2002) Genome Res , vol.12 , pp. 458-461
    • Down, T.A.1    Hubbard, T.J.2
  • 17
    • 0033057962 scopus 로고    scopus 로고
    • Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis
    • Vlodavsky I, Friedmann Y, Elkin M, Aingorn H, Atzmon R, et al. (1999) Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis. Nat Med 5: 793-802.
    • (1999) Nat Med , vol.5 , pp. 793-802
    • Vlodavsky, I.1    Friedmann, Y.2    Elkin, M.3    Aingorn, H.4    Atzmon, R.5
  • 18
    • 0037088587 scopus 로고    scopus 로고
    • Cloning and characterization of the human heparanase-1 (HPR1) gene promoter: role of GA-binding protein and Sp1 in regulating HPR1 basal promoter activity
    • Jiang P, Kumar A, Parrillo JE, Dempsey LA, Platt JL, et al. (2002) Cloning and characterization of the human heparanase-1 (HPR1) gene promoter: role of GA-binding protein and Sp1 in regulating HPR1 basal promoter activity. J Biol Chem 277: 8989-8998.
    • (2002) J Biol Chem , vol.277 , pp. 8989-8998
    • Jiang, P.1    Kumar, A.2    Parrillo, J.E.3    Dempsey, L.A.4    Platt, J.L.5
  • 19
    • 0034622506 scopus 로고    scopus 로고
    • Genomic organization and chromosome localization of the newly identified human heparanase gene
    • Dong J, Kukula AK, Toyoshima M, Nakajima M, (2000) Genomic organization and chromosome localization of the newly identified human heparanase gene. Gene 253: 171-178.
    • (2000) Gene , vol.253 , pp. 171-178
    • Dong, J.1    Kukula, A.K.2    Toyoshima, M.3    Nakajima, M.4
  • 20
    • 0033588093 scopus 로고    scopus 로고
    • Human heparanase. Purification, characterization, cloning, and expression
    • Toyoshima M, Nakajima M, (1999) Human heparanase. Purification, characterization, cloning, and expression. J Biol Chem 274: 24153-24160.
    • (1999) J Biol Chem , vol.274 , pp. 24153-24160
    • Toyoshima, M.1    Nakajima, M.2
  • 21
    • 0033028789 scopus 로고    scopus 로고
    • Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis
    • Hulett MD, Freeman C, Hamdorf BJ, Baker RT, Harris MJ, et al. (1999) Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis. Nat Med 5: 803-809.
    • (1999) Nat Med , vol.5 , pp. 803-809
    • Hulett, M.D.1    Freeman, C.2    Hamdorf, B.J.3    Baker, R.T.4    Harris, M.J.5
  • 22
    • 33847070442 scopus 로고    scopus 로고
    • The role of chromatin during transcription
    • Li B, Carey M, Workman JL, (2007) The role of chromatin during transcription. Cell 128: 707-719.
    • (2007) Cell , vol.128 , pp. 707-719
    • Li, B.1    Carey, M.2    Workman, J.L.3
  • 23
    • 44349131472 scopus 로고    scopus 로고
    • Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
    • Kondo Y, Shen L, Cheng AS, Ahmed S, Boumber Y, et al. (2008) Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation. Nat Genet 40: 741-750.
    • (2008) Nat Genet , vol.40 , pp. 741-750
    • Kondo, Y.1    Shen, L.2    Cheng, A.S.3    Ahmed, S.4    Boumber, Y.5
  • 24
    • 33847036990 scopus 로고    scopus 로고
    • Strategies for silencing human disease using RNA interference
    • Kim DH, Rossi JJ, (2007) Strategies for silencing human disease using RNA interference. Nat Rev Genet 8: 173-184.
    • (2007) Nat Rev Genet , vol.8 , pp. 173-184
    • Kim, D.H.1    Rossi, J.J.2
  • 26
    • 77952241027 scopus 로고    scopus 로고
    • Interaction of RNA polymerase II and the small RNA machinery affects heterochromatic silencing in Drosophila
    • Kavi H, Birchler J, (2009) Interaction of RNA polymerase II and the small RNA machinery affects heterochromatic silencing in Drosophila. Epigenetics Chromatin 2: 15.
    • (2009) Epigenetics Chromatin , vol.2 , pp. 15
    • Kavi, H.1    Birchler, J.2
  • 27
    • 1942422184 scopus 로고    scopus 로고
    • Functional Interaction between TFIIB and the Rpb2 Subunit of RNA Polymerase II: Implications for the Mechanism of Transcription Initiation
    • Chen BS, Hampsey M, (2004) Functional Interaction between TFIIB and the Rpb2 Subunit of RNA Polymerase II: Implications for the Mechanism of Transcription Initiation. Mol Cell Biol 24: 3983-3991.
    • (2004) Mol Cell Biol , vol.24 , pp. 3983-3991
    • Chen, B.S.1    Hampsey, M.2
  • 28
    • 5444275331 scopus 로고    scopus 로고
    • Mapping the location of TFIIB within the RNA polymerase II transcription preinitiation complex: a model for the structure of the PIC
    • Chen HT, Hahn S, (2004) Mapping the location of TFIIB within the RNA polymerase II transcription preinitiation complex: a model for the structure of the PIC. Cell 119: 169-180.
    • (2004) Cell , vol.119 , pp. 169-180
    • Chen, H.T.1    Hahn, S.2
  • 29
    • 70349239135 scopus 로고    scopus 로고
    • Efficient regulation of VEGF expression by promoter-targeted lentiviral shRNAs based on epigenetic mechanism: a novel example of epigenetherapy
    • Turunen MP, Lehtola T, Heinonen SE, Assefa GS, Korpisalo P, et al. (2009) Efficient regulation of VEGF expression by promoter-targeted lentiviral shRNAs based on epigenetic mechanism: a novel example of epigenetherapy. Circ Res 105: 604-609.
    • (2009) Circ Res , vol.105 , pp. 604-609
    • Turunen, M.P.1    Lehtola, T.2    Heinonen, S.E.3    Assefa, G.S.4    Korpisalo, P.5
  • 30
    • 64549113392 scopus 로고    scopus 로고
    • Retroviral delivery of promoter-targeted shRNA induces long-term silencing of HIV-1 transcription
    • Yamagishi M, Ishida T, Miyake A, Cooper DA, Kelleher AD, et al. (2009) Retroviral delivery of promoter-targeted shRNA induces long-term silencing of HIV-1 transcription. Microbes Infect 11: 500-508.
    • (2009) Microbes Infect , vol.11 , pp. 500-508
    • Yamagishi, M.1    Ishida, T.2    Miyake, A.3    Cooper, D.A.4    Kelleher, A.D.5
  • 31
    • 0000213492 scopus 로고
    • Reversible methylation and inactivation of marker genes in sequentially transformed tobacco plants
    • Matzke MA, Primig M, Trnovsky J, Matzke AJ, (1989) Reversible methylation and inactivation of marker genes in sequentially transformed tobacco plants. EMBO J 8: 643-649.
    • (1989) EMBO J , vol.8 , pp. 643-649
    • Matzke, M.A.1    Primig, M.2    Trnovsky, J.3    Matzke, A.J.4
  • 32
    • 33748368912 scopus 로고    scopus 로고
    • Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells
    • Kim DH, Villeneuve LM, Morris KV, Rossi JJ, (2006) Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells. Nat Struct Mol Biol 13: 793-797.
    • (2006) Nat Struct Mol Biol , vol.13 , pp. 793-797
    • Kim, D.H.1    Villeneuve, L.M.2    Morris, K.V.3    Rossi, J.J.4
  • 33
    • 74049138715 scopus 로고    scopus 로고
    • Transcriptional regulation by promoter targeted RNAs
    • Suzuki K, Kelleher AD, (2009) Transcriptional regulation by promoter targeted RNAs. Curr Top Med Chem 9: 1079-1087.
    • (2009) Curr Top Med Chem , vol.9 , pp. 1079-1087
    • Suzuki, K.1    Kelleher, A.D.2
  • 34
    • 0346118917 scopus 로고    scopus 로고
    • Regulation of inducible heparanase gene transcription in activated T cells by early growth response 1
    • de Mestre AM, Khachigian LM, Santiago FS, Staykova MA, Hulett MD, (2003) Regulation of inducible heparanase gene transcription in activated T cells by early growth response 1. J Biol Chem 278: 50377-50385.
    • (2003) J Biol Chem , vol.278 , pp. 50377-50385
    • de Mestre, A.M.1    Khachigian, L.M.2    Santiago, F.S.3    Staykova, M.A.4    Hulett, M.D.5
  • 35
    • 34948849835 scopus 로고    scopus 로고
    • SiRNAs do not induce RNA-dependent transcriptional silencing of retrovirus in human cells
    • Haraguchi T, Mizutani T, Yamamichi N, Ito T, Minoguchi S, et al. (2007) SiRNAs do not induce RNA-dependent transcriptional silencing of retrovirus in human cells. FEBS Lett 581: 4949-4954.
    • (2007) FEBS Lett , vol.581 , pp. 4949-4954
    • Haraguchi, T.1    Mizutani, T.2    Yamamichi, N.3    Ito, T.4    Minoguchi, S.5
  • 36
    • 84984758049 scopus 로고    scopus 로고
    • Inhibiting gene expression at transcription start sites in chromosomal DNA with antigene RNAs
    • Janowski BA, Huffman KE, Schwartz JC, Ram R, Hardy D, et al. (2005) Inhibiting gene expression at transcription start sites in chromosomal DNA with antigene RNAs. Nat Chem Biol 1: 216-222.
    • (2005) Nat Chem Biol , vol.1 , pp. 216-222
    • Janowski, B.A.1    Huffman, K.E.2    Schwartz, J.C.3    Ram, R.4    Hardy, D.5
  • 38
    • 17444412299 scopus 로고    scopus 로고
    • Local RNA target structure influences siRNA efficacy: systematic analysis of intentionally designed binding regions
    • Schubert S, Grünweller A, Erdmann VA, Kurreck J, (2005) Local RNA target structure influences siRNA efficacy: systematic analysis of intentionally designed binding regions. J Mol Biol 348: 883-893.
    • (2005) J Mol Biol , vol.348 , pp. 883-893
    • Schubert, S.1    Grünweller, A.2    Erdmann, V.A.3    Kurreck, J.4
  • 39
    • 34547626629 scopus 로고    scopus 로고
    • Promoter-associated RNA is required for RNA-directed transcriptional gene silencing in human cells
    • Han J, Kim D, Morris KV, (2007) Promoter-associated RNA is required for RNA-directed transcriptional gene silencing in human cells. Proc Natl Acad Sci USA 104: 12422-12427.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 12422-12427
    • Han, J.1    Kim, D.2    Morris, K.V.3
  • 40
    • 67649537602 scopus 로고    scopus 로고
    • Promoter-specific transcriptional interference and c-myc gene silencing by siRNAs in human cells
    • Napoli S, Pastori C, Magistri M, Carbone GM, Catapano CV, (2009) Promoter-specific transcriptional interference and c-myc gene silencing by siRNAs in human cells. EMBO J 28: 1708-1719.
    • (2009) EMBO J , vol.28 , pp. 1708-1719
    • Napoli, S.1    Pastori, C.2    Magistri, M.3    Carbone, G.M.4    Catapano, C.V.5
  • 41
    • 33748337330 scopus 로고    scopus 로고
    • Silencing gene expression by targeting chromosomal DNA with antigene peptide nucleic acids and duplex RNAs
    • Janowski BA, Hu J, Corey DR, (2006) Silencing gene expression by targeting chromosomal DNA with antigene peptide nucleic acids and duplex RNAs. Nat Protocols 1: 436-443.
    • (2006) Nat Protocols , vol.1 , pp. 436-443
    • Janowski, B.A.1    Hu, J.2    Corey, D.R.3
  • 43
    • 39149123836 scopus 로고    scopus 로고
    • Heparanase expression in B16 melanoma cells and peripheral blood neutrophils before and after extravasation detected by novel anti-mouse heparanase monoclonal antibodies
    • Komatsu N, Waki M, Sue M, Tokuda C, Kasaoka T, et al. (2008) Heparanase expression in B16 melanoma cells and peripheral blood neutrophils before and after extravasation detected by novel anti-mouse heparanase monoclonal antibodies. J Immunol Methods 331: 82-93.
    • (2008) J Immunol Methods , vol.331 , pp. 82-93
    • Komatsu, N.1    Waki, M.2    Sue, M.3    Tokuda, C.4    Kasaoka, T.5
  • 44
    • 42949154207 scopus 로고    scopus 로고
    • Reduced expression and tumor suppressor function of the ETS transcription factor ESE-3 in prostate cancer
    • Cangemi R, Mensah A, Albertini V, Jain A, Mello-Grand M, et al. (2007) Reduced expression and tumor suppressor function of the ETS transcription factor ESE-3 in prostate cancer. Oncogene 27: 2877-2885.
    • (2007) Oncogene , vol.27 , pp. 2877-2885
    • Cangemi, R.1    Mensah, A.2    Albertini, V.3    Jain, A.4    Mello-Grand, M.5
  • 45
    • 34547095270 scopus 로고    scopus 로고
    • Small interfering RNA directed reversal of urokinase plasminogen activator demethylation inhibits prostate tumor growth and metastasis
    • Pulukuri SMK, Rao JS, (2007) Small interfering RNA directed reversal of urokinase plasminogen activator demethylation inhibits prostate tumor growth and metastasis. Cancer Res 67: 6637-6646.
    • (2007) Cancer Res , vol.67 , pp. 6637-6646
    • Pulukuri, S.M.K.1    Rao, J.S.2
  • 46
    • 77949508295 scopus 로고    scopus 로고
    • Small RNA interference-mediated gene silencing of heparanase abolishes the invasion, metastasis and angiogenesis of gastric cancer cells
    • Zheng L, Jiang G, Mei H, Pu J, Dong J, et al. (2010) Small RNA interference-mediated gene silencing of heparanase abolishes the invasion, metastasis and angiogenesis of gastric cancer cells. BMC Cancer 10: 33.
    • (2010) BMC Cancer , vol.10 , pp. 33
    • Zheng, L.1    Jiang, G.2    Mei, H.3    Pu, J.4    Dong, J.5
  • 47
    • 28044465143 scopus 로고    scopus 로고
    • Regulation of endothelial nitric oxide synthase by small RNA
    • Zhang MX, Ou H, Shen YH, Wang J, Coselli J, et al. (2005) Regulation of endothelial nitric oxide synthase by small RNA. Proc Natl Acad Sci USA 102: 16967-16972.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 16967-16972
    • Zhang, M.X.1    Ou, H.2    Shen, Y.H.3    Wang, J.4    Coselli, J.5
  • 48
    • 57749199042 scopus 로고    scopus 로고
    • PARP-1 suppresses adiponectin expression through poly(ADP-ribosyl)ation of PPAR gamma in cardiac fibroblasts
    • Huang D, Yang C, Wang Y, Liao Y, Huang K, (2009) PARP-1 suppresses adiponectin expression through poly(ADP-ribosyl)ation of PPAR gamma in cardiac fibroblasts. Cardiovasc Res 81: 98-107.
    • (2009) Cardiovasc Res , vol.81 , pp. 98-107
    • Huang, D.1    Yang, C.2    Wang, Y.3    Liao, Y.4    Huang, K.5
  • 49
    • 2442640516 scopus 로고    scopus 로고
    • Transduction of soluble Flt-1 gene to peritoneal mesothelial cells can effectively suppress peritoneal metastasis of gastric cancer
    • Sako A, Kitayama J, Koyama H, Ueno H, Uchida H, et al. (2004) Transduction of soluble Flt-1 gene to peritoneal mesothelial cells can effectively suppress peritoneal metastasis of gastric cancer. Cancer Res 64: 3624-3628.
    • (2004) Cancer Res , vol.64 , pp. 3624-3628
    • Sako, A.1    Kitayama, J.2    Koyama, H.3    Ueno, H.4    Uchida, H.5
  • 50
    • 34548286862 scopus 로고    scopus 로고
    • Silencing of heparanase by siRNA inhibits tumor metastasis and angiogenesis of human breast cancer in vitro and in vivo
    • Zhang ZH, Chen Y, Zhao HJ, Xie CY, Ding J, et al. (2007) Silencing of heparanase by siRNA inhibits tumor metastasis and angiogenesis of human breast cancer in vitro and in vivo. Cancer Biol Ther 6: 587-595.
    • (2007) Cancer Biol Ther , vol.6 , pp. 587-595
    • Zhang, Z.H.1    Chen, Y.2    Zhao, H.J.3    Xie, C.Y.4    Ding, J.5
  • 51
    • 77949668384 scopus 로고    scopus 로고
    • Abnormal expression of early growth response 1 in gastric cancer: association with tumor invasion, metastasis and heparanase transcription
    • Zheng L, Pu J, Jiang G, Weng M, He J, et al. (2010) Abnormal expression of early growth response 1 in gastric cancer: association with tumor invasion, metastasis and heparanase transcription. Pathol Int 60: 268-277.
    • (2010) Pathol Int , vol.60 , pp. 268-277
    • Zheng, L.1    Pu, J.2    Jiang, G.3    Weng, M.4    He, J.5


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