The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition

Journal of Biological Chemistry

Volumn 281, Issue 32, 2006, Pages 23167-23179

  Cheng, Kin Yip ^a   Noble, Martin E M ^a   Skamnaki, Vicky ^a   Brown, Nick R ^a   Lowe, Ed D ^a   Kontogiannis, Luke ^a   Shen, Kui ^b   Cole, Philip A ^b   Siligardi, Giuliano ^c   Johnson, Louise N ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DIAMOND LIGHT SOURCE LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CATALYSIS; MOLECULAR BIOLOGY; POLYPEPTIDES; SUBSTRATES; X RAY ANALYSIS;

BISPEPTIDE INHIBITOR; PHOSPHO-CDK2; SUBSTRATE RECOGNITION;

ENZYMES;

ADENOSINE TRIPHOSPHATE; CELL CYCLE PROTEIN 6; CYCLIN A; CYCLIN DEPENDENT KINASE 2; HEPTAPEPTIDE;

ARTICLE; CIRCULAR DICHROISM; COVALENT BOND; ENZYME SUBSTRATE; KINETICS; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE; X RAY ANALYSIS;

ADENOSINE TRIPHOSPHATE; AMINO ACID MOTIFS; CATALYTIC DOMAIN; CYCLIN A; CYCLIN-DEPENDENT KINASE 2; HUMANS; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY;

EID: 33747359918     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M600480200     Document Type: Article

References (63)

1. Manning, G., Whyte, D. B., Martinez, R., Hunter, T., and Sudarsanan, S. (2002) Science 298, 1912-1934
2. Kemp, B. E., Bylund, D. B., Huang, T. S., and Krebs, E. G. (1975) Proc. Natl. Acad. Sci. U. S. A. 72, 3448-3452
3. Zhu, G., Fujii, K., Belkina, N., Liu, Y., James, M., Herrero, J., and Shaw, S. (2005) J. Biol. Chem. 280, 10743-10748
4. Harper, J. W., and Adams, P. D. (2001) Chem. Rev. 101, 2511-2526
5. Ewen, M. E., Faha, B., Harlow, E., and Livingston, D. M. (1992) Science 255, 85-87
6. Faha, B., Ewen, M., Tsai, L.-H., Livingston, D., and Harlow, E. (1992) Science 255, 87-90
7. Lees, E., Faha, B., Dulic, V., Reed, S. I., and Harlow, E. (1992) Genes Dev. 6, 1874-1885
8. Hannon, G. J., Demetrick, D., and Beach, D. (1993) Genes Dev. 7, 2378-2391
9. Zhu, L., Harlow, E., and Dynlacht, B. D. (1995) Genes and Dev. 9, 1740-1752
10. Chen, J., Saha, P., Kornbluth, S., Dynlacht, B. D., and Dutta, A. (1996) Mol. Cell. Biol. 16, 4673-4682
11. Wohlschlegel, J. A., Dwyer, B. T., Takeda, D. Y., and Dutta, A. (2001) Mol. Cell Biol. 21, 4868-4874
12. Sorensen, C. S., Lukas, C., Kramer, E. R., Peters, J. M., Bartek, J., and Lukas, J. (2001) Mol. Cell Biol. 21, 3692-3703
13. Zhao, J., Dynlacht, B., Imai, T., Hori, T.-A., and Harlow, E. (1998) Genes Dev. 12, 456-461
14. Esashi, F., Christ, N., Gannon, J., Liu, Y., Hunt, T., Jasin, M., and West, S. C. (2005) Nature 434, 598-604
15. Russo, A. A., Jeffrey, P. D., Patten, A. K., Massague, J., and Pavletich, N. P. (1996) Nature 382, 325-331
16. Lowe, E. D., Tews, I., Cheng, K. Y., Brown, N. R., Gul, S., Noble, M. E., Gamblin, S. J., and Johnson, L. N. (2002) Biochemistry 41, 15625-15634
17. Honda, R., Lowe, E. D., Dubinina, E., Skamnaki, V. T., Cook, A., Brown, N. R., and Johnson, L. N. (2005) EMBO J. 24, 452-463
18. Brown, N. R., Noble, M. E. M., Endicott, J. A., and Johnson, L. N. (1999) Nature Cell Biology 1, 438-443
19. Schulman, B., Lindstrom, D. L., and Harlow, E. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 10453-10458
20. Adams, P. D., Li, X., Sellars, W. R., Baker, K. B., Leng, X., Harper, J. W., Taya, Y., and Kaelin, W. G. (1999) Mol. Cell Biol. 19, 1068-1080
21. Driscoll, B., T'ang, A., Hu, Y.-H., Yan, C. L., Fu, Y., Luo, Y., Wu, K. J., Wen, S., Shi, X.-H., Barsky, L., Weinberg, K., Murphree, A. L., and Fung, Y. K. (1999) J. Biol. Chem. 274, 9463-9471
22. Luciani, M. G., Hutchins, J. R. A., Zheleva, D., and Hupp, T. R. (2000) J. Mol. Biol. 300, 503-518
23. Guida, P., and Zhu, L. (1999) Biochim. Biophys. Res. Commun. 258, 596-604
24. Leng, X., Noble, M. E. M., Adams, P. D., Qin, J., and Harper, J. W. (2002) Mol. Cell Biol. 22, 2242-2254
25. Stevenson-Lindert, L. M., Fowler, P., and Lew, J. (2003) J. Biol. Chem. 278, 50956-50960
26. Andrews, M. J., McInnes, C., Kontopidis, G., Innes, L., Cowan, A., Plater, A., and Fischer, P. M. (2004) Org. Biomol. Chem. 2, 2735-2741
27. Chen, Y.-N. P., Sharma, S. K., Ramsey, T. M., Liang, L., Martin, M. S., Baker, K., Adams, P. D., Bair, K. W., and Kaelin, W. G. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 4325-4329
28. Mendoza, N., Fong, S., Marsters, J., Koeppen, H., Schwall, R., and Wickramasinghe, D. (2003) Cancer Res. 63, 1020-1024
29. Takeda, D. Y., Wohlschlegel, J. A., and Dutta, A. (2001) J. Biol. Chem. 276, 1993-1997
30. Songyang, Z., Blechner, S., Hoagland, N., Hoekstra, M. F., Piwica-Worms, H., and Cantley, L. C. (1994) Curr. Biol. 4, 973-982
31. Ablooglu, A. J., Till, J. H., Kim, K., Parang, K., Cole, P. A., Hubbard, S. R., and Kohanski, R. A. (2000) J. Biol. Chem. 275, 30394-30398
32. Parang, K., Till, J. H., Ablooglu, A. J., Kohanski, R. A., Hubbard, S. R., and Cole, P. A. (2001) Nat. Structural Biology 8, 37-41
33. Hines, A. C., and Cole, P. A. (2004) Bioorg. Med. Chem. Lett. 14, 2951-2954
34. Leslie, A. G. W. (1992) MOSFLM. Joint CCP4 and ESF-EACMB Newsletter on Protein Crystallography, Daresbury Laboratory, Warrington
35. CCP4 (1994) Acta Crystallogr. Sect. D 50, 760-763
36. Murshudov, G. N., Vagen, A. A., and Dodson, E. J. (1997) Acta Crystallogr. Sect. D 53, 240-255
37. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. Sect. A 47, 110-119
38. Brünger, A. T. (1996) X-PLOR: Version 3.8; A System for Protein Crystallography and NMR, Yale University Press, New Haven
39. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
40. Adams, J. A., McGlone, M. L., Gibson, R., and Taylor, S. S. (1995) Biochemistry 34, 2447-2454
41. Cook, F. N., Neville, M. E., Vrana, K. E., Hartl, F. T., and Roskowski, R. (1982) Biochemistry 21, 5794-5799
42. Leatherbarrow, R. J. (1992) GrafFit Version 3.0, Erithakus Software, Staines, UK
43. Gasteiger, E., Hoogland, C., Gattiker, A., Duvaud, S., Wiklkins, M. R., Appel, R. D., and Bairoch, A. (2005) in Protein Identification and Anaylsis Tools on the ExPASy Server (Walker, J. M., ed) Humana Press
44. Siligardi, G., Panaretou, B., Meyer, P., Singh, S., Woolfson, D. N., Piper, P. W., Pearl, L. H., and Prodromou, C. (2002) J. Biol. Chem. 277, 20151-20159
45. Cook, A., Lowe, E. D., Chrysina, E. D., Skamnaki, V. T., Oikonomkaos, N. G., and Johnson, L. N. (2002) Biochemistry 41, 7301-7311
46. Hubbard, S. R. (1997) EMBO J. 16, 5572-5581
47. Adams, P. D., Sellers, W. R., Sharma, S. K., Wu, A. D., Nalin, C. M., and Kaelin, W. G., Jr. (1996) Mol. Cell Biol. 16, 6623-6633
48. Siligardi, G., and Hussain, R. (1998) Enantiomer 3, 77-87
49. Brown, N. R., Noble, M. E. M., Lawrie, A. M., Morris, M. C., Tunnah, P., Divita, G., Johnson, L. N., and Endicott, J. A. (1999) J. Biol. Chem. 274, 8746-8756
50. Mailand, N., and Diffley, J. F. (2005) Cell 122, 915-926
51. Jenks, W. P. (1981) Biochemistry 18, 4046-4050
52. Song, H., Hanlan, N., Brown, N. R., Noble, M. E. M., Johnson, L. N., and Barford, D. (2001) Mol. Cell 7, 615-626
53. Lolli, G., Lowe, E. D., Brown, N. R., and Johnson, L. N. (2004) Structure (Camb.) 12, 2067-2079
54. Aubol, B. E., Ungs, L., Lukasiewicz, R., Ghosh, G., and Adams, J. A. (2004) J. Biol. Chem. 279, 30182-30188
55. Lieser, S. A., Shindler, C., Aubol, B. E., Lee, S., Sun, G., and Adams, J. A. (2005) J. Biol. Chem. 280, 7769-7776
56. Biondi, R. M., and Nebreda, A. R. (2003) Biochem. J. 372, 1-13
57. Lee, T., Hoofnagle, A. N., Kabuyama, Y., Stroud, J., Min, X., Goldsmith, E. J., Chen, L., Resing, K. A., and Ahn, N. G. (2004) Mol. Cell 14, 43-55
58. Kim, C., Xuong, N. H., and Taylor, S. S. (2005) Science 307, 690-696
59. Qiao, F., Harada, B., Song, H., Whitelegge, J., Courey, A. J., and Bowie, J. U. (2006) EMBO J. 25, 70-79
60. Fenton, J. W. (1981) Ann. N. Y. Acad. Sci. 370, 468-495
61. Stubbs, M. T., and Bode, W. (1993) Thrombosis Res. 69, 1-58
62. Fuentes-Prior, P., Iwanaga, Y., Huber, R., Pagila, R., Rumennik, G., Seto, M., Morser, J., Light, D. R., and Bode, W. (2000) Nature 404, 518-525
63. Pechik, I., Madrazo, J., Mosesson, M. W., Hernandez, I., Gilliland, G. L., and Medved, L. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 2718-2723