A-995662 [(R)-8-(4-methyl-5-(4-(trifluoromethyl)phenyl)oxazol-2-ylamino)-1, 2,3,4-tetrahydronaphthalen-2-ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model

Pain

Volumn 150, Issue 2, 2010, Pages 319-326

  Puttfarcken, Pamela S ^a   Han, Ping ^a   Joshi, Shailen K ^a   Neelands, Torben R ^a   Gauvin, Donna M ^a   Baker, Scott J ^a   Lewis, La Geisha R ^a   Bianchi, Bruce R ^a   Mikusa, Joseph P ^a   Koenig, John R ^a   Perner, Richard J ^a   Kort, Michael E ^a   Honore, Prisca ^a   Faltynek, Connie R ^a   Kym, Philip R ^a   Reilly, Regina M ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

CGRP release; Neurotransmitter release; Nociception; Osteoarthritis; Spinal cord; TRPV1

Indexed keywords

8 (4 METHYL 5 (4 TRIFLUOROMETHYL)PHENYL)OXAZOL 2 YLAMINO) 1,2,3 4 TETRAHYDRONAPHTHALEN 2 OL; A 995662; ANTIRHEUMATIC AGENT; BRADYKININ; CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN; CELECOXIB; GLUTAMIC ACID; IODOACETIC ACID; NEUROPEPTIDE; SUBSTANCE P; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; IN VITRO STUDY; IN VIVO STUDY; KNEE OSTEOARTHRITIS; MALE; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT; REPEATED DRUG DOSE; SPINAL CORD;

ANALYSIS OF VARIANCE; ANIMALS; BRADYKININ; CALCITONIN GENE-RELATED PEPTIDE; GLUTAMIC ACID; OSTEOARTHRITIS, KNEE; PAIN; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; SUBSTANCE P; TETRAHYDRONAPHTHALENES; TRPV CATION CHANNELS;

EID: 77955304164     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2010.05.015     Document Type: Article

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