Amelioration of neuropathic pain by novel transient receptor potential vanilloid 1 antagonist AS1928370 in rats without hyperthermic effect

Journal of Pharmacology and Experimental Therapeutics

Volumn 336, Issue 3, 2011, Pages 743-750

  Watabiki, Tomonari ^a   Kiso, Tetsuo ^a   Kuramochi, Takahiro ^a   Yonezawa, Koichi ^a   Tsuji, Noriko ^a   Kohara, Atsuyuki ^a   Kakimoto, Shuichiro ^a   Aoki, Toshiaki ^a   Matsuoka, Nobuya ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; AS 1928370; CALCIUM ION; CAPSAICIN; DICLOFENAC; FREUND ADJUVANT; GABAPENTIN; N (1 METHYL 2 OXO 1,2,3,4 TETRAHYDRO 7 QUINOLYL)2 [(2 METHYLPYRROLIDIN 1 YL)METHYL]BIPHENYL 4 CARBOXAMIDE; N (4 TERT BUTYLPHENYL) 4 (3 CHLORO 2 PYRIDINYL) 1 PIPERAZINECARBOXAMIDE; RESINIFERATOXIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST; VANILLOID RECEPTOR 4;

ALLODYNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CALCIUM TRANSPORT; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG SAFETY; DRUG STRUCTURE; HUMAN; HUMAN CELL; HYPERALGESIA; IC 50; MALE; MOTOR COORDINATION; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; PAIN; PH; PRIORITY JOURNAL; PROTON TRANSPORT; RAT; RECTUM TEMPERATURE; SPINAL NERVE;

ANALGESICS; ANIMALS; BENZAMIDES; CAPSAICIN; FEVER; HEK293 CELLS; HUMANS; MALE; NEURALGIA; PAIN; PAIN MEASUREMENT; PROTEIN BINDING; QUINOLONES; RATS; RATS, SPRAGUE-DAWLEY; TRPV CATION CHANNELS;

EID: 79951977972     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.175570     Document Type: Article

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