Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial

Pain

Volumn 152, Issue 5, 2011, Pages 1192-1200

  Rowbotham, Michael C ^a   Nothaft, Wolfram ^b   Duan, W Rachel ^b   Wang, Yi ^b   Faltynek, Connie ^b   McGaraughty, Steve ^b   Chu, Katharine L ^b   Svensson, Peter ^c  

^a CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^b ABBOTT LABORATORIES   (United States)

^c AARHUS UNIVERSITY   (Denmark)

Author keywords

ABT 102; Heat pain threshold; Thermosensation; TRPV1

Indexed keywords

(5 TERT BUTYL 2,3 DIHYDRO 1H INDEN 1 YL) 3 (1H INDAZOL 4 YL)UREA; PLACEBO; VANILLOID RECEPTOR 1;

ABDOMINAL PAIN; ADULT; ARTICLE; BODY TEMPERATURE SENSATION; CONTROLLED STUDY; CORE TEMPERATURE; CUTANEOUS PAIN INTENSITY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG DOSE ESCALATION; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; FEVER; FLUSHING; FOLLOW UP; HEADACHE; HEAT PAIN THRESHOLD; HOSPITAL PATIENT; HUMAN; HUMAN EXPERIMENT; MALE; NAUSEA; NOCICEPTION; NORMAL HUMAN; ORAL AND CUTANEOUS COLD DETECTION; ORAL PERCEIVED HEAT INTENSITY; OUTCOME ASSESSMENT; PAIN ASSESSMENT; PAIN THRESHOLD; PARESTHESIA; PHARMACODYNAMICS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TEMPERATURE SENSITIVITY; TIME TO HAND WITHDRAWAL; TIME TO MAXIMUM PLASMA CONCENTRATION; VOMITING; WARM DETECTION;

ABDOMEN; ADMINISTRATION, CUTANEOUS; ADMINISTRATION, ORAL; ADOLESCENT; ADULT; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INDAZOLES; MALE; MIDDLE AGED; PAIN; PAIN THRESHOLD; SKIN; THERMOSENSING; TIME FACTORS; TRPV CATION CHANNELS; UREA; YOUNG ADULT;

EID: 79954584227     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2011.01.051     Document Type: Article

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