Recent insights into the complexity of Tank-binding kinase 1 signaling networks: The emerging role of cellular localization in the activation and substrate specificity of TBK1

FEBS Letters

Volumn 587, Issue 8, 2013, Pages 1230-1237

  Helgason, Elizabeth ^a   Phung, Qui T ^a   Dueber, Erin C ^a  

^a GENENTECH INC   (United States)

Author keywords

Activation; Autophosphorylation; Kinase; Localization; Signaling; Substrate specificity

Indexed keywords

ADAPTOR PROTEIN; TANK BINDING KINASE 1; UNCLASSIFIED DRUG;

AUTOPHAGY; CARCINOGENESIS; CELL FUNCTION; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME LOCALIZATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; HUMAN; INNATE IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; BINDING SITES; ENZYME ACTIVATION; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

EID: 84876059224     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2013.01.059     Document Type: Review

References (113)

1. J.D. Jordan, E.M. Landau, and R. Iyengar Signaling networks: the origins review of cellular multitasking Cell 2000
2. J.E. Dueber, B.J. Yeh, R.P. Bhattacharyya, and W.A. Lim Rewiring cell signaling: the logic and plasticity of eukaryotic protein circuitry Curr. Opin. Struct. Biol. 14 2004 690 699
3. R.P. Bhattacharyya, A. Reményi, B.J. Yeh, and W.A. Lim Domains, Motifs, and Scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits Annu. Rev. Biochem. 75 2006 655 680
4. W. Xiong, and J.E. Ferrell A positive-feedback-based bistable "memory module" that governs a cell fate decision Nature 426 2003 460 465
5. U.S. Bhalla, P.T. Ram, and R. Iyengar MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network Sci. Signal. 297 2002 1018
6. J.J. Tyson, K.C. Chen, and B. Novak Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell Curr. Opin. Cell Biol. 2003
7. S. Li, L. Wang, M. Berman, Y.-Y. Kong, and M.E. Dorf Mapping a dynamic innate immunity protein interaction network regulating type I interferon production Immunity 35 2011 426 440
8. J.-F. Clément, S. Meloche, and M.J. Servant The IKK-related kinases: from innate immunity to oncogenesis Cell Res. 18 2008 889 899
9. T.L.M. Thurston, G. Ryzhakov, S. Bloor, N. Muhlinen von, and F. Randow The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria Nat. Immunol. 10 2009 1215 1221
10. C.E. Gleason, A. Ordureau, R. Gourlay, J.S.C. Arthur, and P. Cohen Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β J. Biol. Chem. 286 2011 35663 35674
11. P. Wild, H. Farhan, D.G. Mcewan, S. Wagner, V.V. Rogov, N.R. Brady, B. Richter, J. Korac, O. Waidmann, C. Choudhary, V. Dotsch, D. Bumann, and I. Dikic Phosphorylation of the autophagy receptor optineurin restricts salmonella growth Science 333 2011 228 233
12. F. Randow How cells deploy ubiquitin and autophagy to defend their cytosol from bacterial invasion Autophagy 7 2011 304 309
13. M. Pilli, J. Arko-Mensah, M. Ponpuak, E. Roberts, S. Master, M.A. Mandell, N. Dupont, W. Ornatowski, S. Jiang, S.B. Bradfute, J.-A. Bruun, T.E. Hansen, T. Johansen, and V. Deretic TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation Immunity 37 2012 223 234
14. Y. Chien, and M.A. White Characterization of RalB-Sec5-TBK1 function in human oncogenesis Methods Enzymol. 438 2008 321 329
15. Y.-H. Ou, M. Torres, R. Ram, E. Formstecher, C. Roland, T. Cheng, R. Brekken, R. Wurz, A. Tasker, T. Polverino, S.-L. Tan, and M.A. White TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation Mol. Cell 41 2011 458 470
16. D.A. Barbie, P. Tamayo, J.S. Boehm, S.Y. Kim, S.E. Moody, I.F. Dunn, A.C. Schinzel, P. Sandy, E. Meylan, C. Scholl, S. Fröhling, E.M. Chan, M.L. Sos, K. Michel, C. Mermel, S.J. Silver, B.A. Weir, J.H. Reiling, Q. Sheng, P.B. Gupta, R.C. Wadlow, H. Le, S. Hoersch, B.S. Wittner, S. Ramaswamy, D.M. Livingston, D.M. Sabatini, M. Meyerson, R.K. Thomas, E.S. Lander, J.P. Mesirov, D.E. Root, D.G. Gilliland, T. Jacks, and W.C. Hahn Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 Nature 462 2009 108 112
17. A.C. Newman, C.L. Scholefield, A.J. Kemp, M. Newman, E.G. Mciver, A. Kamal, and S. Wilkinson TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling PLoS ONE 7 2012 e50672
18. X. Xie, D. Zhang, Zhao Bin, M.-K. Lu, M. You, G. Condorelli, C.-Y. Wang, and K.-L. Guan IκB kinase and TANK-binding kinase 1 activate AKT by direct phosphorylation Proc. Natl. Acad. Sci. USA 2011
19. F. Ikeda, C.M. Hecker, A. Rozenknop, R.D. Nordmeier, V. Rogov, K. Hofmann, S. Akira, V. Dötsch, and I. DIKIC Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes EMBO J. 26 2007 3451 3462
20. H. Häcker, and M. Karin Regulation and function of IKK and IKK-felated kinases Sci. Signal. 357 2006 1 20
21. X. Ma, E. Helgason, Q.T. Phung, C.L. Quan, R.S. Iyer, M.W. Lee, K.K. Bowman, M.A. Starovasnik, and E.C. Dueber Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation Proc. Natl. Acad. Sci. USA 109 2012 9378 9383
22. G. Xu, Y.-C. Lo, Q. Li, G. Napolitano, X. Wu, X. Jiang, M. Dreano, M. Karin, and H. Wu Crystal structure of inhibitor of κB kinase β Nature 472 2011 325 330
23. A. Goncalves, T. Bürckstümmer, E. Dixit, R. Scheicher, M.W. Górna, E. Karayel, C. Sugar, A. Stukalov, T. Berg, R. Kralovics, M. Planyavsky, K.L. Bennett, J. Colinge, and G. Superti-Furga Functional dissection of the TBK1 molecular network PLoS ONE 6 2011 e23971
24. G. Ryzhakov, and F. Randow SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK EMBO J. 26 2007 3180 3190
25. A.C.W. Pike, P. Rellos, F.H. Niesen, A. Turnbull, A.W. Oliver, S.A. Parker, B.E. Turk, L.H. Pearl, and S. Knapp Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites EMBO J. 27 2008 704 714
26. A.W. Oliver, S. Knapp, and L.H. Pearl Activation segment exchange: a common mechanism of kinase autophosphorylation? Trends Biochem. Sci. 32 2007 351 356
27. A.W. Oliver, A. Paul, K.J. Boxall, S.E. Barrie, G.W. Aherne, M.D. Garrett, S. Mittnacht, and L.H. Pearl Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange EMBO J. 25 2006 3179 3190
28. F. Hou, L. Sun, H. Zheng, B. Skaug, Q.-X. Jiang, and Z.J. Chen MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response Cell 146 2011 448 461
29. K. Clark, M. Peggie, L. Plater, R.J. Sorcek, E.R.R. Young, J.B. Madwed, J. Hough, E.G. Mciver, and P. Cohen Novel cross-talk within the IKK family controls innate immunity Biochem. J. 434 2011 93 104
30. P. Hof, S. Pluskey, S. Dhe-Paganon, M.J. Eck, and S.E. Shoelson Crystal structure of the tyrosine phosphatase SHP-2 Cell 92 1998 441 450
31. B. Kobe, J. Heierhorst, S.C. Feil, M.W. Parker, G.M. Benian, K.R. Weiss, and B.E. Kemp Giant protein kinases: domain interactions and structural basis of autoregulation EMBO J. 15 1996 6810 6821
32. F. Sicheri, and J. Kuriyan Structures of Src-family tyrosine kinases Curr. Opin. Struct. Biol. 7 1997 777 785
33. O. Hantschel, B. Nagar, S. Guettler, J. Kretzschmar, K. Dorey, J. Kuriyan, and G. Superti-Furga A myristoyl/phosphotyrosine switch regulates c-Abl Cell 112 2003 845 857
34. B. Nagar, O. Hantschel, M.A. Young, K. Scheffzek, D. Veach, W. Bornmann, B. Clarkson, G. Superti-Furga, and J. Kuriyan Structural basis for the autoinhibition of c-Abl tyrosine kinase Cell 1747 2003 859 871
35. D. Soulat, Tilmann Bürckstümmer, S. Westermayer, A. Goncalves, A. Bauch, A. Stefanovic, O. Hantschel, K.L. Bennett, T. Decker, and G. Superti-Furga The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response EMBO J. 27 2008 2135 2146
36. J.E. Hutti, M.A. Porter, A.W. Cheely, L.C. Cantley, X. Wang, D. Kireev, A.S. Baldwin, and W.P. Janzen Development of a high-throughput assay for identifying inhibitors of TBK1 and IKK -PLoS ONE 7 2012 e41494
37. J.A. Ubersax, and J.E. Ferrell Jr Mechanisms of specificity in protein phosphorylation Nat. Rev. Mol. Cell Biol. 8 2007 530 541
38. N.R. Brown, M.E. Noble, J.A. Endicott, and L.N. Johnson The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases Nat. Cell Biol. 1 1999 438 443
39. J.K. Holmes, and M.J. Solomon The role of Thr160 phosphorylation of Cdk2 in substrate recognition Eur. J. Biochem. 268 2001 4647 4652
40. P.D. Jeffrey, A.A. Russo, K. Polyak, E. Gibbs, J. Hurwitz, J. Massagué, and N.P. Pavletich Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex Nature 376 1995 313 320
41. B.A. Schulman, D.L. Lindstrom, and E. Harlow Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A Proc. Natl. Acad. Sci. USA 95 1998 10453 10458
42. M.E. Miller, and F.R. Cross Cyclin specificity: how many wheels do you need on a unicycle? J. Cell Sci. 2001
43. K.-Y. Cheng, M.E.M. Noble, V. Skamnaki, N.R. Brown, E.D. Lowe, L. Kontogiannis, K. Shen, P.A. Cole, G. Siligardi, and L.N. Johnson The role of the phospho-CDK2/cyclin a recruitment site in substrate recognition J. Biol. Chem. 281 2006 23167 23179
44. V. Archambault, N.E. Buchler, G.M. Wilmes, M.D. Jacobson, and F.R. Cross Two-faced cyclins with eyes on the targets Cell Cycle 4 2005 125 130
45. F.R. Cross, M. Yuste-Rojas, S. Gray, and M.D. Jacobson Specialization and targeting of B-type cyclins Mol. Cell 4 1999 11 19
46. K.A. Heichman, and J.M. Roberts Rules to replicate by Cell 1994
47. J. Sobczak-Thepot, F. Harper, Y. Florentin, F. Zindy, C. Brechot, and E. Puvion Localization of cyclin A at the sites of cellular DNA replication Exp. Cell Res. 206 1993 43 48
48. R.W. King, P.K. Jackson, and M.W. Kirschner Mitosis in transition review Cell 79 1994 563 571
49. M. Tanaka Cell-cycle-dependent regulation of human Aurora A transcription is mediated by periodic repression of E4TF1 J. Biol. Chem. 277 2002 10719 10726
50. S. Taguchi, K. Honda, K. Sugiura, A. Yamaguchi, K. Furukawa, and T. Urano Degradation of human Aurora-A protein kinase is mediated by hCdh1 FEBS Lett. 519 2002 59 65
51. C. Lindon, and J. Pines Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells J. Cell Biol. 164 2004 233 241
52. S. Floyd, J. Pines, and C. Lindon APC/C Cdh1 targets aurora kinase to control reorganization of the mitotic spindle at anaphase Curr. Biol. 18 2008 1649 1658
53. T. Sardon, R.A. Pache, A. Stein, H. Molina, I. Vernos, and P. Aloy Uncovering new substrates for Aurora A kinase EMBO Rep. 2010 1 8
54. R. Bayliss, T. Sardon, I. Vernos, and E. Conti Structural basis of Aurora-A activation by TPX2 at the mitotic spindle Mol. Cell 12 2003 851 862
55. M. Giubettini, I.A. Asteriti, J. Scrofani, M. De Luca, C. Lindon, P. Lavia, and G. Guarguaglini Control of Aurora-A stability through interaction with TPX2 J. Cell Sci. 124 2010 113 122
56. M. De Luca, P. Lavia, and G. Guarguaglini A functional interplay between Aurora-A, Plk1 and TPX2 at spindle poles: Plk1 controls centrosomal localization of Aurora-A and TPX2 spindle association Cell Cycle 5 2006 296 303
57. E.L. Rudashevskaya, R. Sacco, K. Kratochwill, M.L. Huber, M. Gstaiger, G. Superti-Furga, and K.L. Bennett A method to resolve the composition of heterogeneous affinity-purified protein complexes assembled around a common protein by chemical cross-linking, gel electrophoresis and mass spectrometry Nat. Protoc. 8 2012 75 97
58. C.H. Chang, L.C. Lai, H.C. Cheng, K.R. Chen, Y.Z. Syue, H.C. Lu, W.Y. Lin, S.H. Chen, H.S. Huang, A.L. Shiau, H.Y. Lei, J. Qin, and P. Ling TBK1-associated protein in endolysosomes (TAPE) is an innate immune regulator modulating the TLR3 and TLR4 signaling pathways J. Biol. Chem. 286 2011 7043 7051
59. X.-Y. Liu, W. Chen, B. Wei, Y.-F. Shan, and C. Wang IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1 J. Immunol. 187 2011 2559 2568
60. L. Wang, S. Li, and M.E. Dorf NEMO binds ubiquitinated TANK-binding kinase 1 (TBK1) to regulate innate immune responses to RNA viruses PLoS ONE 7 2012 e43756
61. B. Schröfelbauer, S. Polley, M. Behar, G. Ghosh, and A. Hoffmann NEMO Ensures Signaling Specificity of the Pleiotropic IKKβ by Directing Its Kinase Activity toward IκBα Mol. Cell. 2012
62. W. Zeng, M. Xu, S. Liu, L. Sun, and Z.J. Chen Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3 Mol. Cell 36 2009 315 325
63. J.S. Gatot, R. Gioia, T.L. Chau, F. Patrascu, M. Warnier, P. Close, J.P. Chapelle, E. Muraille, K. Brown, U. Siebenlist, J. Piette, E. Dejardin, and A. Chariot Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKK-dependent Lys63-linked polyubiquitination and phosphorylation of TANK/I-TRAF J. Biol. Chem. 282 2007 31131 31146
64. C. Wang, T. Chen, J. Zhang, M. Yang, N. Li, X. Xu, and X. Cao The E3 ubiquitin ligase Nrdp1 "preferentially" promotes TLR-mediated production of type I interferon Nat. Immunol. 10 2009 744 752
65. T. Chau, R. Gioia, J. Gatot, and F. Patrascu Are the IKKs and IKK-related kinases TBK1 and IKK-similarly activated? Trends Biochem. Sci. 2008
66. Z.J. Chen Ubiquitination in signaling to and activation of IKK Immunol. Rev. 246 2012 95 106
67. M. Zhang, L. Wang, X. Zhao, K. Zhao, H. Meng, W. Zhao, and C. Gao TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1 J. Exp. Med. 209 2012 1703 1711
68. W. Zeng, L. Sun, X. Jiang, X. Chen, F. Hou, A. Adhikari, M. Xu, and Z.J. Chen Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity Cell 141 2010 315 330
69. C. Castanier, N. Zemirli, A. Portier, D. Garcin, N. Bidère, A. Vazquez, and D. Arnoult MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors BMC Biol. 10 2012 44
70. L. Sun, Y. Xing, X. Chen, Y. Zheng, Y. Yang, D.B. Nichols, M.A. Clementz, B.S. Banach, K. Li, S.C. Baker, and Z. Chen Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling PLoS ONE 7 2012 e30802
71. D. Wang, L. Fang, P. Li, L. Sun, and J. Fan The Leader Proteinase of Foot-and-Mouth Disease Virus Negatively Regulates the Type I Interferon Pathway by Acting as a Viral Deubiquitinase J. Virol. 2011
72. S. Charoenthongtrakul, L. Gao, K. Parvatiyar, D. Lee, and E.W. Harhaj RING finger protein 11 targets TBK1/IKKi kinases to inhibit antiviral signaling PLoS ONE 8 2013 e53717
73. W.J. van Zuylen, P. Doyon, J.-F. Clément, K.A. Khan, L.M. D'Ambrosio, F. Dô, M. St-Amant-Verret, T. Wissanji, G. Emery, A.-C. Gingras, S. Meloche, and M.J. Servant Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity PLoS Pathog. 8 2012 e1002747
74. G. Zhu, and Y. Liu Protein kinase specificity: a strategic collaboration between kinase peptide specificity and substrate recruitment Cell Cycle 4 2005 52 56
75. A.P. Won, J.E. Garbarino, and W.A. Lim Recruitment interactions can override catalytic interactions in determining the functional identity of a protein kinase Proc. Natl. Acad. Sci. USA 108 2011 9809 9814
76. F. Pincet Membrane recruitment of scaffold proteins drives specific signaling PLoS ONE 2 2007 e977
77. S.H. Park, A. Zarrinpar, and W.A. Lim Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms Sci. Signal. 299 2003 1061
78. V.M. Draviam, S. Orrechia, M. Lowe, R. Pardi, and J. Pines The localization of human cyclins B1 and B2 determines Cdk1 substrate specificity and neither enzyme requires Mek to disassemble the Golgi apparatus J. Cell Biol. 152 2001 945 958
79. M.-H.J. Ng, T.-H. Ho, K.-H. Kok, K.-L. Siu, J. Li, and D.-Y. Jin MIP-T3 is a negative regulator of innate type I IFN response J. Immunol. 187 2011 6473 6482
80. H. Chen, H. Sun, F. You, W. Sun, X. Zhou, L. Chen, J. Yang, Y. Wang, H. Tang, Y. Guan, W. Xia, J. Gu, H. Ishikawa, D. Gutman, G. Barber, Z. Qin, and Z. Jiang Activation of STAT6 by STING is critical for antiviral innate immunity Cell 147 2011 436 446
81. L. Gao, H. Coope, S. Grant, A. Ma, S.C. Ley, and E.W. Harhaj ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling J. Biol. Chem. 286 2011 36592 36602
82. Z. Zhang, B. Yuan, M. Bao, N. Lu, T. Kim, and Y.-J. Liu The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells Nat. Immunol. 12 2011 959 965
83. S. Chattopadhyay, M. Yamashita, and Y. Zhang The IRF-3/Bax-mediated apoptotic pathway, activated by viral cytoplasmic RNA and DNA, inhibits virus replication J. Virol. 2011
84. X.-Y. Liu, B. Wei, H.-X. Shi, Y.-F. Shan, and C. Wang Tom70 mediates activation of interferon regulatory factor 3 on mitochondria Cell Res. 20 2010 994 1011
85. K. Parvatiyar, Z. Zhang, R.M. Teles, S. Ouyang, Y. Jiang, S.S. Iyer, S.A. Zaver, M. Schenk, S. Zeng, W. Zhong, Z.-J. Liu, R.L. Modlin, Y.-J. Liu, and G. Cheng The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response Nat. Immunol. 13 2012 1155 1161
86. S. Charoenthongtrakul, L. Gao, and E.W. Harhaj The NLRP4-DTX4 axis: a key suppressor of TBK1 and innate antiviral signaling Cell. Mol. Immunol. 9 2012 431 433
87. K.R. Chen, C.H. Chang, C.Y. Huang, C.Y. Lin, W.Y. Lin, Y.C. Lo, C.Y. Yang, E.W. Hsing, L.F. Chen, S.R. Shih, A.L. Shiau, H.Y. Lei, T.H. Tan, and P. Ling TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity J. Biol. Chem. 287 2012 32216 32221
88. J. Cui, Y. Li, L. Zhu, D. Liu, Z. Songyang, H.Y. Wang, and R.-F. Wang NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4 Nat. Immunol. 13 2012 387 395
89. Q. Liang, B. Fu, F. Wu, X. Li, Y. Yuan, and F. Zhu ORF45 of Kaposi's sarcoma-associated herpesvirus inhibits phosphorylation of interferon regulatory factor 7 by IKK and TBK1 as an alternative substrate J. Virol. 86 2012 10162 10172
90. J. Zhang, M.M. Hu, Y.Y. Wang, and H.-B. Shu TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination J. Biol. Chem. 287 2012 28646 28655
91. T. Yu, Y.-S. Yi, Y. Yang, J. Oh, D. Jeong, and J.Y. Cho The pivotal role of tbk1 in inflammatory responses mediated by macrophages Mediators Inflamm. 2012 2012 979105
92. B.J. Ferguson, D.S. Mansur, N.E. Peters, H. Ren, and G.L. Smith DNA-PK is a DNA sensor for IRF-3-dependent innate immunity eLife 1 2012
93. S. Seo, F. Solivan-Timpe, B.R. Roos, A.L. Robin, E.M. Stone, Y.H. Kwon, W.L.M. Alward, and J.H. Fingert Identification of proteins that interact with TANK binding kinase 1 and testing for mutations associated with glaucoma Curr. Eye Res. 2013 1 6
94. J. Korac, V. Schaeffer, I. Kovacevic, A.M. Clement, B. Jungblut, C. Behl, J. Terzic, and I. DIKIC Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates J. Cell Sci. 2012
95. S.M. Joung, Z.-Y. Park, S. Rani, O. Takeuchi, S. Akira, and J.Y. Lee Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1 J. Immunol. 186 2011 499 507
96. E.G. Mciver, J. Bryans, K. Birchall, J. Chugh, T. Drake, S.J. Lewis, J. Osborne, E. Smiljanic-Hurley, W. Tsang, A. Kamal, A. Levy, M. Newman, D. Taylor, J.S.C. Arthur, K. Clark, and P. Cohen Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKK kinases Bioorg. Med. Chem. Lett. 22 2012 7169 7173
97. T. Wang, M.A. Block, S. Cowen, A.M. Davies, E. Devereaux, L. Gingipalli, J. Johannes, N.A. Larsen, Q. Su, J.A. Tucker, D. Whitston, J. Wu, H.-J. Zhang, M. Zinda, and C. Chuaqui Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKK kinases Bioorg. Med. Chem. Lett. 22 2012 2063 2069
98. F. Qu, H. Gao, S. Zhu, P. Shi, Y. Zhang, Y. Liu, B. Jallal, Y. Yao, Y. Shi, and Y. Qian TRAF6-dependent Act1 phosphorylation by the IκB kinase-related kinases suppresses interleukin-17-induced NF-κB activation Mol. Cell. Biol. 32 2012 3925 3937
99. J. Harris, S. Olière, S. Sharma, Q. Sun, R. Lin, J. Hiscott, and N. Grandvaux Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon J. Immunol. 177 2006 2527 2535
100. Y. Tojima, A. Fujimoto, M. Delhase, Y. Chen, S. Hatakeyama, K. Nakayama, Y. Kaneko, Y. Nimura, N. Motoyama, K. Ikeda, M. Karin, and M. Nakanishi NAK is an IkappaB kinase-activating kinase Nature 404 2000 778 782
101. B. Bergstroem, I.B. Johnsen, T.T. Nguyen, L. Hagen, G. Slupphaug, L. Thommesen, and M.W. Anthonsen Identification of a novel in vivo virus-targeted phosphorylation site in interferon regulatory factor-3 (IRF3) J. Biol. Chem. 285 2010 24904 24914
102. T. Saitoh, A. Tun-Kyi, A. Ryo, M. Yamamoto, G. Finn, T. Fujita, S. Akira, N. Yamamoto, K.P. Lu, and S. Yamaoka Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1 Nat. Immunol. 7 2006 598 605
103. D. Panne, S.M. McWhirter, T. Maniatis, and S.C. Harrison Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch J. Biol. Chem. 282 2007 22816 22822
104. S. Paz, Q. Sun, P. Nakhaei, R. Romieu-Mourez, D. Goubau, I. Julkunen, R. Lin, and J. Hiscott Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway Cell. Mol. Biol. 52 2006 17 28
105. B.R. tenOever, S. Sharma, W. Zou, Q. Sun, N. Grandvaux, I. Julkunen, H. Hemmi, M. Yamamoto, S. Akira, W.-C. Yeh, R. Lin, and J. Hiscott Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity J. Virol. 78 2004 10636 10649
106. J. Jin, Y. Xiao, J.-H. Chang, J. Yu, H. Hu, R. Starr, G.C. Brittain, M. Chang, X. Cheng, and S.-C. Sun The kinase TBK1 controls IgA class switching by negatively regulating non-canonical NF-κB signaling Nat. Immunol. 13 2012 1101 1109
107. H. Buss Constitutive and interleukin-1-inducible phosphorylation of p65 NF- B at serine 536 is mediated by multiple protein kinases including I B kinase (IKK)-IKK IKK TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription J. Biol. Chem. 279 2004 55633 55643
108. H. Smith, X.Y. Liu, L. Dai, E.T.H. Goh, A.T. Chan, J. Xi, C.C. Seh, I.A. Qureshi, J. Lescar, C. Ruedl, R. Gourlay, S. Morton, J. Hough, E.G. Mciver, P. Cohen, and P.C.F. Cheung The role of TBK1 and IKK in the expression and activation of Pellino 1 Biochem. J. 434 2011 537 548
109. B. Zhong, Y. Yang, S. Li, Y.-Y. Wang, Y. Li, F. Diao, C. Lei, X. He, L. Zhang, P. Tien, and H.-B. Shu The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation Immunity 29 2008 538 550
110. J. Zha, K.-J. Han, L.-G. Xu, W. He, Q. Zhou, D. Chen, Z. Zhai, and H.-B. Shu The Ret finger protein inhibits signaling mediated by the non-canonical and canonical IkappaB kinase family members J. Immunol. 176 2006 1072 1080
111. P. Nakhaei, Q. Sun, M. Solis, T. Mesplede, E. Bonneil, S. Paz, R. Lin, and J. Hiscott IκB kinase -dependent phosphorylation and degradation of X-linked inhibitor of apoptosis sensitizes cells to virus-induced apoptosis J. Virol. 86 2012 726 737
112. N. Dzamko, F. Inesta-Vaquera, J. Zhang, C. Xie, H. Cai, S. Arthur, L. Tan, H. Choi, N. Gray, P. Cohen, P. Pedrioli, K. Clark, and D.R. Alessi The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during toll-like receptor signaling PLoS ONE 7 2012 e39132
113. M.C. Muñoz, J.F. Giani, M.A. Mayer, J.E. Toblli, D. Turyn, and F.P. Dominici TANK-binding kinase 1 mediates phosphorylation of insulin receptor at serine residue 994: a potential link between inflammation and insulin resistance J. Endocrinol. 201 2009 185 197