Effects of simvastatin on hepatic cholesterol metabolism, bile lithogenicity and bile acid hydrophobicity in patients with gallstones

Journal of Gastroenterology and Hepatology (Australia)

Volumn 15, Issue 8, 2000, Pages 871-879

  Smith, Jeffery L ^a   Roach, Paul D ^b   Wittenberg, Leonie N ^a   Riottot, Michel ^c   Praga Pillay, S ^a   Nestel, Paul J ^b   Nathanson, Les K ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b CSIRO   (Australia)

^c UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

3 hydroxy 3 methylglutaryl coenzyme A reductase inhibitors; Biliary lipids; Choleretic; Lithogenic index; Low density lipoprotein receptor

Indexed keywords

BILE ACID; CHOLERETIC AGENT; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LATHOSTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; PHYTOSTEROL; SIMVASTATIN; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; BILE; CHOLESTEROL BILE LEVEL; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CLINICAL TRIAL; COMMON BILE DUCT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; FEMALE; GALLBLADDER; GALLSTONE; HUMAN; HUMAN TISSUE; HYDROPHOBICITY; LIPID ABSORPTION; LIVER METABOLISM; MAJOR CLINICAL STUDY; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STONE FORMATION;

EID: 0033799058     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1746.2000.02231.x     Document Type: Article

References (52)

1. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
2. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
3. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and recurrent events trial investigators
4. Effects of long-term treatment with low-dose pravastatin on biliary lipid and bile acid composition in patients with nonfamilial hyperlipoproteinemia
5. The effects of the 3-hydroxy,3-methylglutaryl coenzyme A reductase inhibitor pravastatin on bile composition and nucleation of cholesterol crystals in cholesterol gallstone disease
6. Short-term effects of simvastatin on bile acid synthesis and bile lipid secretion in human subjects
7. Effect of simvastatin, ursodeoxycholic acid and simvastatin plus ursodeoxycholic acid on biliary lipid secretion and cholic acid kinetics in nonfamilial hypercholesterolemia
8. Influence of pravastatin, a specific inhibitor of HMG-CoA reductase, on hepatic metabolism of cholesterol
9. Simvastatin, a competitive inhibitor of HMG-CoA reductase, lowers cholesterol saturation index of gallbladder bile
10. Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog
11. Regulation of hepatic receptor-dependent degradation of LDL by mevinolin in rabbits with hypercholesterolemia induced by a wheat starch-casein diet
12. Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprorein receptor in livers of hamsters and rabbits
13. Coordinate changes in the low density lipoprorein receptor activity of liver and mononuclear cells in the rabbit
14. Lovastatin therapy reduces low density lipoprotein apoB levels in subjects with combined hyperlipidemia by reducing the production of apoB-containing lipoproteins: Implications for the pathophysiology of apoB production
15. Effects of lovastatin therapy on very-low-density lipoprotein triglyceride metabolism in subjects with combined hyperlipidemia: Evidence for reduced assembly and secretion of triglyceride-rich lipoproteins
16. Effects of simvastatin on plasma lipoprotein concentrations and very-low-density lipoprotein secretion in the rat
17. Simvastatin decreases the hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 in heterozygous familial hypercholesterolaemia: Pathophysiological and therapeutic implications
18. Changes in biliary lipid secretion and cholic acid kinetics induced by diet, diet plus simvastatin and diet plus ursodeoxycholic acid in obese subjects
19. Effects of lovastatin on biliary lipid secretion and bile acid metabolism in humans
20. Physical-chemical basis of gallstone formation
21. Bile sampling, processing and analysis in clinical studies
22. The effects of hypercholesterolaemia, simvastatin and dietary fat on the low density lipoprotein receptor of unstimulated mononuclear cells
23. Regulation of rat liver microsomal cholesterol 7α-hydroxylase: Presence of a cytosolic activator
24. Developmental expression of elements of hepatic cholesterol metabolism in the rat
25. 7-Ketocholesterol. Its effects on hepatic cholesterogenesis and its hepatic metabolism in vivo and in vitro
26. Hepatic acyl-coenzyme A: Cholesterol acyltransferase activity is decreased in patients with cholesterol gallstones
27. Effect of exogenous cholesterol and dithiothreitol on the activity of human liver microsomal acyl-coenzyme A: Cholesterol acyltransferase (ACAT)
28. The low-density lipoprotein receptor and cholesterol synthesis are affected differently by dietary cholesterol in the rat
29. Protein measurement with the folin phenol reagant
30. Use of determinations of 7-lathosterol (5α-cholest-7-en-3β-ol) and other cholesterol precursors in serum in the study and treatment of disturbances of sterol metabolism, particularly cerebrotendinous xanthomatosis
31. A simple method for the isolation and purification of total lipids from animal tissues
32. Hypocholesterolemic action of β-cyclodextrin and its effects on cholesterol metabolism in pigs fed a cholesterol-enriched diet
33. Analysis of metabolic profiles of bile acids in urine using a lipophilic anion exchanger and computerized gas-liquid chromatography-mass spectrometry
34. Quantitative estimation of the hydrophilic-hydrophobic balance of mixed bile salt solutions
35. Critical tables for calculating the cholesterol saturation of native bile
36. A simple calculation of the lithogenic index of bile: Expressing biliary lipid composition on rectangular coordinates
37. Inhibition of cholesterogenesis decreases hepatic secretion of apoB-100 in normolipidemic subjects
38. Attenuation of plasma low density lipoprotein cholesterol by select 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in mice devoid of low density lipoprotein receptors
39. Inhibition of hepatic ACAT decreases apoB secretion in miniature pigs fed a cholesterol-free diet
40. Inhibition of acyl-CoA: Cholesterol acyltransferase decreases apolipoprotein B-100-containing lipoprorein secretion from HepG2 cells
41. Cholesterol metabolism and serum and biliary noncholesterol sterols in gallstone patients during simvastatin and ursodeoxycholic acid treatments
42. Pathogenesis of cholesterol gallstones: A parsimonious hypothesis
43. Influence of bile acid structure on bile flow and biliary lipid secretion in the hamster
44. Bile salt hydrophobicity influences cholesterol recruitment from rat liver in vivo when cholesterol synthesis and lipoprotein uptake are constant
45. Regulation of bile acid synthesis. III. Correlation between biliary bile salt hydrophobicity index and the activities of enzymes regulating cholesterol and bile acid synthesis in the rat
46. Short-term effects of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor on cholesterol and bile acid synthesis in humans
47. Function and regulation of hydroxylases involved in the bile acid biosynthesis pathways
48. Formation of cholic acid and chenodeoxycholic acid from 7 alpha-hydroxycholesterol and 27-hydroxycholesterol by primary cultures of human hepatocytes
49. Simvastatin and ursodeoxycholic acid for rapid gallstone dissolution
50. Dissolution of gallstones with simvastatin, an HMG CoA reductase inhibitor
51. A combination therapy with simvastatin and ursodeoxycholic acid is more effective for cholesterol gallstone dissolution than is ursodeoxycholic acid monotherapy
52. Lith1, a major gene affecting cholesterol gallstone formation among inbred strains of mice