Oncogenic and anti-oncogenic effects of transient receptor potential channels

Current Topics in Medicinal Chemistry

Volumn 13, Issue 3, 2013, Pages 344-366

  Liberati, Sonia ^a,b   Morelli, Maria Beatrice ^a   Nabissi, Massimo ^a   Santoni, Matteo ^c   Santoni, Giorgio ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

Angiogenesis; Apoptosis; Target therapy; Transient receptor potential channels; Tumor promoting proteins; Tumor suppressor proteins

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; ANDROGEN RECEPTOR ANTAGONIST; ANDROSTANOLONE; AZOXYMETHANE; BCG VACCINE; CANNABIDIOL; CAPSAICIN; CARCINOGEN; DOCETAXEL; DOCOSAHEXAENOIC ACID; EPIDERMAL GROWTH FACTOR RECEPTOR; FAS ANTIGEN; ICOSAPENTAENOIC ACID; MESSENGER RNA; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; POLYUNSATURATED FATTY ACID; SOMATOMEDIN C; TAMOXIFEN; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL 2; TRANSIENT RECEPTOR POTENTIAL CHANNEL 4; TRANSIENT RECEPTOR POTENTIAL CHANNEL 5; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; TRANSIENT RECEPTOR POTENTIAL CHANNEL M1; TRANSIENT RECEPTOR POTENTIAL CHANNEL M6; TRANSIENT RECEPTOR POTENTIAL CHANNEL M7; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; VANILLOID RECEPTOR; VITAMIN D;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BASAL CELL CARCINOMA; BLADDER CANCER; BREAST ADENOCARCINOMA; BREAST CANCER; CALCIUM CELL LEVEL; CANCER INHIBITION; CANCER STAGING; CELL CYCLE ARREST; CELL PROLIFERATION; COLON CANCER; COLON CARCINOMA; ESOPHAGUS CARCINOMA; GLIOBLASTOMA; GLIOMA CELL; HEPATOBLASTOMA; HIGH RISK POPULATION; HUMAN; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; KIDNEY CANCER; LIVER CELL CARCINOMA; LUNG CANCER; MELANOMA; MOUTH SQUAMOUS CELL CARCINOMA; NASOPHARYNX CARCINOMA; NEUROBLASTOMA; NEUROENDOCRINE TUMOR; NONHUMAN; OVARY CANCER; PANCREAS ADENOCARCINOMA; PATHOPHYSIOLOGY; PROSTATE CANCER; PROSTATECTOMY; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; STOMACH ADENOCARCINOMA; SURVIVAL RATE; UTERINE CERVIX CANCER; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; HUMANS; MOLECULAR TARGETED THERAPY; NEOPLASMS; RNA, MESSENGER; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TUMOR MARKERS, BIOLOGICAL;

EID: 84876720724     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/1568026611313030011     Document Type: Review

References (248)

1. Prevarskaya, N.; Zhang, L.; Barritt, G. TRP channels in cancer. Biochim. Biophys. Acta, 2007,1772(8), 937-946.
2. Gkika, D.; Prevarskaya, N. Molecular mechanisms of TRP regulation in tumor growth and metastasis. Biochim. Biophys. Acta, 2009, 1793(6), 953-958.
3. Santoni, G.; Farfariello, V.; Amantini, C. TRPV channels in tumor growth and progression. Adv. Exp. Med. Biol.; 2011,704, 947-967.
4. Hoeft, B.; Linseisen, J.; Beckmann, L.; Müller-Decker, K.; Canzian, F.; Hüsing, A.; Kaaks, R.; Vogel, U.; Jakobsen, M.U.; Overvad, K.; Hansen, R.D.; Knüppel, S.; Boeing, H.; Trichopoulou, A.; Yvoni, K.; Trichopoulos, D.; Berrino, F.; Palli, D.; Panico, S.; Tumino, R.; Bueno-de-Mesquita, H.B.; van Duijnhoven, F.J.; van Gils, C.H.; Peeters, P.H.; Dumeaux, V.; Lund, E.; Huerta Castaño, J.M.; Muñoz, X.; Rodriguez, L.; Barricarte, A.; Manjer, J.; Jirström, K.; Van Guelpen, B.; Hallmans, G.; Spencer, E.A.; Crowe, F.L.; Khaw, K.T.; Wareham, N.; Morois, S.; Boutron-Ruault, M.C.; Clavel-Chapelon, F.; Chajes, V.; Jenab, M.; Boffetta, P.; Vineis, P.; Mouw, T.; Norat, T.; Riboli, E.; Nieters, A. Polymorphisms in fatty acid metabolism-related genes are associated with colorectal cancer risk. Carcinogenesis, 2009, 31(3), 466-472.
5. Morris, J.A.; Shcochat, S.J.; Smith, E.I.; Look, A.T.; Brodeur, G.M.; Cantor, A.B.; Castleberry, R.P. Biological variables in thoracic neuroblastoma: a Pediatric Oncology Group study. J. Pediatr. Surg., 1995, 30(2), 296-302.
6. Kaatsch, P. Epidemiology of childhood cancer 2010, Cancer Treat. Rev., 2010, 36, 277.
7. Monclair, T.; Brodeur, G.M.; Ambros, P.F.; Brisse, H.J.; Cecchetto, G.; Holmes, K.; Kaneko, M.; London, W.B.; Matthay, K.K.; Nuchtern, J.G.; von Schweinitz, D.; Simon, T.; Cohn, S.L.; Pearson, A.D The International Neuroblastoma Risk Group (INRG) staging system: An INRG task force report. J. Clin. Oncol., 2009, 27(2), 298-303.
8. Alvarado, C.S.; London, W.B.; Look, A.T.; Brodeur, G.M.; Altmiller, D.H.; Thorner, P.S.; Joshi, V.V.; Rowe, S.T.; Nash, M.B.; Smith, E.I.; Castleberry, R.P.; Cohn, S.L. Natural history and biology of stage A neuroblastoma: a Pediatric Oncology Group Study. J. Pediatr. Hematol. Oncol., 2000, 22(3), 197-205.
9. Weinstein, J.L.; Katzenstein, H.M.; Cohn, S.L. Advances in the diagnosis and treatment of neuroblastoma. Oncologist, 2003, 8(3), 278-292.
10. Bollimuntha, S.; Singh, B.B.; Shavali, S.; Sharma, S.K.; Ebadi, M. TRPC1-mediated inhibition of 1-methyl-4-phenylpyridinium ion neurotoxicity in human SH-SY5Y neuroblastoma cells. J. Biol. Chem., 2005, 280(3), 2132-2140.
11. Bollimuntha, S.; Ebadi, M.; Singh, B.B. TRPC1 protects human SH-SY5Y cells against salsolinol-induced cytotoxicity by inhibiting apoptosis. Brain Res., 2006, 1099(1), 141-149.
12. Lilja, J.; Laulund, F.; Forsby, A. Insulin and Insulin-Like Growth Factor Type-I Up-Regulate the Vanilloid Receptor-1 (TRPV1) in Stably TRPV1-Expressing SH-SY5Y Neuroblastoma Cells. J. Neurosci. Res., 2007, 85(7), 1413-1419.
13. Louhivuori, L.M.; Bart, G.; Larsson, K.P.; Louhivuori, V.; Näsman, J.; Nordström, T.; Koivisto, A.P.; Akerman, K.E. Differentiation dependent expression of TRPA1 and TRPM8 channels in IMR-32 human neuroblastoma cells J Cell Physiol., 2009, 221(1), 67-74.
14. Wong, M.L.; Kaye, A.H.; Hovens, C.M. Targeting malignant glioma survival signalling to improve clinical outcomes. J. Clin. Neurosci., 2007, 14(4), 301-308.
15. Van Meir, E.G.; Hadjipanayis, C.G.; Norden, A.D.; Shu, H.K.; Wen, P.Y.; Olson, J.J. Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma. CA Cancer J. Clin., 2010, 60(3), 166-193.
16. Amantini, C.; Mosca, M.; Nabissi, M.; Lucciarini, R.; Caprodossi, S.; Arcella, A.; Giangaspero, F.; Santoni, G. Capsaicin-induced apoptosis of glioma cells is mediated by TRPV1 vanilloid receptor and requires p38 MAPK activation. J. Neurochem., 2007, 102(3), 977-990.
17. Stock, K.; Kumar, J.; Synowitz, M.; Petrosino, S.; Imperatore, R.; Smith, E.S.; Wend, P.; Purfürst, B.; Nuber, U.A.; Gurok, U.; Matyash, V.; Wälzlein, J.H.; Chirasani, S.R.; Dittmar, G.; Cravatt, B.F.; Momma, S.; Lewin, G.R.; Ligresti, A.; De Petrocellis, L.; Cristino, L.; Di Marzo, V.; Kettenmann, H.; Glass, R. Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1. Nat. Med., 2012, doi: 10.1038/nm.2827.
18. Contassot, E.; Wilmotte, R.; Tenan, M.; Belkouch, M.C.; Schnüriger, V.; de Tribolet, N.; Burkhardt, K.; Dietrich, P.Y. Arachidonylethanolamide induces apoptosis of human glioma cells through vanilloid receptor-1. J. Neuropathol. Exp. Neurol., 2004, 63(11), 956.
19. Nabissi, M.; Morelli, M.B.; Amantini, C.; Farfariello, V.; Ricci-Vitiani, L.; Caprodossi, S.; Arcella, A.; Santoni, M.; Giangaspero, F.; De Maria, R.; Santoni, G. TRPV2 channel negatively controls glioma cell proliferation and resistance to Fas-induced apoptosis in ERK-dependent manner. Carcinogenesis, 2010, 31(5), 794-803.
20. Galli, R.; Binda, E.; Orfanelli, U.; Cipelletti, B.; Gritti, A.; De Vitis, S.; Fiocco, R.; Foroni, C.; Dimeco, F.; Vescovi, A. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res., 2004, 64(19), 7011-7021.
21. Singh, S.K.; Clarke, I.D.; Terasaki, M.; Bonn, V.E.; Hawkins, C.; Squire, J.; Dirks, P.B. Identification of a cancer stem cell in human brain tumors. Cancer Res., 2003, 63(5), 5821-5828.
22. Yuan, X.; Curtin, J.; Xiong, Y.; Liu, G.; Waschsmann-Hogiu, S.; Farkas, D.L.; Black, K.L.; Yu, J.S. Isolation of cancer stem cells from adult glioblastoma multiforme. Oncogene, 2004, 23(58), 9392-9400.
23. Morelli, M.B.; Nabissi, M.; Amantini, C.; Farfariello, V.; Ricci-Vitiani, L.; di Martino, S.; Pallini, R.; Larocca, L.M.; Caprodossi, S.; Santoni, M.; De Maria, R.; Santoni, G. The transient receptor potential vanilloid-2 cation channel impairs glioblastoma stem-like cell proliferation and promotes differentiation. Int. J. Cancer, 2012, 131(7), E1067-1077, doi: 10.1002/ijc.27588.
24. Benfenati, V.; Amiry-Moghaddam, M.; Caprini, M.; Mylonakou, M.N.; Rapisarda, C.; Ottersen, O.P.; Ferroni, S. Expression and functional characterization of transient receptor potential vanilloidrelated channel 4 (TRPV4) in rat cortical astrocytes. Neuroscience, 2007, 148(4), 876-892.
25. Bomben, V.C.; Sontheimer, H.W. Inhibition of transient receptor potential canonical channels impairs cytokinesis in human malignant gliomas. Cell Prolif., 2008, 41(1), 98-121.
26. Odell, A.F.; Scott, J.L.; Van Helden D.F. Epidermal growth factor induces tyrosine phosphorylation, membrane insertion, and activation of transient receptor potential channel 4. J. Biol. Chem., 2005, 280(45), 37974-37987.
27. Bryant, J.A.; Finn, R.S.; Slamon, D.J.; Cloughesy, T.F.; Charles, A.C. EGF activates intracellular and intercellular calcium signaling by distinct pathways in tumor cells. Cancer Biol.Ther., 2004, 3(12), 1243-1249.
28. Nilius, B.; Droogmans, G.; Wondergem, R. Transient receptor potential channels in endothelium: solving the calcium entry puzzle? Endothelium, 2003, 10(1), 5-15.
29. Tiruppathi, C.; Freichel, M.; Vogel, S.M.; Paria, B.C.; Mehta, D.; Flockerzi, V.; Malik, A.B. Impairment of store-operated Ca2+ entry in TRPC4-/-mice interferes with increases in lung microvascular permeability. Circ. Res., 2002, 91(1), 70-76.
30. Hofmann, T.; Schaefer, M.; Shultz, G.; Gudermann, T. Subunit composition of mammalian transient receptor potential channels in living cells. Proc. Natl. Acad. Sci. USA, 2002, 99(11), 7461-7466.
31. Wang, B.; Li, W.; Meng, X.; Zou, F. Hypoxia up-regulates vascular endothelial growth factor in U-87 MG cells: involvement of TRPC1. Neurosci. Lett., 2009, 459(3), 132-136.
32. Ding, X.; He, Z.; Zhou, K.; Cheng, J.; Yao, H.; Lu, D.; Cai, R.; Jin, Y.; Dong, B.; Xu, Y.; Wang, Y. Essential role of TRPC6 channels in G2/M phase transition and development of human glioma. J. Natl. Cancer Inst., 2010, 102(4), 1052-1068.
33. Hamdollah Zadeh, M.A.; Glass, C.A.; Magnussen, A.; Hancox, J.C.; Bates, D.O. VEGF-mediated elevated intracellular calcium and angiogenesis in human microvascular endothelial cells in vitro are inhibited by dominant negative TRPC6. Microcirculation, 2008, 15(7), 605-614.
34. Ge, R.; Tai, Y.; Sun, Y.; Zhou, K.; Yang, S.; Cheng, T.; Zou, Q.; Shen, F.; Wang, Y. Critical role of TRPC6 channels in VEGFmediated angiogenesis. Cancer Lett., 2009, 283(1), 43-51.
35. Mosieniak, G.; Pyrzynska, B.; Kaminska, B. Nuclear factor of activated T cells (NFAT) as a new component of the signal transduction pathway in glioma cells. J. Neurochem., 1998, 71(1), 134-141.
36. Chigurupati, S.; Venkataraman, R.; Barrera, D.; Naganathan, A.; Madan, M.; Paul, L.; Pattisapu, J.V.; Kyriazis, G.A.; Sugaya, K.; Bushnev, S.; Lathia, J.D.; Rich, J.N.; Chan, S.L. Receptor Channel TRPC6 Is a Key Mediator of Notch-Driven Glioblastoma Growth and Invasiveness. Cancer Res., 2010, 70(1), 418-427.
37. Singh, I.; Knezevic, N.; Ahmmed, G.U.; Kini, V.; Malik, A.B.; Mehta, D. G q-TRPC6-mediated Ca2+ Entry Induces RhoA Activation and Resultant Endothelial Cell Shape Change in Response to Thrombin. J. Biol. Chem., 2007, 282(11), 7833-7843.
38. Kini, V.; Chavez, A.; Mehta, D. A new role for PTEN in regulating transient receptor potential canonical channel 6-mediated Ca2+ entry, endothelial permeability, and angiogenesis. J. Biol. Chem.; 2010, 285(43), 33082-33091.
39. Yu, P.C.; Gu, S.Y.; Bu, J.W.; Du, J.L. TRPC1 is essential for in vivo angiogenesis in zebrafish. Circ. Res., 2010, 106(7), 1221-1232.
40. Jho, D.; Metha, D.; Ahmed, G.; Gao, X.P.; Tiruppahi, C.; Broman, M.; Malik, A.B. Angiopoietin-1 opposes VEGF-induced increase in endothelial permeability by inhibiting TRPC1-dependent Ca2 influx. Circ. Res., 2005, 96(12), 1282-1290.
41. Bomben, V.C.; Turner, K.L.; Barclay, T.C.; Sontheimer, H. Transient Receptor Potential Canonical Channels Are Essential for Chemotactic Migration of Human Malignant Gliomas. J. Cell. Physiol., 2011, 226(7), 1879-1888.
42. Bezzerides, V.J.; Ramsey, I.S.; Kotecha, S.; Greka, A.; Clapham, D.E. Rapid vesicular translocation and insertion of TRP channels. Nat. Cell Biol.; 2004, 6(8), 709-720.
43. Beech, D.J. TRPC1: store-operated channel and more. Pflügers Archiv., 2005, 451(1), 53-60.
44. Bomben, V.C.; Sontheimer, H. Disruption of Transient Receptor Potential Canonical Channel 1 causes incomplete cytokinesis and slows the growth of human malignant gliomas. Glia, 2010, 58(10), 1145-1156.
45. Grimaldi, M.; Maratos, M.; Verma, A. Transient receptor potential channel activation causes a novel form of [Ca 2+]I oscillations and is not involved in capacitative Ca 2+ entry in glial cells. J. Neurosci., 2003, 23(11), 4737-4745.
46. Wondergem, R.; Ecay, T.W.; Mahieu, F.; Owsianik, G.; Nilius, B. HGF/SF and menthol increase human glioblastoma cell calcium and migration. Biochem. Biophys. Res. Commun., 2008, 372(1), 210-215.
47. Clark, K.; Langeslag, M.; van Leeuwen, B.; Ran, L.; Ryazanov, A.G.; Figdor, C.G.; Moolenaar, W.H.; Jalink, K.; van Leeuwen, F.N. TRPM7, a novel regulator of actomyosin contractility and cell adhesion. EMBO J., 2006, 25(2), 290-301.
48. Ishii, M.; Oyama, A.; Hagiwara, T.; Miyazaki, A.; Mori, Y.; Kiuchi, Y.; Shimizu, S. Facilitation of H2O2-induced A172 human glioblastoma cell death by insertion of oxidative stress-sensitive TRPM2 channels. Anticancer Res., 2007, 27(6B), 3987-3992.
49. Garcia, M.; Jemal, A.; Ward, E.M.; Center, M.M.; Hao, Y.; Siegel, R.L.; Thun, M.J. Global Cancer Facts and Figures 2007; American Cancer Society: Atlanta, 2007.
50. Hery, C.; Ferlay, J.; Boniol, M.; Autier, P. Quantification of changes in breast cancer incidence and mortality since 1990 in 35 countries with Caucasian-majority populations. Ann. Oncol., 2008, 19(6), 1187-1194.
51. Chen, D.T.; Nasir, A.; Culhane, A.; Venkataramu, C.; Fulp, W.; Rubio, R.; Wang, T.; Agrawal, D.; McCarthy, S.M.; Gruidl, M.; Bloom, G.; Anderson, T.; White, J.; Quackenbush, J.; Yeatman, T. Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue. Breast Cancer Res. Treat., 2010, 119(2), 335-346.
52. Ouadid-Ahidouch, H.; Dhennin-Duthille, I.; Gautier, M.; Sevestre, H.; Ahidouch, A. [TRP calcium channel and breast cancer: expression, role and correlation with clinical parameters]. Bull. Cancer, 2012, 99(6), 655-664.
53. Dhennin-Duthille, I.; Gautier, M.; Faouzi, M.; Guilbert, A.; Brevet, M.; Vaudry, D.; Ahidouch, A.; Sevestre, H.; Ouadid-Ahidouch, H. High expression of transient receptor potential channels in human breast cancer epithelial cells and tissues: correlation with pathological parameters. Cell Physiol. Biochem., 2011, 28(5), 813-822.
54. Chodon, D.; Guilbert, A.; Dhennin-Duthille, I.; Gautier, M.; Telliez, M.; Sevestre, H.; Ouadid-Ahidouch, H. Estrogen regulation of TRPM8 expression in breast cancer cells. BMC Cancer, 2010, 10, 212.
55. Guilbert A.; Gautier, M.; Dhennin-Duthille, I.; Haren, N.; Sevestre, H.; Ouadid-Ahidouch, H. Evidence that TRPM7 is required for breast cancer cell proliferation. Am. J. Physiol. Cell. Physiol., 2009, 297(3), C493-502.
56. Middelbeek, J.; Kuipers, A.J.; Henneman, L.; Visser, D.; Eidhof, I.; van Horssen, R.; Wieringa, B.; Canisius, S.V.; Zwart, W.; Wessels, L.F.; Sweep, F.C.G.J.; Bult, P.; Span, P.N.; van Leeuwen, F.N.; Jalink, K. TRPM7 is required for breast tumor cell metastasis. Cancer Res., 2012, 72(16), 4250-4261.
57. Aydar, E.; Yeo, S.; Djamgoz, M.; Palmer, C. Abnormal expression, localization and interaction of canonical transient receptor potential ion channels in human breast cancer cell lines and tissues: a potential target for breast cancer diagnosis and therapy. Cancer Cell Int., 2009, 9, 23.
58. El Hiani, Y.; Ahidouch, A.; Lehen'Kyi, V.; Hague, F.; Gouilleux, F.; Mentaverri, R.; Kamel, S.; Lassoued, K.; Brûlé, G.; Ouadid-Ahidouch, H. Extracellular signal-regulated kinases 1 and 2 and TRPC1 channels are required for calcium-sensing receptorstimulated MCF-7 breast cancer cell proliferation. Cell. Physiol. Biochem., 2009, 23(4-6), 335-346.
59. Bolanz, K.A.; Hediger, M.A.; Landowski, C.P. The role of TRPV6 in breast carcinogenesis. Mol. Cancer Ther., 2008, 7(2), 271-279.
60. Peters, A.A.; Simpson, P.T.; Bassett, J.J.; Lee, J.M.; Da Silva, L.; Reid, L.E.; Song, S.; Parat, M.O.; Lakhani, S.R.; Kenny, P.A.; Roberts-Thomson, S.J.; Monteith, G.R. Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor-negative breast cancer. Mol. Cancer Ther., 2012, 11(10), 2158-2168.
61. Schwarz, E.C.; Wissenbach, U.; Niemeyer, B.A.; Strauss, B.; Philipp, S.E.; Flockerzi, V.; Hoth, M. TRPV6 potentiates calciumdependent cell proliferation. Cell Calcium, 2006, 39(2), 163-173.
62. Bolanz, K.A.; Kovacs, G.G.; Landowski, C.P.; Hediger, M.A. Tamoxifen inhibits TRPV6 activity via estrogen receptorindependent pathways in TRPV6-expressing MCF-7 breast cancer cells. Mol. Cancer Res., 2009, 7(12), 2000-2010.
63. Zhang, H.; Zhou, L.; Shi, W.; Song, N.; Yu, K.; Gu, Y. A mechanism underlying the effects of polyunsaturated fatty acids on breast cancer. Int. J. Mol. Med., 2012, 30(3), 487-494.
64. El Hiani, Y.; Ahidouch, A.; Roudbaraki, M.; Guenin, S.; Brûlé, G. Ouadid-Ahidouch, H. Calcium-sensing receptor stimulation induces nonselective cation channel activation in breast cancer cells. J. Membr. Biol., 2006, 211(2), 127-137.
65. El Hiani, Y.; Lehen'Kyi, V.; Ouadid-Ahidouch, H.; Ahidouch, A. Activation of the calcium-sensing receptor by high calcium induced breast cancer cell proliferation and TRPC1 cation channel overexpression potentially through EGFR pathways. Arch. Biochem. Biophys., 2009, 486(1), 58-63.
66. Jemal, A.; Siegel, R.; Ward, E.; Hao, Y.; Xu, J.; Murray, T.; Thun, M.J. Cancer statistics 2008, CA Cancer J. Clin., 2008, 58(2), 71-96.
67. Allen, D.H.; Lepple-Wienhues, A.; Cahalan, M.D. Ion channel phenotype of melanoma cell lines. J. Membr. Biol., 1997, 155(1), 27-34.
68. Duncan, L.M.; Deeds, J.; Hunter, J.; Shao, J.; Holmgren, L.M.; Woolf, E.A.; Tepper, R.I.; Shyjan, A.W. Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis. Cancer Res., 1998, 58(7), 1515-1520.
69. Hunter, J.J.; Shao, J.; Smutko, J.S.; Dussault, B.J.; Nagle, D.L.; Woolf, E.A.; Holmgren, L.M.; Moore, K.J.; Shyjan, A.W. Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1). Genomics, 1998, 54(1), 116-123.
70. Xu, X.Z.; Moebius, F.; Gill, D.L.; Montell, C. Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform. Proc. Natl. Acad. Sci. USA, 2001, 98(19), 10692-10697.
71. Nilius, B. TRP channels in disease. Biochim. Biophys. Acta, 2007, 1772(8), 805-812.
72. Fang, D.; Setaluri, V. Expression and Up-regulation of alternatively spliced transcripts of melastatin, a melanoma metastasis-related gene, in human melanoma cells. Biochem. Biophys. Res. Commun., 2000, 279(1), 53-61.
73. Deeds, J.; Cronin, F.; Duncan, L.M. Patterns of melastatin mRNA expression in melanocytic tumors. Hum. Pathol., 2000, 31(11), 1346-1356.
74. Miller, A.J.; Du, J.; Rowan, S.; Hershey, C.L.; Widlund, H.R.; Fisher, D.E. Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma. Cancer Res., 2004, 64(2), 509-516.
75. Zhiqi, S.; Soltani, M.H.; Bhat, K.M.; Sangha, N.; Fang, D.; Hunter, J.J.; Setaluri, V. Human melastatin 1 (TRPM1) is regulated by MITF and produces multiple polypeptide isoforms in melanocytes and melanoma. Melanoma Res., 2004, 14(6), 509-516.
76. Hammock, L.; Cohen, C.; Carlson, G.; Murray, D.; Ross, J.S.; Sheehan, C.; Nazir, T.M.; Carlson, J.A. Chromogenic in situ hybridization analysis of melastatin mRNA expression in melanomas from American Joint Committee on Cancer stage I and II patients with recurrent melanoma. J. Cutan. Pathol., 2006, 33(9), 599-607.
77. Felicetti, F.; Errico, M.C.; Segnalini, P.; Mattia, G.; Care, A. MicroRNA-221 and -222 pathway controls melanoma progression. Expert. Rev. Anticancer. Ther., 2008, 8(11), 1759-1765.
78. Mazar, J.; DeYoung, K.; Khaitan, D.; Meister, E.; Almodovar, A.; Goydos, J.; Ray, A.; Perera, R.J. The Regulation of miRNA-211 Expression and Its Role in Melanoma Cell Invasiveness. PLoS ONE, 2010, 5(11), e13779.
79. Yamamura, H.; Ugawa, S.; Ueda, T.; Morita, A.; Shimada, S. TRPM8 activation suppresses cellular viability in human melanoma. Am. J. Physiol. Cell. Physiol., 2008, 295(2), C296-301.
80. Slominski, A. Cooling skin cancer: menthol inhibits melanoma growth. Focus on "TRPM8 activation suppresses cellular viability in human melanoma". Am. J. Physiol. Cell. Physiol., 2008, 295(2), C293-295.
81. Baylin, S.B.; Ohm, J.E. Epigenetic gene silencing in cancer-a mechanism for early oncogenic pathway addiction? Nat. Rev. Cancer, 2006, 6(2), 107-116.
82. Ehrlich, M. In: DNA Alterations in Cancer; Ehrlich, Ed.; Massachusetts, 2000, 273-291.
83. Orfanelli, U.; Wenke, A.K.; Doglioni, C.; Russo, V.; Bosserhoff, A.K.; Lavorgna, G. Identification of novel sense and antisense transcription at the TRPM2 locus in cancer. Cell Res., 2008, 18(11), 1128-1140.
84. Jin, Y.; Jin, C. Oral squamous cell carcinoma; Atlas Genet. Cytogenet. Oncol. Haematol, 2006.
85. Byers, R.M.; El-Naggar, A.K.; Lee, Y.Y.; Rao, B.; Fornage, B.; Terry, N.H.; Sample, D.; Hankins, P.; Smith, T.L.; Wolf, P.J. Can we detect or predict the presence of occult nodal metastases in patients with squamous carcinoma of the oral tongue? Head Neck, 1998, 20(2), 138-144.
86. Bödding, M. TRP proteins and cancer. Cell Signal., 2007, 19(3), 617-624.
87. Marincsák, R.; Tóth, B.I.; Czifra, G.; Márton, I.; Rédl, P.; Tar, I.; Tóth, L.; Kovács, L.; Bíró, T. Increased expression of TRPV1 in squamous cell carcinoma of the human tongue. Oral Dis., 2009, 15(5), 328-335.
88. Bode, A.M.; Cho, Y.Y.; Zheng, D.; Zhu, F.; Ericson, M.E.; Ma, W.Y.; Yao, K.; Dong, Z. Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis. Cancer Res., 2009, 69(3), 905-913.
89. Li, S.; Bode, A.M.; Zhu, F.; Liu, K.; Zhang, J.; Kim, M.O.; Reddy, K.; Zykova, T.; Ma, W.; Carper, A.L.; Langfald, A.K.; Dong, Z. TRPV1-antagonist AMG9810 promotes mouse skin tumorigenesis through EGFR/Akt signaling. Carcinogenesis, 2011, 32(5), 779-785.
90. Ye, Y.; Dang, D.; Zhang, J.; Viet, C.T.; Lam, D.K.; Dolan, J.C.; Gibbs, J.L.; Schmidt, B.L. Nerve growth factor links oral cancer progression, pain, and cachexia. Mol. Cancer Ther., 2011, 10(9), 1667-1676.
91. Okamoto, Y.; Ohkubo, T.; Ikebe, T.; Yamazaki, J. Blockade of TRPM8 activity reduces the invasion potential of oral squamous carcinoma cell lines. Int. J. Oncol., 2012, 40(5), 1431-1440.
92. Miller, S.J. Biology of basal cell carcinoma (Part II). J. Am. Acad. Dermatol., 1991, 24, 161-175.
93. Beck, B.; Lehen'Kyi, V.; Roudbaraki, M.; Flourakis, M.; Charveron, M.; Bordat, P.; Polakowska, R.; Prevarskaya, N.; Skryma, R. TRPC channels determine human keratinocyte differentiation: new insight into basal cell carcinoma. Cell Calcium, 2008, 43(5), 492-505.
94. Parkin, D.M.; Whelan, S.L.; Ferlay, J.; Teppo, L.; Thomas, D.B. Cancer incidence in five continents; IARC Sci Publ.: Lyon, 2002,
95. Chen, J-P.; Luan, Y.; You, C-X.; Chen, X-H.; Luo, R-C.; Li, R. TRPM7 regulates the migration of human nasopharyngeal carcinoma cell by mediating Ca(2+) influx. Cell Calcium, 2010, 47(5), 425-432.
96. Jiang, J.; Li, M.H.; Inoue, K.; Chu, X.P.; Seeds, J.; Xiong, Z.G. Transient receptor potential melastatin 7-like current in human head and neck carcinoma cells: role in cell proliferation. Cancer Res., 2007, 67(22), 10929-10938.
97. He, B.; Liu, F.; Ruan, J.; Li, A.; Chen, J.; Li, R.; Shen, J.; Zheng, D.; Luo, R. Silencing TRPC1 expression inhibits invasion of CNE2 nasopharyngeal tumor cells. Oncol, Rep., 2012, 27(5), 1548-1554.
98. Jemal, A.; Murray, T.; Ward, E.; Samuels, A.; Tiwari, R.C.; Ghafoor, A.; Feuer, E.J.; Thun, M.J. Cancer statistics, 2005. CA Cancer J. Clin., 2005, 55(1), 10-30.
99. Heilig, E.A.; Thompson, K.J.; Molina, R.M.; Ivanov, A.R.; Brain, J.D.; Wessling-Resnick, M. Manganese and iron transport across pulmonary epithelium. Am. J. Physiol. Lung Cell. Mol. Physiol., 2006, 290(6), L1247-1259.
100. Wei, C.; Wang, X.; Chen, M.; Ouyang, K.; Song, L.S.; Cheng, H. Calcium flickers steer cell migration. Nature, 2009, 457(7231), 901-905.
101. Gao, H.; Chena, X.; Dua, X.; Guana, B.; Liua, Y.; Zhanga, H. EGF enhances the migration of cancer cells by up-regulation of TRPM7. Cell Calcium, 2011, 50(6), 559-568.
102. Tajeddine, N.; Gailly, P. TRPC1 protein channel is major regulator of epidermal growth factor receptor signaling. J. Biol. Chem., 2012, 287(20), 16146-16157.
103. Saito, H.; Minamiya, Y.; Watanabe, H.; Takahashi, N.; Ito, M.; Toda, H.; Konno, H.; Mitsui, M.; Motoyama, S.; Ogawa, J. Expression of the transient receptor potential channel c3 correlates with a favorable prognosis in patients with adenocarcinoma of the lung. Ann Surg Oncol., 2011, 18(12), 3377-3383.
104. Shi, Y.; Ding, X.; He, Z.H.; Zhou, K.C.; Wang, Q.; Wang, Y.Z. Critical role of TRPC6 channels in G2 phase transition and the development of human oesophageal cancer. Gut, 2009, 58(11), 1443-1450.
105. Cunningham, D.; Allum, W.H.; Stenning, S.P.; Thompson, J.N.; Van de Velde, C.J.; Nicolson, M.; Scarffe, J.H.; Lofts, F.J.; Falk, S.J.; Iveson, T.J.; Smith, D.B.; Langley, R.E.; Verma, M.; Weeden, S.; Chua, Y.J. Perioperative chemotherapy versus surgery alone for resectablegastroesophageal cancer. N. Engl. J. Med., 2006, 355(1), 11-20.
106. Macdonald, J.S.; Smalley, S.R.; Benedetti, J.; Smalley, S.R.; Benedetti, J.; Hundahl, S.A.; Estes, N.C.; Stemmermann, G.N.; Haller, D.G.; Ajani, J.A.; Gunderson, L.L.; Jessup, J.M.; Martenson, J.A. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N. Engl. J. Med., 2001, 345(10), 725-730.
107. Wagner, A.D.; Unverzagt, S.; Grothe, W.; Kleber, G.; Grothey, A.; Haerting, J.; Fleig, W.E. Chemotherapy for advanced gastric cancer. Cochrane Database Syst. Rev., 2010, 17, CD004064.
108. Price, T.J.; Shapiro, J.D.; Segelov, E.; Karapetis, C.S.; Pavlakis, N.; Van Cutsem, E.; Shah, M.A.; Kang, Y.K.; Tebbutt, N.C. Management of advanced gastric cancer. Expert. Rev. Gastroenterol. Hepatol., 2012, 6(2), 199-208.
109. Chow, J.; Norng, M.; Zhang, J.; Chai, J. TRPV6 mediates capsaicin-induced apoptosis in gastric cancer cells--Mechanisms behind a possible new hot cancer treatment. Biochim. Biophys. Acta., 2007, 1773(4), 565-576.
110. Cai, R.; Ding, X.; Zhou, K.; Shi, Y.; Ge, R.; Ren, G.; Jin, Y.; Wang, Y. Blockade of TRPC6 channels induced G2/M phase arrest and suppressed growth in human gastric cancer cells. Int. J. Cancer., 2009, 125(10), 2281-2287.
111. Kim, B.J.; Park, E.J.; Lee, J.H.; Jeon, J.H.; Kim, S.J.; So, I. Suppression of transient receptor potential melastatin 7 channel induces cell death in gastric cancer. Cancer Sci., 2008, 99(12), 2502-2509.
112. Kim, B.J.; Nah, S.Y.; Jeon, J.H.; So, I.; Kim, S.J. Transient receptor potential melastatin 7 channels are involved in ginsenoside Rg3-induced apoptosis in gastric cancer cells. Basic Clin. Pharmacol. Toxicol., 2011, 109(4), 233-239.
113. Kim, B.J.; Kim, S.Y.; Lee, S.; Jeon, J.H.; Matsui, H.; Kwon, Y.K.; Kim, S.J.; So, I. The role of transient receptor potential channel blockers in human gastric cancer cell viability. Can. J. Physiol. Pharmacol., 2012, 90(2), 175-186.
114. Siegel, R.; Cuesta, M.A.; Targarona, E.; Bader, F.G.; Morino, M.; Corcelles, R.; Lacy, A.M.; Påhlman, L.; Haglind, E.; Bujko, K.; Bruch, H.P.; Heiss, M.M.; Eikermann, M.; Neugebauer, E.A. Laparoscopic extraperitoneal rectal cancer surgery: the clinical practice guidelines of the European Association for Endoscopic Surgery (EAES). Surg. Endosc., 2011, 25(8), 2423-2440.
115. Markowitz, S.D.; Bertagnolli, M.M. Molecular origins of cancer: Molecular basis of colorectal cancer. N. Engl. J. Med., 2009, 361(25), 2449-2460.
116. Giovannucci, E.; Liu, Y.; Willett, W.C. Cancer incidence and mortality and vitamin D in black and white male health professionals. Cacner Epidemiol. Biomarkers Prev., 2006, 15(12), 2467-2472.
117. Holt, P.R.; Bresalier, R.S.; Ma, C.K.; Liu, K.F.; Lipkin, M.; Byrd, J.C.; Yang, K. Calcium plus vitamin D alters preneoplastic features of colorectal adenomas and rectal mucosa. Cancer, 2006, 106(2), 287-296.
118. Newmark, H.L.; Yang, K.; Lipkin, M.; Kopelovich, L.; Liu, Y.; Fan, K.; Shinozaki, H. Carcinogenesis, 2001, 22, 1871.
119. Yang, K.; Yang, W.; Mariadason, J.; Velcich, A.; Lipkin, M.; Augenlicht, L. Dietary components modify gene expression: implications for carcinogenesis. J. Nutr., 2005, 135(11), 2710-2714.
120. Ueda, T.; Yamada, T.; Ugawa, S.; Ishida, Y.; Shimada, S. TRPV3, a thermosensitive channel is expressed in mouse distal colon epithelium. Biochem. Biophys. Res. Commun., 2009, 383(1), 130-134.
121. Lee, H.; Caterina, M.J. TRPV channels as thermosensory receptors in epithelial cells. Pflugers Arch., 2005, 451(1), 160-167.
122. Caterina, M.J. Transient receptor potential ion channels as participants in thermosensation and thermoregulation. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2007, 292(1), R64-76.
123. Levine, J.D.; Alessandri-Haber, N. TRP channels: targets for the relief of pain. Biochim. Biophys. Acta, 2007, 1772(8), 989-1003.
124. Hu, H.Z.; Xiao, R.; Wang, C.; Gao, N.; Colton, C.K.; Wood, J.D.; Zhu, M.X. TRPV3 channel function by unsaturated fatty acids. J. Cell. Physiol., 2006, 208(1), 201-212.
125. Peng, J.B.; Chen, X.Z.; Berger, U.V.; Weremowicz, S.; Morton, C.C.; Vassilev, P.M.; Brown, E.M.; Hediger, M.A. Human calcium transport protein CaT1. Biochem. Biophys. Res. Commun., 2000, 278(2), 326-332.
126. Bartik, L.; Whitfield, G.K.; Kaczmarska, M.; Lowmiller, C.L.; Moffet, E.W.; Furmick, J.K.; Hernandez, Z.; Haussler, C.A.; Haussler, M.R.; Jurutka, P.W. Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention. J. Nutr. Biochem., 2010, 21(12), 1153-1161.
127. Nijenhuis, T.; Hoenderop, J.G.; Nilius, B.; Bindels, R.J. (Patho)physiological implications of the novel epithelial Ca2+ channels TRPV5 and TRPV6. Pflugers Arch., 2003, 446(4), 401-409.
128. Lipkin, M.; Newmark, H. Effect of added dietary calcium on colonic epithelial-cell proliferation in subjects at high risk for familial colonic cancer. N. Engl. J. Med., 1985, 313(22), 1381-1384.
129. Slattery, M.L.; Sorenson, A.W.; Ford, M.H. Dietary calcium intake as a mitigating factor in colon cancer. Am. J. Epidemiol., 1988, 128(3), 504-514.
130. Peleg, S.; Sellin, J.H.; Wang, Y.; Freeman, M.R.; Umar, S. Suppression of aberrant transient receptor potential cation channel, subfamily V, member 6 expression in hyperproliferative colonic crypts by dietary calcium. Am. J. Physiol. Gastrointest. Liver Physiol.; 2010, 299(3), G593-601.
131. Lu, H.; Huan, C. Transcription factor NFAT, its role in cancer development, and as a potential target for chemoprevention. Curr. Cancer Drug Targets, 2007, 7(4), 343-353.
132. Beals, C.R.; Clipstone, N.A.; Ho, S.N.; Crabtree, G.R. Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporinsensitive intramolecular interaction. Genes Dev., 1997, 11(7), 824-834.
133. Duque, J.; Fresno, M.; Iñiguez, M.A. Expression and function of the nuclear factor of activated T cells in colon carcinoma cells: involvement in the regulation of cyclooxygenase-2. J. Biol. Chem., 2005, 280(10), 8686-8693.
134. Sieber, M.; Baumgrass, R. Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506? Cell Commun. Signal., 2009, 7, 25.
135. Aviello, G.; Romano, B.; Borrelli, F.; Capasso, R.; Gallo, L.; Piscitelli, F.; Di Marzo, V.; Izzo, A.A. Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer. J. Mol. Med., 2012, 90(8), 925-934.
136. Ferlay, J.; Shin, H.R.; Bray, F.; Forman, D.; Mathers, C.; Parkin, D.M. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer, 2010, 127(12), 2893-2917.
137. Liu, G.; Xie, C.; Sun, F.; Xu, X.; Yang, Y.; Zhang, T.; Deng, Y.; Wang, D.; Huang, Z.; Yang, L.; Huang, S.; Wang, Q.; Liu, G.; Zhong, D.; Miao, X. Clinical significance of transient receptor potential vanilloid 2 expression in human hepatocellular carcinoma. Cancer Genet. Cytogenet., 2010, 197(1), 54-59.
138. Miao, X.; Liu, G.; Xu, X.; Xie, C.; Sun, F.; Yang, Y.; Zhang, T.; Hua, S.; Fan, W.; Li, Q.; Huang, S.; Wang, Q.; Liu, G.; Zhong, D. High expression of vanilloid receptor-1 is associated with better prognosis of patients with hepatocellular carcinoma. Cancer Genet. Cytogenet., 2008, 186(1), 25-32.
139. El Boustany, C.; Bidaux, G.; Enfissi, A.; Delcourt, P.; Prevarskaya, N.; Capiod, T. Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation. Hepatology, 2008, 47(6), 2068-2077.
140. Mishra, R.; Rao, V.; Ta, R.; Shobeiri, N.; Hill, C.E. Mg2+-and MgATP-inhibited and Ca2+/calmodulin-sensitive TRPM7-like current in hepatoma and hepatocytes. Am. J. Physiol. Gastrointest. Liver Physiol., 2009, 297(4), G687-694.
141. Spector, L.G.; Birch, J. The epidemiology of hepatoblastoma. Pediatr. Blood Cancer, 2012, doi: 10.1002/pbc.24215.
142. Zhang, Y.W.; Vande Woude, G.F. HGF/SF-met signaling in the control of branching morphogenesis and invasion. J. Cell. Biochem., 2003, 88(2), 408-417.
143. Waning, J.; Vriens, J.; Owsianik, G.; Stüwe, L.; Mally, S.; Fabian, A.; Frippiat, C.; Nilius, B.; Schwab, A. A novel function of capsaicin-sensitive TRPV1 channels: involvement in cell migration. Cell Calcium, 2007, 42(1), 17-25.
144. Vriens, J.; Janssens, A.; Prenen, J.; Nilius, B.; Wondergem, R. TRPV channels and modulation by hepatocyte growth factor/scatter factor in human hepatoblastoma (HepG2) cells. Cell Calcium, 2004, 36(1), 19-28.
145. Becker, D.; Bereiter-Hahn, J.; Jendrach, M. Functional interaction of the cation channel transient receptor potential vanilloid 4 (TRPV4) and actin in volume regulation. Eur. J. Cell. Biol., 2009, 88(3), 141-152.
146. Jemal, A.; Siegel, R.; Ward, E.; Hao, Y.; Xu, J.; Thun, MJ. Cancer statistics, 2009. CA Cancer J Clin., 2009, 59(4), 225-249.
147. Ferlay, J.; Autier, P.; Boniol, M.; Heanue, M.; Colombet, M.; Boyle, P. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 2007, 2007, 18(3), 581-592.
148. Yee, N.S.; Zhou, W.; Lee, M. Transient receptor potential channel TRPM8 is over-expressed and required for cellular proliferation in pancreatic adenocarcinoma. Cancer Lett., 2010, 297(1), 49-55.
149. Yee, N.S.; Brown, R.D.; Lee, M.S.; Zhou, W.; Jensen, C.; Gerke, H.; Yee, R.K. TRPM8 ion channel is aberrantly expressed and required for preventing replicative senescence in pancreatic adenocarcinoma: potential role of TRPM8 as a biomarker and target. Cancer Biol. Ther., 2012, 13(8), 592-599.
150. Yee, N.S.; Zhou, W.; Liang, I-C. Transient receptor potential ion channel Trpm7 mediates control of exocrine pancreatic growth via Mg2+-sensitive Socs3a signaling in development and cancer. Dis. Model. Mech., 2011, 4(2), 240-254.
151. Rybarczyk, P.; Gautier, M.; Hague, F.; Dhennin-Duthille, I.; Chatelain, D.; Kerr-Conte, J.; Pattou, F.; Regimbeau, J.M.; Sevestre, H.; Ouadid-Ahidouch, H Transient receptor potential melastatinrelated 7 channel is overexpressed in human pancreatic ductal adenocarcinomas and regulates human pancreatic cancer cell migration. Int. J. Cancer., 2012, 131(6), E851-861.
152. Yee, N.S.; Lorent, K.; Pack, M. Exocrine pancreas development in zebrafish. Dev. Biol., 2005, 284(1), 84-101.
153. Hartel, M.; di Mola, F.F.; Selvaggi, F.; Mascetta, G.; Wente, M.N.; Felix, K.; Giese, N.A.; Hinz, U.; Di Sebastiano, P.; Büchler, M.W.; Friess, H. Vanilloids in pancreatic cancer: potential for chemotherapy and pain management. Gut, 2006, 55(4), 519-528.
154. Wiedenmann, B.; John, M.; Ahnert-Hilger, G.; Riecken, E.O. Molecular and cell biological aspects of neuroendocrine tumors of the gastroenteropancreatic system. J. Mol. Med., 1998, 76(9), 637-647.
155. Fjallskog, M.L.; Lejonklou, M.H.; Oberg, K.E.; Eriksson, B.K.; Janson, E.T. Expression of molecular targets for tyrosine kinase receptor antagonists in malignant endocrine pancreatic tumors. Clin. Cancer Res., 2003, 9(4), 1469-1473.
156. Mergler, S.; Skrzypski, M.; Sassek, M.; Pietrzak, P.; Pucci, C.; Wiedenmann, B.; Strowski, M.Z. Thermo-sensitive transient receptor potential vanilloid channel-1 regulates intracellular calcium and triggers chromogranin A secretion in pancreatic neuroendocrine BON-1 tumor cells. Cell. Signal., 2012, 24(1), 233-246.
157. Mergler, S.; Strowski, M.Z.; Kaiser, S.; Plath, T.; Giesecke, Y.; Neumann, M.; Hosokawa, H.; Kobayashi, S.; Langrehr, J.; Neuhaus, P.; Plockinger, U.; Wiedenmann, B.; Grotzinger, C. Transient receptor potential channel TRPM8 agonists stimulate calcium influx and neurotensin secretion in neuroendocrine tumor cells. Neuroendocrinology, 2007, 85(2), 81-92.
158. Schrader, A.J.; Hofmann, R. Metastatic renal cell carcinoma: recent advances and current therapeutic options. Anticancer Drugs, 2008, 19(3), 35-45.
159. Jemal, A.; Siegel, R.; Xu, J.; Ward, E. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J. Clin., 2011, 61(4), 133-136.
160. Pascual, D.; Borque, A. Epidemiology of kidney cancer. Adv. Urol., 2008, 782381.
161. Protzel, C.; Maruschke, M.; Hakenberg, O.W. Chemotherapy in penile cancer. Europ. Urol. Supplements, 2012, 11(3), 52-58.
162. Wu, Y.; Miyamoto, T.; Li, K.; Nakagomi, H.; Sawada, N.; Kira, S.; Kobayashi, H.; Zakohji, H.; Tsuchida, T.; Fukazawa, M.; Araki, I.; Takeda, M. Decreased expression of the epithelial Ca2+ channel TRPV5 and TRPV6 in human renal cell carcinoma associated with vitamin D receptor. J. Urol., 2011, 186(6), 2419-2425.
163. Hoenderop, J.G.; Müller, D.; Van Der Kemp, A.W.; Hartog, A.; Suzuki, M.; Ishibashi, K.; Imai, M.; Sweep, F.; Willems, P.H.; Van Os, C.H.; Bindels, R.J. Calcitriol controls the epithelial calcium channel in kidney. J. Am. Soc. Nephrol., 2001, 12(7), 1342-1349.
164. Müller, D.; Hoenderop, J.G.; Meij, I.C.; van den Heuvel, L.P.; Knoers, N.V.; den Hollander, A.I.; Eggert, P.; García-Nieto, V.; Claverie-Martín, F.; Bindels, R.J. Molecular cloning, tissue distribution, and chromosomal mapping of the human epithelial Ca2+ channel (ECAC1). Genomics, 2000, 67(1), 48-53.
165. Kuro-o, M.; Matsumura, Y.; Aizawa, H.; Kawaguchi, H.; Suga, T.; Utsugi, T.; Ohyama, Y.; Kurabayashi, M.; Kaname, T.; Kume, E.; Iwasaki, H.; Iida, A.; Shiraki-Iida, T.; Nishikawa, S.; Nagai, R.; Nabeshima, Y.I. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature, 1997, 390(6655), 45-51.
166. Chang, Q.; Hoefs, S.; van der Kemp, A.W.; Topala, C.N.; Bindels, R.J.; Hoenderop, J.G. The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. Science, 2005, 310(5747), 490-493.
167. Bianco, S.D.; Peng, J.B.; Takanaga, H.; Suzuki, Y.; Crescenzi, A.; Kos, C.H.; Zhuang, L.; Freeman, M.R.; Gouveia, C.H.; Wu, J.; Luo, H.; Mauro, T.; Brown, E.M.; Hediger, M.A. Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J. Bone Miner. Res., 2007, 22(2), 274-285.
168. Fleet, J.C.; Eksir, F.; Hance, K.W.; Wood, R.J Vitamin Dinducible calcium transport and gene expression in three Caco-2 cell lines. Am. J. Physiol. Gastrointest Liver Physiol., 2002, 283(3), G618-625.
169. Van Cromphaut, S.J.; Dewerchin, M.; Hoenderop, J.G.; Stockmans, I.; Van Herck, E.; Kato, S.; Bindels, R.J.; Collen, D.; Carmeliet, P.; Bouillon, R.; Carmeliet G. Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects. Proc. Natl. Acad. Sci. U S A, 2001, 98(23), 13324-13329.
170. Karami, S.; Brennan, P.; Navratilova, M.; Mates, D.; Zaridze, D.; Janout, V.; Kollarova, H.; Bencko, V.; Matveev, V.; Szesznia-Dabrowska, N.; Holcatova, I.; Yeager, M.; Chanock, S.; Rothman, N.; Boffetta, P.; Chow, W.H. Moore LE. Vitamin d pathway genes, diet, and risk of renal cell carcinoma. Int. J. Endocrinol., 2010, 2010, 879362.
171. Gallicchio, L.; Moore, L.E.; Stevens, V.L.; Ahn, J.; Albanes, D.; Hartmuller, V.; Setiawan, V.W.; Helzlsouer, K.J.; Yang, G.; Xiang, Y.B.; Shu, X.O.; Snyder, K.; Weinstein, S.J.; Yu, K.; Zeleniuch-Jacquotte, A.; Zheng, W.; Cai, Q.; Campbell, D.S.; Chen, Y.; Chow, W.H.; Horst, R.L.; Kolonel, L.N.; McCullough, M.L.; Purdue, M.P.; Koenig, K.L. Circulating 25-hydroxyvitamin D and risk of kidney cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am. J. Epidemiol., 2010, 172(1), 47-57.
172. Fujioka, T.; Hasegawa, M.; Ishikura, K.; Matsushita, Y.; Sato, M.; Tanji, S. Inhibition of tumor growth and angiogenesis by vitamin D3 agents in murine renal cell carcinoma. J. Urol., 1998, 160(1), 247-251.
173. Blomberg Jensen, M.; Andersen, C.B.; Nielsen, J.E.; Bagi, P.; Jørgensen, A.; Juul, A.; Leffers, H. Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract. Hum Reprod., 2010, 25(5), 1303-1311.
174. Obara, W.; Suzuki, Y.; Kato, K.; Tanji, S.; Konda, R.; Fujioka, T. Vitamin D receptor gene polymorphisms are associated with increased risk and progression of renal cell carcinoma in a Japanese population. Int. J. Urol., 2007, 14(6), 483-487.
175. Zuac, D.P.; Bostad, L.; Kihl, B.; Seidal, T.; Wentzel-Larsen, T.; Haukaas, S.A. The expression of thrombospondin-1 and p53 in clear cell renal cell carcinoma: its relationship to angiogenesis, cell proliferation and cancer specific survival. J. Urol., 2009, 182(5), 2144-2149.
176. Veliceasa, D.; Ivanovic, M.; Hoepfner, F.T.; Thumbikat, P.; Volpert, O.V.; Smith, N.D. Transient potential receptor channel 4 controls thrombospondin-1 secretion and angiogenesis in renal cell carcinoma. FEBS J., 2007, 274(24), 6365-6377.
177. Jemal, A.; Murray, T.; Ward, E.; Samuels, A.; Tiwari, R.C.; Ghafoor, A.; Feuer, E.J.; Thun, M.J. Cancer statistics, 2005, CA Cancer J. Clin., 2005, 55(1), 10-30.
178. Kwak, C.; Ku, J.H.; Park, J.Y.; Lee, E.; Lee, S.E.; Lee, C. Initial tumor stage and grade as a predictive factor for recurrence in patients with stage T1 grade 3 bladder cancer. J. Urol., 2004, 171(1), 149-152.
179. Lazzeri, M.; Vannucchi, M.G.; Spinelli, M.; Bizzoco, E.; Beneforti, P.; Turini, D.; Faussone-Pellegrini, M.S. Transient receptor potential vanilloid type 1 (TRPV1) expression changes from normal urothelium to transitional cell carcinoma of human bladder. Eur. Urol., 2005, 48(4), 691-698.
180. Amantini, C.; Ballarini, P.; Caprodossi, S.; Nabissi, M.; Morelli, M.B.; Lucciarini, R.; Cardarelli, M.A.; Mammana, G.; Santoni, G. Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner. Carcinogenesis, 2009, 30(8), 1320-1329.
181. Yang, Z.H.; Wang, X.H.; Wang, H.P.; Hu, L.Q.; Zheng, X.M.; Li, S.W. Capsaicin mediates cell death in bladder cancer T24 cells through reactive oxygen speciesproduction and mitochondrial depo larization. Urology, 2010, 75(3), 735-741.
182. Lee, J.S.; Chang, J.S.; Lee, J.Y.; Kim, J.A. Capsaicininduced apoptosis and reduced release of reactive oxygen species in MBT-2 murine bladder tumor cells. Archiv. Pharmacol. Res., 2004, 27(11), 1147-1153.
183. Caprodossi, S.; Amantini, C.; Nabissi, M.; Morelli, M.B.; Farfariello, V.; Santoni, M.; Gismondi, A.; Santoni, G. Capsaicin promotes a more aggressive gene expression phenotype and invasiveness in null-TRPV1 urothelial cancer cells. Carcinogenesis, 2011, 32(5), 686-694.
184. Kalogris, C.; Caprodossi, S.; Amantini, C.; Lambertucci, F.; Nabissi, M.; Morelli, M.B.; Farfariello, V.; Filosa, A.; Emiliozzi, M.C.; Mammana, G.; Santoni, G. Expression of transient receptor potential vanilloid-1 (TRPV1) in urothelial cancers of human bladder: relation to clinicopathological and molecular parameters. Histopathol, 2010, 57(5), 744-752.
185. Sindhwani, P.; Hampton, J.A.; Baig, M.M.; Keck, R.; Selman, S.H. Curcumin prevents intravescical tumor implantation of the MBT-2 tumor cell line in C3H mice. J. Urol., 2001, 6(4), 1498-1501.
186. Caprodossi, S.; Lucciarini, R.; Amantini, C.; Nabissi, M.; Canesin, G.; Ballarini, P.; Di Spilimbergo, A.; Cardarelli, M.A.; Servi, L.; Mammana, G.; Santoni, G. Transient receptor potential vanilloid type 2 (TRPV2) expression in normal urothelium and in urothelial carcinoma of human bladder: correlation with the pathologic stage. Eur. Urol., 2008, 54(3), 612-620.
187. Rochester, M.A.; Patel, N.; Turney, B.W.; Davies, D.R.; Roberts, I.S.; Crew, J.; Protheroe, A.; Macaulay, V.M. The type 1 insulinlike growth factor receptor is over-expressed in bladder cancer. BJU Int., 2007, 100(6), 1396-1401.
188. Zhao, H.; Grossman, H.B.; Spitz, M.R.; Lerner, S.P.; Zhang, K.; Wu, X. Plasma levels of insulin-like growth factor-1 and binding protein-3, and their association with bladder cancer risk. J. Urol., 2003, 169(2), 714-717.
189. Yamada, T.; Ugawa, S.; Ueda, T.; Ishida, Y.; Kajita, K.; Shimada, S. Differential localizations of the transient receptor potential channels TRPV4 and TRPV1 in the mouse urinary bladder. J. Histochem. Cytochem., 2009, 57(3), 277-287.
190. Everaerts, W.; Vriens, J.; Owsianik, G.; Appendino, G.; Voets, T.; De Ridder, D.; Nilius, B. Functional characterization of transient receptor potential channels in mouse urothelial cells. Am J. Physiol. Renal. Physiol., 2010, 298(3), F692-701.
191. Li, Q.; Wang, X.; Yang, Z.; Wang, B.; Li, S. Menthol induces cell death via the TRPM8 channel in the human bladder cancer cell line T24. Oncology, 2009, 77(6), 335-341.
192. Jemal, A.; Siegel, R.; Ward, E.; Murray, T.; Xu, J.; Thun, M.J. Cancer statistics, 2007. CA Cancer J. Clin., 2007, 57(1), 43-66.
193. Liao, X.; Tang, S.; Thrasher, J.B.; Griebling, T.L.; Li, B. Smallinterfering RNA-induced androgen receptor silencing leads to apoptotic cell death in prostate cancer. Mol. Cancer Therap., 2012, 4(4), 505-515.
194. Amaral, T.M.; Macedo, D.; Fernandes, I.; Costa, L. Castrationresistant prostate cancer: mechanisms, targets, and treatment. Prostate Cancer, 2012, 2012, 327253.
195. Stein, R.J.; Santos, S.; Nagatomi, J.; Hayashi, Y.; Minnery, B.S.; Xavier, M.; Patel, A.S.; Nelson, J.B.; Futrell, W.J.; Yoshimura, N.; Chancellor, M.B.; De Miguel, F. Cool (TRPM8) and hot (TRPV1) receptors in the bladder and male genital tract. J. Urol., 2004, 172(3), 1175-1178.
196. Sanchez, M.G.; Sanchez, A.M.; Collado, B.; Malagarie-Cazenave, S.; Olea, N.; Carmena, M.J.; Prieto, J.C.; Diaz-Laviada, I.I. Expression of the transient receptor potential vanilloid 1 (TRPV1) in LNCaP and PC-3 prostate cancer cells and in human prostate tissue. Eur. J. Pharmacol., 2005, 515(1-3), 20-27.
197. Dinis, P.; Charrua, A.; Avelino, A.; Nagy, I.; Quintas, J.; Ribau, U.; Cruz, F. The distribution of sensory fibers immunoreactive for the TRPV1 (capsaicin) receptor in the human prostate. Eur. Urol., 2005, 48(1), 162-167.
198. Czifra, G.; Varga, A.; Nyeste, K.; Marincsák, R.; Tóth, B.I.; Kovács, I.; Kovács, L.; Bíró, T. Increased expressions of cannabinoid receptor-1 and transient receptor potential vanilloid-1 in human prostate carcinoma. J. Cancer Res. Clin. Oncol., 2009, 135(4), 507-514.
199. Sanchez, A.M.; Sanchez, M.G.; Malagarie-Cazenave, S.; Olea, N.; Diaz-Laviada, I. Induction of apoptosis in prostate tumor PC-3 cells and inhibition of xenograft prostate tumor growth by the vanilloid capsaicin. Apoptosis, 2006, 11(1), 89-99.
200. Malagarie-Cazenave, S.; Olea-Herrero, N.; Vara, D.; Díaz-Laviada, I. Capsaicin, a component of red peppers, induces expression of androgen receptor via PI3K and MAPK pathways in prostate LNCaP cells. FEBS Lett., 2009, 583(1), 141-147.
201. Wang, H.P.; Pu, X.Y.; Wang, X.H. Improvement in erectile dysfunction after insulin-like growth factor-1 gene therapy in diabetic rats. Asian J. Androl., 2007, 9(1), 634-691.
202. Monet, M.; Lehen'Kyi, V.; Gackiere, F.; Firlej, V.; Vandenberghe, M.; Roudbaraki, M.; Gkika, D.; Pourtier, A.; Bidaux, G.; Slomianny, C.; Delcourt, P.; Rassendren, F.; Bergerat, J.P.; Ceraline, J.; Cabon, F.; Humez, S.; Prevarskaya, N. Role of cationic channel TRPV2 in promoting prostate cancer migration and progression to androgen resistance. Cancer Res., 2010, 70(3), 1225-1235.
203. Monet, M.; Gkika, D.; Lehen'Kyi, V.; Pourtier, A.; Vanden Abeele, F.; Bidaux, G.; Juvin, V.; Rassendren, F.; Humez, S.; Prevarsakaya, N. Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation. Biochim. Biophys. Acta, 2009, 1793(3), 528-539.
204. Fixemer, T.; Wissenbach, U.; Flockerzi, V.; Bonkhoff, H. Expression of the Ca2+-selective cation channel TRPV6 in human prostate cancer: a novel prognostic marker for tumor progression. Oncogene, 2003, 22(49), 7858-7861.
205. Kessler, T.; Wissenbach, U.; Grobholz, R.; Flockerzi, V. TRPV6 alleles do not influence prostate cancer progression. BMC Cancer, 2009, 9, 380.
206. Peng, J.B.; Zhuang, L.; Berger, U.V.; Adam, R.M.; Williams, B.J.; Brown, E.M.; Hediger, M.A.; Freeman, M.R. CaT1 expression correlates with tumor grade in prostate cancer. Biochem. Biophys. Res. Commun., 2001, 282(3), 729-734.
207. Lehen'Kyi, V.; Flourakis, M.; Skryma, R.; Prevarskaya, N. TRPV6 channel controls prostate cancer cell proliferation via Ca(2+)/NFAT-dependent pathways Oncogene, 2007, 26(52), 7380-7385.
208. Lallet-Daher, H.; Roudbaraki, M.; Bavencoffe, A.; Mariot, P.; Gackiere, F.; Bidaux, G.; Urbain, R.; Gosset, P.; Delcourt, P.; Fleurisse, L.; Slomianny, C.; Dewailly, E.; Mauroy, B.; Bonnal, J.L.; Skryma, R.; Prevarskaya, N. Intermediate-conductance Ca2+-activated K+ channels (IKCa1) regulate human prostate cancer cell proliferation through a close control of calcium entry. Oncogene, 2009, 28(15), 1792-1806.
209. Zhu, X.; Jiang, M.; Peyton, M.; Boulay, G.; Hurst, R.; Stefani, E.; Birnbaumer, L. trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell, 1996, 85(5), 661-671.
210. Riccio, A.; Medhurst, A.D.; Mattei, C.; Kelsell, R.E.; Calver, A.R.; Randall, A.D.; Benham, C.D.; Pangalos, M.N. mRNA distribution analysis of human TRPC family in CNS and peripheral tissues. Brain Res. Mol. Brain Res., 2002, 109(1-2), 95-104.
211. Sydorenko, V.; Shuba, Y.; Thebault, S.; Roudbaraki, M.; Lepage, G.; Prevarskaya, N.; Skryma, R. Receptor-coupled, DAG-gated Ca2+-permeable cationic channels in LNCaP human prostate cancer epithelial cells. J. Physiol., 2003, 548(Pt 3), 823-836.
212. Yue, D.; Wang, Y.; Xiao, J.Y.; Wang, P.; Ren, C.S. Expression of TRPC6 in benign and malignant human prostate tissues. Asian J. Androl., 2009, 11(5), 541-547.
213. Vanden Abeele, F.; Shuba, Y.; Roudbaraki, M.; Lemonnier, L.; Vanoverberghe, K.; Mariot, P.; Skryma, R.; Prevarskaya N. Storeoperated Ca2+ channels in prostate cancer epithelial cells: function, regulation, and role in carcinogenesis. Cell Calcium, 2003, 33(5-6), 357-373.
214. Thebault, S.; Flourakis, M.; Vanoverberghe, K.; Vandermoere, F.; Roudbaraki, M.; Lehen'Kyi, V.; Slomianny, C.; Beck, B.; Mariot, P.; Bonnal, J.L.; Mauroy, B.; Shuba, Y.; Capiod, T.; Skryma, R.; Prevarskaya, N. Differential role of transient receptor potential channels in Ca2+ entry and proliferation of prostate cancer epithelial cells. Cancer Res., 2006, 66(4), 2038-2047.
215. Pigozzi, D.; Ducret, T.; Tajeddine, N.; Gala, JL.; Tombal, B.; Gailly, P. Calcium store contents control the expression of TRPC1, TRPC3 and TRPV6 proteins in LNCaP prostate cancer cell line. Cell Calcium, 2006, 39(5), 401-415.
216. Wang, Y.; Yue, D.; Li, K.; Liu, Y.L.; Ren, C.S.; Wang, P.; The role of TRPC6 in HGF-induced cell proliferation of human prostate cancer DU145 and PC3 cells. Asian J. Androl., 2010, 12(6), 841-852.
217. Zhang, L.; Barritt, G.J. TRPM8 in prostate cancer cells: a potential diagnostic and prognostic marker with a secretory function? Endocr. Relat. Cancer, 2006, 13(1), 27-38.
218. Bidaux, G.; Roudbaraki, M.; Merle, C.; Crepin, A.; Delcourt, P.; Slomianny, C.; Thebault, S.; Bonnal, J.L.; Benahmed, M.; Cabon, F.; Mauroy, B.; Prevarskaya, N. Evidence for specific TRPM8 expression in human prostate secretory epithelial cells: functional androgen receptor requirement. Endocr. Relat. Cancer, 2005, 12(2), 367-382.
219. Bidaux, G.; Flourakis, M.; Thebault, S.; Zholos, A.; Beck, B.; Gkika, D.; Roudbaraki, M.; Bonnal, J.L.; Mauroy, B.; Shuba, Y.; Skryma, R.; Prevarskaya, N. Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function. J. Clin. Invest., 2007, 117(6), 1647-1657.
220. Bidaux, G.; Beck, B.; Zholos, A.; Gordienko, D.; Lemonnier, L.; Flourakis, M.; Roudbaraki, M.; Borowiec, A.S.; Fernández, J.; Delcourt, P.; Lepage, G.; Shuba, Y.; Skryma, R.; Prevarskaya, N. Regulation of activity of transient receptor potential melastatin 8 (TRPM8) channel by its short isoforms. J. Biol. Chem., 2012, 287(5), 2948-2962.
221. Schmidt, U.; Fuessel, S.; Koch, R.; Baretton, G.B.; Lohse, A.; Tomasetti, S.; Unversucht, S.; Froehner, M.; Wirth, MP.; Meye, A. Quantitative multi-gene expression profiling of primary prostate cancer. Prostate, 2006, 66(14), 1521-1534.
222. Thebault, S.; Lemonnier, L.; Bidaux, G.; Flourakis, M.; Bavencoffe, A.; Gordienko, D.; Roudbaraki, M.; Delcourt, P.; Panchin, Y.; Shuba, Y.; Skryma, R.; Prevarskaya, N Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cells. J. Biol. Chem., 2005, 280(47), 39423-39435.
223. Mahieu, F.; Owsianik, G.; Verbert, L.; Janssens, A.; De Smedt, H.; Nilius, B.; Voets, T. TRPM8-independent menthol-induced Ca2+ release from endoplasmic reticulum and Golgi. J. Biol. Chem., 2007, 282(5), 3325-3336.
224. Kim, S.H.; Nam, J.H.; Park, E.J.; Kim, B.J.; Kim, S.J.; So, I.; Jeon, J.H. Menthol regulates TRPM8-independent processes in PC-3 prostate cancer cells. Biochim. Biophys. Acta, 2009, 1792(1), 33-38.
225. Zhang, L.; Barritt, G.J. Evidence that TRPM8 is an androgendependent Ca2+ channel required for the survival of prostate cancer cells., 2004, 64(22), 8365-8373.
226. Polascik, T.J.; Oesterling, J.E.; Partin, A.W. Prostate specific antigen: a decade of discovery--what we have learned and where we are going. J. Urol., 1999, 162(2), 293-306.
227. Kiessling, A.; Fussel, S.; Schmitz, M.; Stevanovic, S.; Meye, A.; Weigle, B.; Klenk, U.; Wirth, M.P.; Rieber, E.P. Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein trp-p8. Prostate, 2003, 56(4), 270-279.
228. Fuessel, S.; Sickert, D.; Meye, A.; Klenk, U.; Schmidt, U.; Schmitz, M.; Rost, A.K.; Weigle, B.; Kiessling, A.; Wirth, MP. Multiple tumor marker analyses (PSA, hK2, PSCA, trp-p8) in primary prostate cancers using quantitative RT-PCR. Int. J. Oncol., 2003, 23(1), 221-228.
229. Henshall, S.M.; Afar, D.E.; Hiller, J.; Horvath, L.G.; Quinn, D.I.; Rasiah, K.K.; Gish, K.; Willhite, D.; Kench, J.G.; Gardiner-Garden, M.; Stricker, P.D.; Scher, H.I.; Grygiel, J.J.; Agus, D.B.; Mack, D.H.; Sutherland, R.L. Survival analysis of genome-wide gene expression profiles of prostate cancers identifies new prognostic targets of disease relapse. Cancer Res., 2003, 63(14), 4196-4203.
230. Gkika, D.; Flourakis, M.; Lemonnier, L.; Prevarskaya, N. PSA reduces prostate cancer cell motility by stimulating TRPM8 activity and plasma membrane expression. Oncogene, 2010, 29(32), 4611-4616.
231. Tsavaler, L.; Shapero, M.H.; Morkowski, S.; Laus, R. Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. Cancer Res., 2001, 61(3), 3760-3769.
232. Perraud, A.L.; Fleig, A.; Dunn, C.A.; Bagley, L.A.; Launay, P.; Schmitz, C.; Stokes, A.J.; Zhu, Q.; Bessman, M.J.; Penner, R.; Kinet, J.P.; Scharenberg, A.M. ADP-ribose gating of the calciumpermeable LTRPC2 channel revealed by Nudix motif homology. Nature, 2001, 411(6837), 595-599.
233. Sano, Y.; Inamura, K.; Miyake, A.; Mochizuki, S.; Yokoi, H.; Matsushime, H.; Furuichi, K. Immunocyte Ca2+ influx system mediated by LTRPC2. Science, 2001, 293(5533), 1327-1330.
234. Zhang, W.; Hirschler-Laszkiewicz, I.; Tong, Q.; Conrad, K.; Sun, S.C.; Penn, L.; Barber, D.L.; Stahl, R.; Carey, D.J.; Cheung, J.Y.; Miller, B.A. TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage. Am. J. Physiol. Cell. Physiol., 2006, 290(4), C1146-1159.
235. Hara, H.; Wakamori, M.; Ishii, M.; Maeno, E.; Nishida, M.; Yoshida, T.; Yamada, H.; Shimizu, S.; Mori, E.; Kudoh, J.; Shimizu, N.; Kurose, H.; Okada, Y.; Imoto, K.; Mori, Y. LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol. Cell., 2002, 9(1), 163-173.
236. Zhang, W.; Chu, X.; Tong, Q.; Cheung, J.Y.; Conrad, K.; Masker, K.; Miller, B.A. A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death. J. Biol. Chem., 2003, 278(18), 16222-16229.
237. Zeng, X.; Sikka, S.C.; Huang, L.; Sun, C.; Xu, C.; Jia, D.; Abdel-Mageed, A.B.; Pottle, J.E.; Taylor, J.T.; Li, M. Novel role for the transient receptor potential channel TRPM2 in prostate cancer cell proliferation. Prostate Cancer Prostatic Dis., 2009, 13(2), 195-201.
238. Nilius, B.; Prenen, J.; Droogmans, G.; Voets, T.; Vennekens, R.; Freichel, M.; Wissenbach, U.; Flockerzi, V. Voltage dependence of the Ca2+-activated cation channel TRPM4. J. Biol. Chem., 2003, 278(33), 30813-30820.
239. Wang, H.P.; Pu, X.Y.; Wang, X.H. Distribution profiles of transient receptor potential melastatin-related and vanilloid-related channels in prostatic tissue in rat. Asian J. Androl., 2007, 9(5), 634-640.
240. Fonfria, E.; Murdock, P.R.; Cusdin, F.S.; Benham, C.D.; Kelsell, R.E.; McNulty, S. Tissue distribution profiles of the human TRPM cation channel family. J. Recept. Signal Transduct. Res., 2006, 26(3), 159-178.
241. Glick, S.B.; Clarke, A.R.; Blanchard, A.; Whitaker, A.K. Cervical cancer screening, diagnosis and treatment interventions for racial and ethnic minorities: a systematic review. J. Gen. Intern. Med.; 2012, 27(8), 1016-1032.
242. Peiretti, M.; Zapardiel, I.; Zanagnolo, V.; Landoni, F.; Morrow, C.P.; Maggioni, A. Management of recurrent cervical cancer: a review of the literature. Surg. Oncol., 2012, 21(2), e59-66.
243. Contassot, E.; Tenan, M.; Schnüriger, V.; Pelte, M.F.; Dietrich, P.Y. Arachidonyl ethanolamide induces apoptosis of uterine cervix cancer cells via aberrantly expressed vanilloid receptor-1. Gynecol. Oncol., 2004, 93(1), 182-188.
244. Ramer, R.; Merkord, J.; Rohde, H.; Hinz, B. Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1. Biochem. Pharmacol., 2010, 79(7), 955-956.
245. Narayan, G.; Bourdon, V.; Chaganti, S.; Arias-Pulido, H.; Nandula, S.V.; Gissmann, L.; Dürst, M.; Schneider, A.; Pothuri, B.; Mansukhani, M.; Basso, K.; Chaganti, R.S.; Murty, V.V. Gene dosage alterations revealed by cDNA microarray analysis in cervical cancer: identification of candidate amplified and overexpressed genes. Genes Chromosomes Cancer, 2007, 46(4), 373-384.
246. Armisén, R.; Marcelain, K.; Simon, F.; Tapia, J.C.; Toro, J.; Quest, A.F.; Stutzin, A. TRPM4 enhances cell proliferation through upregulation of the β-catenin signaling pathway. J. Cell. Physiol., 2011, 226(1), 103-109.
247. Hunn, J.; Rodriguez, G.C. Ovarian cancer: etiology, risk factors, and epidemiology. Clin. Obstet. Gynecol., 2012, 55(1), 3-23.
248. Yang, S.L.; Cao, Q.; Zhou, K.C.; Feng, Y.J.; Wang, Y.Z. Transient receptor potential channel C3 contributes to the progression of human ovarian cancer. Oncogene, 2009, 28(10), 1320-1328.