메뉴 건너뛰기




Volumn 7, Issue 4, 2007, Pages 343-353

Transcription factor NFAT, its role in cancer development, and as a potential target for chemoprevention

Author keywords

Calcineurin; Cancer; Chemoprevention; Gene expression; NFAT; Signaling pathway

Indexed keywords

BINDING PROTEIN; CALCINEURIN; CARCINOGEN; CYCLOSPORIN A; ETOPOSIDE; IMMUNOSUPPRESSIVE AGENT; PROTEIN INHIBITOR; TACROLIMUS; TRANSCRIPTION FACTOR NFAT;

EID: 34249816810     PISSN: 15680096     EISSN: None     Source Type: Journal    
DOI: 10.2174/156800907780809750     Document Type: Review
Times cited : (23)

References (106)
  • 1
    • 33646160623 scopus 로고    scopus 로고
    • Inflammation, a key event in cancer development
    • Lu, H.; Ouyang, W.; Huang, C. Inflammation, a key event in cancer development. Mol. Cancer Res. 2006, 4, 1-13.
    • (2006) Mol. Cancer Res , vol.4 , pp. 1-13
    • Lu, H.1    Ouyang, W.2    Huang, C.3
  • 2
    • 0031034051 scopus 로고    scopus 로고
    • Transcription mediated by NFAT is highly inducible in effector CD4+ T helper 2 (Th2) cells but not in Th1 cells
    • Rincon, M.; Flavell, R. A. Transcription mediated by NFAT is highly inducible in effector CD4+ T helper 2 (Th2) cells but not in Th1 cells. Mol. Cell. Biol. 1997, 17 , 1522-1534.
    • (1997) Mol. Cell. Biol , vol.17 , pp. 1522-1534
    • Rincon, M.1    Flavell, R.A.2
  • 4
    • 0033594887 scopus 로고    scopus 로고
    • NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun
    • López-Rodríguez, C.; Aramburu, J.; Rakeman, A. S.; Rao, A. NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun. Proc. Natl. Acad. Sci. USA 1999, 96 , 7214-7219.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 7214-7219
    • López-Rodríguez, C.1    Aramburu, J.2    Rakeman, A.S.3    Rao, A.4
  • 5
    • 20644466433 scopus 로고    scopus 로고
    • NFAT proteins: Key regulators of T-cell development and function
    • Macian, F. NFAT proteins: key regulators of T-cell development and function. Nat. Rev. Immunol. 2005, 5, 472-484.
    • (2005) Nat. Rev. Immunol , vol.5 , pp. 472-484
    • Macian, F.1
  • 6
    • 0141483523 scopus 로고    scopus 로고
    • Transcriptional regulation by calcium, calcineurin, and NFAT
    • Hogan, P. G.; Chen, L.; Nardone, J.; Rao, A. Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev. 2003, 17 , 2205-2232.
    • (2003) Genes Dev , vol.17 , pp. 2205-2232
    • Hogan, P.G.1    Chen, L.2    Nardone, J.3    Rao, A.4
  • 7
    • 0030973579 scopus 로고    scopus 로고
    • Transcription factors of the NFAT family: Regulation and function
    • Rao, A.; Luo, C.; Hogan, P. G. Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 1997, 15 , 707-747.
    • (1997) Annu. Rev. Immunol , vol.15 , pp. 707-747
    • Rao, A.1    Luo, C.2    Hogan, P.G.3
  • 8
    • 4444260305 scopus 로고    scopus 로고
    • Structural delineation of the calcineurin-NFAT interaction and its parallels to PP1 targeting interactions
    • Li, H.; Rao, A.; Hogan, P. G. Structural delineation of the calcineurin-NFAT interaction and its parallels to PP1 targeting interactions. J. Mol. Biol. 2004, 342, 1659-1674.
    • (2004) J. Mol. Biol , vol.342 , pp. 1659-1674
    • Li, H.1    Rao, A.2    Hogan, P.G.3
  • 12
    • 3142544806 scopus 로고    scopus 로고
    • Dual role of sumoylation in the nuclear localization and transcriptional activation of NFAT1
    • Terui, Y.; Saad, N.; Jia, S.; McKeon, F.; Yuan, J. Dual role of sumoylation in the nuclear localization and transcriptional activation of NFAT1. J. Biol. Chem. 2004, 279, 28257-28265.
    • (2004) J. Biol. Chem , vol.279 , pp. 28257-28265
    • Terui, Y.1    Saad, N.2    Jia, S.3    McKeon, F.4    Yuan, J.5
  • 13
    • 0034603165 scopus 로고    scopus 로고
    • Identification of amino acid residues and protein kinases involved in the regulation of NFATc subcellular localization
    • Porter, C. M.; Havens, M. A.; Clipstone, N. A. Identification of amino acid residues and protein kinases involved in the regulation of NFATc subcellular localization. J. Biol. Chem. 2000, 275, 3543-3551.
    • (2000) J. Biol. Chem , vol.275 , pp. 3543-3551
    • Porter, C.M.1    Havens, M.A.2    Clipstone, N.A.3
  • 14
    • 0035793570 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 inhibits the DNA binding activity of NFATc
    • Neal, J. W.; Clipstone, N. A. Glycogen synthase kinase-3 inhibits the DNA binding activity of NFATc. J. Biol. Chem. 2001, 276, 3666-3673.
    • (2001) J. Biol. Chem , vol.276 , pp. 3666-3673
    • Neal, J.W.1    Clipstone, N.A.2
  • 15
    • 0029851762 scopus 로고    scopus 로고
    • Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression
    • Timmerman, L. A.; Clipstone, N. A.; Ho, S. N.; Northrop, J. P.; Crabtree, G. R. Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression. Nature 1996, 383, 837-840.
    • (1996) Nature , vol.383 , pp. 837-840
    • Timmerman, L.A.1    Clipstone, N.A.2    Ho, S.N.3    Northrop, J.P.4    Crabtree, G.R.5
  • 17
    • 0036094148 scopus 로고    scopus 로고
    • Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases
    • Yang, T. T.; Xiong, Q.; Enslen, H.; Davis, R. J.; Chow, C. W. Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases. Mol. Cell. Biol. 2002, 22 , 3892-3904.
    • (2002) Mol. Cell. Biol , vol.22 , pp. 3892-3904
    • Yang, T.T.1    Xiong, Q.2    Enslen, H.3    Davis, R.J.4    Chow, C.W.5
  • 18
    • 0030890234 scopus 로고    scopus 로고
    • Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3
    • Beals, C. R.; Sheridan, C. M.; Turck, C. W.; Gardner, P.; Crabtree, G. R. Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science 1997, 275, 1930-1934.
    • (1997) Science , vol.275 , pp. 1930-1934
    • Beals, C.R.1    Sheridan, C.M.2    Turck, C.W.3    Gardner, P.4    Crabtree, G.R.5
  • 20
    • 0035844058 scopus 로고    scopus 로고
    • Binding and regulation of the transcription factor NFAT by the peptidyl prolyl cistrans isomerase Pin1
    • Liu, W.; Youn, H. D.; Zhou, X. Z.; Lu, K. P.; Liu, J. O. Binding and regulation of the transcription factor NFAT by the peptidyl prolyl cistrans isomerase Pin1. FEBS Lett. 2001, 496, 105-108.
    • (2001) FEBS Lett , vol.496 , pp. 105-108
    • Liu, W.1    Youn, H.D.2    Zhou, X.Z.3    Lu, K.P.4    Liu, J.O.5
  • 22
    • 33744960492 scopus 로고    scopus 로고
    • Proteolytic regulation of nuclear factor of activated T (NFAT) c2 cells and NFAT activity by caspase-3
    • Wu, W.; Misra, R. S.; Russell, J. Q.; Flavell, R. A.; Rincón, M.; Budd, R. C. Proteolytic regulation of nuclear factor of activated T (NFAT) c2 cells and NFAT activity by caspase-3. J. Biol. Chem 2006, 281(16), 10682-10690.
    • (2006) J. Biol. Chem , vol.281 , Issue.16 , pp. 10682-10690
    • Wu, W.1    Misra, R.S.2    Russell, J.Q.3    Flavell, R.A.4    Rincón, M.5    Budd, R.C.6
  • 23
    • 0344441706 scopus 로고    scopus 로고
    • Structure of NFAT bound to DNA as a monomer
    • Stroud, J.; Chen, L. Structure of NFAT bound to DNA as a monomer. J. Mol. Biol. 2003, 334, 1009-1022.
    • (2003) J. Mol. Biol , vol.334 , pp. 1009-1022
    • Stroud, J.1    Chen, L.2
  • 26
    • 0030604714 scopus 로고    scopus 로고
    • The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4
    • Ho, I. C.; Hodge, M. R.; Rooney, J. W.; Glimcher, L. H. The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell 1996, 85 , 973-983.
    • (1996) Cell , vol.85 , pp. 973-983
    • Ho, I.C.1    Hodge, M.R.2    Rooney, J.W.3    Glimcher, L.H.4
  • 27
    • 0037089575 scopus 로고    scopus 로고
    • Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression
    • Rengarajan, J.; Mowen, K. A.; McBride, K. D.; Smith, E. D.; Singh, H.; Glimcher, L. H. Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression. J. Exp. Med. 2002, 195, 1003-1012.
    • (2002) J. Exp. Med , vol.195 , pp. 1003-1012
    • Rengarajan, J.1    Mowen, K.A.2    McBride, K.D.3    Smith, E.D.4    Singh, H.5    Glimcher, L.H.6
  • 28
    • 0037315381 scopus 로고    scopus 로고
    • Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression
    • Decker, E. L.; Nehmann, N.; Kampen, E.; Eibel, H.; Zipfel, P. F.; Skerka, C. Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression. Nucleic Acids Res. 2003, 31 , 911-921.
    • (2003) Nucleic Acids Res , vol.31 , pp. 911-921
    • Decker, E.L.1    Nehmann, N.2    Kampen, E.3    Eibel, H.4    Zipfel, P.F.5    Skerka, C.6
  • 29
    • 0036713123 scopus 로고    scopus 로고
    • Cooperative interaction between GATA5 and NFATc regulates endothelial-endocardial differentiation of cardiogenic cells
    • Nemer, G.; Nemer, M. Cooperative interaction between GATA5 and NFATc regulates endothelial-endocardial differentiation of cardiogenic cells. Development 2002, 129, 4045-4055.
    • (2002) Development , vol.129 , pp. 4045-4055
    • Nemer, G.1    Nemer, M.2
  • 31
    • 0034283018 scopus 로고    scopus 로고
    • Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun
    • Macián, F.; García-Rodríguez, C.; Rao, A. Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun. EMBO J. 2000, 19 , 4783-4795.
    • (2000) EMBO J , vol.19 , pp. 4783-4795
    • Macián, F.1    García-Rodríguez, C.2    Rao, A.3
  • 33
    • 0036234543 scopus 로고    scopus 로고
    • NFAT signalling: Choreographing the social lives of cells
    • Crabtree, G. R.; Olson, E. N. NFAT signalling: choreographing the social lives of cells. Cell 2002, 109(Suppl.), S67-S79.
    • (2002) Cell , vol.109 , Issue.SUPPL.
    • Crabtree, G.R.1    Olson, E.N.2
  • 34
    • 0037018145 scopus 로고    scopus 로고
    • NFAT: Ubiquitous regulator of cell differentiation and adaptation
    • Horsley, V.; Pavlath, G. K. NFAT: ubiquitous regulator of cell differentiation and adaptation. J. Cell Biol. 2002, 156, 771-774.
    • (2002) J. Cell Biol , vol.156 , pp. 771-774
    • Horsley, V.1    Pavlath, G.K.2
  • 36
    • 0345830423 scopus 로고    scopus 로고
    • Calcineurin signaling and NFAT activation in cardiovascular and skeletal muscle development
    • Schulz, R. A.; Yutzey, K. E. Calcineurin signaling and NFAT activation in cardiovascular and skeletal muscle development. Dev. Biol. 2004, 266, 1-16.
    • (2004) Dev. Biol , vol.266 , pp. 1-16
    • Schulz, R.A.1    Yutzey, K.E.2
  • 37
    • 0346634892 scopus 로고    scopus 로고
    • Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis
    • Hove, J. R.; Köster, R. W.; Forouhar, A. S.; Acevedo-Bolton, G.; Fraser, S. E.; Gharib, M. Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis. Nature 2003, 421, 172-177.
    • (2003) Nature , vol.421 , pp. 172-177
    • Hove, J.R.1    Köster, R.W.2    Forouhar, A.S.3    Acevedo-Bolton, G.4    Fraser, S.E.5    Gharib, M.6
  • 38
    • 0037449818 scopus 로고    scopus 로고
    • NFATc1 mediates vascular endothelial growth factor-induced proliferation of human pulmonary valve endothelial cells
    • Johnson, E. N.; Lee, Y. M.; Sander, T. L.; Rabkin, E.; Schoen, F. J.; Kaushal, S.; Bischoff, J. NFATc1 mediates vascular endothelial growth factor-induced proliferation of human pulmonary valve endothelial cells. J. Biol. Chem. 2003, 278, 1686-1692.
    • (2003) J. Biol. Chem , vol.278 , pp. 1686-1692
    • Johnson, E.N.1    Lee, Y.M.2    Sander, T.L.3    Rabkin, E.4    Schoen, F.J.5    Kaushal, S.6    Bischoff, J.7
  • 40
    • 0031694618 scopus 로고    scopus 로고
    • Activation and cellular localization of the cyclosporine A-sensitive transcription factor NF-AT in skeletal muscle cells
    • Abbott, K. L.; Friday, B. B.; Thaloor, D.; Murphy, T. J.; Pavlath, G. K. Activation and cellular localization of the cyclosporine A-sensitive transcription factor NF-AT in skeletal muscle cells. Mol. Biol. Cell 1998, 9, 2905-2916.
    • (1998) Mol. Biol. Cell , vol.9 , pp. 2905-2916
    • Abbott, K.L.1    Friday, B.B.2    Thaloor, D.3    Murphy, T.J.4    Pavlath, G.K.5
  • 41
    • 0033838874 scopus 로고    scopus 로고
    • A calcineurin-NFATc3-dependent pathway regulates skeletal muscle differentiation and slow myosin heavy-chain expression
    • Delling, U.; Tureckova, J.; Lim, H. W.; De Windt, L. J.; Rotwein, P.; Molkentin, J. D. A calcineurin-NFATc3-dependent pathway regulates skeletal muscle differentiation and slow myosin heavy-chain expression. Mol. Cell. Biol. 2000, 20 , 6600-6611.
    • (2000) Mol. Cell. Biol , vol.20 , pp. 6600-6611
    • Delling, U.1    Tureckova, J.2    Lim, H.W.3    De Windt, L.J.4    Rotwein, P.5    Molkentin, J.D.6
  • 43
    • 0035897418 scopus 로고    scopus 로고
    • Regulation of the growth of multinucleated muscle cells by an NFATc2-dependent pathway
    • Horsley, V.; Friday, B. B.; Matteson, S.; Kegley, K. M.; Gephart, J.; Pavlath, G. K. Regulation of the growth of multinucleated muscle cells by an NFATc2-dependent pathway. J. Cell Biol. 2001, 153, 329-338.
    • (2001) J. Cell Biol , vol.153 , pp. 329-338
    • Horsley, V.1    Friday, B.B.2    Matteson, S.3    Kegley, K.M.4    Gephart, J.5    Pavlath, G.K.6
  • 44
    • 0037726553 scopus 로고    scopus 로고
    • IL-4 acts as a myoblast recruitment factor during mammalian muscle growth
    • Horsley, V.; Jansen, K. M.; Mills, S. T.; Pavlath, G. K. IL-4 acts as a myoblast recruitment factor during mammalian muscle growth. Cell 2003, 113, 483-494.
    • (2003) Cell , vol.113 , pp. 483-494
    • Horsley, V.1    Jansen, K.M.2    Mills, S.T.3    Pavlath, G.K.4
  • 45
    • 0037437175 scopus 로고    scopus 로고
    • Prostaglandin F2α stimulates growth of skeletal muscle cells via an NFATC2-dependent pathway
    • Horsley, V.; Pavlath, G. K. Prostaglandin F2α stimulates growth of skeletal muscle cells via an NFATC2-dependent pathway. J. Cell Biol. 2003, 161, 111-118.
    • (2003) J. Cell Biol , vol.161 , pp. 111-118
    • Horsley, V.1    Pavlath, G.K.2
  • 48
    • 0037174944 scopus 로고    scopus 로고
    • Large scale gene expression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulator
    • Ishida, N.; Hayashi, K.; Hoshijima, M.; Ogawa, T.; Koga, S.; Miyatake, Y.; Kumegawa, M.; Kimura, T.; Takeya, T. Large scale gene expression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulator. J. Biol. Chem. 2002, 277, 41147-41156.
    • (2002) J. Biol. Chem , vol.277 , pp. 41147-41156
    • Ishida, N.1    Hayashi, K.2    Hoshijima, M.3    Ogawa, T.4    Koga, S.5    Miyatake, Y.6    Kumegawa, M.7    Kimura, T.8    Takeya, T.9
  • 50
    • 14044249546 scopus 로고    scopus 로고
    • Convergent signaling by acidosis and receptor activator of NF-κB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts
    • Komarova, S. V.; Pereverzev, A.; Shum, J. W.; Sims, S. M.; Dixon, S. J. Convergent signaling by acidosis and receptor activator of NF-κB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts. Proc. Natl. Acad. Sci. USA 2005, 102, 2643-2648.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 2643-2648
    • Komarova, S.V.1    Pereverzev, A.2    Shum, J.W.3    Sims, S.M.4    Dixon, S.J.5
  • 52
    • 30344459696 scopus 로고    scopus 로고
    • Carcinogenic effect of nickel compounds
    • Lu, H.; Shi, X.; Costa, M.; Huang, C. Carcinogenic effect of nickel compounds. Mol. Cell. Biochem. 2005, 279, 45-67.
    • (2005) Mol. Cell. Biochem , vol.279 , pp. 45-67
    • Lu, H.1    Shi, X.2    Costa, M.3    Huang, C.4
  • 53
    • 0034737733 scopus 로고    scopus 로고
    • Involvement of nuclear factor of activated T cells activation in UV response. Evidence from cell culture and transgenic mice
    • Huang, C.; Mattjus, P.; Ma, W. Y.; Rincon, M.; Chen, N. Y.; Brown, R. E.; Dong, Z. Involvement of nuclear factor of activated T cells activation in UV response. Evidence from cell culture and transgenic mice. J. Biol. Chem. 2000, 275, 9143-9149.
    • (2000) J. Biol. Chem , vol.275 , pp. 9143-9149
    • Huang, C.1    Mattjus, P.2    Ma, W.Y.3    Rincon, M.4    Chen, N.Y.5    Brown, R.E.6    Dong, Z.7
  • 54
    • 33746831980 scopus 로고    scopus 로고
    • NFAT3 is specifically required for TNF-alpha-induced cyclooxygenase-2 (COX-2) expression and transformation of Cl41 cells
    • Yan, Y.; Li, J.; Ouyang, W.; Ma, Q.; Hu, Y.; Zhang, D.; Ding, J.; Qu, Q.; Subbaramaiah, K.; Huang, C. NFAT3 is specifically required for TNF-alpha-induced cyclooxygenase-2 (COX-2) expression and transformation of Cl41 cells. J. Cell Sci. 2006, 119(Pt 14), 2985-2994.
    • (2006) J. Cell Sci , vol.119 , Issue.PART 14 , pp. 2985-2994
    • Yan, Y.1    Li, J.2    Ouyang, W.3    Ma, Q.4    Hu, Y.5    Zhang, D.6    Ding, J.7    Qu, Q.8    Subbaramaiah, K.9    Huang, C.10
  • 55
    • 15744397205 scopus 로고    scopus 로고
    • Expression and function of the nuclear factor of activated T cells in colon carcinoma cells
    • Duque, J.; Fresno, M.; Iniguez, M. A. Expression and function of the nuclear factor of activated T cells in colon carcinoma cells. J. Biol. Chem. 2005, 289, 8686-8693.
    • (2005) J. Biol. Chem , vol.289 , pp. 8686-8693
    • Duque, J.1    Fresno, M.2    Iniguez, M.A.3
  • 56
    • 4644223413 scopus 로고    scopus 로고
    • Effect of phosphodiesterase 4 inhibitors on NFAT-dependent cyclooxygenase-2 expression in human T lymphocytes
    • Jimenez, J. L.; Iniguez, M. A.; Munoz-Fernández, M. A.; Fresno, M. Effect of phosphodiesterase 4 inhibitors on NFAT-dependent cyclooxygenase-2 expression in human T lymphocytes. Cell Signal. 2004, 16 , 1363-1373.
    • (2004) Cell Signal , vol.16 , pp. 1363-1373
    • Jimenez, J.L.1    Iniguez, M.A.2    Munoz-Fernández, M.A.3    Fresno, M.4
  • 57
    • 0027272061 scopus 로고
    • Anti-tumor-promoting action of FK506, a potent immunosuppressive agent
    • Jiang, H.; Yamamoto, S.; Nishikawa, K.; Kato, R. Anti-tumor-promoting action of FK506, a potent immunosuppressive agent. Carcinogenesis 1993, 14 , 67-71.
    • (1993) Carcinogenesis , vol.14 , pp. 67-71
    • Jiang, H.1    Yamamoto, S.2    Nishikawa, K.3    Kato, R.4
  • 58
    • 0029102881 scopus 로고
    • Ultraviolet B irradiation promotes tumorigenic and metastatic properties in primary cutaneous melanoma via induction of interleukin 8
    • Singh, R. K.; Gutman, M.; Reich, R.; Bar-Eli, M. Ultraviolet B irradiation promotes tumorigenic and metastatic properties in primary cutaneous melanoma via induction of interleukin 8. Cancer Res. 1995, 55 , 3669-3674.
    • (1995) Cancer Res , vol.55 , pp. 3669-3674
    • Singh, R.K.1    Gutman, M.2    Reich, R.3    Bar-Eli, M.4
  • 59
    • 3042743983 scopus 로고    scopus 로고
    • Genomic DNA-chip hybridization reveals a higher incidence of genomic amplifications in pancreatic cancer than conventional comparative genomic hybridization and leads to the identification of novel candidate genes
    • Holzmann, K.; Kohlhammer, H.; Schwaenen, C.; Wessendorf, S.; Kestler, H. A.; Schwoerer, A.; Rau, B.; Radlwimmer, B.; Döhner, H.; Lichter, P.; Gress, T.; Bentz, M. Genomic DNA-chip hybridization reveals a higher incidence of genomic amplifications in pancreatic cancer than conventional comparative genomic hybridization and leads to the identification of novel candidate genes. Cancer Res. 2004, 64 , 4428-4433.
    • (2004) Cancer Res , vol.64 , pp. 4428-4433
    • Holzmann, K.1    Kohlhammer, H.2    Schwaenen, C.3    Wessendorf, S.4    Kestler, H.A.5    Schwoerer, A.6    Rau, B.7    Radlwimmer, B.8    Döhner, H.9    Lichter, P.10    Gress, T.11    Bentz, M.12
  • 60
    • 0035890815 scopus 로고    scopus 로고
    • Hydrogen peroxide mediates activation of nuclear factor of activated T cells (NFAT) by nickel subsulfide
    • Huang, C.; Li, J.; Costa, M.; Zhang, Z.; Leonard, S. S.; Castranova, V.; Vallyathan, V.; Ju, G.; Shi, X. Hydrogen peroxide mediates activation of nuclear factor of activated T cells (NFAT) by nickel subsulfide. Cancer Res. 2001, 61 , 8051-8057.
    • (2001) Cancer Res , vol.61 , pp. 8051-8057
    • Huang, C.1    Li, J.2    Costa, M.3    Zhang, Z.4    Leonard, S.S.5    Castranova, V.6    Vallyathan, V.7    Ju, G.8    Shi, X.9
  • 62
    • 32844468634 scopus 로고    scopus 로고
    • Calcineurin inhibitors decreases DNA repair and apoptosis in human keratinocytes following ultraviolet B irradiation
    • Yarosh, D. B.; Pena, A. V.; Nay, S. L.; Canning, M. T.; Brown, D. A. Calcineurin inhibitors decreases DNA repair and apoptosis in human keratinocytes following ultraviolet B irradiation. J. Invest. Dermatol. 2005, 125, 1020-1025.
    • (2005) J. Invest. Dermatol , vol.125 , pp. 1020-1025
    • Yarosh, D.B.1    Pena, A.V.2    Nay, S.L.3    Canning, M.T.4    Brown, D.A.5
  • 64
    • 0742306716 scopus 로고    scopus 로고
    • Molecular mechanisms of arsenic carcinogenesis
    • Huang, C.; Ke, Q.; Costa M.; Shi, X. Molecular mechanisms of arsenic carcinogenesis. Mol. Cell. Biochem., 2004, 255, 57-66.
    • (2004) Mol. Cell. Biochem , vol.255 , pp. 57-66
    • Huang, C.1    Ke, Q.2    Costa, M.3    Shi, X.4
  • 65
    • 0023832768 scopus 로고
    • Transfer by pro gene transfection of tumor promoter-sensitive phenotype to promotion-insensitive JB6 cells
    • Colburn, N. H.; Smith, B. M.; Wendel, E. J.; Dowjat, W. K.; Shimada, T. Transfer by pro gene transfection of tumor promoter-sensitive phenotype to promotion-insensitive JB6 cells. Cancer Res. 1988, 48 , 1195-1200.
    • (1988) Cancer Res , vol.48 , pp. 1195-1200
    • Colburn, N.H.1    Smith, B.M.2    Wendel, E.J.3    Dowjat, W.K.4    Shimada, T.5
  • 66
    • 0037030518 scopus 로고    scopus 로고
    • STAT3 activation is required for interleukin-6 induced transformation in tumor-promotion sensitive mouse skin epithelial cells
    • Yu, C. Y.; Wang, L.; Khaletskiy, A.; Farrar, W. L.; Larner, A.; Colburn, N. H.; Li, J. J. STAT3 activation is required for interleukin-6 induced transformation in tumor-promotion sensitive mouse skin epithelial cells. Oncogene 2002, 21 , 3949-3960.
    • (2002) Oncogene , vol.21 , pp. 3949-3960
    • Yu, C.Y.1    Wang, L.2    Khaletskiy, A.3    Farrar, W.L.4    Larner, A.5    Colburn, N.H.6    Li, J.J.7
  • 68
    • 35148855014 scopus 로고    scopus 로고
    • Direct Evidence for the Critical Role of NFAT3 in Benzo[a]pyrene Diol-Epoxide-Induced Cell Transformation through Mediation of Inflammatory Cytokine TNFa in Mouse Epidermal Cl41 Cells
    • revised
    • Ouyang, W.; Hu, Y.; Li J.; Ding, M.; Lu, Y.; Zhang, D.; Yan, Y.; Song, L.; Qu, Q.; Desai, D.; Amin, S.; Huang, C. Direct Evidence for the Critical Role of NFAT3 in Benzo[a]pyrene Diol-Epoxide-Induced Cell Transformation through Mediation of Inflammatory Cytokine TNFa in Mouse Epidermal Cl41 Cells. Carcinogenesis, revised.
    • Carcinogenesis
    • Ouyang, W.1    Hu, Y.2    Li, J.3    Ding, M.4    Lu, Y.5    Zhang, D.6    Yan, Y.7    Song, L.8    Qu, Q.9    Desai, D.10    Amin, S.11    Huang, C.12
  • 69
    • 33748297452 scopus 로고    scopus 로고
    • NFAT3 is required for EGF-induced COX-2 transcription, but neither iNOS transcription nor cell transformation in Cl 41 Cells
    • Li, J.; Lu, H.; Huang, C. NFAT3 is required for EGF-induced COX-2 transcription, but neither iNOS transcription nor cell transformation in Cl 41 Cells. Mol. Cell. Biochem. 2006, 289(1-2), 73-82.
    • (2006) Mol. Cell. Biochem , vol.289 , Issue.1-2 , pp. 73-82
    • Li, J.1    Lu, H.2    Huang, C.3
  • 70
    • 33746848336 scopus 로고    scopus 로고
    • Knockdown of NFAT3 blocked TPA-induced COX-2 and iNOS expression, and enhanced cell transformation in Cl41 cells
    • Li, J.; Song, L.; Zhang, D.; Wei, L.; Huang, C. Knockdown of NFAT3 blocked TPA-induced COX-2 and iNOS expression, and enhanced cell transformation in Cl41 cells. J. Cell. Biochem., 2006, 99 (4), 1010-1020.
    • (2006) J. Cell. Biochem , vol.99 , Issue.4 , pp. 1010-1020
    • Li, J.1    Song, L.2    Zhang, D.3    Wei, L.4    Huang, C.5
  • 72
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D.; Weinberg, R. A. The hallmarks of cancer. Cell 2000, 100, 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 76
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • Sherr, C. J.; Roberts, J. M. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 1999, 13 , 1501-1512.
    • (1999) Genes Dev , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 77
    • 0036884463 scopus 로고    scopus 로고
    • NFATC2 transcription factor regulates cell cycle progression during lymphocyte activation: Evidence of its involvement in the control of cyclin gene expression
    • Caetano, M. S.; Vieira-de-Abreu, A.; Teixeira, L. K.; Werneck, M. B. F.; Barcinski, M. A.; Viola, J. P. B. NFATC2 transcription factor regulates cell cycle progression during lymphocyte activation: evidence of its involvement in the control of cyclin gene expression. FASEB J. 2002, 16 , 1940-1942.
    • (2002) FASEB J , vol.16 , pp. 1940-1942
    • Caetano, M.S.1    Vieira-de-Abreu, A.2    Teixeira, L.K.3    Werneck, M.B.F.4    Barcinski, M.A.5    Viola, J.P.B.6
  • 80
    • 0037931834 scopus 로고    scopus 로고
    • Neal, J. W.; Clipstone, N. A. A constitutively active NFATc1 mutant induces a transformed phenotype in 3T3-L1 fibroblasts. J. Biol. Chem. 2003, 278, 17246-17254.
    • Neal, J. W.; Clipstone, N. A. A constitutively active NFATc1 mutant induces a transformed phenotype in 3T3-L1 fibroblasts. J. Biol. Chem. 2003, 278, 17246-17254.
  • 82
    • 14144251429 scopus 로고    scopus 로고
    • Calcineurin/NFAT-induced up-regulation of the Fas ligand/Fas death pathway is involved in methamphetamine-induced neuronal apoptosis
    • Jayanthi, S.; Deng, X.; Ladenheim, B.; McCoy, M. T.; Cluster, A.; Cai, N. S.; Cadet, J. L. Calcineurin/NFAT-induced up-regulation of the Fas ligand/Fas death pathway is involved in methamphetamine-induced neuronal apoptosis. Proc. Natl. Acad. Sci. USA 2005, 102, 868-873.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 868-873
    • Jayanthi, S.1    Deng, X.2    Ladenheim, B.3    McCoy, M.T.4    Cluster, A.5    Cai, N.S.6    Cadet, J.L.7
  • 83
    • 23844477888 scopus 로고    scopus 로고
    • The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway
    • Rivera, A.; Maxwell, S. A. The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway. J. Biol. Chem. 2005, 280, 29346-29354.
    • (2005) J. Biol. Chem , vol.280 , pp. 29346-29354
    • Rivera, A.1    Maxwell, S.A.2
  • 84
    • 0031028816 scopus 로고    scopus 로고
    • Cyclosporin A, an immunosuppressive drug, induces programmed cell death in rat C6 glioma cells by a mechanism that involves the AP-1 transcription factor
    • Mosieniak, G.; Figiel, I.; Kaminska, B. Cyclosporin A, an immunosuppressive drug, induces programmed cell death in rat C6 glioma cells by a mechanism that involves the AP-1 transcription factor. J. Neurochem. 1997, 68 , 1142-1149.
    • (1997) J. Neurochem , vol.68 , pp. 1142-1149
    • Mosieniak, G.1    Figiel, I.2    Kaminska, B.3
  • 85
    • 28444491798 scopus 로고    scopus 로고
    • Constitutive NF-κB and NFAT activation in aggressive B-cell lymphomas synergistically activates the CD154 gene and maintains lymphoma cell survival
    • Pham, L. V.; Tamayo, A. T.; Yoshimura, L. C.; Lin-Lee, Y. C.; Ford, R. J. Constitutive NF-κB and NFAT activation in aggressive B-cell lymphomas synergistically activates the CD154 gene and maintains lymphoma cell survival. Blood 2005, 106, 3940-3947.
    • (2005) Blood , vol.106 , pp. 3940-3947
    • Pham, L.V.1    Tamayo, A.T.2    Yoshimura, L.C.3    Lin-Lee, Y.C.4    Ford, R.J.5
  • 86
    • 33744486857 scopus 로고    scopus 로고
    • Constitutive NF-κB and NFAT activation leads to stimulation of the BLyS survival pathway in aggressive B cell lymphomas
    • in press
    • Fu, L.; Lin-Lee, Y. C.; Pham, L. V.; Tamayo, A.; Yoshimura, L.; Ford, R. J. Constitutive NF-κB and NFAT activation leads to stimulation of the BLyS survival pathway in aggressive B cell lymphomas. Blood in press.
    • Blood
    • Fu, L.1    Lin-Lee, Y.C.2    Pham, L.V.3    Tamayo, A.4    Yoshimura, L.5    Ford, R.J.6
  • 87
  • 88
    • 0035809312 scopus 로고    scopus 로고
    • Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: Roles of the nuclear factor of activated T cells and cyclooxygenase-2
    • Hernández, G. L.; Volpert, O. V.; Íniguez, M. A.; Lorenzo, E.; Martínez-Martínez, S.; Grau, R.; Fresno, M.; Redondo, J. M. Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: roles of the nuclear factor of activated T cells and cyclooxygenase-2. J. Exp. Med. 2001, 193, 607-620.
    • (2001) J. Exp. Med , vol.193 , pp. 607-620
    • Hernández, G.L.1    Volpert, O.V.2    Íniguez, M.A.3    Lorenzo, E.4    Martínez-Martínez, S.5    Grau, R.6    Fresno, M.7    Redondo, J.M.8
  • 90
    • 2942657484 scopus 로고    scopus 로고
    • Nuclear factor of activated T cells balances angiogenesis activation and inhibition
    • Zaichuk, T. A.; Shroff, E. H.; Emmanuel, R.; Filleur, S.; Nelius, T.; Volpert, O. V. Nuclear factor of activated T cells balances angiogenesis activation and inhibition. J. Exp. Med. 2004, 199, 1513-1522.
    • (2004) J. Exp. Med , vol.199 , pp. 1513-1522
    • Zaichuk, T.A.1    Shroff, E.H.2    Emmanuel, R.3    Filleur, S.4    Nelius, T.5    Volpert, O.V.6
  • 91
    • 0036104828 scopus 로고    scopus 로고
    • Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor
    • Volpert, O. V.; Zaichuk, T. A.; Zhou, W.; Reiher, F.; Ferguson, T. A.; Stuart, P. M.; Amin, M.; Bouck, N. P. Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor. Nat. Med. 2002, 8, 349-357.
    • (2002) Nat. Med , vol.8 , pp. 349-357
    • Volpert, O.V.1    Zaichuk, T.A.2    Zhou, W.3    Reiher, F.4    Ferguson, T.A.5    Stuart, P.M.6    Amin, M.7    Bouck, N.P.8
  • 92
    • 0029870954 scopus 로고    scopus 로고
    • The war on cancer
    • Sporn, M. B. The war on cancer. Lancet 1996, 347, 1377-1381.
    • (1996) Lancet , vol.347 , pp. 1377-1381
    • Sporn, M.B.1
  • 94
    • 27944446105 scopus 로고    scopus 로고
    • Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT
    • Yoeli-Lerner, M.; Yiu, G. K.; Rabinovitz, I.; Erhardt, P.; Jauliac, S.; Toker, A. Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol. Cell 2005, 20 , 539-550.
    • (2005) Mol. Cell , vol.20 , pp. 539-550
    • Yoeli-Lerner, M.1    Yiu, G.K.2    Rabinovitz, I.3    Erhardt, P.4    Jauliac, S.5    Toker, A.6
  • 95
    • 33744948986 scopus 로고    scopus 로고
    • NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2
    • Yiu, G. K.; Toker, A. NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2. J. Biol. Chem. 2006, 281(18), 12210-12217.
    • (2006) J. Biol. Chem , vol.281 , Issue.18 , pp. 12210-12217
    • Yiu, G.K.1    Toker, A.2
  • 96
    • 27644587860 scopus 로고    scopus 로고
    • NFATc3 deficiency may contribute to the development of mammary gland adenocarcinoma in aging female mice
    • Lee, H.; Chouinard, L.; Bonin, M.; Michel, R. N. NFATc3 deficiency may contribute to the development of mammary gland adenocarcinoma in aging female mice. Mol. Carcinogen. 2005, 44 , 219-222.
    • (2005) Mol. Carcinogen , vol.44 , pp. 219-222
    • Lee, H.1    Chouinard, L.2    Bonin, M.3    Michel, R.N.4
  • 98
    • 0034598356 scopus 로고    scopus 로고
    • The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis
    • Ranger, A. M.; Gerstenfeld, L. C.; Wang, J.; Kon, T.; Bae, H.; Gravallese, E. M.; Glimcher, M. J.; Glimcher, L. H. The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis. J. Exp. Med. 2000, 191, 9-22.
    • (2000) J. Exp. Med , vol.191 , pp. 9-22
    • Ranger, A.M.1    Gerstenfeld, L.C.2    Wang, J.3    Kon, T.4    Bae, H.5    Gravallese, E.M.6    Glimcher, M.J.7    Glimcher, L.H.8
  • 101
    • 2442714017 scopus 로고    scopus 로고
    • Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules
    • Roehrl, M. H. A.; Kang, S.; Aramburu, J.; Wagner, G.; Rao, A.; Hogan, P. G. Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc. Natl. Acad. Sci. USA 2004, 101, 7554-7559.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 7554-7559
    • Roehrl, M.H.A.1    Kang, S.2    Aramburu, J.3    Wagner, G.4    Rao, A.5    Hogan, P.G.6
  • 102
    • 0033698581 scopus 로고    scopus 로고
    • Manipulating immune responses with immunosuppressive agents that target NFAT
    • Kiani, A.; Rao, A.; Aramburu, J. Manipulating immune responses with immunosuppressive agents that target NFAT. Immunity 2000, 12 , 359-372.
    • (2000) Immunity , vol.12 , pp. 359-372
    • Kiani, A.1    Rao, A.2    Aramburu, J.3
  • 103
    • 2942632790 scopus 로고    scopus 로고
    • Chemical genetics to identify FNAT inhibitors: Potential of targeting calcium mobilization in immunosuppression
    • Venkatesh, N.; Feng, Y.; DeDecker, B.; Yacono, P.; Golan, D.; Mitchison, T.; McKeon, F. Chemical genetics to identify FNAT inhibitors: potential of targeting calcium mobilization in immunosuppression. Proc. Nat. Acad. Sci. USA 2004, 101, 8969-8974.
    • (2004) Proc. Nat. Acad. Sci. USA , vol.101 , pp. 8969-8974
    • Venkatesh, N.1    Feng, Y.2    DeDecker, B.3    Yacono, P.4    Golan, D.5    Mitchison, T.6    McKeon, F.7
  • 104
    • 0032039075 scopus 로고    scopus 로고
    • Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT
    • Aramburu, J.; García-Cozár, F.; Raghavan, A.; Okamura, H.; Rao, A.; Hogan, P. G. Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT. Mol. Cell 1998, 1, 627-637.
    • (1998) Mol. Cell , vol.1 , pp. 627-637
    • Aramburu, J.1    García-Cozár, F.2    Raghavan, A.3    Okamura, H.4    Rao, A.5    Hogan, P.G.6
  • 105
    • 0032849010 scopus 로고    scopus 로고
    • Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A
    • Aramburu, J.; Yaffe, M. B.; López-Rodríguez, C.; Cantley, L. C.; Hogan, P. G.; Rao, A. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science 1999, 285, 2129-2133.
    • (1999) Science , vol.285 , pp. 2129-2133
    • Aramburu, J.1    Yaffe, M.B.2    López-Rodríguez, C.3    Cantley, L.C.4    Hogan, P.G.5    Rao, A.6
  • 106
    • 27844549820 scopus 로고    scopus 로고
    • Inhibition of the calcineurin-NFAT interaction by small organic molecules reflects binding at an allosteric site
    • Kang, S.; Li, H.; Rao, A.; Hogan, P. G. Inhibition of the calcineurin-NFAT interaction by small organic molecules reflects binding at an allosteric site. J. Biol. Chem. 2005, 280, 37698-37706.
    • (2005) J. Biol. Chem , vol.280 , pp. 37698-37706
    • Kang, S.1    Li, H.2    Rao, A.3    Hogan, P.G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.