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Volumn 19, Issue 3, 2008, Pages 235-245

Metastatic renal cell carcinoma: Recent advances and current therapeutic options

Author keywords

Mammalian target of rapamycin inhibitors; Metastasis; Monoclonal antibodies; Renal cell cancer; Systemic treatment; Tyrosin kinase inhibitors

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA INTERFERON; AMYLASE; ASPARTATE AMINOTRANSFERASE; AXITINIB; BEVACIZUMAB; CEDIRANIB; DOXORUBICIN; EVEROLIMUS; GEFITINIB; GEMCITABINE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MELOXICAM; MONOCLONAL ANTIBODY; PAZOPANIB; PROTEIN TYROSINE KINASE INHIBITOR; SORAFENIB; SUNITINIB; TEMSIROLIMUS; TRIACYLGLYCEROL LIPASE; VATALANIB; VOLOCIXIMAB; ANTINEOPLASTIC AGENT; PROTEIN KINASE INHIBITOR;

EID: 45549103672     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/CAD.0b013e3282f444de     Document Type: Review
Times cited : (31)

References (58)
  • 1
    • 0035163459 scopus 로고    scopus 로고
    • Recent advances in kidney cancer and metastatic disease
    • Kirkali Z, Tuzel E, Mungan MU. Recent advances in kidney cancer and metastatic disease. BJU Int 2001; 88:818-824.
    • (2001) BJU Int , vol.88 , pp. 818-824
    • Kirkali, Z.1    Tuzel, E.2    Mungan, M.U.3
  • 2
    • 0034796962 scopus 로고    scopus 로고
    • The changing natural history of renal cell carcinoma
    • Pantuck AJ, Zisman A, Belldegrun AS. The changing natural history of renal cell carcinoma. J Urol 2001; 166:1611-1623.
    • (2001) J Urol , vol.166 , pp. 1611-1623
    • Pantuck, A.J.1    Zisman, A.2    Belldegrun, A.S.3
  • 4
    • 2642548866 scopus 로고    scopus 로고
    • The medical treatment of metastatic renal cell carcinoma
    • Whelan P. The medical treatment of metastatic renal cell carcinoma. EAU Update Ser 2003; 1:237-246.
    • (2003) EAU Update Ser , vol.1 , pp. 237-246
    • Whelan, P.1
  • 7
    • 33645002908 scopus 로고    scopus 로고
    • Treatment targeted at vascular endothelial growth factor: A promising approach to managing metastatic kidney cancer
    • Schrader AJ, Varga Z, Pfoertner S, Goelden U, Buer J, Hofmann R. Treatment targeted at vascular endothelial growth factor: a promising approach to managing metastatic kidney cancer. BJU Int 2006; 97: 461-465.
    • (2006) BJU Int , vol.97 , pp. 461-465
    • Schrader, A.J.1    Varga, Z.2    Pfoertner, S.3    Goelden, U.4    Buer, J.5    Hofmann, R.6
  • 8
    • 14644415949 scopus 로고    scopus 로고
    • Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma
    • Rini BI, Small EJ. Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma. J Clin Oncol 2005; 23:1028-1043.
    • (2005) J Clin Oncol , vol.23 , pp. 1028-1043
    • Rini, B.I.1    Small, E.J.2
  • 11
    • 0032772880 scopus 로고    scopus 로고
    • Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma
    • Motzer RJ, Mazumdar M, Bacik J, Berg W, Amsterdam A, Ferrara J. Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol 1999; 17:2530-2540.
    • (1999) J Clin Oncol , vol.17 , pp. 2530-2540
    • Motzer, R.J.1    Mazumdar, M.2    Bacik, J.3    Berg, W.4    Amsterdam, A.5    Ferrara, J.6
  • 12
    • 34548310217 scopus 로고    scopus 로고
    • Sunitinib versus interferon-alfa (IFN-a) as first-line treatment of metastatic renal cell carcinoma (mRCC): Updated results and analysis of prognostic factors
    • abstract 5024
    • Motzer RJ, Figlin RA, Hutson TE, Tomczak P, Bukowski RM, Rixe O, et al. Sunitinib versus interferon-alfa (IFN-a) as first-line treatment of metastatic renal cell carcinoma (mRCC): updated results and analysis of prognostic factors. J Clin Oncol 2007; 25 (abstract 5024).
    • (2007) J Clin Oncol , vol.25
    • Motzer, R.J.1    Figlin, R.A.2    Hutson, T.E.3    Tomczak, P.4    Bukowski, R.M.5    Rixe, O.6
  • 13
    • 35549005750 scopus 로고    scopus 로고
    • Sunitinib therapy for patients (pts) with metastatic renal cell carcinoma (mRCC): Updated results of two phase II trials and prognostic factor analysis for survival
    • abstract 5095
    • Rosenberg JE, Motzer RJ, Michaelson MD, Redman BG, Hudes GR, Bukowski RM, et al. Sunitinib therapy for patients (pts) with metastatic renal cell carcinoma (mRCC): updated results of two phase II trials and prognostic factor analysis for survival. J Clin Oncol 2007; 25 (abstract 5095).
    • (2007) J Clin Oncol , vol.25
    • Rosenberg, J.E.1    Motzer, R.J.2    Michaelson, M.D.3    Redman, B.G.4    Hudes, G.R.5    Bukowski, R.M.6
  • 14
    • 35548945277 scopus 로고    scopus 로고
    • Continuous daily administration of sunitinib in patients (pts) with cytokine-refractory metastatic renal cell carcinoma (mRCC): Updated results
    • abstract 5040
    • Srinivas S, Roigas J, Gillessen S, Harmenberg U, de Mulder PH, Fountzilas G, et al. Continuous daily administration of sunitinib in patients (pts) with cytokine-refractory metastatic renal cell carcinoma (mRCC): updated results. J Clin Oncol 2007; 25 (abstract 5040).
    • (2007) J Clin Oncol , vol.25
    • Srinivas, S.1    Roigas, J.2    Gillessen, S.3    Harmenberg, U.4    de Mulder, P.H.5    Fountzilas, G.6
  • 15
    • 34648873387 scopus 로고    scopus 로고
    • Sunitinib in metastatic renal cell carcinoma (mRCC): Preliminary assessment of toxicity in an expanded access trial with subpopulation analysis
    • abstract 5010
    • Gore ME, Porta C, Oudard S, Bjarnason G, Castellano D, Szczylik C, et al. Sunitinib in metastatic renal cell carcinoma (mRCC): preliminary assessment of toxicity in an expanded access trial with subpopulation analysis. J Clin Oncol 2007; 25 (abstract 5010).
    • (2007) J Clin Oncol , pp. 25
    • Gore, M.E.1    Porta, C.2    Oudard, S.3    Bjarnason, G.4    Castellano, D.5    Szczylik, C.6
  • 16
    • 35548990498 scopus 로고    scopus 로고
    • Phase II trial of sunitinib in bevacizumab-refractory metastatic renal cell carcinoma (mRCC): Updated results and analysis of circulating biomarkers
    • abstract 5035
    • George DJ, Michaelson MD, Rosenberg JE, Bukowski RM, Sosman JA, Stadler WM, et al. Phase II trial of sunitinib in bevacizumab-refractory metastatic renal cell carcinoma (mRCC): updated results and analysis of circulating biomarkers. J Clin Oncol 2007; 25 (abstract 5035).
    • (2007) J Clin Oncol , vol.25
    • George, D.J.1    Michaelson, M.D.2    Rosenberg, J.E.3    Bukowski, R.M.4    Sosman, J.A.5    Stadler, W.M.6
  • 17
    • 35548994027 scopus 로고    scopus 로고
    • Safety of VEGF-targeted tyrosine kinase inhibitors in patients (pts) with metastatic renal cell carcinoma (mRCC) and central nervous system (CNS) metastases
    • abstract 5047
    • Unnithan JS, Choueiri T, Garcia J, Dreicer R, Laura W, Bukowski R, et al. Safety of VEGF-targeted tyrosine kinase inhibitors in patients (pts) with metastatic renal cell carcinoma (mRCC) and central nervous system (CNS) metastases. J Clin Oncol 2007; 25 (abstract 5047).
    • (2007) J Clin Oncol , vol.25
    • Unnithan, J.S.1    Choueiri, T.2    Garcia, J.3    Dreicer, R.4    Laura, W.5    Bukowski, R.6
  • 19
    • 34548315347 scopus 로고    scopus 로고
    • Final results of the randomized phase III trial of sorafenib in advanced renal cell carcinoma: Survival and biomarker analysis
    • abstract 5023
    • Bukowski RM, Eisen T, Szczylik C, Stadler WM, Simantov R, Shan M, et al. Final results of the randomized phase III trial of sorafenib in advanced renal cell carcinoma: survival and biomarker analysis. J Clin Oncol 2007; 25 (abstract 5023).
    • (2007) J Clin Oncol , vol.25
    • Bukowski, R.M.1    Eisen, T.2    Szczylik, C.3    Stadler, W.M.4    Simantov, R.5    Shan, M.6
  • 20
    • 34648863567 scopus 로고    scopus 로고
    • The advanced renal cell carcinoma sorafenib (ARCCS) expanded access trial in North America: Safety and efficacy
    • abstract 5011
    • Knox JJ, Figlin RA, Stadler WM, McDermott DF, Gabrail N, Miller WH, et al. The advanced renal cell carcinoma sorafenib (ARCCS) expanded access trial in North America: safety and efficacy. J Clin Oncol 2007; 25 (abstract 5011).
    • (2007) J Clin Oncol , vol.25
    • Knox, J.J.1    Figlin, R.A.2    Stadler, W.M.3    McDermott, D.F.4    Gabrail, N.5    Miller, W.H.6
  • 21
    • 35548972880 scopus 로고    scopus 로고
    • The advanced renal cell carcinoma sorafenib (ARCCS) expanded access trial: Long-term outcomes in first-line patients (pts)
    • abstract 5096
    • Ryan CW, Bukowski RM, Figlin RA, Knox JJ, Hutson TE, Dutcher JP, et al. The advanced renal cell carcinoma sorafenib (ARCCS) expanded access trial: long-term outcomes in first-line patients (pts). J Clin Oncol 2007; 25 (abstract 5096).
    • (2007) J Clin Oncol , vol.25
    • Ryan, C.W.1    Bukowski, R.M.2    Figlin, R.A.3    Knox, J.J.4    Hutson, T.E.5    Dutcher, J.P.6
  • 22
    • 41149106110 scopus 로고    scopus 로고
    • A large open-label, non-comparative, phase III study of the multi-targeted kinase inhibitor Sorafenib in European patients with advanced renal cell carcinoma
    • abstract 4506
    • Beck J, Bajetta E, Escudier B, Negrier S, Keilholz U, Szczylik C, et al. A large open-label, non-comparative, phase III study of the multi-targeted kinase inhibitor Sorafenib in European patients with advanced renal cell carcinoma. Eur J Cancer Suppl 2007; 5:300 (abstract 4506).
    • (2007) Eur J Cancer Suppl , vol.5 , pp. 300
    • Beck, J.1    Bajetta, E.2    Escudier, B.3    Negrier, S.4    Keilholz, U.5    Szczylik, C.6
  • 23
    • 35548931472 scopus 로고    scopus 로고
    • Randomized phase II trial of first-line treatment with sorafenib versus interferon in patients with advanced renal cell carcinoma: Final results
    • abstract 5025
    • Szczylik C, Demkow T, Staehler M, Rolland F, Negrier S, Hutson TE, et al. Randomized phase II trial of first-line treatment with sorafenib versus interferon in patients with advanced renal cell carcinoma: final results. J Clin Oncol 2007; 25 (abstract 5025).
    • (2007) J Clin Oncol , vol.25
    • Szczylik, C.1    Demkow, T.2    Staehler, M.3    Rolland, F.4    Negrier, S.5    Hutson, T.E.6
  • 24
    • 37549061995 scopus 로고    scopus 로고
    • A phase II trial of intra-patient dose-escalated sorafenib in patients (pts) with metastatic renal cell cancer (MRCC)
    • abstract 5026
    • Amato RJ, Harris P, Dalton M, Khan M, Alter R, Zhai Q, et al. A phase II trial of intra-patient dose-escalated sorafenib in patients (pts) with metastatic renal cell cancer (MRCC). J Clin Oncol 2007; 25 (abstract 5026).
    • (2007) J Clin Oncol , vol.25
    • Amato, R.J.1    Harris, P.2    Dalton, M.3    Khan, M.4    Alter, R.5    Zhai, Q.6
  • 25
    • 37349125184 scopus 로고    scopus 로고
    • The advanced renal cell carcinoma sorafenib (ARCCS) expanded access trial: Safety and efficacy in patients (pts) with prior bevacizumab (BEV) treatment
    • abstract 5041
    • Drabkin HA, Figlin RA, Stadler WM, Hutson TE, Hajdenberg J, Chu L, et al. The advanced renal cell carcinoma sorafenib (ARCCS) expanded access trial: safety and efficacy in patients (pts) with prior bevacizumab (BEV) treatment. J Clin Oncol 2007; 25 (abstract 5041).
    • (2007) J Clin Oncol , vol.25
    • Drabkin, H.A.1    Figlin, R.A.2    Stadler, W.M.3    Hutson, T.E.4    Hajdenberg, J.5    Chu, L.6
  • 26
    • 35548997095 scopus 로고    scopus 로고
    • Pazopanib (GW786034) is active in metastatic renal cell carcinoma (RCC): Interim results of a phase II randomized discontinuation trial (RDT)
    • abstract 5031
    • Hutson TE, Davis ID, Machiels JP, de Souza PL, Hong BF, Rottey S, et al. Pazopanib (GW786034) is active in metastatic renal cell carcinoma (RCC): interim results of a phase II randomized discontinuation trial (RDT). J Clin Oncol 2007; 25 (abstract 5031).
    • (2007) J Clin Oncol , vol.25
    • Hutson, T.E.1    Davis, I.D.2    Machiels, J.P.3    de Souza, P.L.4    Hong, B.F.5    Rottey, S.6
  • 27
    • 36549025941 scopus 로고    scopus 로고
    • Phase II study of the angiogenesis inhibitor AZD2171 in first line, progressive, unresectable, advanced metastatic renal cell carcinoma (RCC): A trial of the PMH Phase II Consortium
    • abstract 5093
    • Sridhar SS, Hotte SJ, Mackenzie MJ, Kollmannsberger C, Haider MA, Pond GR, et al. Phase II study of the angiogenesis inhibitor AZD2171 in first line, progressive, unresectable, advanced metastatic renal cell carcinoma (RCC): a trial of the PMH Phase II Consortium. J Clin Oncol 2007; 25 (abstract 5093).
    • (2007) J Clin Oncol , vol.25
    • Sridhar, S.S.1    Hotte, S.J.2    Mackenzie, M.J.3    Kollmannsberger, C.4    Haider, M.A.5    Pond, G.R.6
  • 28
    • 41149083841 scopus 로고    scopus 로고
    • Evaluation of AZD2171, an oral, highly potent and selective VEGFR signaling inhibitor, in renal cell carcinoma (RCC): Combined results from two phase I studies
    • abstract 3560
    • Van Herpen C, Drevs J, van Cruijsen H,Voest EE, Punt CJ, Robertson J, et al. Evaluation of AZD2171, an oral, highly potent and selective VEGFR signaling inhibitor, in renal cell carcinoma (RCC): combined results from two phase I studies. J Clin Oncol 2007; 25 (abstract 3560).
    • (2007) J Clin Oncol , vol.25
    • Van Herpen, C.1    Drevs, J.2    van Cruijsen, H.3    Voest, E.E.4    Punt, C.J.5    Robertson, J.6
  • 29
    • 35549008792 scopus 로고    scopus 로고
    • Sequential use of sorafenib and sunitinib in renal cancer: Retrospective analysis in 90 patients
    • abstract 5038
    • Sablin MP, Bouaita L, Balleyguier C, Gautier J, Celier C, Balcaceres JL, et al. Sequential use of sorafenib and sunitinib in renal cancer: retrospective analysis in 90 patients. J Clin Oncol 2007; 25 (abstract 5038).
    • (2007) J Clin Oncol , vol.25
    • Sablin, M.P.1    Bouaita, L.2    Balleyguier, C.3    Gautier, J.4    Celier, C.5    Balcaceres, J.L.6
  • 30
    • 36549059204 scopus 로고    scopus 로고
    • Sequential therapy with sorafenib and sunitinib in renal cell carcinoma
    • abstract 5106
    • Dham A, Dudek AZ. Sequential therapy with sorafenib and sunitinib in renal cell carcinoma. J Clin Oncol 2007; 25 (abstract 5106).
    • (2007) J Clin Oncol , vol.25
    • Dham, A.1    Dudek, A.Z.2
  • 31
    • 23844446510 scopus 로고    scopus 로고
    • AG-013736, a multi-target tyrosine kinase receptor inhibitor, demonstrates anti-tumor activity in a phase 2 study of cytokine-refractory, metastatic renal cell cancer (RCC)
    • abstract 4509
    • Rini B, Rixe O, Bukowski R, Michaelson MD, Wilding G, Hudes G, et al. AG-013736, a multi-target tyrosine kinase receptor inhibitor, demonstrates anti-tumor activity in a phase 2 study of cytokine-refractory, metastatic renal cell cancer (RCC). J Clin Oncol 2005; 23 (abstract 4509).
    • (2005) J Clin Oncol , vol.23
    • Rini, B.1    Rixe, O.2    Bukowski, R.3    Michaelson, M.D.4    Wilding, G.5    Hudes, G.6
  • 32
    • 35549007093 scopus 로고    scopus 로고
    • Axitinib (AG-013736; AG) in patients (pts) with metastatic renal cell cancer (RCC) refractory to sorafenib
    • abstract 5032
    • Rini BI, Wilding GT, Hudes G, Stadler WM, Kim S, Tarazi JC, et al. Axitinib (AG-013736; AG) in patients (pts) with metastatic renal cell cancer (RCC) refractory to sorafenib. J Clin Oncol 2007; 25 (abstract 5032).
    • (2007) J Clin Oncol , vol.25
    • Rini, B.I.1    Wilding, G.T.2    Hudes, G.3    Stadler, W.M.4    Kim, S.5    Tarazi, J.C.6
  • 33
    • 34249779568 scopus 로고    scopus 로고
    • Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
    • Hudes G, Carducci M, Tomczak P, Dutcher J, Figlin R, Kapoor A, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007; 356:2271-2281.
    • (2007) N Engl J Med , vol.356 , pp. 2271-2281
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3    Dutcher, J.4    Figlin, R.5    Kapoor, A.6
  • 34
    • 34547636060 scopus 로고    scopus 로고
    • Correlation of survival with tumor histology, age, and prognostic risk group for previously untreated patients with advanced renal cell carcinoma (adv RCC) receiving temsirolimus (TEMSR) or interferon-alpha (IFN)
    • abstract 5033
    • Dutcher JP, Szczylik C, Tannir N, Benedetto P, Ruff P, Hsu A, et al. Correlation of survival with tumor histology, age, and prognostic risk group for previously untreated patients with advanced renal cell carcinoma (adv RCC) receiving temsirolimus (TEMSR) or interferon-alpha (IFN). J Clin Oncol 2007; 25 (abstract 5033).
    • (2007) J Clin Oncol , pp. 25
    • Dutcher, J.P.1    Szczylik, C.2    Tannir, N.3    Benedetto, P.4    Ruff, P.5    Hsu, A.6
  • 35
    • 38649121693 scopus 로고    scopus 로고
    • Comparison of quality-adjusted survival in patients with advanced renal cell carcinoma receiving first-line treatment with temsirolimus (TEMSR) or interferon-α (IFN) or the combination of IFN+TEMSR
    • abstract 5049
    • Parasuraman S, Hudes G, Levy D, Strahs A, Moore L, DeMarinis R, et al. Comparison of quality-adjusted survival in patients with advanced renal cell carcinoma receiving first-line treatment with temsirolimus (TEMSR) or interferon-α (IFN) or the combination of IFN+TEMSR. J Clin Oncol 2007; 25 (abstract 5049).
    • (2007) J Clin Oncol , vol.25
    • Parasuraman, S.1    Hudes, G.2    Levy, D.3    Strahs, A.4    Moore, L.5    DeMarinis, R.6
  • 36
    • 67649542526 scopus 로고    scopus 로고
    • Temsirolimus and sorafenib as second-line therapy in patients with advanced RCC who failed first-line sunitinib. Protocol ID: 3066K1-404, NCT00474786
    • Temsirolimus and sorafenib as second-line therapy in patients with advanced RCC who failed first-line sunitinib. Protocol ID: 3066K1-404, NCT00474786.
  • 37
    • 35548977012 scopus 로고    scopus 로고
    • A phase II trial of RAD001 in patients (pts) with metastatic renal cell carcinoma (MRCC)
    • abstract 5107
    • Jac J, Giessinger S, Khan M, Willis J, Chiang S, Amato R. A phase II trial of RAD001 in patients (pts) with metastatic renal cell carcinoma (MRCC). J Clin Oncol 2007; 25 (abstract 5107).
    • (2007) J Clin Oncol , vol.25
    • Jac, J.1    Giessinger, S.2    Khan, M.3    Willis, J.4    Chiang, S.5    Amato, R.6
  • 38
    • 41149151093 scopus 로고    scopus 로고
    • Final results from phase II study of volociximab, an α5ß1 anti-integrin antibody, in refractory or relapsed metastatic clear cell renal cell carcinoma (mCCRCC)
    • abstract 5094
    • Yazji S, Bukowski R, Kondagunta V, Figlin R. Final results from phase II study of volociximab, an α5ß1 anti-integrin antibody, in refractory or relapsed metastatic clear cell renal cell carcinoma (mCCRCC). J Clin Oncol 2007; 25 (abstract 5094).
    • (2007) J Clin Oncol , vol.25
    • Yazji, S.1    Bukowski, R.2    Kondagunta, V.3    Figlin, R.4
  • 39
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    • Yang JC, Haworth L, Sherry RM, Hwu P, Schwartzentruber DJ, Topalian SL, et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003; 349: 427-434.
    • (2003) N Engl J Med , vol.349 , pp. 427-434
    • Yang, J.C.1    Haworth, L.2    Sherry, R.M.3    Hwu, P.4    Schwartzentruber, D.J.5    Topalian, S.L.6
  • 40
    • 35549006672 scopus 로고    scopus 로고
    • A randomized, controlled, double-blind phase III study (AVOREN) of bevacizumab/interferon-α2a vs placebo/interferon- α2a as first-line therapy in metastatic renal cell carcinoma
    • abstract 3
    • Escudier B, Koralewski P, Pluzanska A, Ravaud A, Bracarda S, Szczylik C, et al. A randomized, controlled, double-blind phase III study (AVOREN) of bevacizumab/interferon-α2a vs placebo/interferon- α2a as first-line therapy in metastatic renal cell carcinoma. J Clin Oncol. 2007; 25 (abstract 3).
    • (2007) J Clin Oncol , vol.25
    • Escudier, B.1    Koralewski, P.2    Pluzanska, A.3    Ravaud, A.4    Bracarda, S.5    Szczylik, C.6
  • 41
    • 35548969211 scopus 로고    scopus 로고
    • Phase I/II study of sunitinib malate in combination with gefitinib in patients (pts) with metastatic renal cell carcinoma (mRCC)
    • abstract 5097
    • Patel PH, Kondagunta GV, Redman BG, Hudes GR, Kim ST, Chen I, et al. Phase I/II study of sunitinib malate in combination with gefitinib in patients (pts) with metastatic renal cell carcinoma (mRCC). J Clin Oncol 2007; 25 (abstract 5097).
    • (2007) J Clin Oncol , vol.25
    • Patel, P.H.1    Kondagunta, G.V.2    Redman, B.G.3    Hudes, G.R.4    Kim, S.T.5    Chen, I.6
  • 42
    • 44449155614 scopus 로고    scopus 로고
    • Sunitinib malate (SU) plus interferon (IFN) in first line metastatic renal cell cancer (mRCC): Results of a dose-finding study
    • abstract 5101
    • Kondagunta GV, Hudes GR, Figlin R, Wilding G, Hariharan S, Kempin SN, et al. Sunitinib malate (SU) plus interferon (IFN) in first line metastatic renal cell cancer (mRCC): results of a dose-finding study. J Clin Oncol 2007; 25 (abstract 5101).
    • (2007) J Clin Oncol , vol.25
    • Kondagunta, G.V.1    Hudes, G.R.2    Figlin, R.3    Wilding, G.4    Hariharan, S.5    Kempin, S.N.6
  • 43
    • 34548229506 scopus 로고    scopus 로고
    • Sorafenib with interferon alfa-2b as first-line treatment of advanced renal carcinoma: A phase II study of the Southwest Oncology Group
    • Ryan CW, Goldman BH, Lara PN Jr, Mack PC, Beer TM, Tangen CM, et al. Sorafenib with interferon alfa-2b as first-line treatment of advanced renal carcinoma: a phase II study of the Southwest Oncology Group. J Clin Oncol 2007; 25:3296-3301.
    • (2007) J Clin Oncol , vol.25 , pp. 3296-3301
    • Ryan, C.W.1    Goldman, B.H.2    Lara Jr, P.N.3    Mack, P.C.4    Beer, T.M.5    Tangen, C.M.6
  • 44
    • 34548263735 scopus 로고    scopus 로고
    • Phase II trial of sorafenib plus interferon alfa-2b as first- or second-line therapy in patients with metastatic renal cell cancer
    • Gollob JA, Rathmell WK, Richmond TM, Marino CB, Miller EK, Grigson G, et al. Phase II trial of sorafenib plus interferon alfa-2b as first- or second-line therapy in patients with metastatic renal cell cancer. J Clin Oncol 2007; 25:3288-3295.
    • (2007) J Clin Oncol , vol.25 , pp. 3288-3295
    • Gollob, J.A.1    Rathmell, W.K.2    Richmond, T.M.3    Marino, C.B.4    Miller, E.K.5    Grigson, G.6
  • 45
    • 48749102361 scopus 로고    scopus 로고
    • Randomized prospective phase II trial of two schedules of sorafenib daily and interferon-α2a (IFN) in metastatic renal cell carcinoma (RAPSODY): GOIRC Study 0681
    • abstract 5100
    • Bracarda S, Porta C, Boni C, Santoro A, Artioli F, di Bartolomeo C, et al. Randomized prospective phase II trial of two schedules of sorafenib daily and interferon-α2a (IFN) in metastatic renal cell carcinoma (RAPSODY): GOIRC Study 0681. J Clin Oncol 2007; 25 (abstract 5100).
    • (2007) J Clin Oncol , vol.25
    • Bracarda, S.1    Porta, C.2    Boni, C.3    Santoro, A.4    Artioli, F.5    di Bartolomeo, C.6
  • 46
    • 35548959952 scopus 로고    scopus 로고
    • Randomized phase II study of sorafenib with or without low-dose IFN in patients with metastatic renal cell carcinoma
    • abstract 5104
    • Jonasch E, Corn P, Ashe RG, Do K, Tannir NM. Randomized phase II study of sorafenib with or without low-dose IFN in patients with metastatic renal cell carcinoma. J Clin Oncol 2007; 25 (abstract 5104).
    • (2007) J Clin Oncol , vol.25
    • Jonasch, E.1    Corn, P.2    Ashe, R.G.3    Do, K.4    Tannir, N.M.5
  • 47
    • 41149152686 scopus 로고    scopus 로고
    • Phase I study of PTK787/ZK222584 (PTK/ZK) and RAD001 for patients with advanced solid tumors and dose expansion in renal cell carcinoma patients
    • abstract 5039
    • Speca JC, Mears AL, Creel PA, Yenser SE, Bendell JC, Morse MA, et al. Phase I study of PTK787/ZK222584 (PTK/ZK) and RAD001 for patients with advanced solid tumors and dose expansion in renal cell carcinoma patients. J Clin Oncol 2007; 25 (abstract 5039).
    • (2007) J Clin Oncol , vol.25
    • Speca, J.C.1    Mears, A.L.2    Creel, P.A.3    Yenser, S.E.4    Bendell, J.C.5    Morse, M.A.6
  • 48
    • 67649564379 scopus 로고    scopus 로고
    • Combination therapy of meloxicam, a selective COX-2 inhibitor, and interferon alfa in metastatic renal cell carcinoma: A phase II study on efficacy and toxicity
    • abstract 5105
    • Shinohara N, Harabayashi T, Sazawa A, Nonomura K, Watarai Y, Kumagai A, et al. Combination therapy of meloxicam, a selective COX-2 inhibitor, and interferon alfa in metastatic renal cell carcinoma: a phase II study on efficacy and toxicity. J Clin Oncol 2007; 25 (abstract 5105).
    • (2007) J Clin Oncol , vol.25
    • Shinohara, N.1    Harabayashi, T.2    Sazawa, A.3    Nonomura, K.4    Watarai, Y.5    Kumagai, A.6
  • 49
    • 0242608613 scopus 로고    scopus 로고
    • The genetic basis of cancer of the kidney
    • Linehan WM, Walther MM, Zbar B. The genetic basis of cancer of the kidney. J Urol 2003; 170:2163-2172.
    • (2003) J Urol , vol.170 , pp. 2163-2172
    • Linehan, W.M.1    Walther, M.M.2    Zbar, B.3
  • 50
    • 0036569472 scopus 로고    scopus 로고
    • Treatment outcome and survival associated with metastatic renal cell carcinoma of non-clear-cell histology
    • Motzer RJ, Bacik J, Mariani T, Russo P, Mazumdar M, Reuter V. Treatment outcome and survival associated with metastatic renal cell carcinoma of non-clear-cell histology. J Clin Oncol 2002; 20:2376-2381.
    • (2002) J Clin Oncol , vol.20 , pp. 2376-2381
    • Motzer, R.J.1    Bacik, J.2    Mariani, T.3    Russo, P.4    Mazumdar, M.5    Reuter, V.6
  • 51
    • 67649499129 scopus 로고    scopus 로고
    • Histologic subtype of metastatic renal cell carcinoma predicts response to combined immunochemotherapy with interleukin 2, interferon alpha and 5-fluorouracil
    • Herrmann E, Brinkmann OA, Bode ME, Bierer S, Kopke T, Bogemann M, et al. Histologic subtype of metastatic renal cell carcinoma predicts response to combined immunochemotherapy with interleukin 2, interferon alpha and 5-fluorouracil. Eur Urol 2006; 13:13.
    • (2006) Eur Urol , vol.13 , pp. 13
    • Herrmann, E.1    Brinkmann, O.A.2    Bode, M.E.3    Bierer, S.4    Kopke, T.5    Bogemann, M.6
  • 52
    • 35548991359 scopus 로고    scopus 로고
    • The advanced renal cell carcinoma sorafenib (ARCCS) expanded access trial: Safety and efficacy in patients (pts) with non-clear cell (NCC) renal cell carcinoma (RCC)
    • abstract 5036
    • Stadler WM, Figlin RA, Ernstoff MS, Curti B, Pendergrass K, Srinivas S, et al. The advanced renal cell carcinoma sorafenib (ARCCS) expanded access trial: safety and efficacy in patients (pts) with non-clear cell (NCC) renal cell carcinoma (RCC). J Clin Oncol 2007; 25 (abstract 5036).
    • (2007) J Clin Oncol , vol.25
    • Stadler, W.M.1    Figlin, R.A.2    Ernstoff, M.S.3    Curti, B.4    Pendergrass, K.5    Srinivas, S.6
  • 53
    • 35549012738 scopus 로고    scopus 로고
    • Treatment outcome for metastatic papillary and chromophobe renal cell carcinoma (RCC) patients treated with tyrosine-kinase inhibitors (TKIs) sunitinib and sorafenib
    • abstract 5037
    • Plantade A, Choueiri T, Escudier B, Rini B, Negrier S, Ravaud A, et al. Treatment outcome for metastatic papillary and chromophobe renal cell carcinoma (RCC) patients treated with tyrosine-kinase inhibitors (TKIs) sunitinib and sorafenib. J Clin Oncol 2007; 25 (abstract 5037).
    • (2007) J Clin Oncol , vol.25
    • Plantade, A.1    Choueiri, T.2    Escudier, B.3    Rini, B.4    Negrier, S.5    Ravaud, A.6
  • 54
    • 43049093582 scopus 로고    scopus 로고
    • Sorafenib (Nexavar) beim metastasierten sarkomatoiden Nierenzellkarzinom nach Versagen einer vorangegangenen Chemotherapie mit Doxorubicin und Gemcitabine [Application of sorafenib (Nexavar) in metastatic sarcomatoid renal cancer after failure to doxirubicin/gemcitabine-based chemotherapy]
    • abstract 143
    • Staehler M, Haseke N, Schöppler G, Stadler T, Stief CG. Sorafenib (Nexavar) beim metastasierten sarkomatoiden Nierenzellkarzinom nach Versagen einer vorangegangenen Chemotherapie mit Doxorubicin und Gemcitabine [Application of sorafenib (Nexavar) in metastatic sarcomatoid renal cancer after failure to doxirubicin/gemcitabine-based chemotherapy]. J Urol Urogyn 2007; 14 (abstract 143).
    • (2007) J Urol Urogyn , vol.14
    • Staehler, M.1    Haseke, N.2    Schöppler, G.3    Stadler, T.4    Stief, C.G.5
  • 55
    • 33846978108 scopus 로고    scopus 로고
    • Hypothyroidism in patients with metastatic renal cell carcinoma treated with sunitinib
    • Rini BI, Tamaskar I, Shaheen P, Salas R, Garcia J, Wood L, et al. Hypothyroidism in patients with metastatic renal cell carcinoma treated with sunitinib. J Natl Cancer Inst 2007; 99:81-83.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 81-83
    • Rini, B.I.1    Tamaskar, I.2    Shaheen, P.3    Salas, R.4    Garcia, J.5    Wood, L.6
  • 56
    • 35549008418 scopus 로고    scopus 로고
    • Exposure-response of sunitinib in metastatic renal cell carcinoma (mRCC): A population pharmacokinetic/pharmacodynamic (PKPD) approach
    • abstract 5027
    • Houk BE, Bello CL, Michaelson MD, Bukowski RM, Redman BG, Hudes GR, et al. Exposure-response of sunitinib in metastatic renal cell carcinoma (mRCC): a population pharmacokinetic/pharmacodynamic (PKPD) approach. J Clin Oncol 2007; 25 (abstract 5027).
    • (2007) J Clin Oncol , vol.25
    • Houk, B.E.1    Bello, C.L.2    Michaelson, M.D.3    Bukowski, R.M.4    Redman, B.G.5    Hudes, G.R.6
  • 57
    • 35548945707 scopus 로고    scopus 로고
    • Phase I trial of bevacizumab plus sunitinib in patients (pts) with metastatic renal cell carcinoma (mRCC)
    • abstract 5099
    • Feldman DR, Kondagunta GV, Ronnen EA, Fischer P, Chang R, Baum M, et al. Phase I trial of bevacizumab plus sunitinib in patients (pts) with metastatic renal cell carcinoma (mRCC). J Clin Oncol 2007; 25 (abstract 5099).
    • (2007) J Clin Oncol , vol.25
    • Feldman, D.R.1    Kondagunta, G.V.2    Ronnen, E.A.3    Fischer, P.4    Chang, R.5    Baum, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.