Homocysteine and folic acid are inversely related in black women with preeclampsia

Hypertension

Volumn 43, Issue 6, 2004, Pages 1279-1282

  Patrick, Thelma E ^a,c   Powers, Robert W ^a,b   Daftary, Ashi R ^a,b   Ness, Roberta B ^a,d   Roberts, James M ^a,b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Preeclampsia; Race

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE;

ADULT; ARTICLE; BLOOD LEVEL; CARDIOVASCULAR RISK; CLINICAL ARTICLE; CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; DIETARY INTAKE; FEMALE; FOLIC ACID DEFICIENCY; HIGH RISK POPULATION; HUMAN; NEGRO; NUTRITIONAL DEFICIENCY; PREECLAMPSIA; PREGNANCY; PRIORITY JOURNAL; RACE DIFFERENCE; VITAMIN SUPPLEMENTATION;

ADOLESCENT; ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; ARTERIOSCLEROSIS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; MATERNAL AGE; PENNSYLVANIA; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY COMPLICATIONS; RISK FACTORS; VITAMIN B 12;

EID: 2542433063     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000126580.81230.da     Document Type: Article

References (25)

1. Eskenazi B, Fenster L, Sidney S. A multivariate analysis of risk factors for preeclampsia. JAMA. 1991;266:237-241.
2. Stone JL, Lockwood CJ, Berkowitz GS, Alvarez M, Lapinski R, Berkowitz RL. risk factors for severe preeclampsia. Obstet Gynecol. 1994;83:357-361.
3. Dekker GA, de Vries JI, Doelitzsch PM, Huijgens PC, von Blomberg BM, Jakobs C, van Geijn HP. Underlying disorders associated with severe early-onset preeclampsia. Am J Obstet Gynecol. 1995;173:1042-1048.
4. Gerhard GT, Malinow MR, DeLoughery TG, Evans AJ, Sexton G, Connor SL, Wander RC, Connor WE. Higher total homocysteine concentrations and lower folate concentrations in premenopausal black women than in premenopausal white women. Am J Clin Nutr. 1999;70:252-260.
5. Jacobsen DW, Gatautis VJ, Green R, Robinson K, Savon SR, Secic M, Ji J, Otto JM, Taylor LM, Jr. Rapid HPLC determination of total homocysteine and other thiols in serum and plasma: sex differences and correlation with cobalamin and folate concentrations in healthy subjects. Clin Chem. 1994;40:873-881.
6. Giles WH, Croft JB, Greenlund KJ, Ford ES, Kittner SJ. Association between total homocyst(e)ine and the likelihood for a history of acute myocardial infarction by race and ethnicity: Results from the Third National Health and Nutrition Examination Survey. Am Heart J. 2000;139:446-453.
7. Saxena S, Carmel R. Racial differences in vitamin B12 levels in the United States. Am J Clin Pathol. 1987;88:95-97.
8. Estrada DA, Billett HH. Racial variation in fasting and random homocysteine levels. Am J Hematol. 2001;66:252-256.
9. Carmel R. Ethnic and racial factors in cobalamin metabolism and its disorders. Seminars in Hematology. 1999;36:88-100.
10. Chandalia M, Abate N, Cabo-Chan AV, Jr., Devaraj S, Jialal I, Grundy SM. Hyperhomocystinemia in Asian Indians living in the United States. J Clin Endocrinol Metab. 2003;88:1089-1095.
11. Bailey LB, Gregory JF. Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: metabolic significance, risks and impact on folate requirement. J Nutri. 1999;129:919-922.
12. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van den Heuvel LP. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995;10:111-113.
13. Gudnason V, Stansbie D, Scott J, Bowron A, Nicaud V, Humphries S. C677T (thermolabile alanine/valine) polymorphism in methylenetetrahydrofolate reductase (MTHFR): its frequency and impact on plasma homocysteine concentration in different European populations. Atherosclerosis. 1998;136:347-354.
14. Giles WH, Kittner SJ, Ou CY, Croft JB, Brown V, Buchholz DW, Earley CJ, Feeser BR, Johnson CJ, Macko RF, McCarter RJ, Price TR, Sloan MA, Stern BJ, Wityk RJ, Wozniak MA, Stolley PD. Thermolabile methylenetetrahydrofolate reductase polymorphism (C677T) and total homocysteine concentration among African-Am and white women. Ethn Dis. 1998;8:149-157.
15. Stevenson RE, Schwartz CE, Du YZ, Adams MJ, Jr. Differences in methylenetetrahydrofolate reductase genotype frequencies, between Whites and Blacks. Am J Hum Genet. 1997;60:229-230.
16. Grandone E, Margaglione M, Colaizzo D, Cappucci G, Paladini D, Martinelli P, Montanaro S, Pavone G, Di Minno G. Factor V Leiden, C>T MTHFR polymorphism and genetic susceptibility to preeclampsia. Thromb Haemost. 1997;77:1052-1054.
17. Lachmeijer AM, Amgrimsson R, Bastiaans EJ, Pals G, ten Kate LP, de Vries JI, Kostense PJ, Aamoudse JG, Dekker GA. Mutations in the gene for methylenetetrahydrofolate reductase, homocysteine levels, and vitamin status in women with a history of preeclampsia. Am J Obstet Gynecol. 2001;184:394-402.
18. Powers RW, Minich LA, Lykins DL, Ness RB, Crombleholme WR, Roberts JM. Methylenetetrahydrofolate reductase polymorphism, folate, and susceptibility to preeclampsia. J Soc Gynecol Invest. 1999;6:74-79.
19. Sohda S, Arinami T, Hamada H, Yamada N, Hamaguchi H, Kubo T. Methylenetetrahydrofolate reductase polymorphism and pre-eclampsia. J Med Genet. 1997;34:525-526.
20. Rimm EB, Willett WC, Hu FB, Sampson L, Colditz GA, Manson JE, Hennekens C, Stampfer MJ. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. JAMA. 1998;279:359-364.
21. Robinson K, Arheart K, Refsum H, Brattstrom L, Boers G, Ueland P, Rubba P, Palma-Reis R, Meleady R, Daly L, Witteman J, Graham I. Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. Circulation. 1998;97:437-443.
22. Verhoef P, Stampfer MJ, Buring JE, Gaziano JM, Allen RH, Stabler SP, Reynolds RD, Kok FJ, Hennekens CH, Willett WC. Homocysteine metabolism and risk of myocardial infarction: relation with vitamins B6, B12, and folate. Am J Epidemiol. 1996;143:845-859.
23. Nallamothu BK, Fendrick AM, Omenn GS. Homocyst(e)ine and coronary heart disease: pharmacoeconomic support for interventions to lower hyperhomocyst(e)inaemia. Pharmacoeconomics. 2002;20:429-442.
24. Walker MC, Smith GN, Perkins SL, Keely EJ, Garner PR. Changes in homocysteine levels during normal pregnancy. Am J Obstet Gynecol. 1999;180:660-664.
25. Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline a report of the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline and Subcommittee on Upper Reference Levels of Nutrients, Food and Nutrition Board, Institute of Medicine. Washington, DC: National Academy Press; 1998.