(R)-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) blocks polymodal activation of transient receptor potential vanilloid 1 receptors in vitro and heat-evoked firing of spinal dorsal horn neurons in vivo

Journal of Pharmacology and Experimental Therapeutics

Volumn 326, Issue 3, 2008, Pages 879-888

  Surowy, Carol S ^a   Neelands, Torben R ^a   Bianchi, Bruce R ^a   McGaraughty, Steve ^a   El Kouhen, Rachid ^a   Han, Ping ^a   Chu, Katharine L ^a   McDonald, Heath A ^a   Vos, Melissa ^a   Niforatos, Wende ^a   Bayburt, Erol K ^a   Gomtsyan, Arthur ^a   Lee, Chih Hung ^a   Honore, Prisca ^a   Sullivan, James P ^a   Jarvis, Michael F ^a   Faltynek, Connie R ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(5 TERT BUTYL 2,3 DIHYDRO 1H INDEN 1 YL) 3 (1H INDAZOL 4 YL)UREA; ABT 102; ALLYL ISOTHIOCYANATE; ANANDAMIDE; CALCITONIN GENE RELATED PEPTIDE; CALCIUM ION; CAPSAICIN; CAPSAZEPINE; FREUND ADJUVANT; MENTHOL; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; INDAZOLE DERIVATIVE; TRPV1 RECEPTOR; UREA; VANILLOID RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM TRANSPORT; CELL STRAIN HEK293; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG STRUCTURE; HEAT; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INFLAMMATION; MALE; NERVE CELL CULTURE; NONHUMAN; NUCLEOTIDE SEQUENCE; PAIN; PATCH CLAMP; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; SENSORY NERVE; SPINAL CORD DORSAL HORN; ACTION POTENTIAL; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL LINE; CHEMISTRY; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; POSTERIOR HORN CELL; SPRAGUE DAWLEY RAT;

ACTION POTENTIALS; ANIMALS; CELL LINE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HOT TEMPERATURE; HUMANS; INDAZOLES; MALE; POSTERIOR HORN CELLS; RATS; RATS, SPRAGUE-DAWLEY; TRPV CATION CHANNELS; UREA;

EID: 53849138741     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.138511     Document Type: Article

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