Current views on genetics and epigenetics of cholesterol gallstone disease

Cholesterol

Volumn 2013, Issue , 2013, Pages

  Di Ciaula, Agostino ^a   Wang, David Q H ^b   Bonfrate, Leonilde ^c   Portincasa, Piero ^c,d  

^a Division of Internal Medicine Hospital of Bisceglie   (Italy)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

^d European Society for Clinical Investigation (ESCI)   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; CHOLESTEROL; FARNESOID X RECEPTOR; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MICRORNA;

ABCG5 GENE; ABCG8 GENE; BILE; CHOLESTEROL METABOLISM; CHOLESTEROL STONE; ENVIRONMENTAL FACTOR; EPIGENETICS; GENE; GENE EXPRESSION; GENOTYPE ENVIRONMENT INTERACTION; HEREDITY; HOMEOSTASIS; HUMAN; INTESTINE; LITH GENE; LIVER METABOLISM; NONHUMAN; PATHOGENESIS; PRIMARY PREVENTION; PRIORITY JOURNAL; REVIEW; RISK FACTOR;

EID: 84877289258     PISSN: 20901283     EISSN: 20901291     Source Type: Journal    
DOI: 10.1155/2013/298421     Document Type: Review

References (130)

1. Everhart J. E., Ruhl C. E., Burden of digestive diseases in the united states part I: overall and upper gastrointestinal diseases. Gastroenterology 2009 136 2 376 386 2-s2.0-58649100685 10.1053/j.gastro.2008.12.015
2. Shaffer E. A., Epidemiology and risk factors for gallstone disease: has the paradigm changed in the 21st century? Current Gastroenterology Reports 2005 7 2 132 140 2-s2.0-20444377268 (Pubitemid 40796699)
3. Attili A. F., Capocaccia R., Carulli N., Festi D., Roda E., Barbara L., Capocaccia L., Menotti A., Okolicsanyi L., Ricci G., Lalloni L., Mariotti S., Sama C., Scafato E., Factors associated with gallstone disease in the MICOL experience. Hepatology 1997 26 4 809 818 2-s2.0-12644255694 (Pubitemid 27413641)
4. Attili A. F., Carulli N., Roda E., Barbara B., Capocaccia L., Menotti A., Okoliksanyi L., Ricci G., Capocaccia R., Festi D., Lalloni L., Mariotti S., Sama C., Scafato E., Epidemiology of gallstone disease in Italy: prevalence data of the multicenter Italian study on cholelithiasis (M.I.COL.). The American Journal of Epidemiology 1995 141 2 158 165 2-s2.0-0028814821
5. Diehl A. K., Epidemiology and natural history of gallstone disease. Gastroenterology Clinics of North America 1991 20 1 1 19 2-s2.0-0025891277
6. Portincasa P., Wang D. Q., Intestinal absorption, hepatic synthesis, and biliary secretion of cholesterol: where are we for cholesterol gallstone formation? Hepatology 2012 55 5 1313 1316 10.1002/hep.25604
7. Eckel R. H., Grundy S. M., Zimmet P. Z., The metabolic syndrome. The Lancet 2005 365 9468 1415 1428 2-s2.0-17144380822 10.1016/S0140-6736(05)66378-7 (Pubitemid 40523737)
8. Grundy S. M., Metabolic syndrome scientific statement by the American heart association and the national heart, lung, and blood institute. Arteriosclerosis, Thrombosis, and Vascular Biology 2005 25 11 2243 2244 2-s2.0-27644519985 10.1161/01.ATV.0000189155.75833.c7 (Pubitemid 41552637)
9. Grundy S. M., Barnett J. P., Metabolic and health complications of obesity. Disease-a-Month 1990 36 12 641 731 2-s2.0-0025663247
10. Grundy S. M., Cleeman J. I., Daniels S. R., Donato K. A., Eckel R. H., Franklin B. A., Gordon D. J., Krauss R. M., Savage P. J., Smith S. C., Spertus J. A., Costa F., Diagnosis and management of the metabolic syndrome: an American heart association/national heart, lung, and blood institute scientific statement. Circulation 2005 112 17 2735 2752 2-s2.0-27444443876 10.1161/CIRCULATIONAHA.105.169404 (Pubitemid 41532612)
11. Tsai C. J., Leitzmann M. F., Willett W. C., Giovannucci E. L., Prospective study of abdominal adiposity and gallstone disease in US men. The American Journal of Clinical Nutrition 2004 80 1 38 44 2-s2.0-3042737714 (Pubitemid 41115552)
12. Méndez-Sánchez N., Chavez-Tapia N. C., Motola-Kuba D., Sanchez-Lara K., Ponciano-Rodríguez G., Baptista H., Ramos M. H., Uribe M., Metabolic syndrome as a risk factor for gallstone disease. World Journal of Gastroenterology 2005 11 11 1653 1657 2-s2.0-17144367370 (Pubitemid 40520807)
13. Nervi F., Miquel J. F., Alvarez M., Ferreccio C., García-Zattera M. J., González R., Pérez-Ayuso R. M., Rigotti A., Villarroel L., Gallbladder disease is associated with insulin resistance in a high risk Hispanic population. Journal of Hepatology 2006 45 2 299 305 2-s2.0-33745837831 10.1016/j.jhep.2006.01.026 (Pubitemid 44026566)
14. Ata N., Kucukazman M., Yavuz B., Bulus H., Dal K., Ertugrul D. T., Yalcin A. A., Polat M., Varol N., Akin K. O., Karabag A., Nazligul Y., The metabolic syndrome is associated with complicated gallstone disease. Canadian Journal of Gastroenterology 2011 25 5 274 276
15. Wang D. Q., Cohen D. E., Carey M. C., Biliary lipids and cholesterol gallstone disease. Journal of Lipid Research 2009 50, supplement S406 S411 2-s2.0-66349121963 10.1194/jlr.R800075-JLR200
16. Mazzio E. A., Soliman K. F., Basic concepts of epigenetics: impact of environmental signals on gene expression. Epigenetics 2012 7 2 119 130 10.4161/epi.7.2.18764
17. Portincasa P., Moschetta A., Palasciano G., Cholesterol gallstone disease. The Lancet 2006 368 9531 230 239 2-s2.0-33745833652 10.1016/S0140-6736(06)69044-2 (Pubitemid 44037798)
18. Hofmann A. F., Amelsberg A., Vansonnenberg E., Pathogenesis and treatment of gallstones. The New England Journal of Medicine 1993 328 25 1854 1855
19. Lamont J. T., Carey M. C., Cholesterol gallstone formation. 2. Pathobiology and pathomechanics. Progress in liver diseases 1992 10 165 191 2-s2.0-0027017761
20. Portincasa P., Di Ciaula A., Baldassarre G., Palmieri V., Gentile A., Cimmino A., Palasciano G., Gallbladder motel function in gallstone patients: sonographic and in vitro studies on the role of gallstones; smooth muscle function and gallbladder wall inflammation. Journal of Hepatology 1994 21 3 430 440 2-s2.0-0028169872 10.1016/S0168-8278(05)80324-1 (Pubitemid 24308769)
21. Wang D. Q., Neuschwander-Tetri B. A., Portincasa P., The Biliary System 2012 Princeton, NJ, USA Morgan & Claypool Life Sciences
22. Lammert F., Miquel J. F., Gallstone disease: from genes to evidence-based therapy. Journal of Hepatology 2008 48 supplement 1 S124 S135 2-s2.0-40849097477 10.1016/j.jhep.2008.01.012
23. Lammert F., Sauerbruch T., Mechanisms of disease: the genetic epidemiology of gallbladder stones. Nature Clinical Practice Gastroenterology and Hepatology 2005 2 9 423 433 2-s2.0-27144518494 10.1038/ncpgasthep0257 (Pubitemid 41486095)
24. Portincasa P., Di Ciaula A., Wang H. H., Palasciano G., van Erpecum K. J., Moschetta A., Wang D. Q. H., Coordinate regulation of gallbladder motor function in the gut-liver axis. Hepatology 2008 47 6 2112 2126 2-s2.0-44849102561 10.1002/hep.22204 (Pubitemid 351945576)
25. Portincasa P., Moschetta A., Puglisi F., Wang D. Q. H., Borzellino G., Cordiano C., Medical treatment of gallstone disease. Biliary Lithiasis: Basic Science, Current Diagnosis and Management 2008 Milan, Italy Springer Italia S.r.l. 149 157
26. Wang D. Q. H., Zhang L., Wang H. H., High cholesterol absorption efficiency and rapid biliary secretion of chylomicron remnant cholesterol enhance cholelithogenesis in gallstone-susceptible mice. Biochimica et Biophysica Acta 2005 1733 1 90 99 2-s2.0-14644429715 10.1016/j.bbalip.2004.12. 005 (Pubitemid 40321174)
27. Wang H. H., Portincasa P., Wang D. Q. H., Molecular pathophysiology and physical chemistry of cholesterol gallstones. Frontiers in Bioscience 2008 13 2 401 423 2-s2.0-37349028141 10.2741/2688 (Pubitemid 351599753)
28. Wittenburg H., Lammert F., Genetic predisposition to gallbladder stones. Seminars in Liver Disease 2007 27 1 109 121 2-s2.0-33847051653 10.1055/s-2006-960174
29. Wang D. Q. H., Afdhal N. H., Feldman M., Friedman L. S., Brand L. J., Gallstone disease. Sleisenger and Fordtran's Gastrointestinal and Liver Disease 2010 9 Philadelphia, Pa, USA Elsevier 1089 1120
30. Portincasa P., Calamita G., Water channel proteins in bile formation and flow in health and disease: when immiscible becomes miscible. Molecular Aspects of Medicine 2012 33 5-6 651 664 10.1016/j.mam.2012.03.010
31. Admirand W. H., Small D. M., The physicochemical basis of cholesterol gallstone formation in man. Journal of Clinical Investigation 1968 47 5 1043 1052 2-s2.0-0014283788
32. Wang D. Q. H., Carey M. C., Characterization of crystallization pathways during cholesterol precipitation from human gallbladder biles: identical pathways to corresponding model biles with three predominating sequences. Journal of Lipid Research 1996 37 12 2539 2549 2-s2.0-0030454457 (Pubitemid 27051501)
33. Clarenbach J. J., Reber M., Lütjohann D., von Bergmann K., Sudhop T., The lipid-lowering effect of ezetimibe in pure vegetarians. Journal of Lipid Research 2006 47 12 2820 2824 2-s2.0-33845578757 10.1194/jlr.P600009-JLR200 (Pubitemid 44936096)
34. Kozarsky K. F., Donahee M. H., Rigotti A., Iqbal S. N., Edelman E. R., Krieger M., Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels. Nature 1997 387 6631 414 417 2-s2.0-0030960169 10.1038/387414a0 (Pubitemid 27227207)
35. Robins S. J., Fasulo J. M., High density lipoproteins, but not other lipoproteins, provide a vehicle for sterol transport to bile. Journal of Clinical Investigation 1997 99 3 380 384 2-s2.0-0030763198 (Pubitemid 27414793)
36. Sehayek E., Ono J. G., Shefer S., Nguyen L. B., Wang N., Batta A. K., Salen G., Smith J. D., Tall A. R., Breslow J. L., Biliary cholesterol excretion: a novel mechanism that regulates dietary cholesterol absorption. Proceedings of the National Academy of Sciences of the United States of America 1998 95 17 10194 10199 2-s2.0-13144253097 10.1073/pnas.95.17.10194 (Pubitemid 28415317)
37. Oram J. F., Heinecke J. W., ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease. Physiological Reviews 2005 85 4 1343 1372 2-s2.0-25444463073 10.1152/physrev.00005.2005 (Pubitemid 41362273)
38. Kesaniemi Y. A., Miettinen T. A., Cholesterol absorption efficiency regulates plasma cholesterol level in the Finnish population. European Journal of Clinical Investigation 1987 17 5 391 395 2-s2.0-0023544459 (Pubitemid 18063904)
39. Bosner M. S., Lange L. G., Stenson W. F., Ostlund R. E. Jr., Percent cholesterol absorption in normal women and men quantified with dual stable isotopic tracers and negative ion mass spectrometry. Journal of Lipid Research 1999 40 2 302 308 2-s2.0-0032913411 (Pubitemid 29069805)
40. Altmann S. W., Davis H. R. Jr., Zhu L. J., Yao X., Hoos L. M., Tetzloff G., Iyer S. P. N., Maguire M., Golovko A., Zeng M., Wang L., Murgolo N., Graziano M. P., Niemann-pick C1 like 1 protein is critical for intestinal cholesterol absorption. Science 2004 303 5661 1201 1204 2-s2.0-10744221008 10.1126/science.1093131 (Pubitemid 38233587)
41. Wang D. Q. H., Regulation of intestinal cholesterol absorption. Annual Review of Physiology 2007 69 221 248 2-s2.0-33947380185 10.1146/annurev.physiol. 69.031905.160725 (Pubitemid 46457642)
42. Wang D. Q. H., Lee S. P., Physical chemistry of intestinal absorption of biliary cholesterol in mice. Hepatology 2008 48 1 177 185 2-s2.0-47149096885 10.1002/hep.22286 (Pubitemid 351975542)
43. Turley S. D., Dietschy J. M., Arias I. M., Iakoby W. B., Popper H., Schachter D., Shafritz D. A., The metabolism and excretion of cholesterol by the liver. The Liver: Biology and Pathobiology 1988 New York, NY, USA Raven Press 617 641
44. Long M. A., Kaler E. W., Lee S. P., Structural characterization of the micelle-vesicle transition in lecithin-bile salt solutions. Biophysical Journal 1994 67 4 1733 1742 2-s2.0-0028093488 (Pubitemid 24304345)
45. Quarfordt S. H., Oswald B., Landis B., Xu H. S., Zhang S. H., Maeda N., In vivo cholesterol kinetics in apolipoprotein E-deficient and control mice. Journal of Lipid Research 1995 36 6 1227 1235 2-s2.0-0029041572
46. Robins S. J., Brunengraber H., Origin of biliary cholesterol and lecithin in the rat: contribution of new synthesis and preformed hepatic stores. Journal of Lipid Research 1982 23 4 604 608 2-s2.0-0019900761 (Pubitemid 12009014)
47. Schwartz C. C., Berman M., Vlahcevic Z. R., Multicompartmental analysis of cholesterol metabolism in man. Characterization of the hepatic bile acid and biliary cholesterol precursor sites. Journal of Clinical Investigation 1978 61 2 408 423 2-s2.0-0017808235 (Pubitemid 8280412)
48. Chen Q., Li W. J., Wan Y. Y., Yu C. D., Li W. G., Fibroblast growth factor receptor 4 Gly388Arg polymorphism associated with severity of gallstone disease in a Chinese population. Genetics and Molecular Research 2012 11 1 548 555 10.4238/2012.March.8.3
49. Beaven S. W., Tontonoz P., Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia. Annual Review of Medicine 2006 57 313 329 2-s2.0-32944473282 10.1146/annurev.med.57.121304.131428 (Pubitemid 43261994)
50. Peet D. J., Janowski B. A., Mangelsdorf D. J., The LXRs: a new class of oxysterol receptors. Current Opinion in Genetics and Development 1998 8 5 571 575 2-s2.0-0032191340 10.1016/S0959-437X(98)80013-0 (Pubitemid 28477361)
51. Tontonoz P., Mangelsdorf D. J., Liver X receptor signaling pathways in cardiovascular disease. Molecular Endocrinology 2003 17 6 985 993 2-s2.0-0037503924 10.1210/me.2003-0061 (Pubitemid 36683707)
52. Uppal H., Zhai Y., Gangopadhyay A., Khadem S., Ren S., Moser J. A., Xie W., Activation of liver X receptor sensitizes mice to gallbladder cholesterol crystallization. Hepatology 2008 47 4 1331 1342 2-s2.0-42249093132 10.1002/hep.22175 (Pubitemid 351547919)
53. Tsai C. J., Leitzmann M. F., Willett W. C., Giovannucci E. L., Statin use and the risk of cholecystectomy in women. Gastroenterology 2009 136 5 1593 1600 2-s2.0-65349098719 10.1053/j.gastro.2009.01.042
54. Erichsen R., Frøslev T., Lash T. L., Pedersen L., Sørensen H. T., Long-term statin use and the risk of gallstone disease: a population-based case-control study. The American Journal of Epidemiology 2011 173 2 162 170 2-s2.0-78650644688 10.1093/aje/kwq361
55. Chapman B. A., Burt M. J., Chisholm R. J., Allan R. B., Yeo K. H. J., Ross A. G., Dissolution of gallstones with simvastatin, an HMG CoA reductase inhibitor. Digestive Diseases and Sciences 1998 43 2 349 353 2-s2.0-0031893966 10.1023/A:1018862507469 (Pubitemid 28124612)
56. Hanson D. S., Duane W. C., Effects of lovastatin and chenodiol on bile acid synthesis, bile lipid composition, and biliary lipid secretion in healthy human subjects. Journal of Lipid Research 1994 35 8 1462 1468 2-s2.0-0027989292 (Pubitemid 24251041)
57. Smit J. W. A., van Erpecum K. J., Portincasa P., Renooij W., Erkelens D. W., van Berge-Henegouwen G. P., Effects of simvastatin and cholestyramine on bile lipid composition and gall bladder motility in patients with hypercholesterolaemia. Gut 1995 37 5 654 659 2-s2.0-0028827499
58. Mitchell J. C., Logan G. M., Stone B. G., Duane W. C., Effects of lovastatin on biliary lipid secretion and bile acid metabolism in humans. Journal of Lipid Research 1991 32 1 71 78 2-s2.0-0026077951
59. Smith J. L., Roach P. D., Wittenberg L. N., Riottot M., Pillay S. P., Nestel P. J., Nathanson L. K., Effects of simvastatin on hepatic cholesterol metabolism, bile lithogenicity and bile acid hydrophobicity in patients with gallstones. Journal of Gastroenterology and Hepatology 2000 15 8 871 879 2-s2.0-0033799058 10.1046/j.1440-1746.2000.02231.x
60. Vanhanen H., Kesaniemi Y. A., Miettinen T. A., Pravastatin lowers serum cholesterol, cholesterol-precursor sterols, fecal steroids, and cholesterol absorption in man. Metabolism: Clinical and Experimental 1992 41 6 588 595 2-s2.0-0026623506 10.1016/0026-0495(92)90050-K
61. Lammert F., Wang D. Q. H., Paigen B., Carey M. C., Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: integrated activities of hepatic lipid regulatory enzymes. Journal of Lipid Research 1999 40 11 2080 2090 2-s2.0-0032692921 (Pubitemid 29523434)
62. Grundy S. M., Metzger A. L., Adler R. D., Mechanisms of lithogenic bile formation in American Indian women with cholesterol gallstones. Journal of Clinical Investigation 1972 51 12 3026 3043 2-s2.0-0015459799
63. Key P. H., Bonorris G. G., Marks J. W., Biliary lipid synthesis and secretion in gallstone patients before and during treatment with chenodeoxycholic acid. Journal of Laboratory and Clinical Medicine 1980 95 6 816 826 2-s2.0-0018853445 (Pubitemid 10116955)
64. Nervi F. O., Covarrubias C. F., Valdivieso V. D., Ronco B. O., Solari A., Tocornal J., Hepatic cholesterogenesis in Chileans with cholesterol gallstone disease. Evidence for sex differences in the regulation of hepatic cholesterol metabolism. Gastroenterology 1981 80 3 539 545 2-s2.0-0019372109 (Pubitemid 11183956)
65. Salen G., Nicolau G., Shefer S., Mosbach E. H., Hepatic cholesterol metabolism in patients with gallstones. Gastroenterology 1975 69 3 676 684 2-s2.0-0016829706
66. Stange E. F., Dietschy J. M., Danielsson H., Sjovall J., Cholesterol absorption and metabolism by the intestinal epithelium. Sterols and Bile Acids 1985 Amsterdam, The Netherlands Elsevier 121 149
67. Mok H. Y. I., von Bergmann K., Grundy S. M., Effects of continuous and intermittent feeding on biliary lipid outputs in man: application for measurements of intestinal absorption of cholesterol and bile acids. Journal of Lipid Research 1979 20 3 389 398 2-s2.0-0018774327 (Pubitemid 9137746)
68. Buhman K. K., Accad M., Novak S., Choi R. S., Wong J. S., Hamilton R. L., Turley S., Farese R. V., Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice. Nature Medicine 2000 6 12 1341 1347 2-s2.0-0034529633 10.1038/82153 (Pubitemid 32001017)
69. Wang H. H., Wang D. Q. H., Reduced susceptibility to cholesterol gallstone formation in mice that do not produce apolipoprotein B48 in the intestine. Hepatology 2005 42 4 894 904 2-s2.0-23244453526 10.1002/hep.20867 (Pubitemid 41401128)
70. Amigo L., Quiones V., Mardones P., Zanlungo S., Miquel J. F., Nervi F., Rigotti A., Impaired biliary cholesterol secretion and decreased gallstone formation in apolipoprotein E-deficient mice fed a high-cholesterol diet. Gastroenterology 2000 118 4 772 779 2-s2.0-0034067249 (Pubitemid 30171627)
71. DenBesten L., Connor W. E., Bell S., The effect of dietary cholesterol on the composition of human bile. Surgery 1973 73 2 266 273 2-s2.0-0015576037
72. Dam H., Prange I., Jensen M. K., Kallehauge H. E., Fenger H. J., Studies on human bile-IV. Influence of ingestion of cholesterol in the form of eggs on the composition of bile in healthy subjects. Zeitschrift für Ernährungswissenschaft 1971 10 3 178 187 2-s2.0-0015047421 10.1007/BF02020929
73. Andersen E., Hellstrom K., The effect of cholesterol feeding on bile acid kinetics and biliary lipids in normolipidemic and hypertriglyceridemic subjects. Journal of Lipid Research 1979 20 8 1020 1027 2-s2.0-0018579132 (Pubitemid 10157716)
74. Lee D. W. T., Gilmore C. J., Bonorris G., Cohen H., Marks J. W., Cho-Sue M., Meiselman M. S., Schoenfield L. J., Effect of dietary cholesterol on biliary lipids in patients with gallstones and normal subjects. The American Journal of Clinical Nutrition 1985 42 3 414 420 2-s2.0-0021919607 (Pubitemid 15227627)
75. Gilat T., Feldman C., Halpern Z., An increased familial frequency of gallstones. Gastroenterology 1983 84 2 242 246 2-s2.0-0020666940 (Pubitemid 13224261)
76. Sampliner R. E., Bennett P. H., Comess L. J., Rose F. A., Burch T. A., Gallbladder disease in pima indians. Demonstration of high prevalence and early onset by cholecystography. The New England Journal of Medicine 1970 283 25 1358 1364 2-s2.0-0014953484
77. Sarin S. K., Negi V. S., Dewan R., Sasan S., Saraya A., High familial prevalence of gallstones in the first-degree relatives of gallstone patients. Hepatology 1995 22 1 138 141 2-s2.0-0029133596
78. Stokes C. S., Krawczyk M., Lammert F., Gallstones: environment, lifestyle and genes. Digestive Diseases 2011 29 2 191 201 2-s2.0-79960112981 10.1159/000323885
79. Wittenburg H., Hereditary liver disease: gallstones. Best Practice and Research: Clinical Gastroenterology 2010 24 5 747 756 2-s2.0-77958095586 10.1016/j.bpg.2010.07.004
80. Katsika D., Grjibovski A., Einarsson C., Lammert F., Lichtenstein P., Marschall H. U., Genetic and environmental influences on symptomatic gallstone disease: a Swedish study of 43,141 twin pairs. Hepatology 2005 41 5 1138 1143 2-s2.0-17144408092 10.1002/hep.20654 (Pubitemid 40593922)
81. Katsika D., Magnusson P., Krawczyk M., Grünhage F., Lichtenstein P., Einarsson C., Lammert F., Marschall H. U., Gallstone disease in Swedish twins: risk is associated with ABCG8 D19H genotype. Journal of Internal Medicine 2010 268 3 279 285 2-s2.0-77955240404 10.1111/j.1365-2796.2010.02249.x
82. Acalovschi M., Ciocan A., Mostean O., Tirziu S., Chiorean E., Keppeler H., Schirin-Sokhan R., Lammert F., Are plasma lipid levels related to ABCG5/ABCG8 polymorphisms? A preliminary study in siblings with gallstones. European Journal of Internal Medicine 2006 17 7 490 494 2-s2.0-33750692363 10.1016/j.ejim.2006.04.012 (Pubitemid 44708739)
83. Gylling H., Hallikainen M., Pihlajamäki J., Ågren J., Laakso M., Rajaratnam R. A., Rauramaa R., Miettinen T. A., Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity. Journal of Lipid Research 2004 45 9 1660 1665 2-s2.0-4644279032 10.1194/jlr.M300522-JLR200 (Pubitemid 39296205)
84. Chuang S. C., Hsi E., Lee K. T., Mucin genes in gallstone disease. Clinica Chimica Acta 2012 413 19-20 1466 1471 10.1016/j.cca.2012.06.015
85. Chuang S. C., Hsi E., Wang S. N., Yu M. L., Lee K. T., Juo S. H., Polymorphism at the mucin-like protocadherin gene influences susceptibility to gallstone disease. Clinica Chimica Acta 2011 412 23-24 2089 2093 10.1016/j.cca.2011.07.015
86. Xu H. L., Cheng J. R., Andreotti G., Gao Y. T., Rashid A., Wang B. S., Shen M. C., Chu L. W., Yu K., Hsing A. W., Cholesterol metabolism gene polymorphisms and the risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China. Carcinogenesis 2011 32 1 58 62 2-s2.0-79952117556
87. Berends L. M., Ozanne S. E., Early determinants of type-2 diabetes. Best Practice and Research Clinical Endocrinology and Metabolism 2012 26 5 569 580 10.1016/j.beem.2012.03.002
88. Gilbert E. R., Liu D., Epigenetics: the missing link to understanding beta-cell dysfunction in the pathogenesis of type 2 diabetes. Epigenetics 2012 7 8 841 852 10.4161/epi.21238
89. Martin-Gronert M. S., Ozanne S. E., Metabolic programming of insulin action and secretion. Diabetes, Obesity and Metabolism 2012 14 supplement 3 29 39 10.1111/j.1463-1326.2012.01653.x
90. Milagro F. I., Mansego M. L., De M. C., Martinez J. A., Dietary factors, epigenetic modifications and obesity outcomes: progresses and perspectives. Molecular Aspects of Medicine 2012 10.1016/j.mam.2012.06.010
91. Sookoian S., Pirola C. J., DNA methylation and hepatic insulin resistance and steatosis. Current Opinion in Clinical Nutrition and Metabolic Care 2012 15 4 350 356 10.1097/MCO.0b013e3283546f9f
92. Wang J., Wu Z., Li D., Li N., Dindot S. V., Satterfield M. C., Bazer F. W., Wu G., Nutrition, epigenetics, and metabolic syndrome. Antioxidants and Redox Signaling 2012 17 2 282 301 10.1089/ars.2011.4381
93. Dawson M. A., Kouzarides T., Cancer epigenetics: from mechanism to therapy. Cell 2012 150 1 12 27 10.1016/j.cell.2012.06.013
94. Dawson M. A., Kouzarides T., Huntly B. J., Targeting epigenetic readers in cancer. The New England Journal of Medicine 2012 367 7 647 657 10.1056/NEJMra1112635
95. Marsit C., Christensen B., Blood-derived DNA methylation markers of cancer risk. Advances in Experimental Medicine and Biology 2013 754 233 252 10.1007/978-1-4419-9967-2-12
96. Udali S., Guarini P., Moruzzi S., Choi S. W., Friso S., Cardiovascular epigenetics: from DNA methylation to microRNAs. Molecular Aspects of Medicine 2012 10.1016/j.mam.2012.08.001
97. Kwok J. B., Role of epigenetics in Alzheimers and Parkinsons disease. Epigenomics 2010 2 5 671 682 2-s2.0-78149433116 10.2217/epi.10.43
98. Piedrahita J. A., The role of imprinted genes in fetal growth abnormalities. Birth Defects Research A 2011 91 8 682 692 2-s2.0-79961147541 10.1002/bdra.20795
99. Loke Y. J., Novakovic B., Ollikainen M., Wallace E. M., Umstad M. P., Permezel M., Morley R., Ponsonby A. L., Gordon L., Galati J. C., Saffery R., Craig J. M., The peri/postnatal epigenetic twins study (PETS). Twin Research and Human Genetics 2013 16 1 13 20 10.1017/thg.2012.114
100. Low F. M., Gluckman P. D., Hanson M. A., Developmental plasticity and epigenetic mechanisms underpinning metabolic and cardiovascular diseases. Epigenomics 2011 3 3 279 294 2-s2.0-79960029052 10.2217/epi.11.17
101. Cong R., Jia Y., Li R., Ni Y., Yang X., Sun Q., Parvizi N., Zhao R., Maternal low-protein diet causes epigenetic deregulation of HMGCR and CYP7alpha1 in the liver of weaning piglets. The Journal of Nutritional Biochemistry 2012 23 12 1647 1654 10.1016/j.jnutbio.2011.11.007
102. Sohi G., Marchand K., Revesz A., Arany E., Hardy D. B., Maternal protein restriction elevates cholesterol in adult rat offspring due to repressive changes in histone modifications at the cholesterol 7 α -hydroxylase promoter. Molecular Endocrinology 2011 25 5 785 798 2-s2.0-79955764891 10.1210/me.2010-0395
103. Cheng T. F., Choudhuri S., Muldoon-Jacobs K., Epigenetic targets of some toxicologically relevant metals: a review of the literature. Journal of Applied Toxicology 2012 32 9 643 653 10.1002/jat.2717
104. Martinez-Zamudio R., Ha H. C., Environmental epigenetics in metal exposure. Epigenetics 2011 6 7 820 827 2-s2.0-79960112920 10.4161/epi.6.7.16250
105. Reichard J. F., Puga A., Effects of arsenic exposure on DNA methylation and epigenetic gene regulation. Epigenomics 2010 2 1 87 104 2-s2.0-77954107743 10.2217/epi.09.45
106. Sadli N., Ackland M. L., De M. D., Sinclair A. J., Suphioglu C., Effects of zinc and DHA on the epigenetic regulation of human neuronal cells. Cellular Physiology and Biochemistry 2012 29 1-2 87 98 10.1159/000337590
107. Wang B., Li Y., Shao C., Tan Y., Cai L., Cadmium and its epigenetic effects. Current Medicinal Chemistry 2012 19 16 2611 2620 10.2174/ 092986712800492913
108. Ding T., McConaha M., Boyd K. L., Osteen K. G., Bruner-Tran K. L., Developmental dioxin exposure of either parent is associated with an increased risk of preterm birth in adult mice. Reproductive Toxicology 2011 31 3 351 358 2-s2.0-79953759048 10.1016/j.reprotox.2010.11.003
109. McKinlay R., Plant J. A., Bell J. N. B., Voulvoulis N., Calculating human exposure to endocrine disrupting pesticides via agricultural and non-agricultural exposure routes. Science of the Total Environment 2008 398 1-3 1 12 2-s2.0-43849083096 10.1016/j.scitotenv.2008.02.056
110. Nilsson E., Larsen G., Manikkam M., Guerrero-Bosagna C., Savenkova M. I., Skinner M. K., Environmentally induced epigenetic transgenerational inheritance of ovarian disease. PloS ONE 2012 7 5 e36129 10.1371/journal.pone.0036129
111. Takeda T., Fujii M., Taura J., Ishii Y., Yamada H., Dioxin silences gonadotropin expression in perinatal pups by inducing histone deacetylases: a new insight into the mechanism for the imprinting of sexual immaturity by dioxin. The Journal of Biological Chemistry 2012 287 18440 18450 10.1074/jbc.M111.335158
112. Weinhold B., More chemicals show epigenetic effects across generations. Environmental Health Perspectives 2012 120 article A228
113. Ferrari A., Fiorino E., Giudici M., Gilardi F., Galmozzi A., Mitro N., Cermenati G., Godio C., Caruso D., de Fabiani E., Crestani M., Linking epigenetics to lipid metabolism: focus on histone deacetylases. Molecular Membrane Biology 2012 29 7 257 266 10.3109/09687688.2012.729094
114. Chuang J. C., Jones P. A., Epigenetics and microRNAs. Pediatric Research 2007 61 5 24R 29R 2-s2.0-34247540446 10.1203/pdr.0b013e3180457684 (Pubitemid 46653064)
115. Tang W. Y., Ho S. M., Epigenetic reprogramming and imprinting in origins of disease. Reviews in Endocrine and Metabolic Disorders 2007 8 2 173 182 2-s2.0-34548757364 10.1007/s11154-007-9042-4 (Pubitemid 47434642)
116. Martinez J. A., Cordero P., Campion J., Milagro F. I., Interplay of early-life nutritional programming on obesity, inflammation and epigenetic outcomes. The Proceedings of the Nutrition Society 2012 71 2 276 283 10.1017/S0029665112000055
117. Rhee S. Y., Hwang Y. C., Woo J. T., Sinn D. H., Chin S. O., Chon S., Kim Y. S., Blood lead is significantly associated with metabolic syndrome in Korean adults: an analysis based on the Korea national health and nutrition examination survey (KNHANES), 2008. Cardiovascular Diabetology 2013 12 1, article 9 10.1186/1475-2840-12-9
118. Unisa S., Jagannath P., Dhir V., Khandelwal C., Sarangi L., Roy T. K., Population-based study to estimate prevalence and determine risk factors of gallbladder diseases in the rural Gangetic basin of North India. HPB 2011 13 2 117 125 2-s2.0-78751675750 10.1111/j.1477-2574.2010.00255.x
119. Ambros V., The functions of animal microRNAs. Nature 2004 431 7006 350 355 2-s2.0-4644309196 10.1038/nature02871 (Pubitemid 39265675)
120. Bartel D. P., MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004 116 2 281 297 2-s2.0-0347444723 10.1016/S0092-8674(04)00045-5 (Pubitemid 38167318)
121. Bartel D. P., MicroRNAs: target recognition and regulatory functions. Cell 2009 136 2 215 233 2-s2.0-58249088751 10.1016/j.cell.2009.01.002
122. Moore K. J., Rayner K. J., Suárez Y., Fernández-Hernando C., MicroRNAs and cholesterol metabolism. Trends in Endocrinology and Metabolism 2010 21 12 699 706 2-s2.0-78650262887 10.1016/j.tem.2010.08.008
123. Ross M. G., Beall M. H., Adult sequelae of intrauterine growth restriction. Seminars in Perinatology 2008 32 3 213 218 2-s2.0-43049179429 10.1053/j.semperi.2007.11.005 (Pubitemid 351636319)
124. Lamarche B., Lemieux S., Dagenais G. R., Després J. P., Visceral obesity and the risk of ischaemic heart disease: insights from the Québec cardiovascular study. Growth Hormone and IGF Research 1998 8 1 8 2-s2.0-0032468846
125. Makishima M., Okamoto A. Y., Repa J. J., Tu H., Learned R. M., Luk A., Hull M. V., Lustig K. D., Mangelsdorf D. J., Shan B., Identification of a nuclear receptor for bite acids. Science 1999 284 5418 1362 1365 2-s2.0-0033591297 10.1126/science.284.5418.1362 (Pubitemid 29289663)
126. Parks D. J., Blanchard S. G., Bledsoe R. K., Chandra G., Consler T. G., Kliewer S. A., Stimmel J. B., Willson T. M., Zavacki A. M., Moore D. D., Lehmann J. M., Bile acids: natural ligands for an orphan nuclear receptor. Science 1999 284 5418 1365 1368 2-s2.0-0033591387 10.1126/science.284.5418.1365 (Pubitemid 29289664)
127. Repa J. J., Mangelsdorf D. J., The liver X receptor gene team: potential new players in atherosclerosis. Nature Medicine 2002 8 11 1243 1248 2-s2.0-0036851863 10.1038/nm1102-1243 (Pubitemid 35373555)
128. Kalaany N. Y., Mangelsdorf D. J., LXRs and FXR: the Yin and Yang of cholesterol and fat metabolism. Annual Review of Physiology 2006 68 159 191 2-s2.0-33645983221 10.1146/annurev.physiol.68.033104.152158
129. Lee J., Seok S., Yu P., Kim K., Smith Z., Rivas-Astroza M., Zhong S., Kemper J. K., Genomic analysis of hepatic farnesoid X receptor binding sites reveals altered binding in obesity and direct gene repression by farnesoid X receptor in mice. Hepatology 2012 56 1 108 117 10.1002/hep.25609
130. de Bari O., Neuschwander-Tetri B. A., Liu M., Portincasa P., Wang D. Q., Ezetimibe: its novel effects on the prevention and the treatment of cholesterol gallstones and nonalcoholic fatty liver disease. Journal of Lipids 2012 2012 16 302847 10.1155/2012/302847