(Patho)physiological implications of the novel epithelial Ca2+ channels TRPV5 and TRPV6

Pflugers Archiv European Journal of Physiology

Volumn 446, Issue 4, 2003, Pages 401-409

  Nijenhuis, Tom ^b   Hoenderop, Joost G J ^b   Nilius, Bernd ^c   Bindels, René J M ^a,b  

^a Centrale Ontvangst Goederen   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Calcium transport; ECaC1; ECaC2; Estrogen; Hypercalciuria; Vitamin D

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; ESTROGEN RECEPTOR; VANILLOID RECEPTOR;

ANIMAL CELL; APICAL MEMBRANE; BASOLATERAL MEMBRANE; CALCIUM ABSORPTION; CALCIUM TRANSPORT; EPITHELIUM CELL; GENE; HYPERCALCIURIA; MOLECULAR CLONING; MOUSE; NEUROTRANSMITTER RELEASE; NONHUMAN; NORTHERN BLOTTING; PATHOPHYSIOLOGY; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; RAT; RECEPTOR POTENTIAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; TRPV5 GENE; TRPV6 GENE; VITAMIN D DEFICIENCY;

ANIMALS; CALCIUM; CALCIUM CHANNELS; EPITHELIAL CELLS; HUMANS; METABOLIC DISEASES; TRPV CATION CHANNELS;

EID: 0041665084     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00424-003-1038-7     Document Type: Review

References (90)

1. Arjmandi BH, Hollis BW, Kalu DN (1994) In vivo effect of 17 beta-estradiol on intestinal calcium absorption in rats. Bone Miner 26:181-189
2. Beck L, Karaplis AC, Amizuka N, Hewson AS, Ozawa H, Tenenhouse HS (1998) Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. Proc Natl Acad Sci USA 95:5372-5377
3. Brenner BM (ed) (1996) Brenner and Rector's the kidney. WB Saunders company, Philadelphia 5th:
4. Brown EM, MacLeod RJ (2001) Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev 81:239-297
5. 3 level in the Rat. J Bone Miner Res 14:57-64
6. Costanzo LS, Windhager EE (1978) Calcium and sodium transport by the distal convoluted tubule of the rat. Am J Physiol 235:F492-F506
7. Cruz DN, Simon DB, Nelson-Williams C, Farhi A, Finberg K, Burleson L, Gill JR, Lifton RP (2001) Mutations in the Na-Cl cotransporter reduce blood pressure in humans. Hypertension 37:1458-1464
8. 3-1(alpha)-hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D-deficiency rickets. Endocrinology 142:3135-3141
9. Ellison DH (2000) Divalent cation transport by the distal nephron: insights from Bartter's and Gitelman's syndromes. Am J Physiol 279:F616-F625
10. Fleet JC, Eksir F, Hance KW, Wood RJ (2002) Vitamin D-inducible calcium transport and gene expression in three Caco-2 cell lines. Am J Physiol 283:G618-G625
11. Friedman PA (1998) Codependence of renal calcium and sodium transport. Annu Rev Physiol 60:179-197
12. Friedman PA, Bushinsky DA (1999) Diuretic effects on calcium metabolism. Semin Nephrol 19:551-556
13. Friedman PA, Gesek FA (1995) Cellular calcium transport in renal epithelia: measurement, mechanisms, and regulation. Physiol Rev 75:429-471
14. 2+ entry. Cancer Res 60:1002-1008
15. Heller HJ, Sakhaee K, Moe OW, Pak CY (2002) Etiological role of estrogen status in renal stone formation. J Urol 168:1923-1927
16. 3-1α-hydroxylase knockout mice. FASEB J 16:1398-1406
17. 2+ reabsorption in rabbit kidney cortical collecting system is cAMP-independent and involves a phorbol ester- insensitive PKC isotype. Kidney Int 55:225-233
18. 2+ channel in rabbit kidney and intestine. J Am Soc Nephrol 11:1171-1178
19. Hoenderop JG, Muller D, Suzuki M, van Os CH, Bindels RJ (2000) Epithelial calcium channel: gate-keeper of active calcium reabsorption. Curr Opin Nephrol Hypertens 9:335-340
20. Hoenderop JG, Muller D, Van Der Kemp AW, Hartog A, Suzuki M, Ishibashi K, Imai M, Sweep F, Willems PH, Van Os CH, Bindels RJ (2001) Calcitriol controls the epithelial calcium channel in kidney. J Am Soc Nephrol 12:1342-1349
21. 2+ reabsorption in the distal nephron. Annu Rev Physiol 64:529-549
22. 3-responsive epithelia. J Biol Chem 274:8375-8378
23. Hoenderop JG, van der Kemp AW, Hartog A, van Os CH, Willems PH, Bindels RJ (1999) The epithelial calcium channel, ECaC, is activated by hyperpolarization and regulated by cytosolic calcium. Biochem Biophys Res Commun 261:488-492
24. 2+ channel 1 and 2. J Physiol (Lond) 537:747-761
25. 2+ channels, TRPV5 and TRPV6. EMBO J 22:776-785
26. Hoenderop JG, Willems PH, Bindels RJ (2000) Toward a comprehensive molecular model of active calcium reabsorption. Am J Physiol 278:F352-F360
27. Horoszewicz JS, Leong SS, Kawinski E, Karr JP, Rosenthal H, Chu TM, Mirand EA, Murphy GP (1983) LNCaP model of human prostatic carcinoma. Cancer Res 43:1809-1818
28. 3 on pancreatic B and D cell function. Life Sci 33:1779-1786
29. James SY, Mercer E, Brady M, Binderup L, Colston KW (1998) EB1089, a synthetic analogue of vitamin D, induces apoptosis in breast cancer cells in vivo and in vitro. Br J Pharmacol 125:953-962
30. 2+ channel ECaC in rat pancreatic islets. J Histochem Cytochem 50:789-798
31. Koller DL, Econs MJ, Morin PA, Christian JC, Hui SL, Parry P, Curran ME, Rodriguez LA, Conneally PM, Joslyn G, Peacock M, Johnston CC, Foroud T (2000) Genome screen for QTLs contributing to normal variation in bone mineral density and osteoporosis. J Clin Endocrinol Metab 85:3116-3120
32. Lemmink HH, van den Heuvel LP, van Dijk HA, Merkx GF, Smilde TJ, Taschner PE, Monnens LA, Hebert SC, Knoers NV (1996) Linkage of Gitelman syndrome to the thiazide-sensitive sodium-chloride cotransporter gene with identification of mutations in Dutch families. Pediatr Nephrol 10:403-407
33. Lerolle N, Coulet F, Lantz B, Paillard F, Houillier P, Soubrier F, Gattegno B, Jeunemaitre X, Ronco P, Rondeau E (2001) No evidence for point mutations of the calcium-sensing receptor in familial idiopathic hypercalciuria. Nephrol Dial Transplant 16:2317-2322
34. Li YC, Bolt MJ, Cao LP, Sitrin MD (2001) Effects of vitamin D receptor inactivation on the expression of calbindins and calcium metabolism. Am J Physiol 281:E558-E564
35. 2 in patients with hormone refractory prostate cancer. Clin Cancer Res 8:2820-2827
36. Loffing J, Loffing-Cueni D, Valderrabano V, Klausli L, Hebert SC, Rossier BC, Hoenderop JG, Bindels RJ, Kaissling B (2001) Organization of the mouse distal nephron: distributions of transcellular calcium and sodium transport pathways. Am J Physiol 281:F1021-F1027
37. Mastroianni N, Bettinelli A, Bianchetti M, Colussi G, De Fusco M, Sereni F, Ballabio A, Casari G (1996) Novel molecular variants of the Na-Cl cotransporter gene are responsible for Gitelman syndrome. Am J Hum Genet 59:1019-1026
38. 3. Cancer Res 52:515-520
39. - cotransporter: a new model for ions and diuretics interaction. Am J Physiol 279:F161-F169
40. Montell C, Birnbaumer L, Flockerzi V (2002) The TRP channels, a remarkably functional family. Cell 108:595-598
41. 2+ channel (ECAC1). Genomics 67:48-53
42. Muller D, Hoenderop JG, Merkx GF, van Os CH, Bindels RJ (2000) Gene structure and chromosomal mapping of human epithelial calcium channel. Biochem Biophys Res Commun 275:47-52
43. 2+ channel (ECaC) in autosomal dominant idiopathic hypercalciuria. Nephrol Dial Transplant 17:1614-1620
44. Nicotera P, Orrenius S (1998) The role of calcium in apoptosis. Cell Calcium 23:173-180
45. 2+ channels ECaC1 and ECaC2 (TRPV5 and 6): Role of the intracellular loop located between transmembrane segment 2 and 3. J Biol Chem 277:30852-30858
46. Nordin BE, Need AG, Morris HA, Horowitz M, Robertson WG (1991) Evidence for a renal calcium leak in postmenopausal women. J Clin Endocrinol Metab 72:401-407
47. Norman AW, Frankel JB, Heldt AM, Grodsky GM (1980) Vitamin D deficiency inhibits pancreatic secretion of insulin. Science 209:823-825
48. 2+ in impaired sensitivity to glucose of rat pancreatic islets exposed to high glucose in vitro. Diabetes 41:1555-1561
49. Okamoto Y, Ishida H, Tsuura Y, Yasuda K, Kato S, Matsubara H, Nishimura M, Mizuno N, Ikeda H, Seino Y (1995) Hyperresponse in calcium-induced insulin release from electrically permeabilized pancreatic islets of diabetics GK rats and its defective augmentation by glucose. Diabetologia 38:772-778
50. Orrenius S, Nicotera P (1994) The calcium ion and cell death. J Neural Transm Suppl 43:1-11
51. Panda DK, Miao D, Tremblay ML, Sirois J, Farookhi R, Hendy GN, Goltzman D (2001) Targeted ablation of the 25-hydroxyvitamin D 1alpha -hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction. Proc Natl Acad Sci USA 98:7498-7503
52. Parks JH, Coe FL (1986) A urinary calcium-citrate index for the evaluation of nephrolithiasis. Kidney Int 30:85-90
53. 3 on primary cultures of human prostatic cells. Cancer Res 54:805-810
54. Peng JB, Chen XZ, Berger UV, Vassilev PM, Tsukaguchi H, Brown EM, Hediger MA (1999) Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption. J Biol Chem 274:22739-22746
55. Peng JB, Chen XZ, Berger UV, Weremowicz S, Morton CC, Vassilev PM, Brown EM, Hediger MA (2000) Human calcium transport protein CAT1. Biochem Biophys Res Commun 278:326-332
56. Peng JB, Hediger MA (2002) A family of calcium-permeable channels in the kidney: distinct roles in renal calcium handling. Curt Opin Nephrol Hypertens 11:555-561
57. Peng JB, Zhuang L, Berger UV, Adam RM, Williams BJ, Brown EM, Hediger MA, Freeman MR (2001) CaT1 expression correlates with tumor grade in prostate cancer. Biochem Biophys Res Commun 282:729-734
58. Petrucci M, Scott P, Ouimet D, Trouve ML, Proulx Y, Valiquette L, Guay G, Bonnardeaux A (2000) Evaluation of the calcium-sensing receptor gene in idiopathic hypercalciuria and calcium nephrolithiasis. Kidney Int 58:38-42
59. Picotto G, Massheimer V, Boland R (1996) Acute stimulation of intestinal cell calcium influx induced by 17 beta-estradiol via the cAMP messenger system. Mol Cell Endocrinol 119:129-134
60. Prie D, Huart V, Bakouh N, Planelles G, Dellis O, Gerard B, Hulin P, Benque-Blanchet F, Silve C, Grandchamp B, Friedlander G (2002) Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporter. N Engl J Med 347:983-991
61. Prince RL (1994) Counterpoint: estrogen effects on calcitropic hormones and calcium homeostasis. Endocr Rev 15:301-309
62. Prince RL, Smith M, Dick IM, Price RI, Webb PG, Henderson NK, Harris MM (1991) Prevention of postmenopausal osteoporosis. A comparative study of exercise, calcium supplementation, and hormone-replacement therapy. N Engl J Med 325:1189-1195
63. 28K in a pancreatic islet beta-cell line protects against cytokine-induced apoptosis and necrosis. Endocrinology 142:3649-3655
64. Reed BY, Gitomer WL, Heller HJ, Hsu MC, Lemke M, Padalino P, Pak CY (2002) Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density. J Clin Endocrinol Metab 87:1476-1485
65. Reed BY, Heller HJ, Gitomer WL, Pak CY (1999) Mapping a gene defect in absorptive hypercalciuria to chromosome 1q23.3-q24. J Clin Endocrinol Metab 84:3907-3913
66. Reichel H, Koeffler HP, Norman AW (1989) The role of the vitamin D endocrine system in health and disease. N Engl J Med 320:980-991
67. Reilly RF, Ellison DH (2000) Mammalian distal tubule: physiology, pathophysiology, and molecular anatomy. Physiol Rev 80:277-313
68. Roe MW, Lancaster ME, Mertz RJ, Worley JF, 3rd, Dukes ID (1993) Voltage-dependent intracellular calcium release from mouse islets stimulated by glucose. J Biol Chem 268:9953-9956
69. Schlingmann KP, Weber S, Peters M, Niemann Nejsum L, Vitzthum H, Klingel K, Kratz M, Haddad E, Ristoff E, Dinour D, Syrrou M, Nielsen S, Sassen M, Waldegger S, Seyberth HW, Konrad M (2002) Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family. Nat Genet 31:166-170
70. - cotransporter of the distal convoluted tubule. J Biol Chem 273:29150-29155
71. Scott P, Ouimet D, Proulx Y, Trouve ML, Guay G, Gagnon B, Valiquette L, Bonnardeaux A (1998) The 1 alpha-hydroxylase locus is not linked to calcium stone formation or calciuric phenotypes in French-Canadian families. J Am Soc Nephrol 9:425-432
72. Scott P, Ouimet D, Valiquette L, Guay G, Proulx Y, Trouve ML, Gagnon B, Bonnardeaux A (1999) Suggestive evidence for a susceptibility gene near the vitamin D receptor locus in idiopathic calcium stone formation. J Am Soc Nephrol 10:1007-1013
73. Soucie JM, Thun MJ, Coates RJ, McClellan W, Austin H (1994) Demographic and geographic variability of kidney stones in the United States. Kidney Int 46:893-899
74. Stanton BA (1990) Cellular actions of thiazide diuretics in the distal tubule. J Am Soc Nephrol 1:832-836
75. Tenenhouse HS, Gauthier C, Martel J, Hoenderop JG, Hartog A, Meyer MH, Meyer RH Jr, Bindels RJ (2002) Na/Pi cotransporter (Npt2) gene disruption increases duodenal calcium absorption and expression of epithelial calcium channel 1 and 2. Pflugers Arch 444:670-676
76. Thevenod F (2002) Ion channels in secretory granules of the pancreas and their role in exocytosis and release of secretory proteins. Am J Physiol 283:C651-C672
77. 3-independent stimulatory effect of estrogen on the expression of ECaCl in kidney. J Am Soc Nephrol 13:2102-2109
78. van Cromphaut S, Dewerchin M, Hoenderop JG, Stockmans I, van Herck E, Kato S, Bindels RJ, Collen D, Carmeliet P, Bouillon R, Carmeliet G (2001) Active duodenal calcium absorption in vitamin D receptor-knock out mice: functional and molecular aspects. Proc Natl Acad Sci USA 98:13324-13329
79. 2+ channel. J Biol Chem 275:3963-3969
80. Vezzoli G, Tanini A, Ferrucci L, Soldati L, Bianchin C, Franceschelli F, Malentacchi C, Porfirio B, Adamo D, Terranegra A, Falchetti A, Cusi D, Bianchi G, Brandi ML (2002) Influence of calcium-sensing receptor gene on urinary calcium excretion in stone-forming patients. J Am Soc Nephrol 13:2517-2523
81. Walder RY, Landau D, Meyer P, Shalev H, Tsolia M, Borochowitz Z, Boettger MB, Beck GE, Englehardt RK, Carmi R, Sheffield VC (2002) Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia. Nat Genet 31:171-174
82. Weber K, Erben RG, Rump A, Adamski J (2001) Gene structure and regulation of the murine epithelial calcium channels ECaC1 and 2. Biochem Biophys Res Commun 289:1287-1294
83. 28K in C6 glial cells stabilizes intracellular calcium levels and protects against apoptosis induced by calcium ionophore and amyloid beta-peptide. Brain Res Mol Brain Res 64:69-79
84. Wissenbach U, Niemeyer BA, Fixemer T, Schneidewind A, Trost C, Cavalie A, Reus K, Meese E, Bonkhoff H, Flockerzi V (2001) Expression of CaT-like, a novel calcium-selective channel, correlates with the malignancy of prostate cancer. J Biol Chem 276:19461-19468
85. 3 increases the expression of the CaT1 epithelial calcium channel in the Caco-2 human intestinal cell line. BMC Physiol 1:11
86. Young MM, Nordin BE (1969) The effect of the natural and artificial menopause on bone density and fracture. Proc R Soc Med 62:242
87. Zerwekh JE, Hughes MR, Reed BY, Breslau NA, Heller HJ, Lemke M, Nasonkin I, Pak CY (1995) Evidence for normal vitamin D receptor messenger ribonucleic acid and genotype in absorptive hypercalciuria. J Clin Endocrinol Metab 80:2960-2965
88. 3 actions in LNCaP human prostate cancer cells are androgen-dependent. Endocrinology 138:3290-3298
89. 3 inhibits prostate cancer cell growth by androgen-dependent and androgen-independent mechanisms. Endocrinology 141:2548-2556
90. Zhuang L, Peng JB, Tou L, Takanaga H, Adam RM, Hediger MA, Freeman MR (2002) Calcium-selective ion channel, CAT1, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignancies. Lab Invest 82:1755-1764