메뉴 건너뛰기




Volumn 98, Issue 23, 1998, Pages 2520-2526

Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: The result of a meta- analysis

Author keywords

Coronary disease; Homocysteine; Methylenetetrahydrofolate reductase; Risk factors

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

EID: 0032497941     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.98.23.2520     Document Type: Article
Times cited : (624)

References (55)
  • 2
    • 0029066299 scopus 로고
    • A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: Probable benefits of increasing folic acid intakes
    • Boushey CJ, Beresford SAA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes. JAMA. 1995;274: 1049-1057.
    • (1995) JAMA , vol.274 , pp. 1049-1057
    • Boushey, C.J.1    Beresford, S.A.A.2    Omenn, G.S.3    Motulsky, A.G.4
  • 3
    • 0000167774 scopus 로고
    • Disorders of transsulfuration
    • Scriver CR, Beaudet AL, Sly WS, Valle D, eds. New York, NY: McGraw-Hill
    • Mudd SH, Levy HL, Skovby F. Disorders of transsulfuration. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic Basis of Inherited Disease. 7th ed. New York, NY: McGraw-Hill; 1995:1279-1327.
    • (1995) The Metabolic Basis of Inherited Disease. 7th Ed. , pp. 1279-1327
    • Mudd, S.H.1    Levy, H.L.2    Skovby, F.3
  • 4
    • 0017284939 scopus 로고
    • The pathogenesis of coronary artery disease: A possible role for methionine metabolism
    • Wilcken DEL, Wilcken B. The pathogenesis of coronary artery disease: a possible role for methionine metabolism. J Clin Invest. 1976;57: 1079-1082.
    • (1976) J Clin Invest. , vol.57 , pp. 1079-1082
    • Wilcken, D.E.L.1    Wilcken, B.2
  • 5
    • 0021752123 scopus 로고
    • Moderate homocysteinemia: A possible risk factor for arteriosclerotic cerebrovascular disease
    • Brattström LE, Hardebo JE, Hultberg BL. Moderate homocysteinemia: a possible risk factor for arteriosclerotic cerebrovascular disease. Stroke. 1984;15:1012-1015.
    • (1984) Stroke , vol.15 , pp. 1012-1015
    • Brattström, L.E.1    Hardebo, J.E.2    Hultberg, B.L.3
  • 10
    • 0028845307 scopus 로고
    • Prospective study of serum total homocysteine concentration and risk of stroke in middle-age British men
    • Perry IJ, Refsum H, Morris RW, Ebrahim SB, Ueland PM, Shaper AG. Prospective study of serum total homocysteine concentration and risk of stroke in middle-age British men. Lancet. 1995;346:1395-1398.
    • (1995) Lancet , vol.346 , pp. 1395-1398
    • Perry, I.J.1    Refsum, H.2    Morris, R.W.3    Ebrahim, S.B.4    Ueland, P.M.5    Shaper, A.G.6
  • 13
    • 0023696435 scopus 로고
    • Intermediate homocysteinemia: A thermolabile variant of methylenetetrahydrofolate reductase
    • Kang SS, Zhou J, Wong PWK, Kowalisyn J, Strokosch G. Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase. Am J Hum Genet. 1988;43:414-421.
    • (1988) Am J Hum Genet. , vol.43 , pp. 414-421
    • Kang, S.S.1    Zhou, J.2    Wong, P.W.K.3    Kowalisyn, J.4    Strokosch, G.5
  • 19
    • 0029968008 scopus 로고    scopus 로고
    • Genetic polymorphism of methylenetetrahydrofolate reductase and myocardial infarction: A case-control study
    • Schmitz C, Lindpaintner K, Verhoef P, Gaziano JM, Buring J. Genetic polymorphism of methylenetetrahydrofolate reductase and myocardial infarction: a case-control study. Circulation. 1996;94:1812-1814.
    • (1996) Circulation , vol.94 , pp. 1812-1814
    • Schmitz, C.1    Lindpaintner, K.2    Verhoef, P.3    Gaziano, J.M.4    Buring, J.5
  • 20
    • 0029806746 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians
    • Ma J, Stampfer MJ, Hennekens CH, Frosst P, Selhub J, Horsford J, Malinow R, Willett WC, Rozen R. Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians. Circulation. 1996;94:2410-2416.
    • (1996) Circulation , vol.94 , pp. 2410-2416
    • Ma, J.1    Stampfer, M.J.2    Hennekens, C.H.3    Frosst, P.4    Selhub, J.5    Horsford, J.6    Malinow, R.7    Willett, W.C.8    Rozen, R.9
  • 21
    • 0030476385 scopus 로고    scopus 로고
    • Common mutation in methylenetetrahydrofolate reductase: Correlation with homocysteine metabolism and late-onset vascular disease
    • Deloughery TG, Evans A, Sadeghi A, McWilliams J, Henner WD, Taylor LM, Press RD. Common mutation in methylenetetrahydrofolate reductase: correlation with homocysteine metabolism and late-onset vascular disease. Circulation. 1996;94:3074-3078.
    • (1996) Circulation , vol.94 , pp. 3074-3078
    • Deloughery, T.G.1    Evans, A.2    Sadeghi, A.3    McWilliams, J.4    Henner, W.D.5    Taylor, L.M.6    Press, R.D.7
  • 22
    • 0030612756 scopus 로고    scopus 로고
    • The 677CT mutation in the methylenetetrahydrofolate reductase gene: Associations with plasma total homocysteine levels and risk for coronary atherosclerotic disease
    • Verhoef P, Kok FJ. Kluijtmans LAJ, Blom HJ, Refsum H, Ueland PM, Kruyssen HACM. The 677CT mutation in the methylenetetrahydrofolate reductase gene: associations with plasma total homocysteine levels and risk for coronary atherosclerotic disease. Atherosclerosis. 1997;132: 105-113.
    • (1997) Atherosclerosis , vol.132 , pp. 105-113
    • Verhoef, P.1    Kok, F.J.2    Kluijtmans, L.A.J.3    Blom, H.J.4    Refsum, H.5    Ueland, P.M.6    Kruyssen, H.A.C.M.7
  • 24
  • 28
    • 0029975240 scopus 로고    scopus 로고
    • Genetic analysis of thermolabile memylenetetrahydrofolate reductase as a risk factor for myocardial infarction
    • Adams M, Smith PD, Martin D, Thomson JR, Lodwick D, Samani NJ. Genetic analysis of thermolabile memylenetetrahydrofolate reductase as a risk factor for myocardial infarction. Q J Med. 1996;89:437-444.
    • (1996) Q J Med. , vol.89 , pp. 437-444
    • Adams, M.1    Smith, P.D.2    Martin, D.3    Thomson, J.R.4    Lodwick, D.5    Samani, N.J.6
  • 29
    • 0030006275 scopus 로고    scopus 로고
    • Molecular variant of 5,10-methylenetetrahydrofolate reductase is a risk factor of ischemic heart disease in the Japanese population
    • Izumi M, Iwai N, Ohmichi N, Nakamura Y, Shimoike H, Kinoshita M. Molecular variant of 5,10-methylenetetrahydrofolate reductase is a risk factor of ischemic heart disease in the Japanese population. Atherosclerosis. 1996;121:293-294.
    • (1996) Atherosclerosis , vol.121 , pp. 293-294
    • Izumi, M.1    Iwai, N.2    Ohmichi, N.3    Nakamura, Y.4    Shimoike, H.5    Kinoshita, M.6
  • 31
    • 0029895024 scopus 로고    scopus 로고
    • Elevated total plasma homocysteine and 677c→T mutation of the 5,10-methylenetetrahydrofolate reductase gene in thrombotic vascular disease
    • de Franchis R, Mancini FP, D'Angelo A, Sebastio G, Fermo I, de Stefano V. Elevated total plasma homocysteine and 677C→T mutation of the 5,10-methylenetetrahydrofolate reductase gene in thrombotic vascular disease. Am J Hum Genet. 1996;59:262-264.
    • (1996) Am J Hum Genet. , vol.59 , pp. 262-264
    • De Franchis, R.1    Mancini, F.P.2    D'Angelo, A.3    Sebastio, G.4    Fermo, I.5    De Stefano, V.6
  • 33
    • 0031029698 scopus 로고    scopus 로고
    • The (Ala-Val) mutation of methylenetetrahydrofolate reductase as a genetic risk factor for vascular disease in non-insulin-dependent diabetic patients
    • Brulhart MC, Dussoix P, Ruiz J, Passa P, Froguel P, James RW. The (Ala-Val) mutation of methylenetetrahydrofolate reductase as a genetic risk factor for vascular disease in non-insulin-dependent diabetic patients. Am J Hum Genet. 1997;60:228-229.
    • (1997) Am J Hum Genet. , vol.60 , pp. 228-229
    • Brulhart, M.C.1    Dussoix, P.2    Ruiz, J.3    Passa, P.4    Froguel, P.5    James, R.W.6
  • 35
    • 0031049530 scopus 로고    scopus 로고
    • A common mutation in methylenetetrahydrofolate reductase gene is not a major risk of coronary artery disease or myocardial infarction
    • Brugada R, Marian AJ. A common mutation in methylenetetrahydrofolate reductase gene is not a major risk of coronary artery disease or myocardial infarction. Atherosclerosis. 1997;128:107-112.
    • (1997) Atherosclerosis , vol.128 , pp. 107-112
    • Brugada, R.1    Marian, A.J.2
  • 38
    • 0030844717 scopus 로고    scopus 로고
    • The VITA project. C677T mutation in the methylene-tetrahydrofolate reductase gene and risk of venous thromboembolism
    • Tosetto A, Míssíaglía E, Frezzato M, Rodeghiero F, the VITA Project. C677T mutation in the methylene-tetrahydrofolate reductase gene and risk of venous thromboembolism. Br J Haematol. 1997;97:804-806.
    • (1997) Br J Haematol. , vol.97 , pp. 804-806
    • Tosetto, A.1    Míssíaglía, E.2    Frezzato, M.3    Rodeghiero, F.4
  • 40
    • 0030880665 scopus 로고    scopus 로고
    • A common polymorphism in the methylenetetrahydrofolate reductase gene, homocysteine, and ischemic cerebrovascular disease
    • Markus H, Ali N, Swaminathan R, Sankaralingam A, Molloy J, Powell J. A common polymorphism in the methylenetetrahydrofolate reductase gene, homocysteine, and ischemic cerebrovascular disease. Stroke. 1997; 28:1739-1743.
    • (1997) Stroke , vol.28 , pp. 1739-1743
    • Markus, H.1    Ali, N.2    Swaminathan, R.3    Sankaralingam, A.4    Molloy, J.5    Powell, J.6
  • 41
    • 0030723480 scopus 로고    scopus 로고
    • The C677T MTHFR variant and the risk of venous thrombosis
    • Salden A, Keeney S, Hay CRM, Cumming AM. The C677T MTHFR variant and the risk of venous thrombosis. Br J Haematol. 1997;99:464-472.
    • (1997) Br J Haematol. , vol.99 , pp. 464-472
    • Salden, A.1    Keeney, S.2    Hay, C.R.M.3    Cumming, A.M.4
  • 42
    • 0030610090 scopus 로고    scopus 로고
    • The mutation Ala677→Val in the methylenetetrahydrofolate reductase gene: A risk factor for arterial disease and venous thrombosis
    • Arruda VR, von Zuben PM, Chiaparini LC, Annichino-Bizzacchi JM, Costa FF. The mutation Ala677→Val in the methylenetetrahydrofolate reductase gene: a risk factor for arterial disease and venous thrombosis. Thromb Haemost. 1997;77:818-821.
    • (1997) Thromb Haemost. , vol.77 , pp. 818-821
    • Arruda, V.R.1    Von Zuben, P.M.2    Chiaparini, L.C.3    Annichino-Bizzacchi, J.M.4    Costa, F.F.5
  • 43
    • 0030859681 scopus 로고    scopus 로고
    • A mutation in the methylenetetrahydrofolate reductase gene is not associated with increased risk for coronary artery disease or myocardial infarction
    • Anderson JL, King GJ, Thomson MJ, Todd M, Bair TL, Muhlestein JB, Carlquist JF. A mutation in the methylenetetrahydrofolate reductase gene is not associated with increased risk for coronary artery disease or myocardial infarction. J Am Coll Cardiol. 1997;30:1206-1211.
    • (1997) J Am Coll Cardiol. , vol.30 , pp. 1206-1211
    • Anderson, J.L.1    King, G.J.2    Thomson, M.J.3    Todd, M.4    Bair, T.L.5    Muhlestein, J.B.6    Carlquist, J.F.7
  • 44
    • 0024412009 scopus 로고
    • The odds ratio: A useful tool in neurosciences
    • Sandercock P. The odds ratio: a useful tool in neurosciences. J Neurol Neurosurg Psychiatry. 1989;52:817-820.
    • (1989) J Neurol Neurosurg Psychiatry , vol.52 , pp. 817-820
    • Sandercock, P.1
  • 46
    • 0029974036 scopus 로고    scopus 로고
    • The hordaland homocysteine study. Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (≥40 μmol/L)
    • Guttormsen AB, Ueland PM, Nesthus I, Nygård O, Schneede J, Vollset SE, the Hordaland homocysteine study. Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (≥40 μmol/L). J Clin Invest. 1996;98:2174-2183.
    • (1996) J Clin Invest. , vol.98 , pp. 2174-2183
    • Guttormsen, A.B.1    Ueland, P.M.2    Nesthus, I.3    Nygård, O.4    Schneede, J.5    Vollset, S.E.6
  • 48
    • 0030811925 scopus 로고    scopus 로고
    • Genetic predisposition to hyperhomocysteinemia: Deficiency of methylenetetrahydrofolate reductase (MTHFR)
    • Rozen R. Genetic predisposition to hyperhomocysteinemia: deficiency of methylenetetrahydrofolate reductase (MTHFR). Thromb Haemost. 1997; 78:523-526.
    • (1997) Thromb Haemost. , vol.78 , pp. 523-526
    • Rozen, R.1
  • 50
    • 0030832486 scopus 로고    scopus 로고
    • Kinetic basis of hyperhomocysteinemia in patients with chronic renal failure
    • Guttormsen AB, Ueland PM, Svarstad E, Refsum H. Kinetic basis of hyperhomocysteinemia in patients with chronic renal failure. Kidney Int. 1997;52:495-502.
    • (1997) Kidney Int. , vol.52 , pp. 495-502
    • Guttormsen, A.B.1    Ueland, P.M.2    Svarstad, E.3    Refsum, H.4
  • 51
    • 0030022202 scopus 로고    scopus 로고
    • The effect of reduced glomerular filtration rate on plasma total homocysteine concentration
    • Arnadottir M, Hultberg B, Nilsson-Ehle P, Thysell H. The effect of reduced glomerular filtration rate on plasma total homocysteine concentration. Scand J Lab Invest. 1996;56:41-46.
    • (1996) Scand J Lab Invest. , vol.56 , pp. 41-46
    • Arnadottir, M.1    Hultberg, B.2    Nilsson-Ehle, P.3    Thysell, H.4
  • 52
    • 0028600627 scopus 로고
    • Homocysteine and cysteine: Determinants of plasma levels in middle-aged and elderly subjects
    • Brattström L, Lindgren A, Israelsson B, Andersson A, Hultberg B. Homocysteine and cysteine: determinants of plasma levels in middle-aged and elderly subjects. J Intern Med. 1994;236:633-641.
    • (1994) J Intern Med. , vol.236 , pp. 633-641
    • Brattström, L.1    Lindgren, A.2    Israelsson, B.3    Andersson, A.4    Hultberg, B.5
  • 55
    • 0030904875 scopus 로고    scopus 로고
    • The natural history of vascular disease in homocystinuria and the effect of treatment
    • Wilcken DEL, Wilcken B. The natural history of vascular disease in homocystinuria and the effect of treatment. J Inherit Metab Dis. 1997; 20:295-300.
    • (1997) J Inherit Metab Dis. , vol.20 , pp. 295-300
    • Wilcken, D.E.L.1    Wilcken, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.