7-tert-butyl-6-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d] pyrimidin-4-one, a classic polymodal inhibitor of transient receptor potential vanilloid type 1 with a reduced liability for hyperthermia, is analgesic and ameliorates visceral hypersensitivity

Journal of Pharmacology and Experimental Therapeutics

Volumn 342, Issue 2, 2012, Pages 389-398

  Nash, Mark S ^a   McIntyre, Peter ^b   Groarke, Alex ^a   Lilley, Elliot ^a   Culshaw, Andrew ^a   Hallett, Allan ^a   Panesar, Moh ^a   Fox, Alyson ^a   Bevan, Stuart ^c  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

7 TERT BUTYL 6 (4 CHLORO PHENYL) 2 THIOXO 2,3 DIHYDRO 1H PYRIDO[2,3 D]PYRIMIDIN 4 ONE; DICLOFENAC; N [4 [6 [4 (TRIFLUOROMETHYL)PHENYL] 4 PYRIMIDINYLOXY]BENZOTHIAZOL 2 YL]ACETAMIDE; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST;

ABDOMINAL ALLODYNIA; ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORE TEMPERATURE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG MECHANISM; DRUG SELECTIVITY; DRUG TREATMENT FAILURE; HUMAN; HUMAN CELL; HYPERALGESIA; HYPERSENSITIVITY; IC 50; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RAT; TREATMENT RESPONSE; VISCERAL HYPERSENSITIVITY; VISCERAL PAIN;

ANALGESICS; ANIMALS; BENZOTHIAZOLES; BODY TEMPERATURE; BODY TEMPERATURE REGULATION; CAPSAICIN; CHO CELLS; CRICETINAE; FEVER; HUMANS; HYPERALGESIA; HYPERSENSITIVITY; MALE; MICE; MICE, INBRED C57BL; PYRIMIDINES; PYRIMIDINONES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; THIONES; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRPV CATION CHANNELS;

EID: 84864142720     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.112.191932     Document Type: Article

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