Characterization of primary sensory neurons mediating static and dynamic allodynia in rat chronic constriction injury model

Journal of Pharmacy and Pharmacology

Volumn 60, Issue 6, 2008, Pages 717-722

  Yamamoto, Wataru ^a   Sugiura, Akemi ^a   Nakazato Imasato, Etsuko ^a   Kita, Yasuhiro ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N (4 TERT BUTYLPHENYL) 4 (3 CHLOROPYRIDIN 2 YL) TETRAHYDROPYRAZINE 1(2H)CARBOXAMIDE; NEUROFILAMENT PROTEIN; POLYACRYLONITRILE; RECEPTOR BLOCKING AGENT; RESINIFERATOXIN; VANILLOID RECEPTOR 1;

AFFERENT NERVE GROUP 1; ALLODYNIA; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DESENSITIZATION; DOSE RESPONSE; DRUG EFFECT; DYNAMIC ALLODYNIA; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MOLECULAR SIZE; NERVE COMPRESSION; NONHUMAN; PROTEIN EXPRESSION; RAT; SENSORY NERVE CELL; SENSORY NERVE CONDUCTION; SPINAL GANGLION; STATIC ALLODYNIA;

ANIMALS; CELL SIZE; CONSTRICTION, PATHOLOGIC; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; MALE; NEUROFILAMENT PROTEINS; NEURONS, AFFERENT; PAIN; PAIN MEASUREMENT; PHYSICAL STIMULATION; RATS; RATS, SPRAGUE-DAWLEY; TRPV CATION CHANNELS;

EID: 43949109903     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.60.6.0006     Document Type: Article

References (17)

1. Bennett, G. J., Xie, Y. K. (1988) A peripheral mononeuropathy in rat that produces abnormal pain sensation like those seen in man. Pain 33: 87-107
2. Burgess, P. R., Perl, E. R. (1973) Cutaneous mechanoreceptors and nociceptors. In: Iggo, A. (ed.) Handbook of physiology. Vol. 2, Somatosensory system, 2nd edn. Springer-Verlag, New York, pp 29-78
3. Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., Julius, D. (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389: 816-824
4. Field, M. J., Bramwell, S., Hughes, J., Singh, L. (1999) Detection of static and dynamic components of mechanical allodynia in rat models of neuropathic pain: are they signaled by distinct primary sensory neurones? Pain 83: 303-311
5. Field, M. J., Cox, P. J., Stott, E., Melrose, H., Offord, J., Su, T. Z., Bramwell, S., Corradini, L., England, S., Winks, J., Kinloch, R. A., Hendrich, J., Dolphin, A. C., Webb, T., Williams, D. (2006) Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin. Proc. Natl Acad. Sci. USA 103: 17537-17542
6. Hao, J. X., Yu, W., Xu, X. J., Wiesenfeld-Hallin, Z. (1996) Capsaicin-sensitive afferents mediate chronic cold, but not mechanical, allodynia-like behavior in spinally injured rats. Brain Res. 25: 177-180
7. Hudson, L. J., Bevan, S., Wotherspoon, G., Gentry, C., Fox, A., Winter, J. (2001) VR1 protein expression increases in undamaged DRG neurons after partial nerve injury. Eur. J. Neurosci. 13: 2105-2114
8. Hwang, S. J., Burette, A., Rustioni, A., Valtschanoff, J. G. (2004) Vanilloid receptor VR1-positive primary afferents are glutamatergic and contact spinal neurons that co-express neurokinin receptor NK1 and glutamate receptors. J. Neurocytol. 33: 321-329
9. Kanai, Y., Nakazato, E., Fujiuchi, A., Hara, T., Imai, A. (2005) Involvement of an increased spinal TRPV1 sensitization through its up-regulation in mechanical allodynia of CCI rats. Neuropharmacology 49:977-984
10. Ma, Q. P. (2002) Expression of capsaicin receptor (VR1) by myelinated primary afferent neurons in rats. Neurosci. Lett. 319: 87-90
11. Michael, G. J., Priestley, J. V. (1999) Differential expression of the mRNA for the vanilloid receptor subtype 1 in cells of the adult rat dorsal root and nodose ganglia and its downregulation by axotomy. J. Neurosci. 19: 1844-1854
12. Ochoa, J. L., Yarnitsky, D. (1993) Mechanical hyperalgesias in neuropathic pain patients; dynamic and static subtypes. Ann. Neurol. 33: 465-472
13. Ossipov, M. H., Bian, D., Malan, T. P. Jr., Lai, J., Porreca, F. (1999) Lack of involvement of capsaicin-sensitive primary afferents in nerve-ligation injury induced tactile allodynia in rats. Pain 79: 127-133
14. Pomonis, J. D., Harrison, J. E., Mark, L., Bristol, D. R., Valenzano, K. J., Walker, K. (2003) N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl) tetrahydropyrazine-1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropathic pain. J. Pharmacol. Exp. Ther. 306: 387-393
15. Roh, D.H., Kim, H.W., Yoon, S.Y., Seo, H.S., Kwon, Y.B., Han, H.J., Beitz, A.J., Lee, J.H. (2007) Depletion of capsaicin sensitive afferents prevents lamina-dependent increases in spinal N-methyl-d-aspartate receptor subunit 1 expression and phosphorylation associated with thermal hyperalgesia in neuropathic rats. Eur. J. Pain. Oct 12; [Epub ahead of print]
16. Tominaga, M., Caterina, M. J., Malmberg, A. B., Rosen, T. A., Gilbert, H., Skinner, K., Raumann, B. E., Basbaum, A. I., Julius, D. (1998) The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21: 531-543
17. Valenzano, K. J., Grant, E. R., Wu, G., Hachicha, M., Schmid, L., Tafesse, L., Sun, Q., Rotshteyn, Y., Francis, J., Limberis, J., Malik, S., Whittemore, E. R., Hodges, D. (2003) N-(4-tertiary-butylphenyl)-4-(3- chloropyridin-2-yl)tetrahydropyrazine-1 (2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties. J. Pharmacol. Exp. Ther. 306: 377-386