메뉴 건너뛰기




Volumn 42, Issue 8, 2011, Pages 677-685

Association between polymorphism of methylenetetrahydrofolate reductase (MTHFR) C677T and risk of myocardial infarction: A meta-analysis for 8,140 cases and 10,522 controls

Author keywords

Meta analysis; MTHFR; Myocardial infarction; Polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

EID: 84856900237     PISSN: 01884409     EISSN: 18735487     Source Type: Journal    
DOI: 10.1016/j.arcmed.2011.11.009     Document Type: Article
Times cited : (65)

References (61)
  • 1
    • 0027124612 scopus 로고
    • The primary prevention of myocardial infarction
    • Manson J.E., Tosteson H., Ridker P.M., et al. The primary prevention of myocardial infarction. N Engl J Med 1992, 326:1406-1416.
    • (1992) N Engl J Med , vol.326 , pp. 1406-1416
    • Manson, J.E.1    Tosteson, H.2    Ridker, P.M.3
  • 2
    • 0034995147 scopus 로고    scopus 로고
    • Myocardial ischemia and infarction: growth of ideas
    • Bing R.J. Myocardial ischemia and infarction: growth of ideas. Cardiovasc Res 2001, 51:13-20.
    • (2001) Cardiovasc Res , vol.51 , pp. 13-20
    • Bing, R.J.1
  • 3
    • 27844455882 scopus 로고    scopus 로고
    • The influence of genetic and environmental factors on plasma homocysteine concentrations in a population at high risk for coronary artery disease
    • Bowron A., Scott J., Stansbie D. The influence of genetic and environmental factors on plasma homocysteine concentrations in a population at high risk for coronary artery disease. Ann Clin Biochem 2005, 42:459-462.
    • (2005) Ann Clin Biochem , vol.42 , pp. 459-462
    • Bowron, A.1    Scott, J.2    Stansbie, D.3
  • 4
    • 0023251891 scopus 로고
    • Environmental risk factors in coronary artery disease
    • Tyroler H.A., Haynes S.G., Cobb L.A., et al. Environmental risk factors in coronary artery disease. Circulation 1987, 76:I139-I144.
    • (1987) Circulation , vol.76
    • Tyroler, H.A.1    Haynes, S.G.2    Cobb, L.A.3
  • 5
    • 78649522127 scopus 로고    scopus 로고
    • Familial aggregation of early-onset myocardial infarction
    • Cipriani V., Mannucci P.M., Ardissino D., et al. Familial aggregation of early-onset myocardial infarction. Eur J Intern Med 2010, 21:511-515.
    • (2010) Eur J Intern Med , vol.21 , pp. 511-515
    • Cipriani, V.1    Mannucci, P.M.2    Ardissino, D.3
  • 6
    • 18744397183 scopus 로고    scopus 로고
    • Familial aggregation of early-onset myocardial infarction
    • Brown D.W., Giles W.H., Burke W., et al. Familial aggregation of early-onset myocardial infarction. Community Genet 2002, 5:232-238.
    • (2002) Community Genet , vol.5 , pp. 232-238
    • Brown, D.W.1    Giles, W.H.2    Burke, W.3
  • 7
    • 0036963414 scopus 로고    scopus 로고
    • Endothelial dysfunction and atherothrombosis in mild hyperhomocysteinemia
    • Weiss N., Keller C., Hoffmann U., et al. Endothelial dysfunction and atherothrombosis in mild hyperhomocysteinemia. Vasc Med 2002, 7:227-239.
    • (2002) Vasc Med , vol.7 , pp. 227-239
    • Weiss, N.1    Keller, C.2    Hoffmann, U.3
  • 8
    • 33749628469 scopus 로고    scopus 로고
    • Homocysteine, vitamin B12 and folate levels in premature coronary artery disease
    • Sadeghian S., Fallahi F., Salarifar M., et al. Homocysteine, vitamin B12 and folate levels in premature coronary artery disease. BMC Cardiovasc Disord 2006, 6:38.
    • (2006) BMC Cardiovasc Disord , vol.6 , pp. 38
    • Sadeghian, S.1    Fallahi, F.2    Salarifar, M.3
  • 9
    • 0031588339 scopus 로고    scopus 로고
    • Plasma homocysteine levels and mortality in patients with coronary artery disease
    • von Eckardstein A., Assmann G. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 1997, 337:1632-1633.
    • (1997) N Engl J Med , vol.337 , pp. 1632-1633
    • von Eckardstein, A.1    Assmann, G.2
  • 10
    • 34547146470 scopus 로고    scopus 로고
    • Folate deficiency and plasma homocysteine during increased oxidative stress
    • Rogers E.J., Chen S., Chan A. Folate deficiency and plasma homocysteine during increased oxidative stress. N Engl J Med 2007, 357:421-422.
    • (2007) N Engl J Med , vol.357 , pp. 421-422
    • Rogers, E.J.1    Chen, S.2    Chan, A.3
  • 11
    • 16644385296 scopus 로고    scopus 로고
    • Serum homocysteine and endothelial dysfunction in circulatory disorders in women
    • Tsuda K., Nishio I. Serum homocysteine and endothelial dysfunction in circulatory disorders in women. Circulation 2004, 110:e37.
    • (2004) Circulation , vol.110
    • Tsuda, K.1    Nishio, I.2
  • 12
    • 77949912889 scopus 로고    scopus 로고
    • Genetic polymorphisms involved in folate metabolism and concentrations of methylmalonic acid and folate on plasma homocysteine and risk of coronary artery disease
    • Biselli P.M., Guerzoni A.R., de Godoy M.F., et al. Genetic polymorphisms involved in folate metabolism and concentrations of methylmalonic acid and folate on plasma homocysteine and risk of coronary artery disease. J Thromb Thrombolysis 2010, 29:32-40.
    • (2010) J Thromb Thrombolysis , vol.29 , pp. 32-40
    • Biselli, P.M.1    Guerzoni, A.R.2    de Godoy, M.F.3
  • 13
    • 0028788020 scopus 로고
    • Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study
    • Nygard O., Vollset S.E., Refsum H., et al. Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study. JAMA 1995, 274:1526-1533.
    • (1995) JAMA , vol.274 , pp. 1526-1533
    • Nygard, O.1    Vollset, S.E.2    Refsum, H.3
  • 14
    • 0032497941 scopus 로고    scopus 로고
    • Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis
    • Brattstrom L., Wilcken D.E., Ohrvik J., et al. Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis. Circulation 1998, 98:2520-2526.
    • (1998) Circulation , vol.98 , pp. 2520-2526
    • Brattstrom, L.1    Wilcken, D.E.2    Ohrvik, J.3
  • 15
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase
    • Frosst P., Blom H.J., Milos R., et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995, 10:111-113.
    • (1995) Nat Genet , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3
  • 16
    • 0030811670 scopus 로고    scopus 로고
    • Myocardial infarction in young women in relation to plasma total homocysteine, folate, and a common variant in the methylenetetrahydrofolate reductase gene
    • Schwartz S.M., Siscovick D.S., Malinow M.R., et al. Myocardial infarction in young women in relation to plasma total homocysteine, folate, and a common variant in the methylenetetrahydrofolate reductase gene. Circulation 1997, 96:412-417.
    • (1997) Circulation , vol.96 , pp. 412-417
    • Schwartz, S.M.1    Siscovick, D.S.2    Malinow, M.R.3
  • 17
    • 33646348716 scopus 로고    scopus 로고
    • Hyperhomocysteinaemia, methylenetetrahydrofolate reductase polymorphism and risk of coronary artery disease
    • Kerkeni M., Addad F., Chauffert M., et al. Hyperhomocysteinaemia, methylenetetrahydrofolate reductase polymorphism and risk of coronary artery disease. Ann Clin Biochem 2006, 43:200-206.
    • (2006) Ann Clin Biochem , vol.43 , pp. 200-206
    • Kerkeni, M.1    Addad, F.2    Chauffert, M.3
  • 18
    • 0035721992 scopus 로고    scopus 로고
    • Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide?
    • Doshi S.N., McDowell I.F., Moat S.J., et al. Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide?. Arterioscler Thromb Vasc Biol 2001, 21:1196-1202.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1196-1202
    • Doshi, S.N.1    McDowell, I.F.2    Moat, S.J.3
  • 19
    • 0031049530 scopus 로고    scopus 로고
    • A common mutation in methylenetetrahydrofolate reductase gene is not a major risk of coronary artery disease or myocardial infarction
    • Brugada R., Marian A.J. A common mutation in methylenetetrahydrofolate reductase gene is not a major risk of coronary artery disease or myocardial infarction. Atherosclerosis 1997, 128:107-112.
    • (1997) Atherosclerosis , vol.128 , pp. 107-112
    • Brugada, R.1    Marian, A.J.2
  • 20
    • 6944220009 scopus 로고    scopus 로고
    • An association analysis between genetic polymorphisms of matrix metalloproteinase-3 and methylenetetrahydrofolate reductase and myocardial infarction in Japanese
    • Shioji K., Kokubo Y., Goto Y., et al. An association analysis between genetic polymorphisms of matrix metalloproteinase-3 and methylenetetrahydrofolate reductase and myocardial infarction in Japanese. J Thromb Haemost 2004, 2:527-528.
    • (2004) J Thromb Haemost , vol.2 , pp. 527-528
    • Shioji, K.1    Kokubo, Y.2    Goto, Y.3
  • 21
    • 33747117971 scopus 로고    scopus 로고
    • Assessment of genetic risk for myocardial infarction
    • Yamada Y., Matsuo H., Segawa T., et al. Assessment of genetic risk for myocardial infarction. Thromb Haemost 2006, 96:220-227.
    • (2006) Thromb Haemost , vol.96 , pp. 220-227
    • Yamada, Y.1    Matsuo, H.2    Segawa, T.3
  • 22
    • 24144436042 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of the association between β2-adrenoceptor polymorphisms and asthma: a HuGE review
    • Thakkinstian A., McEvoy M., Minelli C., et al. Systematic review and meta-analysis of the association between β2-adrenoceptor polymorphisms and asthma: a HuGE review. Am J Epidemiol 2005, 162:201-211.
    • (2005) Am J Epidemiol , vol.162 , pp. 201-211
    • Thakkinstian, A.1    McEvoy, M.2    Minelli, C.3
  • 23
    • 79953689306 scopus 로고    scopus 로고
    • Quantifying, displaying and accounting for heterogeneity in the meta-analysis of RCTs using standard and generalised Q statistics
    • Bowden J., Tierney J.F., Copas A.J., et al. Quantifying, displaying and accounting for heterogeneity in the meta-analysis of RCTs using standard and generalised Q statistics. BMC Med Res Methodol 2011, 11:41.
    • (2011) BMC Med Res Methodol , vol.11 , pp. 41
    • Bowden, J.1    Tierney, J.F.2    Copas, A.J.3
  • 24
    • 0037098199 scopus 로고    scopus 로고
    • Quantifying heterogeneity in a meta-analysis
    • Higgins J.P., Thompson S.G. Quantifying heterogeneity in a meta-analysis. Stat Med 2002, 21:1539-1558.
    • (2002) Stat Med , vol.21 , pp. 1539-1558
    • Higgins, J.P.1    Thompson, S.G.2
  • 25
    • 0028659004 scopus 로고
    • Operating characteristics of a rank correlation test for publication bias
    • Begg C.B., Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994, 50:1088-1101.
    • (1994) Biometrics , vol.50 , pp. 1088-1101
    • Begg, C.B.1    Mazumdar, M.2
  • 26
    • 0029975240 scopus 로고    scopus 로고
    • Genetic analysis of thermolabile methylenetetrahydrofolate reductase as a risk factor for myocardial infarction
    • Adams M., Smith P.D., Martin D., et al. Genetic analysis of thermolabile methylenetetrahydrofolate reductase as a risk factor for myocardial infarction. QJM 1996, 89:437-444.
    • (1996) QJM , vol.89 , pp. 437-444
    • Adams, M.1    Smith, P.D.2    Martin, D.3
  • 27
    • 0029968008 scopus 로고    scopus 로고
    • Genetic polymorphism of methylenetetrahydrofolate reductase and myocardial infarction. A case-control study
    • Schmitz C., Lindpaintner K., Verhoef P., et al. Genetic polymorphism of methylenetetrahydrofolate reductase and myocardial infarction. A case-control study. Circulation 1996, 94:1812-1814.
    • (1996) Circulation , vol.94 , pp. 1812-1814
    • Schmitz, C.1    Lindpaintner, K.2    Verhoef, P.3
  • 28
    • 0029806746 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians
    • Ma J., Stampfer M.J., Hennekens C.H., et al. Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians. Circulation 1996, 94:2410-2416.
    • (1996) Circulation , vol.94 , pp. 2410-2416
    • Ma, J.1    Stampfer, M.J.2    Hennekens, C.H.3
  • 29
    • 0030859681 scopus 로고    scopus 로고
    • A mutation in the methylenetetrahydrofolate reductase gene is not associated with increased risk for coronary artery disease or myocardial infarction
    • Anderson J.L., King G.J., Thomson M.J., et al. A mutation in the methylenetetrahydrofolate reductase gene is not associated with increased risk for coronary artery disease or myocardial infarction. J Am Coll Cardiol 1997, 30:1206-1211.
    • (1997) J Am Coll Cardiol , vol.30 , pp. 1206-1211
    • Anderson, J.L.1    King, G.J.2    Thomson, M.J.3
  • 30
    • 0032081312 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase C677T mutation, plasma homocysteine, and folate in subjects from northern Italy with or without angiographically documented severe coronary atherosclerotic disease: evidence for an important genetic-environmental interaction
    • Girelli D., Friso S., Trabetti E., et al. Methylenetetrahydrofolate reductase C677T mutation, plasma homocysteine, and folate in subjects from northern Italy with or without angiographically documented severe coronary atherosclerotic disease: evidence for an important genetic-environmental interaction. Blood 1998, 91:4158-4163.
    • (1998) Blood , vol.91 , pp. 4158-4163
    • Girelli, D.1    Friso, S.2    Trabetti, E.3
  • 31
    • 0031969688 scopus 로고    scopus 로고
    • The high prevalence of thermolabile 5-10 methylenetetrahydrofolate reductase (MTHFR) in Italians is not associated to an increased risk for coronary artery disease (CAD)
    • Abbate R., Sardi I., Pepe G., et al. The high prevalence of thermolabile 5-10 methylenetetrahydrofolate reductase (MTHFR) in Italians is not associated to an increased risk for coronary artery disease (CAD). Thromb Haemost 1998, 79:727-730.
    • (1998) Thromb Haemost , vol.79 , pp. 727-730
    • Abbate, R.1    Sardi, I.2    Pepe, G.3
  • 32
    • 0031727054 scopus 로고    scopus 로고
    • The mutation C677T in the methylene tetrahydrofolate reductase gene as a risk factor for myocardial infarction in the Portuguese population
    • Ferrer-Antunes C., Palmeiro A., Morais J., et al. The mutation C677T in the methylene tetrahydrofolate reductase gene as a risk factor for myocardial infarction in the Portuguese population. Thromb Haemost 1998, 80:521-522.
    • (1998) Thromb Haemost , vol.80 , pp. 521-522
    • Ferrer-Antunes, C.1    Palmeiro, A.2    Morais, J.3
  • 33
    • 0033169099 scopus 로고    scopus 로고
    • Prothrombotic genetic risk factors in young survivors of myocardial infarction
    • Anderson J.L., King G.J., Thomson M.J., et al. Prothrombotic genetic risk factors in young survivors of myocardial infarction. Blood 1999, 94:46-51.
    • (1999) Blood , vol.94 , pp. 46-51
    • Anderson, J.L.1    King, G.J.2    Thomson, M.J.3
  • 34
    • 0032941872 scopus 로고    scopus 로고
    • The TT genotype of the methylenetetrahydrofolate reductase C677T gene polymorphism is associated with the extent of coronary atherosclerosis in patients at high risk for coronary artery disease
    • Gardemann A., Weidemann H., Philipp M., et al. The TT genotype of the methylenetetrahydrofolate reductase C677T gene polymorphism is associated with the extent of coronary atherosclerosis in patients at high risk for coronary artery disease. Eur Heart J 1999, 20:584-592.
    • (1999) Eur Heart J , vol.20 , pp. 584-592
    • Gardemann, A.1    Weidemann, H.2    Philipp, M.3
  • 35
    • 0032773903 scopus 로고    scopus 로고
    • The genotype interactions of methylenetetrahydrofolate reductase and renin-angiotensin system genes are associated with myocardial infarction
    • Fernandez-Arcas N., Dieguez-Lucena J.L., Munoz-Moran E., et al. The genotype interactions of methylenetetrahydrofolate reductase and renin-angiotensin system genes are associated with myocardial infarction. Atherosclerosis 1999, 145:293-300.
    • (1999) Atherosclerosis , vol.145 , pp. 293-300
    • Fernandez-Arcas, N.1    Dieguez-Lucena, J.L.2    Munoz-Moran, E.3
  • 36
    • 0034745480 scopus 로고    scopus 로고
    • Homozygosity for the C677→T mutation of 5,10-methylenetetrahydrofolate reductase and total plasma homocyst(e) ine are not associated with greater than normal risk of a first myocardial infarction in northern Sweden
    • Thogersen A.M., Nilsson T.K., Dahlen G., et al. Homozygosity for the C677→T mutation of 5,10-methylenetetrahydrofolate reductase and total plasma homocyst(e) ine are not associated with greater than normal risk of a first myocardial infarction in northern Sweden. Coron Artery Dis 2001, 12:85-90.
    • (2001) Coron Artery Dis , vol.12 , pp. 85-90
    • Thogersen, A.M.1    Nilsson, T.K.2    Dahlen, G.3
  • 37
    • 0033740460 scopus 로고    scopus 로고
    • Homocyst(e)ine and the C677T mutation of methylenetetrahydrofolate reductase in survivors of premature myocardial infarction
    • Virgos C., Joven J., Simo J.M., et al. Homocyst(e)ine and the C677T mutation of methylenetetrahydrofolate reductase in survivors of premature myocardial infarction. Clin Biochem 2000, 33:509-512.
    • (2000) Clin Biochem , vol.33 , pp. 509-512
    • Virgos, C.1    Joven, J.2    Simo, J.M.3
  • 38
    • 0035319508 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphism and risk of premature myocardial infarction
    • Gulec S., Aras O., Akar E., et al. Methylenetetrahydrofolate reductase gene polymorphism and risk of premature myocardial infarction. Clin Cardiol 2001, 24:281-284.
    • (2001) Clin Cardiol , vol.24 , pp. 281-284
    • Gulec, S.1    Aras, O.2    Akar, E.3
  • 39
    • 0037418247 scopus 로고    scopus 로고
    • No evidence of association between prothrombotic gene polymorphisms and the development of acute myocardial infarction at a young age
    • Atherosclerosis, Thrombosis, and Vascular Biology Italian Study Group
    • No evidence of association between prothrombotic gene polymorphisms and the development of acute myocardial infarction at a young age. Circulation 2003, 107:1117-1122. Atherosclerosis, Thrombosis, and Vascular Biology Italian Study Group.
    • (2003) Circulation , vol.107 , pp. 1117-1122
  • 40
    • 4444252092 scopus 로고    scopus 로고
    • Folate, homocysteine levels, methylenetetrahydrofolate reductase (MTHFR) 677C→T variant, and the risk of myocardial infarction in young women: effect of female hormones on homocysteine levels
    • Tanis B.C., Blom H.J., Bloemenkamp D.G., et al. Folate, homocysteine levels, methylenetetrahydrofolate reductase (MTHFR) 677C→T variant, and the risk of myocardial infarction in young women: effect of female hormones on homocysteine levels. J Thromb Haemost 2004, 2:35-41.
    • (2004) J Thromb Haemost , vol.2 , pp. 35-41
    • Tanis, B.C.1    Blom, H.J.2    Bloemenkamp, D.G.3
  • 41
    • 33244486870 scopus 로고    scopus 로고
    • Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects
    • El-Sammak M., Kandil M., El-Hifni S., et al. Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects. Int J Med Sci 2004, 1:181-192.
    • (2004) Int J Med Sci , vol.1 , pp. 181-192
    • El-Sammak, M.1    Kandil, M.2    El-Hifni, S.3
  • 42
    • 34748834623 scopus 로고    scopus 로고
    • Common polymorphisms and cardiovascular factors in patients with myocardial infarction of Costa Rica
    • Salazar-Sanchez L., Chaves L., Cartin M., et al. Common polymorphisms and cardiovascular factors in patients with myocardial infarction of Costa Rica. Rev Biol Trop 2006, 54:1-11.
    • (2006) Rev Biol Trop , vol.54 , pp. 1-11
    • Salazar-Sanchez, L.1    Chaves, L.2    Cartin, M.3
  • 43
    • 20144387917 scopus 로고    scopus 로고
    • Prevalence of myocardial infarction is related to hyperhomocysteinemia but not influenced by C677T methylenetetrahydrofolate reductase and A2756G methionine synthase polymorphisms in diabetic and non-diabetic subjects
    • Helfenstein T., Fonseca F.A., Relvas W.G., et al. Prevalence of myocardial infarction is related to hyperhomocysteinemia but not influenced by C677T methylenetetrahydrofolate reductase and A2756G methionine synthase polymorphisms in diabetic and non-diabetic subjects. Clin Chim Acta 2005, 355:165-172.
    • (2005) Clin Chim Acta , vol.355 , pp. 165-172
    • Helfenstein, T.1    Fonseca, F.A.2    Relvas, W.G.3
  • 44
    • 40949090614 scopus 로고    scopus 로고
    • Thrombophilia in young patients with acute myocardial infarction
    • Celik M., Altintas A., Celik Y., et al. Thrombophilia in young patients with acute myocardial infarction. Saudi Med J 2008, 29:48-54.
    • (2008) Saudi Med J , vol.29 , pp. 48-54
    • Celik, M.1    Altintas, A.2    Celik, Y.3
  • 45
    • 0034048853 scopus 로고    scopus 로고
    • Genetic polymorphism of 5,10-methylenetetrahydrofolate increases risk of myocardial infarction and is correlated to elevated levels of homocysteine in the Japanese general population
    • Nakai K., Fusazaki T., Suzuki T., et al. Genetic polymorphism of 5,10-methylenetetrahydrofolate increases risk of myocardial infarction and is correlated to elevated levels of homocysteine in the Japanese general population. Coron Artery Dis 2000, 11:47-51.
    • (2000) Coron Artery Dis , vol.11 , pp. 47-51
    • Nakai, K.1    Fusazaki, T.2    Suzuki, T.3
  • 46
    • 0035500262 scopus 로고    scopus 로고
    • Gene polymorphisms of homocysteine metabolism-related enzymes in Chinese patients with occlusive coronary artery or cerebral vascular diseases
    • Zhang G., Dai C. Gene polymorphisms of homocysteine metabolism-related enzymes in Chinese patients with occlusive coronary artery or cerebral vascular diseases. Thromb Res 2001, 104:187-195.
    • (2001) Thromb Res , vol.104 , pp. 187-195
    • Zhang, G.1    Dai, C.2
  • 47
    • 0042974212 scopus 로고    scopus 로고
    • Risk factors and methylenetetrahydrofolate reductase gene polymorphisms in a young South African Indian-based population with acute myocardial infarction
    • Ranjith N., Pegoraro R.J., Rom L. Risk factors and methylenetetrahydrofolate reductase gene polymorphisms in a young South African Indian-based population with acute myocardial infarction. Cardiovasc J S Afr 2003, 14:127-132.
    • (2003) Cardiovasc J S Afr , vol.14 , pp. 127-132
    • Ranjith, N.1    Pegoraro, R.J.2    Rom, L.3
  • 48
    • 4444305073 scopus 로고    scopus 로고
    • Prevalence of MTHFR gene polymorphisms (C677T and A1298C) among Tamilians
    • Angeline T., Jeyaraj N., Granito S., et al. Prevalence of MTHFR gene polymorphisms (C677T and A1298C) among Tamilians. Exp Mol Pathol 2004, 77:85-88.
    • (2004) Exp Mol Pathol , vol.77 , pp. 85-88
    • Angeline, T.1    Jeyaraj, N.2    Granito, S.3
  • 49
    • 34248661043 scopus 로고    scopus 로고
    • Lack of association of methylenetetrahydrofolate reductase 677C>T mutation with coronary artery disease in a Pakistani population
    • Iqbal M.P., Fatima T., Parveen S., et al. Lack of association of methylenetetrahydrofolate reductase 677C>T mutation with coronary artery disease in a Pakistani population. J Mol Genet Med 2005, 1:26-32.
    • (2005) J Mol Genet Med , vol.1 , pp. 26-32
    • Iqbal, M.P.1    Fatima, T.2    Parveen, S.3
  • 50
    • 81755162839 scopus 로고    scopus 로고
    • Sequence variation of the methylene tetrahydrofolate reductase gene (677C>T and 1298 A>C) and traditional risk factors in a South Indian Population
    • [Epub ahead of print]
    • Dayakar S., Goud K.I., Reddy T.P., et al. Sequence variation of the methylene tetrahydrofolate reductase gene (677C>T and 1298 A>C) and traditional risk factors in a South Indian Population. Genet Test Mol Biomarkers 2011, [Epub ahead of print].
    • (2011) Genet Test Mol Biomarkers
    • Dayakar, S.1    Goud, K.I.2    Reddy, T.P.3
  • 51
    • 0035879025 scopus 로고    scopus 로고
    • Mutations in the genes regulating methylene tetrahydrofolate reductase (MTHFR C→T677) and cystathione beta-synthase (CBS G→A919, CBS T→C833) are not associated with myocardial infarction in African Americans
    • Dilley A., Hooper W.C., El-Jamil M., et al. Mutations in the genes regulating methylene tetrahydrofolate reductase (MTHFR C→T677) and cystathione beta-synthase (CBS G→A919, CBS T→C833) are not associated with myocardial infarction in African Americans. Thromb Res 2001, 103:109-115.
    • (2001) Thromb Res , vol.103 , pp. 109-115
    • Dilley, A.1    Hooper, W.C.2    El-Jamil, M.3
  • 52
    • 77649126524 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2010 update: a report from the American Heart Association
    • Lloyd-Jones D., Adams R.J., Brown T.M., et al. Heart disease and stroke statistics-2010 update: a report from the American Heart Association. Circulation 2010, 121:e46-e215.
    • (2010) Circulation , vol.121
    • Lloyd-Jones, D.1    Adams, R.J.2    Brown, T.M.3
  • 53
    • 50249090436 scopus 로고    scopus 로고
    • Molecular genetics of myocardial infarction
    • Yamada Y., Ichihara S., Nishida T. Molecular genetics of myocardial infarction. Genomic Med 2008, 2:7-22.
    • (2008) Genomic Med , vol.2 , pp. 7-22
    • Yamada, Y.1    Ichihara, S.2    Nishida, T.3
  • 54
    • 75949086359 scopus 로고    scopus 로고
    • Multiple mutations in genetic cardiovascular disease: a marker of disease severity?
    • Kelly M., Semsarian C. Multiple mutations in genetic cardiovascular disease: a marker of disease severity?. Circ Cardiovasc Genet 2009, 2:182-190.
    • (2009) Circ Cardiovasc Genet , vol.2 , pp. 182-190
    • Kelly, M.1    Semsarian, C.2
  • 55
    • 69449103870 scopus 로고    scopus 로고
    • Careers in cardiovascular disease epidemiology and prevention
    • Luepker R.V. Careers in cardiovascular disease epidemiology and prevention. Circulation 2009, 120:533-538.
    • (2009) Circulation , vol.120 , pp. 533-538
    • Luepker, R.V.1
  • 56
    • 55549101312 scopus 로고    scopus 로고
    • Homocysteine: the Rubik's cube of cardiovascular risk factors
    • Milani R.V., Lavie C.J. Homocysteine: the Rubik's cube of cardiovascular risk factors. Mayo Clin Proc 2008, 83:1200-1202.
    • (2008) Mayo Clin Proc , vol.83 , pp. 1200-1202
    • Milani, R.V.1    Lavie, C.J.2
  • 57
    • 0037312921 scopus 로고    scopus 로고
    • Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease
    • Lohmueller K.E., Pearce C.L., Pike M., et al. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 2003, 33:177-182.
    • (2003) Nat Genet , vol.33 , pp. 177-182
    • Lohmueller, K.E.1    Pearce, C.L.2    Pike, M.3
  • 58
    • 0030826587 scopus 로고    scopus 로고
    • Thermolabile methylenetetrahydrofolate reductase in coronary artery disease
    • Kluijtmans L.A., Kastelein J.J., Lindemans J., et al. Thermolabile methylenetetrahydrofolate reductase in coronary artery disease. Circulation 1997, 96:2573-2577.
    • (1997) Circulation , vol.96 , pp. 2573-2577
    • Kluijtmans, L.A.1    Kastelein, J.J.2    Lindemans, J.3
  • 59
    • 0033782287 scopus 로고    scopus 로고
    • The methylenetetrahydrofolate reductasegene is associated with increased cardiovascular risk in Japan, but not in other populations
    • Jee S.H., Beaty T.H., Suh I., et al. The methylenetetrahydrofolate reductasegene is associated with increased cardiovascular risk in Japan, but not in other populations. Atherosclerosis 2000, 153:161-168.
    • (2000) Atherosclerosis , vol.153 , pp. 161-168
    • Jee, S.H.1    Beaty, T.H.2    Suh, I.3
  • 60
    • 0344196959 scopus 로고    scopus 로고
    • Association between factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations and events of the arterial circulatory system: a meta-analysis of published studies
    • Kim R.J., Becker R.C. Association between factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations and events of the arterial circulatory system: a meta-analysis of published studies. Am Heart J 2003, 146:948-957.
    • (2003) Am Heart J , vol.146 , pp. 948-957
    • Kim, R.J.1    Becker, R.C.2
  • 61
    • 27744471516 scopus 로고    scopus 로고
    • Meta-analysis of MTHFR 677C→T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate?
    • Lewis S.J., Ebrahim S., Davey Smith G. Meta-analysis of MTHFR 677C→T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate?. BMJ 2005, 331:1053.
    • (2005) BMJ , vol.331 , pp. 1053
    • Lewis, S.J.1    Ebrahim, S.2    Davey Smith, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.