Transient receptor potential channel TRPM8 agonists stimulate calcium influx and neurotensin secretion in neuroendocrine tumor cells

Neuroendocrinology

Volumn 85, Issue 2, 2007, Pages 81-92

  Mergler, Stefan ^a   Strowski, Mathias Z ^a   Kaiser, Simone ^b   Plath, Thomas ^b   Giesecke, Yvonne ^a   Neumann, Marleen ^a   Hosokawa, Hiroshi ^c   Kobayashi, Shigeo ^c   Langrehr, Jan ^a   Neuhaus, Peter ^a   Plöckinger, Ursula ^a   Wiedenmann, Bertram ^a   Grötzinger, Carsten ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Metagen GmbH   (Germany)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

Calcium; Icilin; Neurosecretory system; Neurotensin; TRPM8 channels

Indexed keywords

1 (2 HYDROXYPHENYL) 4 (3 NITROPHENYL) 1,2,3,6 TETRAHYDROPYRIMIDIN 2 ONE; CALCIUM ION; CHROMOGRANIN A; ION TRANSPORT AFFECTING AGENT; METHANOL; NEUROTENSIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM TRANSPORT; CELL STRAIN HEK293; CONTROLLED STUDY; EMBRYO; FLUORESCENCE; GENETIC TRANSFECTION; HORMONE RELEASE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; NEUROENDOCRINE TUMOR; PANCREAS TUMOR; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STIMULATION; TUMOR CELL; WESTERN BLOTTING;

CALCIUM; HUMANS; MEMBRANE POTENTIALS; MENTHOL; MODELS, BIOLOGICAL; NEUROENDOCRINE TUMORS; NEUROTENSIN; PANCREATIC NEOPLASMS; PYRIMIDINONES; TRPM CATION CHANNELS; TUMOR CELLS, CULTURED;

EID: 34248139677     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000101693     Document Type: Article

References (68)

1. Mergler S, Strauss O, Strowski M, Prada J, Drost A, Langrehr J, Neuhaus P, Wiedenmann B, Ploeckinger U: Insulin-like growth factor-1 increases intracellular calcium concentration in human primary neuroendocrine pancreatic tumor cells and a pancreatic neuroendocrine tumor cell line (BON-1) via R-type Ca channels and regulates chromogranin A secretion in BON-1 cells. Neuroendocrinology 2006;82:87-102.
2. Ahnert-Hilger G, Stadtbaumer A, Strubing C, Scherubl H, Schultz G, Riecken EO, Wiedenmann B: Gamma-aminobutyric acid secretion from pancreatic neuroendocrine cells. Gastroenterology 1996;110:1595-1604.
3. Glassmeier G, Strubing C, Riecken EO, Buhr H, Neuhaus P, Ahnert-Hilger G, Wiedenmann B, Scherubl H: Electrophysiological properties of human carcinoid cells of the gut. Gastroenterology 1997;113:90-100.
4. 2+ channel characteristics in neuroendocrine tumor cell cultures analyzed by color contour plots. J Neurosci Methods 2003;129:169-181.
5. 2+ channel activity is associated with chromogranin A secretion in human neuroendocrine tumor BON cells. J Membr Biol 2003;194:177-186.
6. 2+ channel properties in neuroendocrine tumor cell cultures investigated by whole-cell patch-clamp technique. Ann NY Acad Sci 2004;1014:137-139.
7. Scherubl H, Hescheler J, Bychkov R, Cuber JC, John M, Riecken EO, Wiedenmann B: Electrical activity and calcium channels in neuroendocrine cells. Ann NY Acad Sci 1994;733:335-339.
8. Montell C: The TRP superfamily of cation channels. Sci STKE 2005;2005:re3.
9. Nilius B, Voets T, Peters J: TRP channels in disease. Sci STKE 2005;2005:re8.
10. Nilius B, Voets T: TRP channels: a TR(I)P through a world of multifunctional cation channels. Pflügers Arch 2005;451:1-10.
11. Clapham DE: TRP channels as cellular sensors. Nature 2003;426:517-524.
12. Clapham DE, Julius D, Montell C, Schultz G: International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. Pharmacol Rev 2005;57:427-450.
13. Pedersen SF, Owsianik G, Nilius B: TRP channels: an overview. Cell Calcium 2005;38:233-252.
14. Harteneck C: Function and pharmacology of TRPM cation channels. Naunyn Schmiedebergs Arch Pharmacol 2005;371:307-314.
15. Kraft R, Harteneck C: The mammalian melastatin-related transient receptor potential cation channels: an overview. Pflügers Arch 2005;451:204-211.
16. McKemy DD, Neuhausser WM, Julius D: Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 2002;416:52-58.
17. Andersson DA, Chase HW, Bevan S: TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH. J Neurosci 2004;24:5364-5369.
18. Brauchi S, Orio P, Latorre R: Clues to understanding cold sensation: thermodynamics and electrophysiological analysis of the cold receptor TRPM8. Proc Natl Acad Sci USA 2004;101:15494-15499.
19. Chuang HH, Neuhausser WM, Julius D: The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. Neuron 2004;43:859-869.
20. Peier AM, Moqrich A, Hergarden AC, Reeve AJ, Andersson DA, Story GM, Earley TJ, Dragoni I, McIntyre P, Bevan S, Patapoutian A: A TRP channel that senses cold stimuli and menthol. Cell 2002;108:705-715.
21. Thebault S, Lemonnier L, Bidaux G, Flourakis M, Bavencoffe A, Gordienko D, Roudbaraki M, Delcourt P, Panchin Y, Shuba Y, Skryma R, Prevarskaya N: Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cells. J Biol Chem 2005;280:39423-39435.
22. Voets T, Droogmans G, Wissenbach U, Janssens A, Flockerzi V, Nilius B: The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature 2004;430:748-754.
23. Weil A, Moore SE, Waite NJ, Randall A, Gunthorpe MJ: Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8. Mol Pharmacol 2005;68:518-527.
24. Nilius B, Owsianik G, Voets T, Peters JA: Transient receptor potential cation channels in disease. Physiol Rev 2007;87:165-217.
25. Kaiser S: Identification and characterization of the ion channel TRPM8 in prostate cancer; thesis, Mathematisch-Naturwissenschaftliche Fakultät I der Humboldt-Universität zu Berlin, 2004, pp 1-85.
26. Evers BM: Endocrine gene neurotensin: molecular mechanisms and a model of intestinal differentiation. World J Surg 2002;26:799-805.
27. Ferris CF, Carraway RE, Hammer RA, Leeman SE: Release and degradation of neurotensin during perfusion of rat small intestine with lipid. Regul Pept 1985;12:101-111.
28. Andersson S, Rosell S, Hjelmquist U, Chang D, Folkers K: Inhibition of gastric and intestinal motor activity in dogs by (Gln4) neurotensin. Acta Physiol Scand 1977;100:231-235.
29. 3H]oleic acid translocation across rat small intestine. Am J Physiol 1986;251:G823-G829.
30. Baca I, Feurle GE, Schwab A, Mittmann U, Knauf W, Lehnert T: Effect of neurotensin on exocrine pancreatic secretion in dogs. Digestion 1982;23:174-183.
31. Evers BM, Izukura M, Chung DH, Parekh D, Yoshinaga K, Greeley GH Jr, Uchida T, Townsend CM Jr, Thompson JC: Neurotensin stimulates growth of colonic mucosa in young and aged rats. Gastroenterology 1992;103:86-91.
32. Rostene WH, Alexander MJ: Neurotensin and neuroendocrine regulation. Front Neuroendocrinol 1997;18:115-173.
33. Thor K, Rosell S: Neurotensin increases colonic motility. Gastroenterology 1986;90:27-31.
34. Wood JG, Hoang HD, Bussjaeger LJ, Solomon TE: Neurotensin stimulates growth of small intestine in rats. Am J Physiol 1988;255:G813-G817.
35. Carraway RE, Mitra SP, Feurle GE, Hacki WH: Presence of neurotensin and neuromedin-N within a common precursor from a human pancreatic neuroendocrine tumor. J Clin Endocrinol Metab 1988;66:1323-1328.
36. Parekh D, Ishizuka J, Townsend CM Jr, Haber B, Beauchamp RD, Karp G, Kim SW, Rajaraman S, Greeley G Jr, Thompson JC: Characterization of a human pancreatic carcinoid in vitro: morphology, amine and peptide storage, and secretion. Pancreas 1994;9:83-90.
37. Grotzinger C, Kneifel J, Patschan D, Schnoy N, Anagnostopoulos I, Faiss S, Tauber R, Wiedenmann B, Gessner R: LI-cadherin: a marker of gastric metaplasia and neoplasia. Gut 2001;49:73-81.
38. Abe J, Hosokawa H, Okazawa M, Kandachi M, Sawada Y, Yamanaka K, Matsumura K, Kobayashi S: TRPM8 protein localization in trigeminal ganglion and taste papillae. Brain Res Mol Brain Res 2005;136:91-98.
39. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ: Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch 1981;391:85-100.
40. Barry PH: JPCalc, a software package for calculating liquid junction potential corrections in patch-clamp, intracellular, epithelial and bilayer measurements and for correcting junction potential measurements. J Neurosci Methods 1994;51:107-116.
41. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985;260:3440-3450.
42. Nilius B: From TRPs to SOCs, CCEs, and CRACs: consensus and controversies. Cell Calcium 2003;33:293-298.
43. 2+ channel required for the survival of prostate cancer cells. Cancer Res 2004;64:8365-8373.
44. 2+ influx by inhibiting L-type channel activity in cultured human corneal endothelial cells. Exp Eye Res 2005;80:285-293.
45. Evers BM, Ishizuka J, Townsend CM Jr, Thompson JC: The human carcinoid cell line, BON. A model system for the study of carcinoid tumors. Ann NY Acad Sci 1994;733:393-406.
46. Reid G: ThermoTRP channels and cold sensing: what are they really up to? Pflügers Arch 2005;451:250-263.
47. Zhang L, Jones S, Brody K, Costa M, Brookes SJH: Thermosensitive transient receptor potential channels in vagal afferent neurons of the mouse. Am J Physiol 2004;286:G983-G991.
48. Werkheiser JL, Rawls SM, Cowan A: Icilin evokes a dose- and time-dependent increase in glutamate within the dorsal striatum of rats. Amino Acids 2006;30:307-309.
49. Behrendt HJ, Germann T, Gillen C, Hatt H, Jostock R: Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol 2004;141:737-745.
50. Kochukov MY, McNearney TA, Fu Y, Westlund KN: Thermosensitive TRP ion channels mediate cytosolic calcium response in human synoviocytes. Am J Physiol 2006;291:C424-C432.
51. Voets T, Talavera K, Owsianik G, Nilius B: Sensing with TRP channels. Nat Chem Biol 2005;1:85-92.
52. Liu Y, Lubin ML, Reitz TL, Wang Y, Colburn RW, Flores CM, Qin N: Molecular identification and functional characterization of a temperature-sensitive transient receptor potential channel (TRPM8) from canine. Eur J Pharmacol 2006;530:23-32.
53. Talavera K, Yasumatsu K, Voets T, Droogmans G, Shigemura N, Ninomiya Y, Margolskee RF, Nilius B: Heat activation of TRPM5 underlies thermal sensitivity of sweet taste. Nature 2005;438:1022-1025.
54. + channel. Mol Pharmacol 2005;68:1142-1147.
55. Macpherson LJ, Hwang SW, Miyamoto T, Dubin AE, Patapoutian A, Story GM: More than cool: promiscuous relationships of menthol and other sensory compounds. Mol Cell Neurosci 2006;32:335-343.
56. Bandell M, Dubin AE, Petrus MJ, Orth A, Mathur J, Hwang SW, Patapoutian A: High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol. Nat Neurosci 2006;9:493-500.
57. Montell C: A mint of mutations in TRPM8 leads to cool results. Nat Neurosci 2006;9:466-468.
58. Nathan JD, Patel AA, McVey DC, Thomas JE, Prpic V, Vigna SR, Liddle RA: Capsaicin vanilloid receptor-1 mediates substance P release in experimental pancreatitis. Am J Physiol 2001;281:G1322-G1328.
59. Nathan JD, Peng RY, Wang Y, McVey DC, Vigna SR, Liddle RA: Primary sensory neurons: a common final pathway for inflammation in experimental pancreatitis in rats. Am J Physiol 2002;283:G938-G946.
60. Elek J, Pinzon W, Park KH, Narayanan R: Relevant genomics of neurotensin receptor in cancer. Anticancer Res 2000;20:53-58.
61. Sehgal I, Powers S, Huntley B, Powis G, Pittelkow M, Maihle NJ: Neurotensin is an autocrine trophic factor stimulated by androgen withdrawal in human prostate cancer. Proc Natl Acad Sci USA 1994;91:4673-4677.
62. Kapuscinski M, Shulkes A, Read D, Hardy KJ: Expression of neurotensin in endocrine tumors. J Clin Endocrinol Metab 1990;70:100-106.
63. Reubi JC, Waser B, Friess H, Buchler MW, Laissue J: Neurotensin receptors: a new marker for human ductal pancreatic adenocarcinoma. Gut 1998;42:546-550.
64. 2+ channel blockers enhance neurotensin (NT) binding and inhibit NT-induced inositol phosphate formation in prostate cancer PC3 cells. J Pharmacol Exp Ther 2003;307:640-650.
65. Wang L, Friess H, Zhu Z, Graber H, Zimmermann A, Korc M, Reubi JC, Buchler MW: Neurotensin receptor-1 mRNA analysis in normal pancreas and pancreatic disease. Clin Cancer Res 2000;6:566-571.
66. Arnold R, Simon B, Wied M: Treatment of neuroendocrine GEP tumours with somatostatin analogues: a review. Digestion 2000;62(suppl 1):84-91.
67. Wiedenmann B, Ahnert-Hilger G, Kvols LK, Riecken EO: New molecular aspects for the diagnosis and treatment of neuroendocrine gastroenteropancreatic tumors. Ann NY Acad Sci 1994;733:515-525.
68. Wiedenmann B, John M, Ahnert-Hilger G, Riecken EO: Molecular and cell biological aspects of neuroendocrine tumors of the gastroenteropancreatic system. J Mol Med 1998;76:637-647.