메뉴 건너뛰기




Volumn 44, Issue 3, 2013, Pages 159-168

Methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and risk of preeclampsia: An updated meta-analysis based on 51 studies

Author keywords

Homocysteine; Meta analysis; MTHFR; Polymorphism; Preeclampsia

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

EID: 84876851366     PISSN: 01884409     EISSN: 18735487     Source Type: Journal    
DOI: 10.1016/j.arcmed.2013.01.011     Document Type: Article
Times cited : (35)

References (85)
  • 1
    • 0031431326 scopus 로고    scopus 로고
    • Epidemiology of pregnancy-induced hypertension
    • Zhang J., Zeisler J., Hatch M.C., et al. Epidemiology of pregnancy-induced hypertension. Epidemiol Rev 1997, 19:218-232.
    • (1997) Epidemiol Rev , vol.19 , pp. 218-232
    • Zhang, J.1    Zeisler, J.2    Hatch, M.C.3
  • 2
    • 0035725012 scopus 로고    scopus 로고
    • Lipoprotein lipase gene mutations and the genetic susceptibility of preeclampsia
    • Kim Y.J., Williamson R.A., Chen K., et al. Lipoprotein lipase gene mutations and the genetic susceptibility of preeclampsia. Hypertension 2001, 38:992-996.
    • (2001) Hypertension , vol.38 , pp. 992-996
    • Kim, Y.J.1    Williamson, R.A.2    Chen, K.3
  • 3
    • 35348971276 scopus 로고    scopus 로고
    • Genetic aspects of preeclampsia
    • Laivuori H. Genetic aspects of preeclampsia. Front Biosci 2007, 12:2372-2382.
    • (2007) Front Biosci , vol.12 , pp. 2372-2382
    • Laivuori, H.1
  • 4
    • 2542433063 scopus 로고    scopus 로고
    • Homocysteine and folic acid are inversely related in black women with preeclampsia
    • Patrick T.E., Powers R.W., Daftary A.R., et al. Homocysteine and folic acid are inversely related in black women with preeclampsia. Hypertension 2004, 43:1279-1282.
    • (2004) Hypertension , vol.43 , pp. 1279-1282
    • Patrick, T.E.1    Powers, R.W.2    Daftary, A.R.3
  • 5
    • 0033049262 scopus 로고    scopus 로고
    • Plasma homocysteine levels elevated and inversely related to insulin sensitivity in preeclampsia
    • Laivuori H., Kaaja R., Turpeinen U., et al. Plasma homocysteine levels elevated and inversely related to insulin sensitivity in preeclampsia. Obstet Gynecol 1999, 93:489-493.
    • (1999) Obstet Gynecol , vol.93 , pp. 489-493
    • Laivuori, H.1    Kaaja, R.2    Turpeinen, U.3
  • 7
    • 0027330937 scopus 로고
    • Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss
    • Wouters M.G., Boers G.H., Blom H.J., et al. Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss. Fertil Steril 1993, 60:820-825.
    • (1993) Fertil Steril , vol.60 , pp. 820-825
    • Wouters, M.G.1    Boers, G.H.2    Blom, H.J.3
  • 8
    • 0028149224 scopus 로고
    • Maternal hyperhomocysteinemia: a risk factor for neural-tube defects
    • Steegers-Theunissen R.P., Boers G.H., Trijbels F.J., et al. Maternal hyperhomocysteinemia: a risk factor for neural-tube defects. Metabolism 1994, 43:1475-1480.
    • (1994) Metabolism , vol.43 , pp. 1475-1480
    • Steegers-Theunissen, R.P.1    Boers, G.H.2    Trijbels, F.J.3
  • 9
    • 0035923560 scopus 로고    scopus 로고
    • Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine
    • Stuhlinger M.C., Tsao P.S., Her J.H., et al. Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine. Circulation 2001, 104:2569-2575.
    • (2001) Circulation , vol.104 , pp. 2569-2575
    • Stuhlinger, M.C.1    Tsao, P.S.2    Her, J.H.3
  • 10
    • 84865694338 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase enhancer for protection of endothelial function from asymmetric dimethylarginine-induced injury in human internal thoracic artery
    • Xuan C., Chang F.J., Liu X.C., et al. Endothelial nitric oxide synthase enhancer for protection of endothelial function from asymmetric dimethylarginine-induced injury in human internal thoracic artery. J Thorac Cardiovasc Surg 2012, 144:697-703.
    • (2012) J Thorac Cardiovasc Surg , vol.144 , pp. 697-703
    • Xuan, C.1    Chang, F.J.2    Liu, X.C.3
  • 11
    • 0028487161 scopus 로고
    • Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification
    • Goyette P., Sumner J.S., Milos R., et al. Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification. Nat Genet 1994, 7:195-200.
    • (1994) Nat Genet , vol.7 , pp. 195-200
    • Goyette, P.1    Sumner, J.S.2    Milos, R.3
  • 12
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase
    • Frosst P., Blom H.J., Milos R., et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995, 10:111-113.
    • (1995) Nat Genet , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3
  • 13
    • 0032497941 scopus 로고    scopus 로고
    • Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis
    • Brattstrom L., Wilcken D.E., Ohrvik J., et al. Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis. Circulation 1998, 98:2520-2526.
    • (1998) Circulation , vol.98 , pp. 2520-2526
    • Brattstrom, L.1    Wilcken, D.E.2    Ohrvik, J.3
  • 14
    • 0033531184 scopus 로고    scopus 로고
    • Increased frequency of genetic thrombophilia in women with complications of pregnancy
    • Kupferminc M.J., Eldor A., Steinman N., et al. Increased frequency of genetic thrombophilia in women with complications of pregnancy. N Engl J Med 1999, 340:9-13.
    • (1999) N Engl J Med , vol.340 , pp. 9-13
    • Kupferminc, M.J.1    Eldor, A.2    Steinman, N.3
  • 15
    • 0033887407 scopus 로고    scopus 로고
    • Hyperhomocysteinemia and thrombosis
    • Makris M. Hyperhomocysteinemia and thrombosis. Clin Lab Haematol 2000, 22:133-143.
    • (2000) Clin Lab Haematol , vol.22 , pp. 133-143
    • Makris, M.1
  • 16
    • 0030826587 scopus 로고    scopus 로고
    • Thermolabile methylenetetrahydrofolate reductase in coronary artery disease
    • Kluijtmans L.A., Kastelein J.J., Lindemans J., et al. Thermolabile methylenetetrahydrofolate reductase in coronary artery disease. Circulation 1997, 96:2573-2577.
    • (1997) Circulation , vol.96 , pp. 2573-2577
    • Kluijtmans, L.A.1    Kastelein, J.J.2    Lindemans, J.3
  • 17
    • 4344599724 scopus 로고    scopus 로고
    • Association of C677T polymorphism in the methylenetetrahydrofolate reductase gene with hypertension in pregnancy and pre-eclampsia: a meta-analysis
    • Kosmas I.P., Tatsioni A., Ioannidis J.P. Association of C677T polymorphism in the methylenetetrahydrofolate reductase gene with hypertension in pregnancy and pre-eclampsia: a meta-analysis. J Hypertens 2004, 22:1655-1662.
    • (2004) J Hypertens , vol.22 , pp. 1655-1662
    • Kosmas, I.P.1    Tatsioni, A.2    Ioannidis, J.P.3
  • 18
    • 84870824739 scopus 로고    scopus 로고
    • Meta-analysis of the methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to pre-eclampsia
    • Xia X.P., Chang W.W., Cao Y.X. Meta-analysis of the methylenetetrahydrofolate reductase C677T polymorphism and susceptibility to pre-eclampsia. Hypertens Res 2012, 35:1129-1134.
    • (2012) Hypertens Res , vol.35 , pp. 1129-1134
    • Xia, X.P.1    Chang, W.W.2    Cao, Y.X.3
  • 19
    • 84857039485 scopus 로고    scopus 로고
    • Association between OCTN1/2 gene polymorphisms (1672C-T, 207G-C) and susceptibility of Crohn's disease: a meta-analysis
    • Xuan C., Zhang B.B., Yang T., et al. Association between OCTN1/2 gene polymorphisms (1672C-T, 207G-C) and susceptibility of Crohn's disease: a meta-analysis. Int J Colorectal Dis 2012, 27:11-19.
    • (2012) Int J Colorectal Dis , vol.27 , pp. 11-19
    • Xuan, C.1    Zhang, B.B.2    Yang, T.3
  • 20
    • 80051583859 scopus 로고    scopus 로고
    • No association between APOE epsilon 4 allele and multiple sclerosis susceptibility: a meta-analysis from 5472 cases and 4727 controls
    • Xuan C., Zhang B.B., Li M., et al. No association between APOE epsilon 4 allele and multiple sclerosis susceptibility: a meta-analysis from 5472 cases and 4727 controls. J Neurol Sci 2011, 308:110-116.
    • (2011) J Neurol Sci , vol.308 , pp. 110-116
    • Xuan, C.1    Zhang, B.B.2    Li, M.3
  • 21
    • 84856900237 scopus 로고    scopus 로고
    • Association between polymorphism of methylenetetrahydrofolate reductase (MTHFR) C677T and risk of myocardial infarction: a meta-analysis for 8,140 cases and 10,522 controls
    • Xuan C., Bai X.Y., Gao G., et al. Association between polymorphism of methylenetetrahydrofolate reductase (MTHFR) C677T and risk of myocardial infarction: a meta-analysis for 8,140 cases and 10,522 controls. Arch Med Res 2011, 42:677-685.
    • (2011) Arch Med Res , vol.42 , pp. 677-685
    • Xuan, C.1    Bai, X.Y.2    Gao, G.3
  • 22
    • 13244271259 scopus 로고    scopus 로고
    • Genetic thrombophilias and preeclampsia: a meta-analysis
    • Lin J., August P. Genetic thrombophilias and preeclampsia: a meta-analysis. Obstet Gynecol 2005, 105:182-192.
    • (2005) Obstet Gynecol , vol.105 , pp. 182-192
    • Lin, J.1    August, P.2
  • 23
    • 0035212604 scopus 로고    scopus 로고
    • C677T methylenetetrahydrofolate reductase polymorphism is not a risk factor for pre-eclampsia/eclampsia among Australian women
    • Kaiser T., Brennecke S.P., Moses E.K. C677T methylenetetrahydrofolate reductase polymorphism is not a risk factor for pre-eclampsia/eclampsia among Australian women. Hum Hered 2001, 51:20-22.
    • (2001) Hum Hered , vol.51 , pp. 20-22
    • Kaiser, T.1    Brennecke, S.P.2    Moses, E.K.3
  • 24
    • 0033709294 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphisms in preeclampsia and the HELLP syndrome
    • Zusterzeel P.L., Visser W., Blom H.J., et al. Methylenetetrahydrofolate reductase polymorphisms in preeclampsia and the HELLP syndrome. Hypertens Pregnancy 2000, 19:299-307.
    • (2000) Hypertens Pregnancy , vol.19 , pp. 299-307
    • Zusterzeel, P.L.1    Visser, W.2    Blom, H.J.3
  • 25
    • 52949113431 scopus 로고    scopus 로고
    • Carriage of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism does not influence the first and second trimester uterine artery Doppler flow
    • Stonek F., Hafner E., Metzenbauer M., et al. Carriage of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism does not influence the first and second trimester uterine artery Doppler flow. Eur J Obstet Gynecol Reprod Biol 2008, 140:178-182.
    • (2008) Eur J Obstet Gynecol Reprod Biol , vol.140 , pp. 178-182
    • Stonek, F.1    Hafner, E.2    Metzenbauer, M.3
  • 26
    • 0034079143 scopus 로고    scopus 로고
    • Severe preeclampsia and high frequency of genetic thrombophilic mutations
    • Kupferminc M.J., Fait G., Many A., et al. Severe preeclampsia and high frequency of genetic thrombophilic mutations. Obstet Gynecol 2000, 96:45-49.
    • (2000) Obstet Gynecol , vol.96 , pp. 45-49
    • Kupferminc, M.J.1    Fait, G.2    Many, A.3
  • 27
    • 0034854445 scopus 로고    scopus 로고
    • Association of polymorphism of methylenetetrahydrofolate reductase with urinary albumin excretion rate in type 1 diabetes mellitus but not with preeclampsia, retinopathy, and preterm delivery
    • Lauszus F.F., Grøn P.L., Klebe J.G. Association of polymorphism of methylenetetrahydrofolate reductase with urinary albumin excretion rate in type 1 diabetes mellitus but not with preeclampsia, retinopathy, and preterm delivery. Acta Obstet Gynecol Scand 2001, 80:803-806.
    • (2001) Acta Obstet Gynecol Scand , vol.80 , pp. 803-806
    • Lauszus, F.F.1    Grøn, P.L.2    Klebe, J.G.3
  • 28
    • 0037379927 scopus 로고    scopus 로고
    • The 677 C-T methylenetetrahydrofolate reductase mutation does not predict increased maternal homocysteine during pregnancy
    • Powers R.W., Dunbar M.S., Gallaher M.J., et al. The 677 C-T methylenetetrahydrofolate reductase mutation does not predict increased maternal homocysteine during pregnancy. Obstet Gynecol 2003, 101:762-766.
    • (2003) Obstet Gynecol , vol.101 , pp. 762-766
    • Powers, R.W.1    Dunbar, M.S.2    Gallaher, M.J.3
  • 29
    • 33745699903 scopus 로고    scopus 로고
    • Evaluation of factor V Leiden, prothrombin and methylenetetrahydrofolate reductase gene mutations in patients with severe pregnancy complications in northern Finland
    • Jarvenpaa J., Pakkila M., Savolainen E.R., et al. Evaluation of factor V Leiden, prothrombin and methylenetetrahydrofolate reductase gene mutations in patients with severe pregnancy complications in northern Finland. Gynecol Obstet Invest 2006, 62:28-32.
    • (2006) Gynecol Obstet Invest , vol.62 , pp. 28-32
    • Jarvenpaa, J.1    Pakkila, M.2    Savolainen, E.R.3
  • 30
    • 33646818342 scopus 로고    scopus 로고
    • The relationship between thrombophilic mutations and preeclampsia: a prospective case-control study
    • Yalinkaya A., Erdemoglu M., Akdeniz N., et al. The relationship between thrombophilic mutations and preeclampsia: a prospective case-control study. Ann Saudi Med 2006, 26:105-109.
    • (2006) Ann Saudi Med , vol.26 , pp. 105-109
    • Yalinkaya, A.1    Erdemoglu, M.2    Akdeniz, N.3
  • 31
    • 0030919077 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism and pre-eclampsia
    • Sohda S., Arinami T., Hamada H., et al. Methylenetetrahydrofolate reductase polymorphism and pre-eclampsia. J Med Genet 1997, 34:525-526.
    • (1997) J Med Genet , vol.34 , pp. 525-526
    • Sohda, S.1    Arinami, T.2    Hamada, H.3
  • 32
    • 0030743692 scopus 로고    scopus 로고
    • Factor V Leiden, C>T MTHFR polymorphism and genetic susceptibility to preeclampsia
    • Grandone E., Margaglione M., Colaizzo D., et al. Factor V Leiden, C>T MTHFR polymorphism and genetic susceptibility to preeclampsia. Thromb Haemost 1997, 77:1052-1054.
    • (1997) Thromb Haemost , vol.77 , pp. 1052-1054
    • Grandone, E.1    Margaglione, M.2    Colaizzo, D.3
  • 33
    • 0032697849 scopus 로고    scopus 로고
    • 5,10 methylenetetrahydrofolate reductase polymorphism in black South African women with pre-eclampsia
    • Chikosi A.B., Moodley J., Pegoraro R.J., et al. 5,10 methylenetetrahydrofolate reductase polymorphism in black South African women with pre-eclampsia. Br J Obstet Gynaecol 1999, 106:1219-1220.
    • (1999) Br J Obstet Gynaecol , vol.106 , pp. 1219-1220
    • Chikosi, A.B.1    Moodley, J.2    Pegoraro, R.J.3
  • 34
    • 0032978344 scopus 로고    scopus 로고
    • Factor V Leiden and thermolabile methylenetetrahydrofolate reductase gene variants in an East Anglian preeclampsia cohort
    • O'Shaughnessy K.M., Fu B., Ferraro F., et al. Factor V Leiden and thermolabile methylenetetrahydrofolate reductase gene variants in an East Anglian preeclampsia cohort. Hypertension 1999, 33:1338-1341.
    • (1999) Hypertension , vol.33 , pp. 1338-1341
    • O'Shaughnessy, K.M.1    Fu, B.2    Ferraro, F.3
  • 35
    • 0032923636 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism, folate, and susceptibility to preeclampsia
    • Powers R.W., Minich L.A., Lykins D.L., et al. Methylenetetrahydrofolate reductase polymorphism, folate, and susceptibility to preeclampsia. J Soc Gynecol Investig 1999, 6:74-79.
    • (1999) J Soc Gynecol Investig , vol.6 , pp. 74-79
    • Powers, R.W.1    Minich, L.A.2    Lykins, D.L.3
  • 36
    • 0033623927 scopus 로고    scopus 로고
    • 677 C-->T polymorphism of the methylenetetrahydrofolate reductase gene and preeclampsia
    • Laivuori H., Kaaja R., Ylikorkala O., et al. 677 C-->T polymorphism of the methylenetetrahydrofolate reductase gene and preeclampsia. Obstet Gynecol 2000, 96:277-280.
    • (2000) Obstet Gynecol , vol.96 , pp. 277-280
    • Laivuori, H.1    Kaaja, R.2    Ylikorkala, O.3
  • 37
    • 0034679870 scopus 로고    scopus 로고
    • Absence of association between a common mutation in the methylenetetrahydrofolate reductase gene and preeclampsia in Japanese women
    • Kobashi G., Yamada H., Asano T., et al. Absence of association between a common mutation in the methylenetetrahydrofolate reductase gene and preeclampsia in Japanese women. Am J Med Genet 2000, 93:122-125.
    • (2000) Am J Med Genet , vol.93 , pp. 122-125
    • Kobashi, G.1    Yamada, H.2    Asano, T.3
  • 38
    • 0033932801 scopus 로고    scopus 로고
    • Maternal and neonatal outcome of preeclamptic pregnancies: the potential roles of factor V Leiden mutation and 5,10 methylenetetrahydrofolate reductase
    • Rigo J., Nagy B., Fintor L., et al. Maternal and neonatal outcome of preeclamptic pregnancies: the potential roles of factor V Leiden mutation and 5,10 methylenetetrahydrofolate reductase. Hypertens Pregnancy 2000, 19:163-172.
    • (2000) Hypertens Pregnancy , vol.19 , pp. 163-172
    • Rigo, J.1    Nagy, B.2    Fintor, L.3
  • 39
    • 0033969894 scopus 로고    scopus 로고
    • 12 concentrations, and risk of preeclampsia among black African women from Zimbabwe
    • 12 concentrations, and risk of preeclampsia among black African women from Zimbabwe. Mol Genet Metab 2000, 69:33-39.
    • (2000) Mol Genet Metab , vol.69 , pp. 33-39
    • Rajkovic, A.1    Mahomed, K.2    Rozen, R.3
  • 40
    • 0033815121 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphisms are not a risk factor for pre-eclampsia/eclampsia in Australian women
    • Kaiser T., Brennecke S.P., Moses E.K. Methylenetetrahydrofolate reductase polymorphisms are not a risk factor for pre-eclampsia/eclampsia in Australian women. Gynecol Obstet Invest 2000, 50:100-102.
    • (2000) Gynecol Obstet Invest , vol.50 , pp. 100-102
    • Kaiser, T.1    Brennecke, S.P.2    Moses, E.K.3
  • 41
    • 0034054083 scopus 로고    scopus 로고
    • The common C677T polymorphism in the methylenetetrahydrofolate reductase gene is associated with neural tube defects and preeclampsia
    • (in Chinese)
    • Li K., Zheng D., Xue Y., et al. The common C677T polymorphism in the methylenetetrahydrofolate reductase gene is associated with neural tube defects and preeclampsia. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2000, 17:76-78. (in Chinese).
    • (2000) Zhonghua Yi Xue Yi Chuan Xue Za Zhi , vol.17 , pp. 76-78
    • Li, K.1    Zheng, D.2    Xue, Y.3
  • 42
    • 0034912277 scopus 로고    scopus 로고
    • Low-molecular-weight heparin for the prevention of obstetric complications in women with thrombophilias
    • Kupferminc M.J., Fait G., Many A., et al. Low-molecular-weight heparin for the prevention of obstetric complications in women with thrombophilias. Hypertens Pregnancy 2001, 20:35-44.
    • (2001) Hypertens Pregnancy , vol.20 , pp. 35-44
    • Kupferminc, M.J.1    Fait, G.2    Many, A.3
  • 43
    • 0035340294 scopus 로고    scopus 로고
    • Genetic susceptibility to preeclampsia: roles of cytosine-to-thymine substitution at nucleotide 677 of the gene for methylenetetrahydrofolate reductase, 68-base pair insertion at nucleotide 844 of the gene for cystathionine beta-synthase, and factor V Leiden mutation
    • Kim Y.J., Williamson R.A., Murray J.C., et al. Genetic susceptibility to preeclampsia: roles of cytosine-to-thymine substitution at nucleotide 677 of the gene for methylenetetrahydrofolate reductase, 68-base pair insertion at nucleotide 844 of the gene for cystathionine beta-synthase, and factor V Leiden mutation. Am J Obstet Gynecol 2001, 184:1211-1217.
    • (2001) Am J Obstet Gynecol , vol.184 , pp. 1211-1217
    • Kim, Y.J.1    Williamson, R.A.2    Murray, J.C.3
  • 45
    • 0034924655 scopus 로고    scopus 로고
    • Maternal and fetal inherited thrombophilias are not related to the development of severe preeclampsia
    • Livingston J.C., Barton J.R., Park V., et al. Maternal and fetal inherited thrombophilias are not related to the development of severe preeclampsia. Am J Obstet Gynecol 2001, 185:153-157.
    • (2001) Am J Obstet Gynecol , vol.185 , pp. 153-157
    • Livingston, J.C.1    Barton, J.R.2    Park, V.3
  • 46
    • 0035089763 scopus 로고    scopus 로고
    • Mutations in the gene for methylenetetrahydrofolate reductase, homocysteine levels, and vitamin status in women with a history of preeclampsia
    • Lachmeijer A.M., Arngrimsson R., Bastiaans E.J., et al. Mutations in the gene for methylenetetrahydrofolate reductase, homocysteine levels, and vitamin status in women with a history of preeclampsia. Am J Obstet Gynecol 2001, 184:394-402.
    • (2001) Am J Obstet Gynecol , vol.184 , pp. 394-402
    • Lachmeijer, A.M.1    Arngrimsson, R.2    Bastiaans, E.J.3
  • 47
    • 0035652441 scopus 로고    scopus 로고
    • Evidence for an association of the R485K polymorphism in the coagulation factor V gene with severe preeclampsia from screening 35 polymorphisms in 27 candidate genes
    • Watanabe H., Hamada H., Yamakawa-Kobayashi K., et al. Evidence for an association of the R485K polymorphism in the coagulation factor V gene with severe preeclampsia from screening 35 polymorphisms in 27 candidate genes. Thromb Haemost 2001, 86:1594-1595.
    • (2001) Thromb Haemost , vol.86 , pp. 1594-1595
    • Watanabe, H.1    Hamada, H.2    Yamakawa-Kobayashi, K.3
  • 48
    • 0035350680 scopus 로고    scopus 로고
    • Postnatal screening for thrombophilia in women with severe pregnancy complications
    • Alfirevic Z., Mousa H.A., Martlew V., et al. Postnatal screening for thrombophilia in women with severe pregnancy complications. Obstet Gynecol 2001, 97:753-759.
    • (2001) Obstet Gynecol , vol.97 , pp. 753-759
    • Alfirevic, Z.1    Mousa, H.A.2    Martlew, V.3
  • 49
    • 0036271250 scopus 로고    scopus 로고
    • The methylenetetrahydrofolate reductase 677 C-->T polymorphism and preeclampsia in two populations
    • Prasmusinto D., Skrablin S., Hofstaetter C., et al. The methylenetetrahydrofolate reductase 677 C-->T polymorphism and preeclampsia in two populations. Obstet Gynecol 2002, 99:1085-1092.
    • (2002) Obstet Gynecol , vol.99 , pp. 1085-1092
    • Prasmusinto, D.1    Skrablin, S.2    Hofstaetter, C.3
  • 50
    • 0036253127 scopus 로고    scopus 로고
    • Prothrombotic genotypes are not associated with pre-eclampsia and gestational hypertension: results from a large population-based study and systematic review
    • Morrison E.R., Miedzybrodzka Z.H., Campbell D.M., et al. Prothrombotic genotypes are not associated with pre-eclampsia and gestational hypertension: results from a large population-based study and systematic review. Thromb Haemost 2002, 87:779-785.
    • (2002) Thromb Haemost , vol.87 , pp. 779-785
    • Morrison, E.R.1    Miedzybrodzka, Z.H.2    Campbell, D.M.3
  • 51
    • 18344396415 scopus 로고    scopus 로고
    • Frequency of factor V, prothrombin and methylenetetrahydrofolate reductase gene variants in preeclampsia
    • D'Elia A.V., Driul L., Giacomello R., et al. Frequency of factor V, prothrombin and methylenetetrahydrofolate reductase gene variants in preeclampsia. Gynecol Obstet Invest 2002, 53:84-87.
    • (2002) Gynecol Obstet Invest , vol.53 , pp. 84-87
    • D'Elia, A.V.1    Driul, L.2    Giacomello, R.3
  • 52
    • 0041422248 scopus 로고    scopus 로고
    • Association between plasminogen activator inhibitor 1 gene polymorphisms and preeclampsia
    • Fabbro D., D'Elia A.V., Spizzo R., et al. Association between plasminogen activator inhibitor 1 gene polymorphisms and preeclampsia. Gynecol Obstet Invest 2003, 56:17-22.
    • (2003) Gynecol Obstet Invest , vol.56 , pp. 17-22
    • Fabbro, D.1    D'Elia, A.V.2    Spizzo, R.3
  • 53
    • 2442490581 scopus 로고    scopus 로고
    • A mutation in the 5,10-methylenetetrahydrofolate reductase gene is not associated with preeclampsia in women of southeast Mexico
    • Perez-Mutul J., Gonzalez-Herrera L., Sosa-Cabrera T., et al. A mutation in the 5,10-methylenetetrahydrofolate reductase gene is not associated with preeclampsia in women of southeast Mexico. Arch Med Res 2004, 35:231-234.
    • (2004) Arch Med Res , vol.35 , pp. 231-234
    • Perez-Mutul, J.1    Gonzalez-Herrera, L.2    Sosa-Cabrera, T.3
  • 54
    • 8444245917 scopus 로고    scopus 로고
    • Association of pre-eclampsia with hyperhomocysteinaemia and methylenetetrahydrofolate reductase gene C677T polymorphism in a Turkish population
    • Yilmaz H., Unlucerci Y., Gurdol F., et al. Association of pre-eclampsia with hyperhomocysteinaemia and methylenetetrahydrofolate reductase gene C677T polymorphism in a Turkish population. Aust NZ J Obstet Gynaecol 2004, 44:423-427.
    • (2004) Aust NZ J Obstet Gynaecol , vol.44 , pp. 423-427
    • Yilmaz, H.1    Unlucerci, Y.2    Gurdol, F.3
  • 55
    • 3142694934 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase 677 C-->T polymorphism and plasma folate in relation to pre-eclampsia risk among Peruvian women
    • Williams M.A., Sanchez S.E., Zhang C., et al. Methylenetetrahydrofolate reductase 677 C-->T polymorphism and plasma folate in relation to pre-eclampsia risk among Peruvian women. J Matern Fetal Neonatal Med 2004, 15:337-344.
    • (2004) J Matern Fetal Neonatal Med , vol.15 , pp. 337-344
    • Williams, M.A.1    Sanchez, S.E.2    Zhang, C.3
  • 56
    • 2042536689 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphisms in black South Africans and the association with preeclampsia
    • Pegoraro R.J., Chikosi A., Rom L., et al. Methylenetetrahydrofolate reductase gene polymorphisms in black South Africans and the association with preeclampsia. Acta Obstet Gynecol Scand 2004, 83:449-454.
    • (2004) Acta Obstet Gynecol Scand , vol.83 , pp. 449-454
    • Pegoraro, R.J.1    Chikosi, A.2    Rom, L.3
  • 57
    • 19944431329 scopus 로고    scopus 로고
    • Preeclampsia and its interaction with common variants in thrombophilia genes
    • De Maat M.P., Jansen M.W., Hille E.T., et al. Preeclampsia and its interaction with common variants in thrombophilia genes. J Thromb Haemost 2004, 2:1588-1593.
    • (2004) J Thromb Haemost , vol.2 , pp. 1588-1593
    • De Maat, M.P.1    Jansen, M.W.2    Hille, E.T.3
  • 58
    • 21544439321 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase C677T polymorphism and Factor V Leiden variant in Mexican women with preeclampsia/eclampsia
    • Davalos I.P., Moran M.C., Martinez-Abundis E., et al. Methylenetetrahydrofolate reductase C677T polymorphism and Factor V Leiden variant in Mexican women with preeclampsia/eclampsia. Blood Cells Mol Dis 2005, 35:66-69.
    • (2005) Blood Cells Mol Dis , vol.35 , pp. 66-69
    • Davalos, I.P.1    Moran, M.C.2    Martinez-Abundis, E.3
  • 59
    • 18144401263 scopus 로고    scopus 로고
    • Polymorphisms of genes involved in homocysteine metabolism in preeclampsia and in uncomplicated pregnancies
    • Also-Rallo E., Lopez-Quesada E., Urreizti R., et al. Polymorphisms of genes involved in homocysteine metabolism in preeclampsia and in uncomplicated pregnancies. Eur J Obstet Gynecol Reprod Biol 2005, 120:45-52.
    • (2005) Eur J Obstet Gynecol Reprod Biol , vol.120 , pp. 45-52
    • Also-Rallo, E.1    Lopez-Quesada, E.2    Urreizti, R.3
  • 60
    • 31944434778 scopus 로고    scopus 로고
    • Thrombophilia is significantly associated with severe preeclampsia: results of a large-scale, case-controlled study
    • Mello G., Parretti E., Marozio L., et al. Thrombophilia is significantly associated with severe preeclampsia: results of a large-scale, case-controlled study. Hypertension 2005, 46:1270-1274.
    • (2005) Hypertension , vol.46 , pp. 1270-1274
    • Mello, G.1    Parretti, E.2    Marozio, L.3
  • 61
    • 14144250418 scopus 로고    scopus 로고
    • Genetic thrombophilias and uterine artery Doppler velocimetry and preeclampsia
    • Driul L., Damante G., D'Elia A., et al. Genetic thrombophilias and uterine artery Doppler velocimetry and preeclampsia. Int J Gynaecol Obstet 2005, 88:265-270.
    • (2005) Int J Gynaecol Obstet , vol.88 , pp. 265-270
    • Driul, L.1    Damante, G.2    D'Elia, A.3
  • 62
    • 33748803599 scopus 로고    scopus 로고
    • Relationship between polymorphisms in thrombophilic genes and preeclampsia in a Brazilian population
    • Dalmaz C.A., Santos K.G., Botton M.R., et al. Relationship between polymorphisms in thrombophilic genes and preeclampsia in a Brazilian population. Blood Cells Mol Dis 2006, 37:107-110.
    • (2006) Blood Cells Mol Dis , vol.37 , pp. 107-110
    • Dalmaz, C.A.1    Santos, K.G.2    Botton, M.R.3
  • 63
    • 34447288948 scopus 로고    scopus 로고
    • The relationship between pregnancy induced hypertension and congenital thrombophilia
    • Demir S.C., Evruke C., Ozgunen T., et al. The relationship between pregnancy induced hypertension and congenital thrombophilia. Saudi Med J 2006, 27:1161-1166.
    • (2006) Saudi Med J , vol.27 , pp. 1161-1166
    • Demir, S.C.1    Evruke, C.2    Ozgunen, T.3
  • 64
    • 84858704053 scopus 로고    scopus 로고
    • Study on eNOS gene and MTHFR gene polymorphisms in preeclampsia
    • (in Chinese)
    • Zhang Z.H., Zhang R.J., Liu A.M., et al. Study on eNOS gene and MTHFR gene polymorphisms in preeclampsia. J Birth Health Hered 2007, 15:21-23. (in Chinese).
    • (2007) J Birth Health Hered , vol.15 , pp. 21-23
    • Zhang, Z.H.1    Zhang, R.J.2    Liu, A.M.3
  • 65
    • 33847067499 scopus 로고    scopus 로고
    • High frequency of methylenetetrahydrofolate reductase 677TT genotype in Hungarian HELLP syndrome patients determined by quantitative real-time PCR
    • Nagy B., Hupuczi P., Papp Z. High frequency of methylenetetrahydrofolate reductase 677TT genotype in Hungarian HELLP syndrome patients determined by quantitative real-time PCR. J Hum Hypertens 2007, 21:154-158.
    • (2007) J Hum Hypertens , vol.21 , pp. 154-158
    • Nagy, B.1    Hupuczi, P.2    Papp, Z.3
  • 67
    • 34548449918 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase C677T polymorphism and pregnancy complications
    • Stonek F., Hafner E., Philipp K., et al. Methylenetetrahydrofolate reductase C677T polymorphism and pregnancy complications. Obstet Gynecol 2007, 110(2 Pt 1):363-368.
    • (2007) Obstet Gynecol , vol.110 , Issue.2 PART 1 , pp. 363-368
    • Stonek, F.1    Hafner, E.2    Philipp, K.3
  • 68
    • 84858697766 scopus 로고    scopus 로고
    • The relationship between the polymorphism of MTHFR gene and pre-eclampsia
    • (in Chinese)
    • Shen X.N., Huang Y.P., Tang S.H., et al. The relationship between the polymorphism of MTHFR gene and pre-eclampsia. J Pract Obstet Gynecol 2009, 25:236-238. (in Chinese).
    • (2009) J Pract Obstet Gynecol , vol.25 , pp. 236-238
    • Shen, X.N.1    Huang, Y.P.2    Tang, S.H.3
  • 69
    • 84858702961 scopus 로고    scopus 로고
    • Investigation on the association between MTHFR gene C677T polymorphism and pre-eclampsia
    • (in Chinese)
    • Wang S.M., Wang L.G., Liu X.J., et al. Investigation on the association between MTHFR gene C677T polymorphism and pre-eclampsia. Maternal and Child Health Care of China 2008, 23:552-554. (in Chinese).
    • (2008) Maternal and Child Health Care of China , vol.23 , pp. 552-554
    • Wang, S.M.1    Wang, L.G.2    Liu, X.J.3
  • 70
    • 84870816772 scopus 로고    scopus 로고
    • The relationship between plasma homocysteine and preeclampsia
    • (in Chinese)
    • Zhang X.Y., Sun D., Sun J. The relationship between plasma homocysteine and preeclampsia. J Perinat Med 2008, 114:245-248. (in Chinese).
    • (2008) J Perinat Med , vol.114 , pp. 245-248
    • Zhang, X.Y.1    Sun, D.2    Sun, J.3
  • 71
    • 46049099166 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase C677T and glutathione S-transferase P1 A313G are associated with a reduced risk of preeclampsia in Maya-Mestizo women
    • Canto P., Canto-Cetina T., Juarez-Velazquez R., et al. Methylenetetrahydrofolate reductase C677T and glutathione S-transferase P1 A313G are associated with a reduced risk of preeclampsia in Maya-Mestizo women. Hypertens Res 2008, 31:1015-1019.
    • (2008) Hypertens Res , vol.31 , pp. 1015-1019
    • Canto, P.1    Canto-Cetina, T.2    Juarez-Velazquez, R.3
  • 72
    • 70350572246 scopus 로고    scopus 로고
    • Genotype of the CYBA promoter -930A/G, polymorphism C677T of the MTHFR and APOE genotype in patients with hypertensive disorders of pregnancy: an observational study
    • Stiefel P., Miranda M.L., Bellido L.M., et al. Genotype of the CYBA promoter -930A/G, polymorphism C677T of the MTHFR and APOE genotype in patients with hypertensive disorders of pregnancy: an observational study. Med Clin (Barc) 2009, 133:657-661.
    • (2009) Med Clin (Barc) , vol.133 , pp. 657-661
    • Stiefel, P.1    Miranda, M.L.2    Bellido, L.M.3
  • 73
    • 45849144786 scopus 로고    scopus 로고
    • Maternal factor V Leiden mutation is associated with HELLP syndrome in Caucasian women
    • Muetze S., Leeners B., Ortlepp J.R., et al. Maternal factor V Leiden mutation is associated with HELLP syndrome in Caucasian women. Acta Obstet Gynecol Scand 2008, 87:635-642.
    • (2008) Acta Obstet Gynecol Scand , vol.87 , pp. 635-642
    • Muetze, S.1    Leeners, B.2    Ortlepp, J.R.3
  • 74
    • 58749116983 scopus 로고    scopus 로고
    • Inherited thrombophilia and preeclampsia within a multicenter cohort: the Montreal Preeclampsia Study
    • discussion e1-5
    • Kahn S.R., Platt R., McNamara H., et al. Inherited thrombophilia and preeclampsia within a multicenter cohort: the Montreal Preeclampsia Study. Am J Obstet Gynecol 2009, 200:151.e1-151.e9. discussion e1-5.
    • (2009) Am J Obstet Gynecol , vol.200
    • Kahn, S.R.1    Platt, R.2    McNamara, H.3
  • 75
    • 79960700820 scopus 로고    scopus 로고
    • Association of MTHFR A1298C polymorphism (but not of MTHFR C677T) with elevated homocysteine levels and placental vasculopathies
    • Klai S., Fekih-Mrissa N., El H.S., et al. Association of MTHFR A1298C polymorphism (but not of MTHFR C677T) with elevated homocysteine levels and placental vasculopathies. Blood Coagul Fibrinolysis 2011, 22:374-378.
    • (2011) Blood Coagul Fibrinolysis , vol.22 , pp. 374-378
    • Klai, S.1    Fekih-Mrissa, N.2    El, H.S.3
  • 76
    • 80052010580 scopus 로고    scopus 로고
    • Placental markers of folate-related metabolism in preeclampsia
    • Mislanova C., Martsenyuk O., Huppertz B., et al. Placental markers of folate-related metabolism in preeclampsia. Reproduction 2011, 142:467-476.
    • (2011) Reproduction , vol.142 , pp. 467-476
    • Mislanova, C.1    Martsenyuk, O.2    Huppertz, B.3
  • 77
    • 84863902802 scopus 로고    scopus 로고
    • Preeclampsia in North Indian women: the contribution of genetic polymorphisms
    • Aggarwal S., Dimri N., Tandon I., et al. Preeclampsia in North Indian women: the contribution of genetic polymorphisms. J Obstet Gynaecol Res 2011, 37:1335-1341.
    • (2011) J Obstet Gynaecol Res , vol.37 , pp. 1335-1341
    • Aggarwal, S.1    Dimri, N.2    Tandon, I.3
  • 78
    • 84869188617 scopus 로고    scopus 로고
    • Candidate gene study of genetic thrombophilic polymorphisms in pre-eclampsia and recurrent pregnancy loss in Sinhalese women
    • Dissanayake V.H., Sirisena N.D., Weerasekera L.Y., et al. Candidate gene study of genetic thrombophilic polymorphisms in pre-eclampsia and recurrent pregnancy loss in Sinhalese women. J Obstet Gynaecol Res 2012, 38:1168-1176.
    • (2012) J Obstet Gynaecol Res , vol.38 , pp. 1168-1176
    • Dissanayake, V.H.1    Sirisena, N.D.2    Weerasekera, L.Y.3
  • 79
    • 84856115466 scopus 로고    scopus 로고
    • Inherited thrombophilias and adverse pregnancy outcomes: a case-control study in an Australian population
    • Said J.M., Higgins J.R., Moses E.K., et al. Inherited thrombophilias and adverse pregnancy outcomes: a case-control study in an Australian population. Acta Obstet Gynecol Scand 2012, 91:250-255.
    • (2012) Acta Obstet Gynecol Scand , vol.91 , pp. 250-255
    • Said, J.M.1    Higgins, J.R.2    Moses, E.K.3
  • 80
    • 84863475620 scopus 로고    scopus 로고
    • Thrombophilias and adverse pregnancy outcomes: results from the Danish National Birth Cohort
    • Lykke J.A., Bare L.A., Olsen J., et al. Thrombophilias and adverse pregnancy outcomes: results from the Danish National Birth Cohort. J Thromb Haemost 2012, 10:1320-1325.
    • (2012) J Thromb Haemost , vol.10 , pp. 1320-1325
    • Lykke, J.A.1    Bare, L.A.2    Olsen, J.3
  • 81
    • 0025183425 scopus 로고
    • Genetic and familial predisposition to eclampsia and pre-eclampsia in a defined population
    • Arngrimsson R., Bjornsson S., Geirsson R.T., et al. Genetic and familial predisposition to eclampsia and pre-eclampsia in a defined population. Br J Obstet Gynaecol 1990, 97:762-769.
    • (1990) Br J Obstet Gynaecol , vol.97 , pp. 762-769
    • Arngrimsson, R.1    Bjornsson, S.2    Geirsson, R.T.3
  • 82
    • 0035814640 scopus 로고    scopus 로고
    • Pathogenesis and genetics of pre-eclampsia
    • Roberts J.M., Cooper D.W. Pathogenesis and genetics of pre-eclampsia. Lancet 2001, 357:53-56.
    • (2001) Lancet , vol.357 , pp. 53-56
    • Roberts, J.M.1    Cooper, D.W.2
  • 83
    • 0034709264 scopus 로고    scopus 로고
    • Genetic effects on the liability of developing pre-eclampsia and gestational hypertension
    • Salonen R.H., Lichtenstein P., Lipworth L., et al. Genetic effects on the liability of developing pre-eclampsia and gestational hypertension. Am J Med Genet 2000, 91:256-260.
    • (2000) Am J Med Genet , vol.91 , pp. 256-260
    • Salonen, R.H.1    Lichtenstein, P.2    Lipworth, L.3
  • 84
    • 0033985265 scopus 로고    scopus 로고
    • Homocysteine and endothelial dysfunction: a link with cardiovascular disease
    • McDowell I.F., Lang D. Homocysteine and endothelial dysfunction: a link with cardiovascular disease. J Nutr 2000, 130:369S-372S.
    • (2000) J Nutr , vol.130
    • McDowell, I.F.1    Lang, D.2
  • 85
    • 0345169177 scopus 로고    scopus 로고
    • Influence of hyperhomocysteinemia on the cellular redox state-impact on homocysteine-induced endothelial dysfunction
    • Weiss N., Heydrick S.J., Postea O., et al. Influence of hyperhomocysteinemia on the cellular redox state-impact on homocysteine-induced endothelial dysfunction. Clin Chem Lab Med 2003, 41:1455-1456.
    • (2003) Clin Chem Lab Med , vol.41 , pp. 1455-1456
    • Weiss, N.1    Heydrick, S.J.2    Postea, O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.