Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer

New England Journal of Medicine

Volumn 355, Issue 1, 2006, Pages 11-20

  Cunningham, David ^a,b   Allum, William H ^a,b   Stenning, Sally P ^c   Thompson, Jeremy N ^a,b   Van De Velde, Cornelis J H ^j   Nicolson, Marianne ^d   Scarffe, J Howard ^e   Lofts, Fiona J ^f   Falk, Stephen J ^g   Iveson, Timothy J ^h   Smith, David B ⁱ   Langley, Ruth E ^c   Verma, Monica ^c   Weeden, Simon ^c   Yu, Jo Chua ^a,b  

^a ROYAL MARSDEN HOSPITAL   (United Kingdom)

^b ROYAL MARSDEN HOSPITAL   (United Kingdom)

^c MEDICAL RESEARCH COUNCIL   (United Kingdom)

^d ABERDEEN ROYAL INFIRMARY   (United Kingdom)

^e CHRISTIE HOSPITAL   (United Kingdom)

^f ST GEORGE S HOSPITAL   (United Kingdom)

^g BRISTOL HAEMATOLOGY AND ONCOLOGY CENTRE   (United Kingdom)

^h SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

ⁱ CLATTERBRIDGE CENTRE FOR ONCOLOGY   (United Kingdom)

^j LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; EPIRUBICIN; FLUOROURACIL;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER SURGERY; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEATH; DIARRHEA; ESOPHAGUS CANCER; FEMALE; FOLLOW UP; GRANULOCYTOPENIA; HEMOGLOBINOPATHY; HUMAN; LEUKOPENIA; LOWER ESOPHAGUS SPHINCTER; LYMPHOCYTOPENIA; MAJOR CLINICAL STUDY; MALE; NAUSEA; NEUROLOGIC DISEASE; PERIOPERATIVE PERIOD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN DISEASE; STOMACH ADENOCARCINOMA; STOMACH CANCER; STOMATITIS; THROMBOCYTOPENIA; VOMITING;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMOTHERAPY, ADJUVANT; CISPLATIN; DISEASE-FREE SURVIVAL; EPIRUBICIN; ESOPHAGEAL NEOPLASMS; ESOPHAGECTOMY; ESOPHAGOGASTRIC JUNCTION; FEMALE; FLUOROURACIL; GASTRECTOMY; HUMANS; MALE; MIDDLE AGED; PERIOPERATIVE CARE; STOMACH NEOPLASMS; SURVIVAL RATE;

EID: 33745726677     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa055531     Document Type: Article

References (24)

1. Sue-Ling HM, Johnston D, Martin IG, et al. Gastric cancer: a curable disease in Britain. BMJ 1993;307:591-6.
2. Sasako M, Sano T, Katai H, Maruyama K. Radical surgery. In: Sugimura T, Sasako M, eds. Gastric cancer. Oxford, England: Oxford University Press, 1997:223-48.
3. Siewert JR, Bottcher K, Roder JD, Busch R, Hermanek P, Meyer HJ. Prognostic relevance of systematic lymph node dissection in gastric carcinoma. Br J Surg 1993;80:1015-8.
4. Hartgrink HH, van de Velde CJ, Putter H, et al. Extended lymph node dissection for gastric cancer: who may benefit? Final results of the randomized Dutch gastric cancer group trial. J Clin Oncol 2004;22: 2069-77.
5. Cuschieri A, Weeden S, Fielding J, et al. Patient survival after D1 and D2 resections for gastric cancer: long-term results of the MRC randomized surgical trial. Br J Cancer 1999;79:1522-30.
6. Bonenkamp JJ, Hermans J, Sasako M, et al. Extended lymph-node dissection for gastric cancer. N Engl J Med 1999;340:908-14.
7. McCulloch P, Nita ME, Kazi H, Gama-Rodrigues J. Extended versus limited lymph nodes dissection technique for adenocarcinoma of the stomach. Cochrane Database Syst Rev 2004;4:CD001964.
8. Findlay M, Cunningham D, Norman A, et al. A phase II study in advanced gastroesophageal cancer using epirubicin and cisplatin in combination with continuous infusion 5-fluorouracil (ECF). Ann Oncol 1994;5:609-16.
9. Webb A, Cunningham D, Scarffe JH, et al. Randomized trial comparing epirubicin, cisplatin, and fluorouracil versus fluorouracil, doxorubicin, and methotrexate in advanced esophagogastric cancer. J Clin Oncol 1997;15:261-7.
10. Ross P, Nicolson M, Cunningham D, et al. Prospective randomized trial comparing mitomycin, cisplatin, and protracted venous-infusion fluorouracil (PVI 5-FU) with epirubicin, cisplatin, and PVI 5-FU in advanced esophagogastric cancer. J Clin Oncol 2002;20:1996-2004.
11. Waters JS, Norman A, Cunningham D, et al. Long-term survival after epirubicin, cisplatin and fluorouracil for gastric cancer: results of a randomized trial. Br J Cancer 1999;80:269-72.
12. Wagner AD, Grothe W, Behl S, et al. Chemotherapy for advanced gastric cancer. Cochrane Database Syst Rev 2005;2:CD004064.
13. Hermanek P, Sobin L, eds. International Union against Cancer: TNM classification of malignant tumours. Berlin: Springer-Verlag, 1987.
14. Medical Research Council Esophageal Cancer Working Group. Surgical resection with or without preoperative chemotherapy in esophageal cancer: a randomized controlled trial. Lancet 2002;359:1727-33.
15. Allum WH, Hallissey MT, Ward LC, Hockey MS. A controlled, prospective, randomized trial of adjuvant chemotherapy or radiotherapy in resectable gastric cancer: interim report. Br J Cancer 1989;60:739-44.
16. Hartgrink HH, van de Velde CJ, Putter H, et al. Neo-adjuvant chemotherapy for operable gastric cancer: long term results of the Dutch randomized FAMTX trial. Eur J Surg Oncol 2004;30:643-9.
17. Allum W, Cunningham D, Weeden S. Perioperative chemotherapy in operable gastric and lower esophageal cancer: a randomized, controlled trial (the MAGIC trial, ISRCTN 93793971). Proc Am Soc Clin Oncol 2003;22:249. abstract.
18. Allum WH, Hallissey MT, Kelly KA. Adjuvant chemotherapy in operable gastric cancer: 5 year follow-up of first British Stomach Cancer Group trial. Lancet 1989;1:571-4.
19. Macdonald JS, Fleming TR, Peterson RF, et al. Adjuvant chemotherapy with 5-FU, adriamycin, and mitomycin-C (FAM) versus surgery alone for patients with locally advanced gastric adenocarcinoma: a Southwest Oncology Group study. Ann Surg Oncol 1995;2:488-94.
20. Hermans J, Bonenkamp JJ, Boon MC, et al. Adjuvant therapy after curative resection for gastric cancer: meta-analysis of randomized trials. J Clin Oncol 1993;11:1441-7.
21. Earle CC, Maroun JA. Adjuvant chemotherapy after curative resection for gastric cancer in non-Asian patients: revisiting a meta-analysis of randomized trials. Eur J Cancer 1999;35:1059-64.
22. Mari E, Floriani I, Tinazzi A, et al. Efficacy of adjuvant chemotherapy after curative resection for gastric cancer: a metaanalysis of published randomised trials - a study of the GISCAD (Gruppo Italiano per lo Studio dei Carcinomi dell'Apparato Digerente). Ann Oncol 2000;11:837-43.
23. Macdonald JS, Smalley SR, Benedetti J, et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med 2001;345:725-30.
24. Sumpter K, Harper-Wynne C, Cunningham D, et al. Report of two protocol planned interim analyses in a randomized multicentre phase III study comparing capecitabine with f luorouracil and oxaliplatin with cisplatin in patients with advanced esophagogastric cancer receiving ECF. Br J Cancer 2005;92:1976-83.