Cadmium and its epigenetic effects

Current Medicinal Chemistry

Volumn 19, Issue 16, 2012, Pages 2611-2620

  Wang, B ^a,b,c   Li, Y ^a   Shao, C ^a   Tan, Y ^c,d   Cai, L ^c,d  

^a JILIN UNIVERSITY   (China)

^b Inner Mongolia Forestry General Hospital   (China)

^c University of Louisville School of Medicine   (United States)

^d WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Cadmium; DNA methylation; DNA methyltransferases; Epigenetics; Histone modification; MicroRNA

Indexed keywords

CADMIUM; DNA; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; HISTONE; METALLOTHIONEIN; MICRORNA;

ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CHORIOCARCINOMA; CHROMOSOME ABERRATION; CYTOTOXICITY; DNA METHYLATION; DNA MODIFICATION; ENZYME ACTIVITY; EPIGENETICS; GENE EXPRESSION; GENOTOXICITY; HISTONE MODIFICATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN;

EID: 84860703221     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986712800492913     Document Type: Article

References (82)

1. ATSDR, Guidance Manual for the Joint Toxic Action of Chemical Mixtures. http://www.atsdr.cdc.gov/interactionpro fi les/ipga.html2004. 2004.
2. Jin, T.; Lu, J.; Nordberg, M., Toxicokinetics and biochemistry of cadmium with special emphasis on the role of metallothionein. Neurotoxicology., 1998, 19, (4-5), 529-535.
3. Waalkes, M.P., Cadmium carcinogenesis in review. J Inorg Biochem., 2000, 79, (1-4), 241-244. (Pubitemid 30628738)
4. Pesch, B.; Haerting, J.; Ranft, U.; Klimpel, A.; Oelschlagel, B.; Schill, W., Occupational risk factors for renal cell carcinoma: agent-specific results from a case-control study in Germany. MURC Study Group. Multicenter urothelial and renal cancer study. Int J Epidemiol., 2000, 29, (6), 1014-1024. (Pubitemid 32042102)
5. Joseph, P.; Muchnok, T.K.; Klishis, M.L.; Roberts, J.R.; Antonini, J.M.; Whong, W.Z.; Ong, T., Cadmium-induced cell transformation and tumorigenesis are associated with transcriptional activation of c-fos, c-jun, and c-myc proto-oncogenes: role of cellular calcium and reactive oxygen species. Toxicol Sci., 2001, 61, (2), 295-303. (Pubitemid 32499397)
6. Waalkes, M.P., Cadmium carcinogenesis. Mutat Res., 2003, 533, (1-2), 107-120. (Pubitemid 37487863)
7. Calevro, F.; Beyersmann, D.; Hartwig, A., Effect of cadmium(II) on the extent of oxidative DNA damage in primary brain cell cultures from Pleurodeles larvae. Toxicol Lett., 1998, 94, (3), 217-225. (Pubitemid 28231002)
8. Hirano, T.; Yamaguchi, Y.; Kasai, H., Inhibition of 8-hydroxyguanine repair in testes after administration of cadmium chloride to GSH-depleted rats. Toxicol Appl Pharmacol., 1997, 147, (1), 9-14. (Pubitemid 27490390)
9. Slebos, R.J.; Li, M.; Evjen, A.N.; Coffa, J.; Shyr, Y.; Yarbrough, W.G., Mutagenic effect of cadmium on tetranucleotide repeats in human cells. Mutat Res., 2006, 602, (1-2), 92-99. (Pubitemid 44693557)
10. Takiguchi, M.; Achanzar, W.E.; Qu, W.; Li, G.; Waalkes, M.P., Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation. Exp Cell Res., 2003, 286, (2), 355-365. (Pubitemid 36566447)
11. Benbrahim-Tallaa, L.; Waterland, R.A.; Dill, A.L.; Webber, M.M.; Waalkes, M.P., Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de novo DNA methyltransferase. Environ Health Perspect., 2007, 115, (10), 1454-1459. (Pubitemid 47618087)
12. IARC, Beryllium, cadmium, mercury, and exposures in the glass manufacturing industry. In: International Agency for Research on Cancer Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 58. IARC Scientific Publications, Lyon. 1998, (119-237).
13. Waalkes, M.P.; Rehm, S.; Cherian, M.G., Repeated cadmium exposures enhance the malignant progression of ensuing tumors in rats. Toxicol Sci., 2000, 54, (1), 110-120. (Pubitemid 30152462)
14. Waalkes, M.P.; Poirier, L.A., In vitro cadmium-DNA interactions: cooperativity of cadmium binding and competitive antagonism by calcium, magnesium, and zinc. Toxicol Appl Pharmacol., 1984, 75, (3), 539-546. (Pubitemid 14017222)
15. Abalea, V.; Cillard, J.; Dubos, M.P.; Sergent, O.; Cillard, P.; Morel, I., Repair of iron-induced DNA oxidation by the flavonoid myricetin in primary rat hepatocyte cultures. Free Radic Biol Med., 1999, 26, (11-12), 1457-1466. (Pubitemid 29302277)
16. Baccarelli, A.; Bollati, V., Epigenetics and environmental chemicals. Curr Opin Pediatr., 2009, 21, (2), 243-251.
17. Anway, M.D.; Cupp, A.S.; Uzumcu, M.; Skinner, M.K., Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science., 2005, 308, (5727), 1466-1469. (Pubitemid 40791300)
18. Cropley, J.E.; Suter, C.M.; Beckman, K.B.; Martin, D.I., Germ-line epigenetic modification of the murine A vy allele by nutritional supplementation. Proc Natl Acad Sci U S A., 2006, 103, (46), 17308-17312. (Pubitemid 44788965)
19. Dolinoy, D.C.; Huang, D.; Jirtle, R.L., Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. Proc Natl Acad Sci U S A., 2007, 104, (32), 13056-13061. (Pubitemid 351737592)
20. Ali, A.H.; Kondo, K.; Namura, T.; Senba, Y.; Takizawa, H.; Nakagawa, Y.; Toba, H.; Kenzaki, K.; Sakiyama, S.; Tangoku, A., Aberrant DNA methylation of some tumor suppressor genes in lung cancers from workers with chromate exposure. Mol Carcinog., 2011, 50, (2), 89-99.
21. Ji, W.; Yang, L.; Yu, L.; Yuan, J.; Hu, D.; Zhang, W.; Yang, J.; Pang, Y.; Li, W.; Lu, J.; Fu, J.; Chen, J.; Lin, Z.; Chen, W.; Zhuang, Z., Epigenetic silencing of O6-methylguanine DNA methyltransferase gene in NiStransformed cells. Carcinogenesis., 2008, 29, (6), 1267-1275. (Pubitemid 351958708)
22. Kondo, K.; Takahashi, Y.; Hirose, Y.; Nagao, T.; Tsuyuguchi, M.; Hashimoto, M.; Ochiai, A.; Monden, Y.; Tangoku, A., The reduced expression and aberrant methylation of p16(INK4a) in chromate workers with lung cancer. Lung Cancer., 2006, 53, (3), 295-302. (Pubitemid 44192596)
23. Holliday, R., The inheritance of epigenetic defects. Science., 1987, 238, (4824), 163-170. (Pubitemid 17139717)
24. Riddihough, G.; Pennisi, E., The evolution of epigenetics. Science., 2001, 293, (5532), 1063. (Pubitemid 32758073)
25. Rakyan, V.K.; Blewitt, M.E.; Druker, R.; Preis, J.I.; Whitelaw, E., Metastable epialleles in mammals. Trends Genet., 2002, 18, (7), 348-351. (Pubitemid 34804446)
26. Rakyan, V.K.; Chong, S.; Champ, M.E.; Cuthbert, P.C.; Morgan, H.D.; Luu, K.V.; Whitelaw, E., Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission. Proc Natl Acad Sci U S A., 2003, 100, (5), 2538-2543. (Pubitemid 36297534)
27. Bird, A., DNA methylation patterns and epigenetic memory. Genes Dev., 2002, 16, (1), 6-21. (Pubitemid 34049633)
28. Feinberg, A.P., Phenotypic plasticity and the epigenetics of human disease. Nature., 2007, 447, (7143), 433-440. (Pubitemid 46816750)
29. Umlauf, D.; Fraser, P.; Nagano, T., The role of long non-coding RNAs in chromatin structure and gene regulation: variations on a theme. Biol Chem., 2008, 389, (4), 323-331. (Pubitemid 351773916)
30. Alden, C.L., Safety assessment for non-genotoxic rodent carcinogens: curves, low-dose extrapolations, and mechanisms in carcinogenesis. Hum Exp Toxicol., 2000, 19, (10), 557-560; discussion 571-552. (Pubitemid 32117864)
31. Murphy, S.K.; Jirtle, R.L., Imprinting evolution and the price of silence. Bioessays., 2003, 25, (6), 577-588. (Pubitemid 36702326)
32. Jiang, Y.H.; Bressler, J.; Beaudet, A.L., Epigenetics and human disease. Annu Rev Genomics Hum Genet., 2004, 5, 479-510. (Pubitemid 39362754)
33. Bassett, S.S.; Avramopoulos, D.; Fallin, D., Evidence for parent of origin effect in late-onset Alzheimer disease. Am J Med Genet., 2002, 114, (6), 679-686.
34. Bassett, S.S.; Avramopoulos, D.; Perry, R.T.; Wiener, H.; Watson, B., Jr.; Go, R.C.; Fallin, M.D., Further evidence of a maternal parent-of-origin effect on chromosome 10 in late-onset Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet., 2006, 141B, (5), 537-540. (Pubitemid 44024449)
35. Petronis, A., The origin of schizophrenia: genetic thesis, epigenetic antithesis, and resolving synthesis. Biol Psychiatry., 2004, 55, (10), 965-970. (Pubitemid 38581910)
36. Vercelli, D., Genetics, epigenetics, and the environment: switching, buffering, releasing. J Allergy Clin Immunol., 2004, 113, (3), 381-386; quiz 387.
37. Lopez-Rangel, E.; Lewis, M.E., Loud and clear evidence for gene silencing by epigenetic mechanisms in autism spectrum and related neurodevelopmental disorders. Clin Genet., 2006, 69, (1), 21-22. (Pubitemid 43372219)
38. Szyf, M., The dynamic epigenome and its implications in toxicology. Toxicol Sci., 2007, 100, (1), 7-23. (Pubitemid 47617798)
39. Probst, A.V.; Dunleavy, E.; Almouzni, G., Epigenetic inheritance during the cell cycle. Nat Rev Mol Cell Biol., 2009, 10, (3), 192-206.
40. Talbert, P.B.; Henikoff, S., Spreading of silent chromatin: inaction at a distance. Nat Rev Genet., 2006, 7, (10), 793-803. (Pubitemid 44413223)
41. Miller, O.J.; Schnedl, W.; Allen, J.; Erlanger, B.F., 5-Methylcytosine localised in mammalian constitutive heterochromatin. Nature., 1974, 251, (5476), 636-637.
42. Orphanides, G.; Reinberg, D., A unified theory of gene expression. Cell., 2002, 108, (4), 439-451. (Pubitemid 34260870)
43. Jiang, G.; Xu, L.; Song, S.; Zhu, C.; Wu, Q.; Zhang, L.; Wu, L., Effects of long-term low-dose cadmium exposure on genomic DNA methylation in human embryo lung fibroblast cells. Toxicology., 2008, 244, (1), 49-55. (Pubitemid 50013239)
44. Poirier, L.A.; Vlasova, T.I., The prospective role of abnormal methyl metabolism in cadmium toxicity. Environ Health Perspect., 2002, 110 Suppl 5, 793-795. (Pubitemid 35276868)
45. Baylin, S.B., Mechanisms underlying epigenetically mediated gene silencing in cancer. Semin Cancer Biol., 2002, 12, (5), 331-337.
46. Goodman, J.I.; Watson, R.E., Altered DNA methylation: a secondary mechanism involved in carcinogenesis. Annu Rev Pharmacol Toxicol., 2002, 42, 501-525. (Pubitemid 34160534)
47. Razin, A.; Shemer, R., Epigenetic control of gene expression. Results Probl Cell Differ., 1999, 25, 189-204.
48. Tao, L.; Yang, S.; Xie, M.; Kramer, P.M.; Pereira, M.A., Effect of trichloroethylene and its metabolites, dichloroacetic acid and trichloroacetic acid, on the methylation and expression of c-Jun and c-Myc protooncogenes in mouse liver: prevention by methionine. Toxicol Sci., 2000, 54, (2), 399-407. (Pubitemid 30185962)
49. Benbrahim-Tallaa, L.; Waterland, R.A.; Styblo, M.; Achanzar, W.E.; Webber, M.M.; Waalkes, M.P., Molecular events associated with arsenicinduced malignant transformation of human prostatic epithelial cells: aberrant genomic DNA methylation and K-ras oncogene activation. Toxicol Appl Pharmacol., 2005, 206, (3), 288-298. (Pubitemid 41020671)
50. Saito, Y.; Kanai, Y.; Sakamoto, M.; Saito, H.; Ishii, H.; Hirohashi, S., Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis. Proc Natl Acad Sci U S A., 2002, 99, (15), 10060-10065. (Pubitemid 34831172)
51. Huang, D.; Zhang, Y.; Qi, Y.; Chen, C.; Ji, W., Global DNA hypomethylation, rather than reactive oxygen species (ROS), a potential facilitator of cadmium-stimulated K562 cell proliferation. Toxicol Lett., 2008, 179, (1), 43-47.
52. Wang, B.; Luo, Q.; Shao, C.; Li, X.; Li, F.; Liu, Y.N.; Sun, L.K.; Li, Y.; Cai, L., The late and presisent pathogenic effects of cadmium at very low lecels on the kidney of rats. Dose-Response., http://dose-response.metapress. com/app/home/contribution.asp?referrer=parent&backto=issue,27,35;journal,1, 28 ;linkingpublicationresults,1:119866,1.
53. Wang, B.; Wang, S.; Shao, C.; Wang, G.Y.; Li, Y.; Cai, L., Proteomic characterization of the late and persistent effects of cadmium at low doses on the rat liver. Journal of Applied Toxicology., 2011 Nov 11. doi: 10.1002/jat.1757. [Epub ahead of print].
54. Wang, B.; Li, Y.; Tan, Y.; Liu, X.D.; Shao, C.; Yang, X.; Subat Turdi, Ma, L.J.; Ren, J.; Cai, L., Low-dose cadmium induces hepatic gene hypermethylation, along with persistent lose of cell death and increase of cell proliferation in rats and mice. PLoS ONE., 2012, 7, (3), e33853.
55. Zhou, Z.H.; Lei, Y.X.; Wang, C.X., Analysis of aberrant methylation in DNA repair genes during malignant transformation of human bronchial epithelial cells induced by cadmium. Toxicol Sci., 2012, 125, (2), 412-417.
56. Ronco, A.M.; Llaguno, E.; Epunan, M.J.; Llanos, M.N., Effect of cadmium on cortisol production and 11beta-hydroxysteroid dehydrogenase 2 expression by cultured human choriocarcinoma cells (JEG-3). Toxicol In Vitro., 2010, 24, (6), 1532-1537.
57. Lai, S.R.; Phipps, S.M.; Liu, L.; Andrews, L.G.; Tollefsbol, T.O., Epigenetic control of telomerase and modes of telomere maintenance in aging and abnormal systems. Front Biosci., 2005, 10, 1779-1796. (Pubitemid 40529038)
58. Doi, T.; Puri, P.; McCann, A.; Bannigan, J.; Thompson, J., Epigenetic Effect of Cadmium on Global De Novo DNA Hypomethylation in the Cadmium-Induced Ventral Body Wall Defect (VBWD) in the Chick Model. Toxicol Sci., 2011, 120, (2), 475-480.
59. Valinluck, V.; Tsai, H.H.; Rogstad, D.K.; Burdzy, A.; Bird, A.; Sowers, L.C., Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2). Nucleic Acids Res., 2004, 32, (14), 4100-4108. (Pubitemid 39232282)
60. Turk, P.W.; Laayoun, A.; Smith, S.S.; Weitzman, S.A., DNA adduct 8-hydroxyl-2'-deoxyguanosine (8-hydroxyguanine) affects function of human DNA methyltransferase. Carcinogenesis., 1995, 16, (5), 1253-1255.
61. Jenuwein, T.; Allis, C.D., Translating the histone code. Science., 2001, 293, (5532), 1074-1080. (Pubitemid 32758077)
62. Slimova; misurova, E., Effects of Cadmium and Ionizing Radiation on Histones in Rat Testes. ACTA VET. BRNO., 2004, 73, 6.
63. Bartel, D.P., MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004, 116, (2), 281-297.
64. Lee, R.C.; Feinbaum, R.L.; Ambros, V., The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell., 1993, 75, (5), 843-854. (Pubitemid 24014542)
65. Ambros, V., MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing. Cell., 2003, 113, (6), 673-676. (Pubitemid 36724931)
66. Cullen, B.R., Viral and cellular messenger RNA targets of viral microRNAs. Nature., 2009, 457, (7228), 421-425.
67. Chen, C.Z., MicroRNAs as oncogenes and tumor suppressors. N Engl J Med., 2005, 353, (17), 1768-1771.
68. Vandenboom Ii, T.G.; Li, Y.; Philip, P.A.; Sarkar, F.H., MicroRNA and Cancer: Tiny Molecules with Major Implications. Curr Genomics., 2008, 9, (2), 97-109. (Pubitemid 351888527)
69. Huang, S.Q.; Peng, J.; Qiu, C.X.; Yang, Z.M., Heavy metal-regulated new microRNAs from rice. J Inorg Biochem., 2009, 103, (2), 282-287.
70. Choi, A.O.; Brown, S.E.; Szyf, M.; Maysinger, D., Quantum dot-induced epigenetic and genotoxic changes in human breast cancer cells. J Mol Med (Berl)., 2008, 86, (3), 291-302. (Pubitemid 351311423)
71. Li, S.; Wang, Y.; Wang, H.; Bai, Y.; Liang, G.; Huang, N.; Xiao, Z., MicroRNAs as participants in cytotoxicity of CdTe quantum dots in NIH/3T3 cells. Biomaterials., 2011, 32, (15), 3807-3814.
72. Li, S.; Wang, H.; Qi, Y.; Tu, J.; Bai, Y.; Tian, T.; Huang, N.; Wang, Y.; Xiong, F.; Lu, Z.; Xiao, Z., Assessment of nanomaterial cytotoxicity with SOLiD sequencing-based microRNA expression profiling. Biomaterials., 2011, 32, (34), 9021-9030.
73. Ding, Y.; Chen, Z.; Zhu, C., Microarray-based analysis of cadmiumresponsive microRNAs in rice (Oryza sativa). J Exp Bot., 2011, 62, (10), 3563-3573.
74. Yeung, M.L.; Yasunaga, J.; Bennasser, Y.; Dusetti, N.; Harris, D.; Ahmad, N.; Matsuoka, M.; Jeang, K.T., Roles for microRNAs, miR-93 and miR-130b, and tumor protein 53-induced nuclear protein 1 tumor suppressor in cell growth dysregulation by human T-cell lymphotrophic virus 1. Cancer Res., 2008, 68, (21), 8976-8985.
75. Cherian, M.G.; Howell, S.B.; Imura, N.; Klaassen, C.D.; Koropatnick, J.; Lazo, J.S.; Waalkes, M.P., Role of metallothionein in carcinogenesis. Toxicol Appl Pharmacol., 1994, 126, (1), 1-5. (Pubitemid 24168861)
76. Compere, S.J.; Palmiter, R.D., DNA methylation controls the inducibility of the mouse metallothionein-I gene lymphoid cells. Cell., 1981, 25, (1), 233-240. (Pubitemid 11087451)
77. Stallings, R.L.; Crawford, B.D.; Tobey, R.A.; Tesmer, J.; Hildebrand, C.E., 5-Azacytidine-induced conversion to cadmium resistance correlates with early S phase replication of inactive metallothionein genes in synchronized CHO cells. Somat Cell Mol Genet., 1986, 12, (5), 423-432. (Pubitemid 16030762)
78. Somji, S.; Garrett, S.H.; Zhou, X.D.; Zheng, Y.; Sens, D.A.; Sens, M.A., Absence of Metallothionein 3 Expression in Breast Cancer is a Rare, But Favorable Marker of Outcome that is Under Epigenetic Control. Toxicol Environ Chem., 2010, 92, (9), 1673-1695.
79. Majumder, S.; Kutay, H.; Datta, J.; Summers, D.; Jacob, S.T.; Ghoshal, K., Epigenetic regulation of metallothionein-i gene expression: differential regulation of methylated and unmethylated promoters by DNA methyltransferases and methyl CpG binding proteins. J Cell Biochem., 2006, 97, (6), 1300-1316.
80. Somji, S.; Garrett, S.H.; Toni, C.; Zhou, X.D.; Zheng, Y.; Ajjimaporn, A.; Sens, M.A.; Sens, D.A., Differences in the epigenetic regulation of MT-3 gene expression between parental and Cd+2 or As+3 transformed human urothelial cells. Cancer Cell Int., 2011, 11, (1), 2.
81. Fragou, D.; Fragou, A.; Kouidou, S.; Njau, S.; Kovatsi, L., Epigenetic mechanisms in metal toxicity. Toxicol Mech Methods., 2011, 21, (4), 343-352.
82. Singh, K.P.; Kumari, R.; Pevey, C.; Jackson, D.; DuMond, J.W., Long duration exposure to cadmium leads to increased cell survival, decreased DNA repair capacity, and genomic instability in mouse testicular Leydig cells. Cancer Lett., 2009, 279, (1), 84-92.