-
1
-
-
84876092157
-
-
http://www.cnn.com/2008/health/conditions/04/28/pain.
-
-
-
-
2
-
-
33846027607
-
-
IASP Press, Seattle, WA
-
Campbell J, Basbaum A, Dray A, Dubner R, Dworkin R, Sang C. Emerging strategies for the treatment of neuropathic pain. IASP Press, Seattle, WA, 2006.
-
(2006)
Emerging strategies for the treatment of neuropathic pain
-
-
Campbell, J.1
Basbaum, A.2
Dray, A.3
Dubner, R.4
Dworkin, R.5
Sang, C.6
-
3
-
-
33745607370
-
New and emerging treatment options for neuropathic pain
-
Gidal BE. New and emerging treatment options for neuropathic pain. Am J Manag Care 2006; 12(9 Suppl): S269-78.
-
(2006)
Am J Manag Care
, vol.12
, Issue.9 SUPPL.
-
-
Gidal, B.E.1
-
4
-
-
45949106393
-
Dilemmas in chronic/persistent pain management
-
Katz WA, Barkin RL. Dilemmas in chronic/persistent pain management. Am J Ther 2008; 15(3): 256-64.
-
(2008)
Am J Ther
, vol.15
, Issue.3
, pp. 256-264
-
-
Katz, W.A.1
Barkin, R.L.2
-
5
-
-
42149095966
-
Chronic pain and opiates: Balancing pain control and risks in long-term opioid treatment
-
Gallagher RM, Rosenthal LJ. Chronic pain and opiates: balancing pain control and risks in long-term opioid treatment. Arch Phys Med Rehabil 2008; 89(3 Suppl 1): S77-82.
-
(2008)
Arch Phys Med Rehabil
, vol.89
, Issue.3 SUPPL. 1
-
-
Gallagher, R.M.1
Rosenthal, L.J.2
-
6
-
-
84876070088
-
-
http://www.opiates.com/prescription-painkillers-addiction.html.
-
-
-
-
7
-
-
33744544769
-
Toward better pain control
-
Basbaum AI, Julius D. Toward better pain control. Sci Am 2006; 294(6): 60-7.
-
(2006)
Sci Am
, vol.294
, Issue.6
, pp. 60-67
-
-
Basbaum, A.I.1
Julius, D.2
-
8
-
-
33846149200
-
Transient receptor potential ion channels as participants in thermosensation and thermoregulation
-
Caterina MJ. Transient receptor potential ion channels as participants in thermosensation and thermoregulation. Am J Physiol Regul Integr Comp Physiol 2007; 292(1): R64-76.
-
(2007)
Am J Physiol Regul Integr Comp Physiol
, vol.292
, Issue.1
-
-
Caterina, M.J.1
-
9
-
-
0034926291
-
The vanilloid receptor: A molecular gateway to the pain pathway
-
Caterina MJ, Julius D. The vanilloid receptor: a molecular gateway to the pain pathway. Annu Rev Neurosci 2001; 24: 487-517.
-
(2001)
Annu Rev Neurosci
, vol.24
, pp. 487-517
-
-
Caterina, M.J.1
Julius, D.2
-
10
-
-
2442660100
-
Molecular architecture of the vanilloid receptor. Insights for drug design
-
Ferrer-Montiel A, Garcia-Martinez C, Morenilla-Palao C, et al. Molecular architecture of the vanilloid receptor. Insights for drug design. Eur J Biochem 2004; 271(10): 1820-6.
-
(2004)
Eur J Biochem
, vol.271
, Issue.10
, pp. 1820-1826
-
-
Ferrer-Montiel, A.1
Garcia-Martinez, C.2
Morenilla-Palao, C.3
-
11
-
-
33847792875
-
The TRPV1 receptor and nociception
-
Immke DC, Gavva NR. The TRPV1 receptor and nociception. Semin Cell Dev Biol 2006; 17(5): 582-91.
-
(2006)
Semin Cell Dev Biol
, vol.17
, Issue.5
, pp. 582-591
-
-
Immke, D.C.1
Gavva, N.R.2
-
13
-
-
22944473968
-
Activation and activators of TRPV1 and their pharmaceutical implication
-
Suh YG, Oh U. Activation and activators of TRPV1 and their pharmaceutical implication. Curr Pharm Des 2005; 11(21): 2687-98.
-
(2005)
Curr Pharm Des
, vol.11
, Issue.21
, pp. 2687-2698
-
-
Suh, Y.G.1
Oh, U.2
-
14
-
-
16844367591
-
Pain TRPs
-
Wang H, Woolf CJ. Pain TRPs. Neuron 2005; 46(1): 9-12.
-
(2005)
Neuron
, vol.46
, Issue.1
, pp. 9-12
-
-
Wang, H.1
Woolf, C.J.2
-
16
-
-
0002294942
-
Tincture of capsaicin as a remedy for chilblains and toothache
-
Turnbull A. Tincture of capsaicin as a remedy for chilblains and toothache. Dublin Free Press 1850; 1: 95-6.
-
(1850)
Dublin Free Press
, vol.1
, pp. 95-96
-
-
Turnbull, A.1
-
17
-
-
34447611041
-
Beitrage zur physiologischen wirkung der bestandteile des Capsicum annum
-
Hogyes E. Beitrage zur physiologischen wirkung der bestandteile des Capsicum annum. Arch Exp Pathol Pharmakol 1878; 9: 117-30.
-
(1878)
Arch Exp Pathol Pharmakol
, vol.9
, pp. 117-130
-
-
Hogyes, E.1
-
18
-
-
0001926637
-
Desensitization of sensory nerve endings
-
Jancso N, Jancso A. Desensitization of sensory nerve endings. Kísérletes Orvostudomány 1949; 2(2 (Suppl): 15.
-
(1949)
Kísérletes Orvostudomány
, vol.2
, Issue.2 SUPPL.
, pp. 15
-
-
Jancso, N.1
Jancso, A.2
-
19
-
-
0014128266
-
Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin
-
Jancso N, Jancso-Gabor A, Szolcsanyi J. Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin. Br J Pharmacol Chemother 1967; 31(1): 138-51.
-
(1967)
Br J Pharmacol Chemother
, vol.31
, Issue.1
, pp. 138-151
-
-
Jancso, N.1
Jancso-Gabor, A.2
Szolcsanyi, J.3
-
20
-
-
0017720392
-
Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones
-
Jancso G, Kiraly E, Jancso-Gabor A. Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones. Nature 1977; 270(5639): 741-3.
-
(1977)
Nature
, vol.270
, Issue.5639
, pp. 741-743
-
-
Jancso, G.1
Kiraly, E.2
Jancso-Gabor, A.3
-
21
-
-
0017640292
-
A pharmacological approach to elucidation of the role of different nerve fibres and receptor endings in mediation of pain
-
Szolcsanyi J. A pharmacological approach to elucidation of the role of different nerve fibres and receptor endings in mediation of pain. J Physiol (Paris) 1977; 73(3): 251-9.
-
(1977)
J Physiol (Paris)
, vol.73
, Issue.3
, pp. 251-259
-
-
Szolcsanyi, J.1
-
22
-
-
0024382437
-
Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper
-
Szallasi A, Blumberg PM. Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper. Neuroscience 1989; 30(2): 515-20.
-
(1989)
Neuroscience
, vol.30
, Issue.2
, pp. 515-520
-
-
Szallasi, A.1
Blumberg, P.M.2
-
23
-
-
0020432931
-
Capsaicin-sensitive non-cholinergic excitatory innervation of the guinea-pig tracheobronchial smooth muscle
-
Szolcsanyi J, Bartho L. Capsaicin-sensitive non-cholinergic excitatory innervation of the guinea-pig tracheobronchial smooth muscle. Neurosci Lett 1982; 34(3): 247-51.
-
(1982)
Neurosci Lett
, vol.34
, Issue.3
, pp. 247-251
-
-
Szolcsanyi, J.1
Bartho, L.2
-
24
-
-
0023833519
-
The sensory-efferent function of capsaicinsensitive sensory neurons
-
Maggi CA, Meli A. The sensory-efferent function of capsaicinsensitive sensory neurons. Gen Pharmacol 1988; 19(1): 1-43.
-
(1988)
Gen Pharmacol
, vol.19
, Issue.1
, pp. 1-43
-
-
Maggi, C.A.1
Meli, A.2
-
25
-
-
0025871477
-
Capsaicin: Cellular targets, mechanisms of action, and selectivity for thin sensory neurons
-
Holzer P. Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. Pharmacol Rev 1991; 43(2): 143-201.
-
(1991)
Pharmacol Rev
, vol.43
, Issue.2
, pp. 143-201
-
-
Holzer, P.1
-
26
-
-
0032970173
-
Vanilloid (Capsaicin) receptors and mechanisms
-
Szallasi A, Blumberg PM. Vanilloid (Capsaicin) receptors and mechanisms. Pharmacol Rev 1999; 51(2): 159-212.
-
(1999)
Pharmacol Rev
, vol.51
, Issue.2
, pp. 159-212
-
-
Szallasi, A.1
Blumberg, P.M.2
-
27
-
-
0030777012
-
The capsaicin receptor: A heat-activated ion channel in the pain pathway
-
Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 1997; 389(6653): 816-24.
-
(1997)
Nature
, vol.389
, Issue.6653
, pp. 816-824
-
-
Caterina, M.J.1
Schumacher, M.A.2
Tominaga, M.3
Rosen, T.A.4
Levine, J.D.5
Julius, D.6
-
28
-
-
0034646740
-
Impaired nociception and pain sensation in mice lacking the capsaicin receptor
-
Caterina MJ, Leffler A, Malmberg AB, et al. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 2000; 288(5464): 306-13.
-
(2000)
Science
, vol.288
, Issue.5464
, pp. 306-313
-
-
Caterina, M.J.1
Leffler, A.2
Malmberg, A.B.3
-
29
-
-
0034636441
-
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
-
Davis JB, Gray J, Gunthorpe MJ, et al. Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature 2000; 405(6783): 183-7.
-
(2000)
Nature
, vol.405
, Issue.6783
, pp. 183-187
-
-
Davis, J.B.1
Gray, J.2
Gunthorpe, M.J.3
-
30
-
-
33845343959
-
Antinociceptive effect of antisense oligonucleotides against the vanilloid receptor VR1/TRPV1
-
Christoph T, Gillen C, Mika J, et al. Antinociceptive effect of antisense oligonucleotides against the vanilloid receptor VR1/TRPV1. Neurochem Int 2007; 50(1): 281-90.
-
(2007)
Neurochem Int
, vol.50
, Issue.1
, pp. 281-290
-
-
Christoph, T.1
Gillen, C.2
Mika, J.3
-
31
-
-
33749050585
-
Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo
-
Christoph T, Grunweller A, Mika J, et al. Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo. Biochem Biophys Res Commun 2006; 350(1): 238-43.
-
(2006)
Biochem Biophys Res Commun
, vol.350
, Issue.1
, pp. 238-243
-
-
Christoph, T.1
Grunweller, A.2
Mika, J.3
-
32
-
-
34249990908
-
RNA interference-mediated knock-down of transient receptor potential vanilloid 1 prevents forepaw inflammatory hyperalgesia in rat
-
Kasama S, Kawakubo M, Suzuki T, Nishizawa T, Ishida A, Nakayama J. RNA interference-mediated knock-down of transient receptor potential vanilloid 1 prevents forepaw inflammatory hyperalgesia in rat. Eur J Neurosci 2007; 25(10): 2956-63.
-
(2007)
Eur J Neurosci
, vol.25
, Issue.10
, pp. 2956-2963
-
-
Kasama, S.1
Kawakubo, M.2
Suzuki, T.3
Nishizawa, T.4
Ishida, A.5
Nakayama, J.6
-
33
-
-
38549118896
-
Capsaicin (TRPV1 Agonist) therapy for pain relief: Farewell or revival?
-
Knotkova H, Pappagallo M, Szallasi A. Capsaicin (TRPV1 Agonist) therapy for pain relief: farewell or revival? Clin J Pain 2008; 24(2): 142-54.
-
(2008)
Clin J Pain
, vol.24
, Issue.2
, pp. 142-154
-
-
Knotkova, H.1
Pappagallo, M.2
Szallasi, A.3
-
35
-
-
84876087274
-
-
Britain, British national formulary. BMA (No 45)
-
Britain. BMARPSoG. British national formulary. BMA 2003; (No 45).
-
(2003)
BMARPSoG
-
-
-
36
-
-
84876075548
-
-
http://clinicaltrials.gov/ct2/show/NCT00804154?term=Resiniferatoxin& rank=1.
-
-
-
-
37
-
-
33846807748
-
Transient receptor potential cation channels in disease
-
Nilius B, Owsianik G, Voets T, Peters JA. Transient receptor potential cation channels in disease. Physiol Rev 2007; 87(1): 165-217.
-
(2007)
Physiol Rev
, vol.87
, Issue.1
, pp. 165-217
-
-
Nilius, B.1
Owsianik, G.2
Voets, T.3
Peters, J.A.4
-
40
-
-
85047696992
-
Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1
-
Trevisani M, Smart D, Gunthorpe MJ, et al. Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1. Nat Neurosci 2002; 5(6): 546-51.
-
(2002)
Nat Neurosci
, vol.5
, Issue.6
, pp. 546-551
-
-
Trevisani, M.1
Smart, D.2
Gunthorpe, M.J.3
-
41
-
-
0043209362
-
ThermoTRP channels and beyond: Mechanisms of temperature sensation
-
Patapoutian A, Peier AM, Story GM, Viswanath V. ThermoTRP channels and beyond: mechanisms of temperature sensation. Nat Rev Neurosci 2003; 4(7): 529-39.
-
(2003)
Nat Rev Neurosci
, vol.4
, Issue.7
, pp. 529-539
-
-
Patapoutian, A.1
Peier, A.M.2
Story, G.M.3
Viswanath, V.4
-
42
-
-
33750873334
-
Spider toxins activate the capsaicin receptor to produce inflammatory pain
-
Siemens J, Zhou S, Piskorowski R, et al. Spider toxins activate the capsaicin receptor to produce inflammatory pain. Nature 2006; 444(7116): 208-12.
-
(2006)
Nature
, vol.444
, Issue.7116
, pp. 208-212
-
-
Siemens, J.1
Zhou, S.2
Piskorowski, R.3
-
43
-
-
34248138496
-
The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-ofconcept
-
Szallasi A, Cortright DN, Blum CA, Eid SR. The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-ofconcept. Nat Rev Drug Discov 2007; 6(5): 357-72.
-
(2007)
Nat Rev Drug Discov
, vol.6
, Issue.5
, pp. 357-372
-
-
Szallasi, A.1
Cortright, D.N.2
Blum, C.A.3
Eid, S.R.4
-
44
-
-
38349023182
-
Painful toxins acting at TRPV1
-
Cromer BA, McIntyre P. Painful toxins acting at TRPV1. Toxicon 2008; 51(2): 163-73.
-
(2008)
Toxicon
, vol.51
, Issue.2
, pp. 163-173
-
-
Cromer, B.A.1
McIntyre, P.2
-
46
-
-
77956130879
-
Activation of the human transient receptor potential vanilloid subtype 1 by essential oils
-
Ohkawara S, Tanaka-Kagawa T, Furukawa Y, Nishimura T, Jinno H. Activation of the human transient receptor potential vanilloid subtype 1 by essential oils. Biol Pharm Bull 2010; 33(8): 1434-7.
-
(2010)
Biol Pharm Bull
, vol.33
, Issue.8
, pp. 1434-1437
-
-
Ohkawara, S.1
Tanaka-Kagawa, T.2
Furukawa, Y.3
Nishimura, T.4
Jinno, H.5
-
47
-
-
77953531871
-
The deorphanization of TRPV1 and the emergence of octadecadienoids as a new class of lipid transmitters
-
Flores CM, Vasko MR. The deorphanization of TRPV1 and the emergence of octadecadienoids as a new class of lipid transmitters. Mol Interv 2010; 10(3): 137-40.
-
(2010)
Mol Interv
, vol.10
, Issue.3
, pp. 137-140
-
-
Flores, C.M.1
Vasko, M.R.2
-
48
-
-
77953271751
-
A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain
-
Bohlen CJ, Priel A, Zhou S, King D, Siemens J, Julius D. A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain. Cell 2010; 141(5): 834-45.
-
(2010)
Cell
, vol.141
, Issue.5
, pp. 834-845
-
-
Bohlen, C.J.1
Priel, A.2
Zhou, S.3
King, D.4
Siemens, J.5
Julius, D.6
-
49
-
-
77951787575
-
Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents
-
Patwardhan AM, Akopian AN, Ruparel NB, et al. Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents. J Clin Invest 2010; 120(5): 1617-26.
-
(2010)
J Clin Invest
, vol.120
, Issue.5
, pp. 1617-1626
-
-
Patwardhan, A.M.1
Akopian, A.N.2
Ruparel, N.B.3
-
50
-
-
77956513789
-
Tumor necrosis factor alpha sensitizes spinal cord TRPV1 receptors to the endogenous agonist Noleoyldopamine
-
Spicarova D, Palecek J. Tumor necrosis factor alpha sensitizes spinal cord TRPV1 receptors to the endogenous agonist Noleoyldopamine. J Neuroinflammation 2010; 7: 49.
-
(2010)
J Neuroinflammation
, vol.7
, pp. 49
-
-
Spicarova, D.1
Palecek, J.2
-
51
-
-
0035425705
-
Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide
-
Vellani V, Mapplebeck S, Moriondo A, Davis JB, McNaughton PA. Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide. J Physiol 2001; 534(Pt 3): 813-25.
-
(2001)
J Physiol
, vol.534
, Issue.PART 3
, pp. 813-825
-
-
Vellani, V.1
Mapplebeck, S.2
Moriondo, A.3
Davis, J.B.4
McNaughton, P.A.5
-
52
-
-
2342604388
-
Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia
-
Amadesi S, Nie J, Vergnolle N, et al. Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia. J Neurosci 2004; 24(18): 4300-12.
-
(2004)
J Neurosci
, vol.24
, Issue.18
, pp. 4300-4312
-
-
Amadesi, S.1
Nie, J.2
Vergnolle, N.3
-
53
-
-
77957118845
-
Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones
-
Vellani V, Kinsey AM, Prandini M, et al. Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones. Mol Pain 2010; 6(1): 61.
-
(2010)
Mol Pain
, vol.6
, Issue.1
, pp. 61
-
-
Vellani, V.1
Kinsey, A.M.2
Prandini, M.3
-
54
-
-
0036535063
-
The diversity in the vanilloid (TRPV) receptor family of ion channels
-
Gunthorpe MJ, Benham CD, Randall A, Davis JB. The diversity in the vanilloid (TRPV) receptor family of ion channels. Trends Pharmacol Sci 2002; 23(4): 183-91.
-
(2002)
Trends Pharmacol Sci
, vol.23
, Issue.4
, pp. 183-191
-
-
Gunthorpe, M.J.1
Benham, C.D.2
Randall, A.3
Davis, J.B.4
-
55
-
-
0036291431
-
Activation of protein kinase C sensitizes human VR1 to capsaicin and to moderate decreases in pH at physiological temperatures in Xenopus oocytes
-
Crandall M, Kwash J, Yu W, White G. Activation of protein kinase C sensitizes human VR1 to capsaicin and to moderate decreases in pH at physiological temperatures in Xenopus oocytes. Pain 2002; 98(1-2): 109-17.
-
(2002)
Pain
, vol.98
, Issue.1-2
, pp. 109-117
-
-
Crandall, M.1
Kwash, J.2
Yu, W.3
White, G.4
-
56
-
-
78049367698
-
The general anesthetic propofol excites nociceptors by activating Trpv1 and Trpa1 rather than Gabaa receptors
-
Fischer MJ, Leffler A, Niedermirtl F, et al. The general anesthetic propofol excites nociceptors by activating Trpv1 and Trpa1 rather than Gabaa receptors. J Biol Chem 2010; 285(45): 34781-92.
-
(2010)
J Biol Chem
, vol.285
, Issue.45
, pp. 34781-34792
-
-
Fischer, M.J.1
Leffler, A.2
Niedermirtl, F.3
-
57
-
-
0034589732
-
Nociceptor excitation by thermal sensitization--a hypothesis
-
Reeh PW, Petho G. Nociceptor excitation by thermal sensitization--a hypothesis. Prog Brain Res 2000; 129: 39-50.
-
(2000)
Prog Brain Res
, vol.129
, pp. 39-50
-
-
Reeh, P.W.1
Petho, G.2
-
58
-
-
0034700494
-
Induction of vanilloid receptor channel activity by protein kinase C
-
Premkumar LS, Ahern GP. Induction of vanilloid receptor channel activity by protein kinase C. Nature 2000; 408(6815): 985-90.
-
(2000)
Nature
, vol.408
, Issue.6815
, pp. 985-990
-
-
Premkumar, L.S.1
Ahern, G.P.2
-
59
-
-
0035810934
-
Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia
-
Tominaga M, Wada M, Masu M. Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia. Proc Natl Acad Sci U S A 2001; 98(12): 6951-6.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, Issue.12
, pp. 6951-6956
-
-
Tominaga, M.1
Wada, M.2
Masu, M.3
-
60
-
-
0036729532
-
Characterization of the anandamide induced depolarization of guinea-pig isolated vagus nerve
-
Kagaya M, Lamb J, Robbins J, Page CP, Spina D. Characterization of the anandamide induced depolarization of guinea-pig isolated vagus nerve. Br J Pharmacol 2002; 137(1): 39-48.
-
(2002)
Br J Pharmacol
, vol.137
, Issue.1
, pp. 39-48
-
-
Kagaya, M.1
Lamb, J.2
Robbins, J.3
Page, C.P.4
Spina, D.5
-
61
-
-
0037144453
-
Protein kinase C(alpha) is required for vanilloid receptor 1 activation. Evidence for multiple signaling pathways
-
Olah Z, Karai L, Iadarola MJ. Protein kinase C(alpha) is required for vanilloid receptor 1 activation. Evidence for multiple signaling pathways. J Biol Chem 2002; 277(38): 35752-9.
-
(2002)
J Biol Chem
, vol.277
, Issue.38
, pp. 35752-35759
-
-
Olah, Z.1
Karai, L.2
Iadarola, M.J.3
-
62
-
-
0142059776
-
Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)
-
Bhave G, Hu HJ, Glauner KS, et al. Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). Proc Natl Acad Sci U S A 2003; 100(21): 12480-5.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, Issue.21
, pp. 12480-12485
-
-
Bhave, G.1
Hu, H.J.2
Glauner, K.S.3
-
63
-
-
33646498289
-
Relative roles of protein kinase A and protein kinase C in modulation of transient receptor potential vanilloid type 1 receptor responsiveness in rat sensory neurons in vitro and peripheral nociceptors in vivo
-
Varga A, Bolcskei K, Szoke E, et al. Relative roles of protein kinase A and protein kinase C in modulation of transient receptor potential vanilloid type 1 receptor responsiveness in rat sensory neurons in vitro and peripheral nociceptors in vivo. Neuroscience 2006; 140(2): 645-57.
-
(2006)
Neuroscience
, vol.140
, Issue.2
, pp. 645-657
-
-
Varga, A.1
Bolcskei, K.2
Szoke, E.3
-
64
-
-
33748180653
-
The mu opioid agonist morphine modulates potentiation of capsaicin-evoked TRPV1 responses through a cyclic AMP-dependent protein kinase A pathway
-
Vetter I, Wyse BD, Monteith GR, Roberts-Thomson SJ, Cabot PJ. The mu opioid agonist morphine modulates potentiation of capsaicin-evoked TRPV1 responses through a cyclic AMP-dependent protein kinase A pathway. Mol Pain 2006; 2: 22.
-
(2006)
Mol Pain
, vol.2
, pp. 22
-
-
Vetter, I.1
Wyse, B.D.2
Monteith, G.R.3
Roberts-Thomson, S.J.4
Cabot, P.J.5
-
65
-
-
33750510073
-
Why pain gets worse: The mechanism of heat hyperalgesia
-
Zhang X, McNaughton PA. Why pain gets worse: the mechanism of heat hyperalgesia. J Gen Physiol 2006; 128(5): 491-3.
-
(2006)
J Gen Physiol
, vol.128
, Issue.5
, pp. 491-493
-
-
Zhang, X.1
McNaughton, P.A.2
-
66
-
-
0037799198
-
A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity
-
Prescott ED, Julius D. A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity. Science 2003; 300(5623): 1284-8.
-
(2003)
Science
, vol.300
, Issue.5623
, pp. 1284-1288
-
-
Prescott, E.D.1
Julius, D.2
-
67
-
-
34547200183
-
Dissection of the components for PIP2 activation and thermosensation in TRP channels
-
Brauchi S, Orta G, Mascayano C, et al. Dissection of the components for PIP2 activation and thermosensation in TRP channels. Proc Natl Acad Sci U S A 2007; 104(24): 10246-51.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, Issue.24
, pp. 10246-10251
-
-
Brauchi, S.1
Orta, G.2
Mascayano, C.3
-
68
-
-
34250190946
-
The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity
-
Lishko PV, Procko E, Jin X, Phelps CB, Gaudet R. The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity. Neuron 2007; 54(6): 905-18.
-
(2007)
Neuron
, vol.54
, Issue.6
, pp. 905-918
-
-
Lishko, P.V.1
Procko, E.2
Jin, X.3
Phelps, C.B.4
Gaudet, R.5
-
69
-
-
33750524257
-
Phosphoinositide 3-kinase binds to TRPV1 and mediates NGFstimulated TRPV1 trafficking to the plasma membrane
-
Stein AT, Ufret-Vincenty CA, Hua L, Santana LF, Gordon SE. Phosphoinositide 3-kinase binds to TRPV1 and mediates NGFstimulated TRPV1 trafficking to the plasma membrane. J Gen Physiol 2006; 128(5): 509-22.
-
(2006)
J Gen Physiol
, vol.128
, Issue.5
, pp. 509-522
-
-
Stein, A.T.1
Ufret-Vincenty, C.A.2
Hua, L.3
Santana, L.F.4
Gordon, S.E.5
-
70
-
-
34347354387
-
Dual regulation of TRPV1 by phosphoinositides
-
Lukacs V, Thyagarajan B, Varnai P, Balla A, Balla T, Rohacs T. Dual regulation of TRPV1 by phosphoinositides. J Neurosci 2007; 27(26): 7070-80.
-
(2007)
J Neurosci
, vol.27
, Issue.26
, pp. 7070-7080
-
-
Lukacs, V.1
Thyagarajan, B.2
Varnai, P.3
Balla, A.4
Balla, T.5
Rohacs, T.6
-
71
-
-
17144397173
-
Regulation of Ca2+-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMPdependent protein kinase
-
Mohapatra DP, Nau C. Regulation of Ca2+-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMPdependent protein kinase. J Biol Chem 2005; 280(14): 13424-32.
-
(2005)
J Biol Chem
, vol.280
, Issue.14
, pp. 13424-13432
-
-
Mohapatra, D.P.1
Nau, C.2
-
72
-
-
0037104657
-
cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation
-
Bhave G, Zhu W, Wang H, Brasier DJ, Oxford GS, Gereau RWt. cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation. Neuron 2002; 35(4): 721-31.
-
(2002)
Neuron
, vol.35
, Issue.4
, pp. 721-731
-
-
Bhave, G.1
Zhu, W.2
Wang, H.3
Brasier, D.J.4
Oxford, G.S.5
Gereau, R.W.6
-
73
-
-
0346118925
-
Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway
-
Mohapatra DP, Nau C. Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway. J Biol Chem 2003; 278(50): 50080-90.
-
(2003)
J Biol Chem
, vol.278
, Issue.50
, pp. 50080-50090
-
-
Mohapatra, D.P.1
Nau, C.2
-
74
-
-
0038609734
-
Structural determinant of TRPV1 desensitization interacts with calmodulin
-
Numazaki M, Tominaga T, Takeuchi K, Murayama N, Toyooka H, Tominaga M. Structural determinant of TRPV1 desensitization interacts with calmodulin. Proc Natl Acad Sci U S A 2003; 100(13): 8002-6.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, Issue.13
, pp. 8002-8006
-
-
Numazaki, M.1
Tominaga, T.2
Takeuchi, K.3
Murayama, N.4
Toyooka, H.5
Tominaga, M.6
-
75
-
-
0347723780
-
Ca2+/calmodulin modulates TRPV1 activation by capsaicin
-
Rosenbaum T, Gordon-Shaag A, Munari M, Gordon SE. Ca2+/calmodulin modulates TRPV1 activation by capsaicin. J Gen Physiol 2004; 123(1): 53-62.
-
(2004)
J Gen Physiol
, vol.123
, Issue.1
, pp. 53-62
-
-
Rosenbaum, T.1
Gordon-Shaag, A.2
Munari, M.3
Gordon, S.E.4
-
76
-
-
1342346561
-
Phosphorylation of vanilloid receptor 1 by Ca2+/calmodulin-dependent kinase II regulates its vanilloid binding
-
Jung J, Shin JS, Lee SY, et al. Phosphorylation of vanilloid receptor 1 by Ca2+/calmodulin-dependent kinase II regulates its vanilloid binding. J Biol Chem 2004; 279(8): 7048-54.
-
(2004)
J Biol Chem
, vol.279
, Issue.8
, pp. 7048-7054
-
-
Jung, J.1
Shin, J.S.2
Lee, S.Y.3
-
78
-
-
39449102203
-
Peripheral TRPV1 receptors as targets for drug development: New molecules and mechanisms
-
Gunthorpe MJ, Szallasi A. Peripheral TRPV1 receptors as targets for drug development: new molecules and mechanisms. Curr Pharm Des 2008; 14(1): 32-41.
-
(2008)
Curr Pharm Des
, vol.14
, Issue.1
, pp. 32-41
-
-
Gunthorpe, M.J.1
Szallasi, A.2
-
79
-
-
34250202592
-
TRPV1 antagonists as a potential treatment for hyperalgesia
-
Roberts LA, Connor M. TRPV1 antagonists as a potential treatment for hyperalgesia. Recent Pat CNS Drug Discov 2006; 1(1): 65-76.
-
(2006)
Recent Pat CNS Drug Discov
, vol.1
, Issue.1
, pp. 65-76
-
-
Roberts, L.A.1
Connor, M.2
-
80
-
-
40749097682
-
Advances in the design and therapeutic use of capsaicin receptor TRPV1 agonists and antagonists
-
Gharat L, Szallasi A. Advances in the design and therapeutic use of capsaicin receptor TRPV1 agonists and antagonists. Expert Opin Thera Pat 2008; 18: 159-209.
-
(2008)
Expert Opin Thera Pat
, vol.18
, pp. 159-209
-
-
Gharat, L.1
Szallasi, A.2
-
81
-
-
34848820269
-
The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans
-
Chizh BA, O'Donnell MB, Napolitano A, et al. The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans. Pain 2007; 132(1-2): 132-41.
-
(2007)
Pain
, vol.132
, Issue.1-2
, pp. 132-141
-
-
Chizh, B.A.1
O'Donnell, M.B.2
Napolitano, A.3
-
83
-
-
84876093293
-
-
http://www.pharmeste.com/home.asp?op=interna&id=2&id_pag=-10&tit=Pipeline.
-
-
-
-
84
-
-
84876075007
-
-
http://www.daewoong.co.kr/www_pharm/english_new/products/-pipeline.asp.
-
-
-
-
85
-
-
84876079017
-
-
http://clinicaltrials.gov/ct2/show/NCT00960180.
-
-
-
-
86
-
-
84876097564
-
-
http://www.gsk.com/investors/product_pipeline/docs/GSKproduct-pipeline-Feb-2012.pdf.
-
-
-
-
87
-
-
0026767602
-
Capsazepine: A competitive antagonist of the sensory neurone excitant capsaicin
-
Bevan S, Hothi S, Hughes G, et al. Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin. Br J Pharmacol 1992; 107(2): 544-52.
-
(1992)
Br J Pharmacol
, vol.107
, Issue.2
, pp. 544-552
-
-
Bevan, S.1
Hothi, S.2
Hughes, G.3
-
88
-
-
23044500197
-
Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8
-
Weil A, Moore SE, Waite NJ, Randall A, Gunthorpe MJ. Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8. Mol Pharmacol 2005; 68(2): 518-27.
-
(2005)
Mol Pharmacol
, vol.68
, Issue.2
, pp. 518-527
-
-
Weil, A.1
Moore, S.E.2
Waite, N.J.3
Randall, A.4
Gunthorpe, M.J.5
-
89
-
-
37249065119
-
TRPM8 mechanism of cold allodynia after chronic nerve injury
-
Xing H, Chen M, Ling J, Tan W, Gu JG. TRPM8 mechanism of cold allodynia after chronic nerve injury. J Neurosci 2007; 27(50): 13680-90.
-
(2007)
J Neurosci
, vol.27
, Issue.50
, pp. 13680-13690
-
-
Xing, H.1
Chen, M.2
Ling, J.3
Tan, W.4
Gu, J.G.5
-
90
-
-
0037215646
-
The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain
-
Walker KM, Urban L, Medhurst SJ, et al. The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain. J Pharmacol Exp Ther 2003; 304(1): 56-62.
-
(2003)
J Pharmacol Exp Ther
, vol.304
, Issue.1
, pp. 56-62
-
-
Walker, K.M.1
Urban, L.2
Medhurst, S.J.3
-
91
-
-
84155175206
-
The pharmacological challenge to tame the transient receptor potential vanilloid-1 (TRPV1) nocisensor
-
Holzer P. The pharmacological challenge to tame the transient receptor potential vanilloid-1 (TRPV1) nocisensor. Br J Pharmacol 2008; 22: 22.
-
(2008)
Br J Pharmacol
, vol.22
, pp. 22
-
-
Holzer, P.1
-
92
-
-
27844465429
-
Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1
-
Gavva NR, Tamir R, Klionsky L, et al. Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1. Mol Pharmacol 2005; 68(6): 1524-33.
-
(2005)
Mol Pharmacol
, vol.68
, Issue.6
, pp. 1524-1533
-
-
Gavva, N.R.1
Tamir, R.2
Klionsky, L.3
-
93
-
-
45749092572
-
Antihyperalgesic effects of (R, E)-N-(2-hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluorom ethyl)phenyl)-acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats
-
Lehto SG, Tamir R, Deng H, et al. Antihyperalgesic effects of (R, E)-N-(2-hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluorom ethyl)phenyl)-acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats. J Pharmacol Exp Ther 2008; 326(1): 218-29.
-
(2008)
J Pharmacol Exp Ther
, vol.326
, Issue.1
, pp. 218-229
-
-
Lehto, S.G.1
Tamir, R.2
Deng, H.3
-
94
-
-
0036894895
-
Functional properties of the high-affinity TRPV1 (VR1) vanilloid receptor antagonist (4-hydroxy-5-iodo-3-methoxyphenylacetate ester) iodo-resiniferatoxin
-
Seabrook GR, Sutton KG, Jarolimek W, et al. Functional properties of the high-affinity TRPV1 (VR1) vanilloid receptor antagonist (4-hydroxy-5-iodo-3-methoxyphenylacetate ester) iodo-resiniferatoxin. J Pharmacol Exp Ther 2002; 303(3): 1052-60.
-
(2002)
J Pharmacol Exp Ther
, vol.303
, Issue.3
, pp. 1052-1060
-
-
Seabrook, G.R.1
Sutton, K.G.2
Jarolimek, W.3
-
95
-
-
2442498381
-
Molecular determinants of vanilloid sensitivity in TRPV1
-
Gavva NR, Klionsky L, Qu Y, et al. Molecular determinants of vanilloid sensitivity in TRPV1. J Biol Chem 2004; 279(19): 20283-95.
-
(2004)
J Biol Chem
, vol.279
, Issue.19
, pp. 20283-20295
-
-
Gavva, N.R.1
Klionsky, L.2
Qu, Y.3
-
96
-
-
33845222011
-
Acidification of rat TRPV1 alters the kinetics of capsaicin responses
-
Neelands TR, Jarvis MF, Han P, Faltynek CR, Surowy CS. Acidification of rat TRPV1 alters the kinetics of capsaicin responses. Mol Pain 2005; 1: 28.
-
(2005)
Mol Pain
, vol.1
, pp. 28
-
-
Neelands, T.R.1
Jarvis, M.F.2
Han, P.3
Faltynek, C.R.4
Surowy, C.S.5
-
97
-
-
84876072265
-
-
http://www.glenmarkpharma.com/media/pdf/releases/GRC_6211. pdf.
-
-
-
-
98
-
-
84876089995
-
-
http://www.glenmarkpharma.com/research/clinical.html.
-
-
-
-
99
-
-
0038128285
-
N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetr-ahydropyrazine-1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. In: Vivo characterization in rat models of inflammatory and neuropathic pain
-
Pomonis JD, Harrison JE, Mark L, Bristol DR, Valenzano KJ, Walker K. N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetr-ahydropyrazine-1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. In: vivo characterization in rat models of inflammatory and neuropathic pain. J Pharmacol Exp Ther 2003; 306(1): 387-93.
-
(2003)
J Pharmacol Exp Ther
, vol.306
, Issue.1
, pp. 387-393
-
-
Pomonis, J.D.1
Harrison, J.E.2
Mark, L.3
Bristol, D.R.4
Valenzano, K.J.5
Walker, K.6
-
100
-
-
43949109903
-
Characterization of primary sensory neurons mediating static and dynamic allodynia in rat chronic constriction injury model
-
Yamamoto W, Sugiura A, Nakazato-Imasato E, Kita Y. Characterization of primary sensory neurons mediating static and dynamic allodynia in rat chronic constriction injury model. J Pharm Pharmacol 2008; 60(6): 717-22.
-
(2008)
J Pharm Pharmacol
, vol.60
, Issue.6
, pp. 717-722
-
-
Yamamoto, W.1
Sugiura, A.2
Nakazato-Imasato, E.3
Kita, Y.4
-
101
-
-
20144376596
-
Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist
-
Swanson DM, Dubin AE, Shah C, et al. Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist. J Med Chem 2005; 48(6): 1857-72.
-
(2005)
J Med Chem
, vol.48
, Issue.6
, pp. 1857-1872
-
-
Swanson, D.M.1
Dubin, A.E.2
Shah, C.3
-
102
-
-
84155184778
-
-
Washington, DC: Society for Neuroscience
-
Zhong C, Gauvin D, Mikusa J, et al. The novel and potent trpv1 antagonist, A-784168, is a broad-spectrum analgesic in preclinical pain models. Washington, DC: Society for Neuroscience 2005.
-
(2005)
The novel and potent trpv1 antagonist, A-784168, is a broad-spectrum analgesic in preclinical pain models
-
-
Zhong, C.1
Gauvin, D.2
Mikusa, J.3
-
103
-
-
33748680717
-
TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists
-
Cui M, Honore P, Zhong C, et al. TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists. J Neurosci 2006; 26(37): 9385-93.
-
(2006)
J Neurosci
, vol.26
, Issue.37
, pp. 9385-9393
-
-
Cui, M.1
Honore, P.2
Zhong, C.3
-
104
-
-
79951977972
-
Amelioration of neuropathic pain by novel transient receptor potential vanilloid 1 antagonist AS1928370 in rats without hyperthermic effect
-
Watabiki T, Kiso T, Kuramochi T, et al. Amelioration of neuropathic pain by novel transient receptor potential vanilloid 1 antagonist AS1928370 in rats without hyperthermic effect. J Pharmacol Exp Ther 2011; 336(3): 743-50.
-
(2011)
J Pharmacol Exp Ther
, vol.336
, Issue.3
, pp. 743-750
-
-
Watabiki, T.1
Kiso, T.2
Kuramochi, T.3
-
105
-
-
84876091239
-
-
http://www.acsmedchem.org/mediabstracts2011.pdf.
-
-
-
-
106
-
-
84855293744
-
TRPV1 antagonist, A-889425, inhibits mechanotransmission in a subclass of rat primary afferent neurons following peripheral inflammation
-
Brederson JD, Chu KL, Reilly RM, et al. TRPV1 antagonist, A-889425, inhibits mechanotransmission in a subclass of rat primary afferent neurons following peripheral inflammation. Synapse 2011; 66(3): 187-95.
-
(2011)
Synapse
, vol.66
, Issue.3
, pp. 187-195
-
-
Brederson, J.D.1
Chu, K.L.2
Reilly, R.M.3
-
107
-
-
23044496253
-
A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats
-
Honore P, Wismer CT, Mikusa J, et al. A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats. J Pharmacol Exp Ther 2005; 314(1): 410-21.
-
(2005)
J Pharmacol Exp Ther
, vol.314
, Issue.1
, pp. 410-421
-
-
Honore, P.1
Wismer, C.T.2
Mikusa, J.3
-
109
-
-
84876096851
-
-
http://clinicaltrials.gov/ct2/results?term=ABT-102.
-
-
-
-
110
-
-
53849138741
-
(R)-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) blocks polymodal activation of transient receptor potential vanilloid 1 receptors in vitro and heat-evoked firing of spinal dorsal horn neurons in vivo
-
Surowy CS, Neelands TR, Bianchi BR, et al. (R)-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) blocks polymodal activation of transient receptor potential vanilloid 1 receptors in vitro and heat-evoked firing of spinal dorsal horn neurons in vivo. J Pharmacol Exp Ther 2008; 326(3): 879-88.
-
(2008)
J Pharmacol Exp Ther
, vol.326
, Issue.3
, pp. 879-888
-
-
Surowy, C.S.1
Neelands, T.R.2
Bianchi, B.R.3
-
111
-
-
39149117718
-
Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management
-
Gomtsyan A, Bayburt EK, Schmidt RG, et al. Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management. J Med Chem 2008; 51(3): 392-5.
-
(2008)
J Med Chem
, vol.51
, Issue.3
, pp. 392-395
-
-
Gomtsyan, A.1
Bayburt, E.K.2
Schmidt, R.G.3
-
113
-
-
77955304164
-
A-995662 [(R)-8-(4-methyl-5-(4-(trifluoromethyl)phenyl)oxazol-2-ylamino)-1,2,3,4-tetrahydr onaphthalen-2-ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model
-
Puttfarcken PS, Han P, Joshi SK, et al. A-995662 [(R)-8-(4-methyl-5-(4-(trifluoromethyl)phenyl)oxazol-2-ylamino)-1,2,3,4-tetrahydr onaphthalen-2-ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model. Pain 2010; 150(2): 319-26.
-
(2010)
Pain
, vol.150
, Issue.2
, pp. 319-326
-
-
Puttfarcken, P.S.1
Han, P.2
Joshi, S.K.3
-
114
-
-
79959289728
-
Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4-d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist
-
Maher MP, Bhattacharya A, Ao H, et al. Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4-d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist. Eur J Pharmacol 2011; 663(1-3): 40-50.
-
(2011)
Eur J Pharmacol
, vol.663
, Issue.1-3
, pp. 40-50
-
-
Maher, M.P.1
Bhattacharya, A.2
Ao, H.3
-
115
-
-
79960306015
-
Intrathecal administration of AS1928370, a transient receptor potential vanilloid 1 antagonist, attenuates mechanical allodynia in a mouse model of neuropathic pain
-
Watabiki T, Kiso T, Tsukamoto M, Aoki T, Matsuoka N. Intrathecal administration of AS1928370, a transient receptor potential vanilloid 1 antagonist, attenuates mechanical allodynia in a mouse model of neuropathic pain. Biol Pharm Bull 2011; 34(7): 1105-8.
-
(2011)
Biol Pharm Bull
, vol.34
, Issue.7
, pp. 1105-1108
-
-
Watabiki, T.1
Kiso, T.2
Tsukamoto, M.3
Aoki, T.4
Matsuoka, N.5
-
116
-
-
33750611879
-
Ziconotide: A new nonopioid intrathecal analgesic for the treatment of chronic pain
-
Wallace MS. Ziconotide: a new nonopioid intrathecal analgesic for the treatment of chronic pain. Expert Rev Neurother 2006; 6(10): 1423-8.
-
(2006)
Expert Rev Neurother
, vol.6
, Issue.10
, pp. 1423-1428
-
-
Wallace, M.S.1
-
117
-
-
28444467821
-
Analgesic effects of capsazepine and resiniferatoxin on bone cancer pain in mice
-
Menendez L, Juarez L, Garcia E, Garcia-Suarez O, Hidalgo A, Baamonde A. Analgesic effects of capsazepine and resiniferatoxin on bone cancer pain in mice. Neurosci Lett 2006; 393(1): 70-3.
-
(2006)
Neurosci Lett
, vol.393
, Issue.1
, pp. 70-73
-
-
Menendez, L.1
Juarez, L.2
Garcia, E.3
Garcia-Suarez, O.4
Hidalgo, A.5
Baamonde, A.6
-
118
-
-
27644551317
-
Physiologic and antinociceptive effects of intrathecal resiniferatoxin in a canine bone cancer model
-
Brown DC, Iadarola MJ, Perkowski SZ, et al. Physiologic and antinociceptive effects of intrathecal resiniferatoxin in a canine bone cancer model. Anesthesiology 2005; 103(5): 1052-9.
-
(2005)
Anesthesiology
, vol.103
, Issue.5
, pp. 1052-1059
-
-
Brown, D.C.1
Iadarola, M.J.2
Perkowski, S.Z.3
-
119
-
-
0021737076
-
Capsaicin and central control of thermoregulation
-
Hori T. Capsaicin and central control of thermoregulation. Pharmacol Ther 1984; 26(3): 389-416.
-
(1984)
Pharmacol Ther
, vol.26
, Issue.3
, pp. 389-416
-
-
Hori, T.1
-
121
-
-
34047118624
-
The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation
-
Gavva NR, Bannon AW, Surapaneni S, et al. The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation. J Neurosci 2007; 27(13): 3366-74.
-
(2007)
J Neurosci
, vol.27
, Issue.13
, pp. 3366-3374
-
-
Gavva, N.R.1
Bannon, A.W.2
Surapaneni, S.3
-
122
-
-
70349659983
-
The transient receptor potential vanilloid-1 channel in thermoregulation: A thermosensor it is not
-
Romanovsky AA, Almeida MC, Garami A, et al. The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not. Pharmacol Rev 2009; 61(3): 228-61.
-
(2009)
Pharmacol Rev
, vol.61
, Issue.3
, pp. 228-261
-
-
Romanovsky, A.A.1
Almeida, M.C.2
Garami, A.3
-
123
-
-
67649240813
-
Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1
-
Gavva NR. Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1. Trends Pharmacol Sci 2008; 19: 19.
-
(2008)
Trends Pharmacol Sci
, vol.19
, pp. 19
-
-
Gavva, N.R.1
-
124
-
-
41749117999
-
Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans
-
Gavva NR, Treanor JJ, Garami A, et al. Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans. Pain 2008; 136(1-2): 202-10.
-
(2008)
Pain
, vol.136
, Issue.1-2
, pp. 202-210
-
-
Gavva, N.R.1
Treanor, J.J.2
Garami, A.3
-
125
-
-
34447504896
-
Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors
-
Steiner AA, Turek VF, Almeida MC, et al. Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors. J Neurosci 2007; 27(28): 7459-68.
-
(2007)
J Neurosci
, vol.27
, Issue.28
, pp. 7459-7468
-
-
Steiner, A.A.1
Turek, V.F.2
Almeida, M.C.3
-
126
-
-
34548825160
-
Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade
-
Gavva NR, Bannon AW, Hovland DN, et al. Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade. J Pharmacol Exp Ther 2007; 323(1): 128-37.
-
(2007)
J Pharmacol Exp Ther
, vol.323
, Issue.1
, pp. 128-137
-
-
Gavva, N.R.1
Bannon, A.W.2
Hovland, D.N.3
-
127
-
-
84872430052
-
Novel TRPV1 receptor antagonists that partially block acid activation. In vitro pharmacology predicts effects on core body temperature and in vivo efficacy
-
In Press
-
Reilly R, McDonald H, Puttfarcken P, et al. Novel TRPV1 receptor antagonists that partially block acid activation. In vitro pharmacology predicts effects on core body temperature and in vivo efficacy. J Pharmacol Exp Ther 2012; In Press.
-
(2012)
J Pharmacol Exp Ther
-
-
Reilly, R.1
McDonald, H.2
Puttfarcken, P.3
-
128
-
-
84864142720
-
BCTP, a classic polymodal inhibitor of TRPV1 with a reduced liability for hyperthermia, is analgesic and ameliorates visceral hypersensitivity
-
Nash MS, McIntyre P, Groarke A, et al. BCTP, a classic polymodal inhibitor of TRPV1 with a reduced liability for hyperthermia, is analgesic and ameliorates visceral hypersensitivity. J Pharmacol Exp Ther 2012; 342(2): 389-98.
-
(2012)
J Pharmacol Exp Ther
, vol.342
, Issue.2
, pp. 389-398
-
-
Nash, M.S.1
McIntyre, P.2
Groarke, A.3
-
129
-
-
0037133281
-
Attenuation of thermal nociception and hyperalgesia by VR1 blockers
-
Garcia-Martinez C, Humet M, Planells-Cases R, et al. Attenuation of thermal nociception and hyperalgesia by VR1 blockers. Proc Natl Acad Sci U S A 2002; 99(4): 2374-9.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, Issue.4
, pp. 2374-2379
-
-
Garcia-Martinez, C.1
Humet, M.2
Planells-Cases, R.3
-
130
-
-
34247281575
-
Antinociceptive pharmacology of N-(4-chlorobenzyl)-N'-(4-hydroxy-3-iodo-5-methoxybenzyl) thiourea, a high-affinity competitive antagonist of the transient receptor potential vanilloid 1 receptor
-
Tang L, Chen Y, Chen Z, Blumberg PM, Kozikowski AP, Wang ZJ. Antinociceptive pharmacology of N-(4-chlorobenzyl)-N'-(4-hydroxy-3-iodo-5-methoxybenzyl) thiourea, a high-affinity competitive antagonist of the transient receptor potential vanilloid 1 receptor. J Pharmacol Exp Ther 2007; 321(2): 791-8.
-
(2007)
J Pharmacol Exp Ther
, vol.321
, Issue.2
, pp. 791-798
-
-
Tang, L.1
Chen, Y.2
Chen, Z.3
Blumberg, P.M.4
Kozikowski, A.P.5
Wang, Z.J.6
-
132
-
-
70349335960
-
Use of sensory methods for detecting target engagement in clinical trials of new analgesics
-
Chizh BA, Sang CN. Use of sensory methods for detecting target engagement in clinical trials of new analgesics. Neurotherapeutics 2009; 6(4): 749-54.
-
(2009)
Neurotherapeutics
, vol.6
, Issue.4
, pp. 749-754
-
-
Chizh, B.A.1
Sang, C.N.2
-
134
-
-
84863187892
-
Pharmacokinetics of the TRPV1 antagonist ABT-102 in healthy human volunteers: Population analysis of data from 3 phase 1 trials
-
Othman AA, Nothaft W, Awni WM, Dutta S. Pharmacokinetics of the TRPV1 antagonist ABT-102 in healthy human volunteers: population analysis of data from 3 phase 1 trials. J Clin Pharmacol 2012; 52(7): 1028-41.
-
(2012)
J Clin Pharmacol
, vol.52
, Issue.7
, pp. 1028-1041
-
-
Othman, A.A.1
Nothaft, W.2
Awni, W.M.3
Dutta, S.4
-
135
-
-
79954584227
-
Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial
-
Rowbotham MC, Nothaft W, Duan WR, et al. Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial. Pain 2011; 152(5): 1192-200.
-
(2011)
Pain
, vol.152
, Issue.5
, pp. 1192-1200
-
-
Rowbotham, M.C.1
Nothaft, W.2
Duan, W.R.3
-
136
-
-
84876085694
-
-
http://clinicaltrials.gov/ct2/show/NCT00969787?term=05195&rank= 1.
-
-
-
-
137
-
-
84876075329
-
-
http://www.pharmeste.com/include/PHE377.pdf.
-
-
-
-
138
-
-
84876084696
-
-
http://clinicaltrials.gov/ct2/show/NCT00281684?cond.
-
-
-
-
139
-
-
84876097746
-
-
http://clinicaltrials.gov/ct2/show/NCT01424514?term=705498&-rank=1.
-
-
-
-
140
-
-
84876084267
-
-
http://clinicaltrials.gov/ct2/show/NCT01476098?term=705498&-rank=4.
-
-
-
-
141
-
-
79954617292
-
Randomised clinical trial: The efficacy of a transient receptor potential vanilloid 1 antagonist AZD1386 in human oesophageal pain
-
Krarup AL, Ny L, Astrand M, et al. Randomised clinical trial: the efficacy of a transient receptor potential vanilloid 1 antagonist AZD1386 in human oesophageal pain. Aliment Pharmacol Ther 2011; 33(10): 1113-22.
-
(2011)
Aliment Pharmacol Ther
, vol.33
, Issue.10
, pp. 1113-1122
-
-
Krarup, A.L.1
Ny, L.2
Astrand, M.3
-
142
-
-
84876088959
-
-
http://www.astrazenecaclinicaltrials.com/other-drug-products/discontinued-products/AZD1386/?expandAll=true.
-
-
-
-
143
-
-
84876087895
-
-
http://www.astrazenecaclinicaltrials.com/_mshost800325/content/clinical-trials/resources/pdf/D5090C00019.
-
-
-
-
144
-
-
84876092464
-
-
http://www.glenmarkpharma.cz/gln3.php?lang=en.
-
-
-
-
145
-
-
84876081793
-
-
http://www.neurogen.com/index.php?option=com_content&view= article&id=47&Itemid=2&phpMyAdmin=34a2390c0eecf801a871-d79668695b95.
-
-
-
-
146
-
-
84876077445
-
-
http://www.jti.co.jp/investors/others/12g3_2/pdf/20110831_01.pdf.
-
-
-
-
147
-
-
84876090108
-
-
http://clinicaltrials.gov/ct2/show/NCT00969787?term=DWP-05195&rank=3.
-
-
-
-
148
-
-
84876074235
-
-
http://clinicaltrials.gov/ct2/show/NCT01557010?term=DWP-05195&rank=2.
-
-
-
-
149
-
-
84876088570
-
-
http://www.astrazeneca.com/_mshost3690701/content/resources/-media/investors/10809118/AZN-Q2-2010-Pipeline-Summary.pdf.
-
-
-
|